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External Validation of a Gastric Cancer Nomogram Derived from a Large-volume Center Using Dataset from a Medium-volume Center

  • Kim, Pyeong Su;Lee, Kyung-Muk;Han, Dong-Seok;Yoo, Moon-Won;Han, Hye Seung;Yang, Han-Kwang;Bang, Ho Yoon
    • Journal of Gastric Cancer
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    • v.17 no.3
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    • pp.204-211
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    • 2017
  • Purpose: Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea. Materials and Methods: We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011. Age, sex, number of metastatic lymph nodes (LNs), number of examined LNs, depth of invasion, and location of the tumor were investigated as variables for validation of the nomogram. Both discrimination and calibration of the nomogram were evaluated. Results: The discrimination was evaluated using Harrell's C-index. The Harrell's C-index was 0.83 and the discrimination of the gastric cancer nomogram was appropriate. Regarding calibration, the 95% confidence interval of predicted survival appeared to be on the ideal reference line except in the poorest survival group. However, we observed a tendency for actual survival to be constantly higher than predicted survival in this cohort. Conclusions: Although the discrimination power was good, actual survival was slightly higher than that predicted by the nomogram. This phenomenon might be explained by elongated life span in the recent patient cohort due to advances in adjuvant chemotherapy and improved nutritional status. Future gastric cancer nomograms should consider elongated life span with the passage of time.

Effects of a Single Session of Brain Yoga on Brain-Derived Neurotrophic Factor and Cognitive Short-Term Memory in Men Aged 20-29 Years

  • Yang, Hyun-Seong;Kim, Hyun-Jun;Lee, Hwa-Gyeong
    • Journal of The Korean Society of Integrative Medicine
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    • v.9 no.4
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    • pp.91-103
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    • 2021
  • Purpose : This study aimed to evaluate the effects of a cognitive enhancement brain yoga program on short-term memory and serum brain-derived neurotrophic factor (BDNF) levels according to the cognitive state in men aged 20-29 years. Methods : Thirty healthy volunteers aged 20-29 years were divided into four groups: brain yoga group, yoga group, combined exercise group, and control group. Seven people were assigned randomly per group. A single-session intervention was conducted over 50 min and consisted of three parts: warm-up, main exercise (brain yoga, yoga, combined exercise, or non-exercise), and cool-down. Serum BDNF levels were measured using enzyme-linked immunosorbent assay, and short-term memory was evaluated using the forward number span test before and after the intervention. Results : BDNF levels significantly increased within the brain yoga group after the intervention (from 28874.37±5185.57 to 34074.80±7321.12, p=.003), whereas there were no significant differences pre-and post-intervention in the other groups. The inter-group comparison showed a significant interaction between the brain yoga group and the combined exercise group (p=.036) but no significant interaction between any of the other groups. Forward number span scores were significantly increased in the brain yoga group (from 9.43±9.83 to 23±7.92, p=.012) and theyoga group after the intervention (from 13.43±9.41 to 24.14±8.45, p=.011), whereas there were no significant changes after the intervention in any other groups. Conclusion : Our findings showed that a single-session, 50-minute brain yoga exercise improved short-term memory and increased serum BDNF levels in healthy men aged 20-29 years and that yoga improved only short-term memory in healthy men of this age group.

THE λ-NUMBER OF THE CARTESIAN PRODUCT OF A COMPLETE GRAPH AND A CYCLE

  • Kim, Byeong Moon;Song, Byung Chul;Rho, Yoomi
    • Korean Journal of Mathematics
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    • v.21 no.2
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    • pp.151-159
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    • 2013
  • An $L(j,k)$-labeling of a graph G is a vertex labeling such that the difference of the labels of any adjacent vertices is at least $j$ and that of any vertices of distance two is at least $k$ for given $j$ and $k$. The minimum span of all L(2, 1)-labelings of G is called the ${\lambda}$-number of G and is denoted by ${\lambda}(G)$. In this paper, we find a lower bound of the ${\lambda}$-number of the Cartesian product $K_m{\Box}C_n$ of the complete graph $K_m$ of order $m$ and the cycle $C_n$ of order $n$. In fact, we show that when $n{\geq}3$, ${\lambda}(K_4{\Box}C_n){\geq}7$ and the equality holds if and only if n is a multiple of 8. Moreover when $m{\geq}5$, ${\lambda}(K_m{\Box}C_n){\geq}2m-1$ and the equality holds if and only if $n$ is even.

A Genetic Algorithm Approach to the Fire Sequencing Problem

  • Kwon, O-Jeong
    • Journal of the military operations research society of Korea
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    • v.29 no.2
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    • pp.61-80
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    • 2003
  • A fire sequencing problem is considered. Fire sequencing problem is a kind of scheduling problem that seeks to minimize the overall time span under a result of weapon­target allocation problem. The assigned weapons should impact a target simultaneously and a weapon cannot transfer the firing against another target before all planned rounds are consumed. The computational complexity of the fire sequencing problem is strongly NP­complete even if the number of weapons is two, so it is difficult to get the optimal solution in a reasonable time by the mathematical programming approach. Therefore, a genetic algorithm is adopted as a solution method, in which the representation of the solution, crossover and mutation strategies are applied on a specific condition. Computational results using randomly generated data are presented. We compared the solutions given by CPLEX and the genetic algorithm. Above $7(weapon){\times}15(target)$ size problems, CPLEX could not solve the problem even if we take enough time to solve the problem since the required memory size increases dramatically as the number of nodes expands. On the other hand, genetic algorithm approach solves all experimental problems very quickly and gives good solution quality.

Minimum Thickness Requirements of Flat Plate Considering Construction Scheme (시공 계획을 고려한 플랫 플레이트 최소 두께)

  • 강성훈;최경규;박홍근
    • Proceedings of the Korea Concrete Institute Conference
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    • 2002.10a
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    • pp.631-636
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    • 2002
  • It is common in multistory flat-plate structures that newly cast slabs are supported by a number of previously cast floors. Then the weight of newly cast slabs is imposed on shored previously cast floors as load, and this load may be large as double as dead load. Because early-age construction loads cause large immediate deflection and creep deflection with cracks, this loads influence long-term behavior of slabs. In current provision, the minimum thickness is required to satisfy serviceability But this minimum thickness based on historical precedent is determined by span length, therefore the minimum thickness of current provision can not includes properly the effect of construction scheme including the number of shored floors and construction cycle. In the present study, a minimum thickness criterion, which includes the effect of concrete strength, geometry of slabs and construction scheme, was developed from computer-based iteration using deflection calculation procedure of current code method.

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Evaluation of labor aptitude of middle-aged and old workers: Evaluation of manual dexterity (중고령 동노자의 노동적응능력의 평가)

  • 신승헌
    • Journal of the Ergonomics Society of Korea
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    • v.5 no.2
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    • pp.17-25
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    • 1986
  • In recent years, the average life span of people in advanced countries has increased. Conwequently, the number of middle-aged and old workers who have the will to work has increased. On the other hand, the declining birth rate has decreased the number of young workers. However, because many enterprises in advanced countries have extended their mandatory retirement age from 55 to 60 years, labor accidents involving aged workers are on the increase. As a result, the need for a method to evaluate the work skills of middle-age and old workers has become urgent. To explore one such method, this study investigated the relationship between aging and manual dexterity. Dexterity was found to deteriorate with age, but with large variability from individual to individual. The parameters of dexterity used in this experiment were found to be reliable.

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Periodic Preventive Maintenance Policies when Minimal Repair Costs Vary at Failures

  • Joon Keun Yum;Gi Mun Jung;Dong Ho Park
    • Journal of Korean Society for Quality Management
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    • v.25 no.3
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    • pp.86-95
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    • 1997
  • This paper considers a repairable system, which is maintained preventively at periodic times and is minimally repaired at each failure. Most preventive maintenance policies for such repairable systems assume that the cost of minimal repair is constant regardless of its age at failure. However, it is more practical to consider the situations where the cost of minimal repair is dependent not only on its age at failue, but also on the number of preventive maintenance carried out prior to its failure. We consider the preventive maintenance carried out prior to its failure. We consider the preventive maintenance policy with age-dependent minimal repair cost. The optimal policies which minimize the expected cost rate over an infinite time span are discussed. We obtain the optimal period and number of preventive maintenance prior to replacement of the system.

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A Study on the Fracture Safety of Glass Fiber Reinforced Plastic Pipes (유리섬유 보강 플라스틱관의 파괴 안전성에 관한 연구)

  • 채원규
    • Journal of the Korean Society of Safety
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    • v.9 no.1
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    • pp.121-126
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    • 1994
  • In this thesis, a series of loading tests are conducted in order to investigate the fracture safety as structural materials of GFRP(Glass Fiber Reinforced Plastics) which we wifely used in the developed countries becauses of their natural of anticorrosion and lightweight etc.. In the fracture test, the mid-span displacement, the strain and the yield load of the GFRP pipes are measured for different number of laminates, and fracture energy is estimated. From this study, it is known that GFRP pipe could be used as structural materials in underground buried pipes if their ductility and strength are increased by controlling number of laminates. Furthermore, because of their merit of lightweight, they can contribute greatly to reduction of construe-tlon cost when they are employed.

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Numerical Analysis of Three Dimensional Dynamic Stall of an Oscillating Wing (진동하는 날개의 3차원 동실속에 관한 수치해석)

  • Go, Seong-Ho
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.25 no.1
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    • pp.62-70
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    • 2001
  • Three-dimensional dynamic stall over an oscillating wing has been analyzed by using a compressible Navier-Stokes code. The code solved the thin-layer Navirer-Stokes equations with a second-order time accuracy for a semispan wing with 0.3048m chord, a NACA 0015 airfoil section, and zero twist Computations were made for a freestream Mach number of 0.29, a chord Reynolds number of 1.95$\times$10(sup)6 and a reduced frequency equal to 0.1. Numerical results were compared with experimental data which include the hysteresis of lift, drag and moment at various wing span. The comparison reveals the quantitative as well as qualitative nature of the three-dimensional dynamic stall.

Estimation of Dynamic Displacements from Strain Signal using Mode Shapesof Simply Supported Beam (단순보 모드형상을 이용하여 변형률 신호에서 동적변위 응답 추정)

  • Shin, Soo-Bong;Lee, Seon-Ung;Han, Ah-Reum-Sam;Kim, Hyun-Su;Kim, Hee-Dong
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2009.04a
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    • pp.326-331
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    • 2009
  • An algorithm is proposed for computing dynamic displacements of a bridge using FBG sensors. An existing algorithm for estimating dynamic displacements of a simply supported beam through mode superposition is extended and applied to various types of bridges with bending and torsional modes. The proposed algorithm is examined through field tests on a suspension span steel deck plate box girder bridge. Guidelines are provided for determining the number of modes and the number of strain gages to be used.

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