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PLCE1 Gene in Esophageal Cancer and Interaction with Environmental Factors

  • Guo, Li-Yan;Zhang, Shen;Suo, Zhen;Yang, Chang-Shuang;Zhao, Xia;Zhang, Guo-An;Hu, Die;Ji, Xing-Zhao;Zhai, Min
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2745-2749
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    • 2015
  • Objective: To study the PLCE1 gene rs2274223 polymorphism with regard to esophageal cancer and its interaction with diet, lifestyle, psychological and environmental factors in Southwest Shandong province. Materials and Methods: A case series study (case-case) was conducted. Questionnaire data were collected and 3 ml-5ml venous blood was drawn for DNA extraction among the qualified research subjects. PLCE1 gene polymorphism was detected after PCR amplification of DNA. SPSS 13.0 software was used for statistical analysis of the data. Results: The three genotypes A/A, A/G and G/G PLCE1 gene rs2274223 was 31, 16 and 4 cases, accounting for 60.8%, 31.4%, 0.08% respectively. The difference of three genotypes (AA/GA/GG) proportion between negative and positive family history of patients was statistically significant, ${\chi}^2=6.213$, p=0.045. There was no statistically significant relationship between PLCE1 gene rs2274223 polymorphism and smoking, drinking, ${\chi}^2=0.119$, p=0.998, and ${\chi}^2=1.727$, p=0.786. There was no linkage of the three rs2274223 PLCE1 gene genotypes (AA/GA/GG) proportion with eating fried, pickled, hot, mildew, overnight, smoked, excitant food, eat speed, salt taste or not (p>0.05). or with living environment pollution and nine risk factors of occupational exposure (p>0.05). There was no statistically significant difference in TS scores between different genotype of rs2274223 PLCE1 gene. Conclusions: The PLCE1 rs2274223 polymorphism has a relationship with family history of esophageal cancer, but does not have any significant association with age, gender, smoking, alcohol drinking, food hygiene, eating habits, living around the environment and occupation in cases.

BER Performance of an Offset Stacked Spreading CDMA System Based on Orthogonal Complementary Codes (직교 상보코드 기반의 옵셋누적 확산 CDMA 시스템의 비트오율 성능)

  • Kim, Myoung-Jin
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.46 no.3
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    • pp.1-8
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    • 2009
  • DS-CDMA system has very low bandwidth efficiency, hence it is difficult to maintain high spreading gain for high speed data transmission. Offset stacked spreading CDMA(OSS-CDMA) is a transmission scheme where spreading codes with chip offsets are overlapped, then transmitted. This kind of system requires a code set that guarantees orthogonality between codes in the set of any cjip offset. An orthogonal complementary code set has a property that the crosscorrelation function between codes in the group is zero for all shifts, hence it can be used for an OSS-CDMA system. In an OCC-OSS CDMA system each user is assigned an orthogonal complementary code group. User data bit is spread by the given codes and overlapped, and the code sequences are transmitted with multicarrier. However, the offset stacked spread sequences are multilevel, and the number of symbol levels is increases as the spreading efficiency is increased. When the OSS sequence is transmitted with MPSK mapping, the signal constellation becomes dense, and the system is easily affected by channel impairments. In this paper, we propose a level clipping scheme on OSS sequence before MPSK modulated. Simulations have been carried out to investigate the BER performance of the OCC-OSS CDMA system in AWGN environment. The results show that proposed scheme outperform the scheme without level clipping.

A Study on the Development Plan to Increase Supplement of Voice over Internet Protocol (인터넷전화의 보급 확산을 위한 발전방안에 관한 연구)

  • Park, Jae-Yong
    • Management & Information Systems Review
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    • v.28 no.3
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    • pp.191-210
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    • 2009
  • Internet was first designed only for sending data, but as the time passed, internet started to evolve into a broadband multi-media web that is capable of transmitting sound, video, high-capacity data and more due to the demands of internet users and the rapid changing internet-communication technology. Domestically, in January, 2000 Saerom C&T, launched a free VoIP, but due to limited ways of conversation(PC to PC) and absence of a revenue model, and bad speech quality, it had hit it's growth limit. This research studied VoIP based on technological enhancement in super-speed internet. According to IDC, domestic internet market's size was 80,800 million in 2008, and it formed a percentage of 12.5% out of the whole sound-communication market. in case of VoIP, it is able to maximize it's profit by connecting cable and wireless network, also it has a chance of becoming firm-concentrated monopoly market by fusing with IPTV. Considering the fact that our country is insignificant in MVNO revitalization, regulating organizations will play a significant roll on regulating profit between large and small businesses. Further research should be done to give VoIP a secure footing to prosper and become popularized.

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Formation of a large-scale quasi-circular flare ribbon enclosing three-ribbon through two-step eruptive flares

  • Lim, Eun-Kyung;Yurchyshyn, Vasyl;Kumar, Pankaj;Cho, Kyuhyoun;Kim, Sujin;Cho, Kyung-Suk
    • The Bulletin of The Korean Astronomical Society
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    • v.41 no.2
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    • pp.42.1-42.1
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    • 2016
  • The formation process and the dynamical properties of a large-scale quasi-circular flare ribbon were investigated using the SDO AIA and HMI data along with data from RHESSI and SOT. Within one hour time interval, two subsequent M-class flares were detected from the NOAA 12371 that had a ${\beta}{\gamma}{\delta}$ configuration with one bipolar sunspot group in the east and one unipolar spot in the west embedded in a decayed magnetic field. Earlier M2.0 flare was associated with a coronal loop eruption, and a two-ribbon structure formed within the bipolar sunspot group. On the other hand, the later M2.6 flare was associated with a halo CME, and a quasi-circular ribbon developed encircling the full active region. The observed quasi-circular ribbon was strikingly large in size spanning 650" in north-south and 500" in east-west direction. It showed the well-known sequential brightening in the clockwise direction during the decay phase of the M2.6 flare at the estimated speed of 160.7 km s-1. The quasi-circular ribbon also showed the radial expansion, especially in the southern part. Interestingly, at the time of the later M2.6 flare, the third flare ribbon parallel to the early two-ribbon structure also developed near the unipolar sunspot, then showed a typical separation in pair with the eastern most ribbon of the early two ribbons. The potential field reconstruction based on the PFSS model showed a fan shaped magnetic configuration including fan-like field lines stemming from the unipolar spot and fanning out toward the background decayed field. This large-scale fan-like field overarched full active region, and the footpoints of fan-like field lines were co-spatial with the observed quasi-circular ribbon. From the NLFF magnetic field reconstruction, we confirmed the existence of a twisted flux rope structure in the bipolar spot group before the first M2.0 flare. Hard X-ray emission signatures were detected at the site of twisted flux rope during the pre-flare phase of the M2.0 flare. Based on the analysis of both two-ribbon structure and quasi-circular ribbon, we suggest that a tether-cutting reconnection between sheared arcade overarching the twisted flux rope embedded in a fan-like magnetic field may have triggered the first M2.0 flare, then secondary M2.6 flare was introduced by the fan-spine reconnection because of the interaction between the expanding field and the nearby quasi-null and formed the observed large-scale quasi-circular flare ribbon.

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A Study on a Method for Composing a Portfolio for REITs Investment Using Markowitz's Portfolio Model (마코위츠 포트폴리오 모형을 사용한 리츠 투자 포트폴리오 구성방법에 관한 연구)

  • Lee, Chi-Joo;Lee, Ghang;Won, Jong-Sung;Ham, Sung-Ili
    • Korean Journal of Construction Engineering and Management
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    • v.11 no.2
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    • pp.54-63
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    • 2010
  • Domestic construction companies suffer from the difficulty in financing in the wake of economic slump at home and abroad. In the periods of this economic slump, which hit the nation REITs, the facilitator of fluid financing and the stimulating of construction economic, has increasingly been expanded since its introduction in 2001. But, REITs relatively falls behinds any other nations, in terms of its growth speed and marketing volume. The purpose of this research thesis is to suggest the method for composing a portfolio using Markowitz portfolio selection models for stimulating REITs. Main contents are as follows. First, the thesis made the comparative analysis on profit increase in REITs investment in application of models by Markowitz and REITs derivatives from 2007/07/03 to 2008/07/21 during investment analysis periods. The result showed that total profits by Markowitz model amounted to about 10 percent higher than average profits of REITs derivatives. Second, this thesis made the analysis on sensitivity of data-gathering and portfolio change periods of the existing profits, in order to measure the both periods and yield optimum profits. The six month data-collecting periods of profits accounted for some 16% higher profits than profits of REITs derivatives. In case when the two week periods of portfolio change accounted for some 11% higher profits than profits of REITs derivatives.

An Improvement of Still Image Quality Based on Error Resilient Entropy Coding for Random Error over Wireless Communications (무선 통신상 임의 에러에 대한 에러내성 엔트로피 부호화에 기반한 정지영상의 화질 개선)

  • Kim Jeong-Sig;Lee Keun-Young
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.43 no.3 s.309
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    • pp.9-16
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    • 2006
  • Many image and video compression algorithms work by splitting the image into blocks and producing variable-length code bits for each block data. If variable-length code data are transmitted consecutively over error-prone channel without any error protection technique, the receiving decoder cannot decode the stream properly. So the standard image and video compression algorithms insert some redundant information into the stream to provide some protection against channel errors. One of redundancies is resynchronization marker, which enables the decoder to restart the decoding process from a known state in the event of transmission errors, but its usage should be restricted not to consume bandwidth too much. The Error Resilient Entropy Code(EREC) is well blown method which can regain synchronization without any redundant information. It can work with the overall prefix codes, which many image compression methods use. This paper proposes EREREC method to improve FEREC(Fast Error-Resilient Entropy Coding). It first calculates initial searching position according to bit lengths of consecutive blocks. Second, initial offset is decided using statistical distribution of long and short blocks, and initial offset can be adjusted to insure all offset sequence values can be used. The proposed EREREC algorithm can speed up the construction of FEREC slots, and can improve the compressed image quality in the event of transmission errors. The simulation result shows that the quality of transmitted image is enhanced about $0.3{\sim}3.5dB$ compared with the existing FEREC when random channel error happens.

A STUDY ON THE TENSILE STRENGTH OF REINFORCED VENEERING COMPOSITE RESINS FOR CROWN (강화형 치관용 복합레진의 인장강도에 관한 연구)

  • Ahn, Seung-Geun;Kang, Dong-Wan
    • The Journal of Korean Academy of Prosthodontics
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    • v.38 no.2
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    • pp.226-241
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    • 2000
  • Recently a new generation of crown and bridge veneering resins containing submicron glass fillers was introduced. These ultrasmall particle hybrid composite materials distinguish themselves, compared with conventional microfill crown and bridge resins, through improved mechanical properties. It is claimed that these composites are suitable for metal free crowns and even bridges using fiber reinforcement. The purpose of this study was to evaluate the effect of thermal cycling on the tensile strength of the following veneering composites: Artglass(Heraeus Kulzer Co., Wehrheim, Germany), Estonia(Kuraray Co.. Japan), Sculpture(Jeneric Pentron Co., Wallingford, U.S.A.), and Targis(Ivoclar Co., Schaan Liechenstein). According to manufacturer's instructions, rectangular tensile test specimens measuring $1.5{\times}2.0{\times}4.5mm$ were made using a teflon mold. Whole specimens were divided into two groups. One group was dried in a desiccator at $25^{\circ}C$ for 10 days, and another group was subjected to thermal cycling($10,000{\times}$) in water($5/55^{\circ}C$). All test specimens were placed in a universal testing machine and loaded until fracture with a crosshead speed of 0.5mm/min. Weibull analysis and Tukey's test were used to analyze the data. The fracture surfaces of specimens were observed in SEM and the aliphatic C=C absorbance peak of Estenia and Targis resin was analyzed using Fourier transform infrared(FTIR) spectroscopy. Within the limitations imposed in this study, the following conclusions can be drawn: 1. Both in drying condition and thermal cycling condition, the highest tensile strength was observed in Estenia testing group(p<0.05). 2. The strength data were at to single-mode Weibull distribution, and the Weibull modulus of all veneering composite resin specimens increased after thermal cycling treatment. 3. After thermal cycling test, the highest tensile strength was observed in the Estenia group, and the lowest value was observed in the Targis group. The tensile strength values showed the significant differences between each group(p<0.05) 4. The aliphatic C=C absorbance peak of Estonia and Targis resin was decreased after light curing, and there was no distinct change after thermal cycling.

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A Mobile Newspaper Application Interface to Enhance Information Accessibility of the Visually Impaired (시각장애인의 정보 접근성 향상을 위한 모바일 신문 어플리케이션 인터페이스)

  • Lee, Seung Hwan;Hong, Seong Ho;Ko, Seung Hee;Choi, Hee Yeon;Hwang, Sung Soo
    • Journal of the HCI Society of Korea
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    • v.11 no.3
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    • pp.5-12
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    • 2016
  • The number of visually-impaired people using a smartphone is currently increasing with the help Text-to-Speech(TTS). TTS converts text data in a mobile application into sound data, and it only allows sequential search. For this reason, the location of buttons and contents inside an application should be determined carefully. However, little attention has been made on TTS service environment during the development of mobile newspaper application. This makes visually-impaired people difficult to use these applications. Furthermore, a mobile application interface which also reflects the desire of the low vision is necessary. Therefore, this paper presents a mobile newspaper interface which considers the accessibility and the desire of various visually impaired people. To this end, the proposed interface locates buttons with the consideration of TTS service environment and provides search functionality. The proposed interface also enables visually impaired people to use the application smoothly by filtering out the words that are pronounced improperly and providing the proper explanation for every button. Finally, several functionalities such as increasing font size and color reversal are implemented for the low vision. Simulation results show that the proposed interface achieves better performance than other applications in terms of search speed and usability.

A Design of DLL-based Low-Power CDR for 2nd-Generation AiPi+ Application (2세대 AiPi+ 용 DLL 기반 저전력 클록-데이터 복원 회로의 설계)

  • Park, Joon-Sung;Park, Hyung-Gu;Kim, Seong-Geun;Pu, Young-Gun;Lee, Kang-Yoon
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.48 no.4
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    • pp.39-50
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    • 2011
  • In this paper, we presents a CDR circuit for $2^{nd}$-generation AiPi+, one of the Intra-panel Interface. The speed of the proposed clock and data recovery is increased to 1.25 Gbps compared with that of AiPi+. The DLL-based CDR architecture is used to generate the multi-phase clocks. We propose the simple scheme for frequency detector (FD) to mitigate the harmonic-locking and reduce the complexity. In addition, the duty cycle corrector that limits the maximum pulse width is used to avoid the problem of missing clock edges due to the mismatch between rising and falling time of VCDL's delay cells. The proposed CDR is implemented in 0.18 um technology with the supply voltage of 1.8 V. The active die area is $660\;{\mu}m\;{\times}\;250\;{\mu}m$, and supply voltage is 1.8 V. Peak-to-Peak jitter is less than 15 ps and the power consumption of the CDR except input buffer, equalizer, and de-serializer is 5.94 mW.

Cluster Analysis of Synoptic Scale Meteorological Characteristics on High PM10 Concentration Episodes in the Southeastern Part of Korean Peninsula (한반도 남동 지역에서 발생한 고농도 미세먼지 사례의 종관 기상학적 군집 특성 분석)

  • Chae, DaEun;Lee, Kangyeol;Lee, Soon-Hwan
    • Journal of the Korean earth science society
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    • v.41 no.5
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    • pp.447-458
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    • 2020
  • This study presents the K-means clustering analysis-based classification of the meteorological patterns affecting the occurrence of high PM10 concentration in the southeastern region of the Korean peninsula for the last five years (2014-2018). Regional differences in Busan, Ulsan, and Gyeongnam related to high PM10 episodes, were clarified through the statistical comparison study using synoptic scale meteorological elements using NCEP (National Centers for Environmental Prediction/FNL (Final Operational Global Analysis) re-analysis meteorological data. Meteorological patterns were classified into a total of five categories (C1-C5). The incidence of each cluster was 24.8% (C1), 21.3% (C2), 20.4% (C3), 17.3% (C4), and 16.2% (C5), respectively. The high PM10 concentration in the southeastern region resulted from long and short range transports (C1, C3, C5) from outside of the region, and the emissions (C2, C4) inside the region. In the high PM10 episodes in Busan, Ulsan, and Gyeongnam regions, meteorological characteristics such as different geopotential height and wind speed at 500 hPa in each cluster and the change in the location of high pressure over Korean Peninsula is strongly associated with the dispersion of PM10 around inventories in the region and the tendency of long-range transportation of PM10 emitted from outside of region.