• 제목/요약/키워드: source of drug information

검색결과 30건 처리시간 0.021초

중국 중의약 미래 예측 과제(1990${\sim}$ 2010)평가 연구 (Assessment on Forecasting Study of Traditional Chinese Medicine(1990${\sim}$2010))

  • 이경구;배순희;신현규
    • 대한한의학회지
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    • 제28권1호통권69호
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    • pp.117-125
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    • 2007
  • Objectives : This study was to assess the Traditional chinese medicine forecast subjects that had been expected to be accomplished over 20 year (1990-2010). The result will help Korea medical society to compare the status of Korean Medicine with that of Traditional Chinese Medicine and to plan for polices and studies on Korean Traditional Medicine. Methods : Assessed targets were the subjects selected by the China Academy of Chinese Medical Sciences, which are classified into 6 fields. These were assigned by the quantity of related theses. Reference source is CAJ(China academic Journal) of CNKI (China National Knowledge infrastructure). Results : 1) Forecast subject ratio by field was basic theory 31% / clinical research 17% / Chinese herbal drug 17% / acupuncture and moxa 17% / Tui-na(推拿) and Qi-gong(氣功) 9% / medical information, literature history 6%. 2) Accomplishment percentage (full accomplishment) by field was medical information, literature, history 60% / basic theory 50% / acupuncture and moxa 46% Tui-na(推拿) and Qi-gong(氣功) 38% / chinese herbal drug 25% / clinical research 23%. Conclusions : 78% of all forecast subjects were accomplished or partially accomplished. According to 'accomplishment percentage by field', while those in the medical information, literature, history field were most realized of all, those in the clinical research field were least realized.

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Current and Future Molecular Mechanism in Inflammation and Arthritis

  • Sharma, Vikash;Tiwari, Raj Kumar;Shukla, Shiv Shankar;Pandey, Ravindra Kumar
    • 대한약침학회지
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    • 제23권2호
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    • pp.54-61
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    • 2020
  • Inflammation is an immune response of the human body but excessive inflammation is taken as a major factor in the development of many diseases including autoimmune disorders, cancer and nerve disorders etc. In this regards the need is to suppress the inflammatory response. Suppression of extra or imperfect inflammatory response is not a big deal provided there is an exact knowledge of particular target in the body. Recent advancements in Pharmacological aspect made the therapy with improved outcomes in number of patients. Anticytokine therapy might be one of the important and novel approaches for inflammation and Arthritis. This can be achieved only when we go through the pathophysiology of expression and identification of mediators. Let's take an example of cytokine like interleukins (IL), chemokines, interferons (INF), tumor necrosis factors (TNF-α), growth factors, and colony stimulating factors) release pathway which is a major signalling protein in inflammatory response. In the present study we have reviewed the recent pharmacological therapeutic advancement, inflammatory mediators, receptors, and major signalling pathways. Such information will not only provide the idea about the mechanism of action of Pharmaceuticals and molecular targets but also it provides a new aspect for drug designing and new corrective approaches in existing clinical medicines. This study will be a source of good information for the researchers working in the area of drug designing and molecular Pharmacology especially in anti-inflammatory and anti arthritic medicines for target based therapy.

신장 및 간 기능별 약물용량조절에 관한 국내외 약물문헌정보 비교 (Comparative Analysis of Drug Information Resources for Dose Adjustment in terms of Renal and Hepatic Function)

  • 류지현;경은정;이희영;오민아;김은영
    • 한국임상약학회지
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    • 제22권3호
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    • pp.220-227
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    • 2012
  • Kidney and liver are the major organs of metabolism and excretion of drugs. Renal and Hepatic impairment may affect the pharmacokinetics/pharmacodynamics and the safety of drugs. Adjusting the dosage based on organ function is the essential role of pharmacists. However, differences have been noted on the recommended dosage among the literatures. We compared and analyzed the recommendations of 4 literature sources which are commonly used for dosage adjustment. From April, 2011 to August, 2011, we selected data on recommendations for dosage adjustment for impaired renal and hepatic function of 100 drugs through a protocol. We analyzed the definition terms of renal and hepatic impairment, recommendations for dosage adjustment, evidenced references in four literature sources: Korean National Formulary (KNF), American Hospital Formulary System Drug Information (AHFS), Micromedex (MM) and Drug Prescribing of Renal Failure (DPRF). We further examined the data homogeneity by comparing how drugs that required no adjustment according to one source were categorized by the other. Sources use different definition terms among themselves except DRPF. Presence or absence of evidenced references about renal/hepatic functional states are KNF (0%/0%), AHFS (78%/62.6%), MM (87.5%/65.6%) and DPRF (93.2%/no recommendation) respectively. Recommendations of specific dosage and dosing interval are KNF (24%/13%), AHFS (39.6%/12.1%), MM (50%/17.7%), and DPRF (55.4%/no recommendation) respectively. Regarding the data homogeneity, the differences were remarkable. Drugs with no adjustment according to AHFS were categorized to be adjusted/ contraindicated by KNF, MM, DPRF and the values were (44%/5.6%), (22%/0%), and (36%/0%) in renal function, (39%/6.5%), (19%/3.2%), and (no recommendation/no recommendation) in hepatic function respectively. Our study shows remarkable definite variation in definitions and recommendations about definition terms, information of dosage and interval, presence or absence of evidenced references. Especially for KNF, quantitative recommendations on dosages and dosing intervals should be made in the near future. To maximize the drug effect and safety and to minimize the heterogeneity of the literature sources, reviewing at least two sources are suggested when recommending the proper dosage adjustment based on organ function.

Chemical Genomics with Natural Products

  • Jung, Hye-Jin;Ho, Jeong-Kwon
    • Journal of Microbiology and Biotechnology
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    • 제16권5호
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    • pp.651-660
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    • 2006
  • Natural products are a rich source of biologically active small molecules and a fertile area for lead discovery of new drugs [10, 52]. For instance, 5% of the 1,031 new chemical entities approved as drugs by the US Food and Drug Administration (FDA) were natural products between 1981 and 2002, and another 23% were natural product-derived molecules [53]. These molecules have evolved through millions of years of natural selection to interact with biomolecules in the cells or organisms and offer unrivaled chemical and structural diversity [14, 37]. Nonetheless, a large percentage of nature remains unexplored, in particular, in the marine and microbial environments. Therefore, natural products are still major valuable sources of innovative therapeutic agents for human diseases. However, even when a natural product is found to exhibit biological activity, the cellular target and mode of action of the compound are mostly mysterious. This is also true of many natural products that are currently under clinical trials or have already been approved as clinical drugs [11]. The lack of information on a definitive cellular target for a biologically active natural product prevents the rational design and development of more potent therapeutics. Therefore, there is a great need for new techniques to expedite the rapid identification and validation of cellular targets for biologically active natural products. Chemical genomics is a new integrated research engine toward functional studies of genome and drug discovery [40, 69]. The identification and validation of cellular receptors of biologically active small molecules is one of the key goals of the discipline. This eventually facilitates subsequent rational drug design, and provides valuable information on the receptors in cellular processes. Indeed, several biologically crucial proteins have already been identified as targets for natural products using chemical genomics approach (Table 1). Herein, the representative case studies of chemical genomics using natural products derived from microbes, marine sources, and plants will be introduced.

식·의약 위해 감시체계(K-RISS)의 우선순위 평가를 위한 시계열 구조변화 기반 기준선 설정 모델 개발 (Development of a Baseline Setting Model Based on Time Series Structural Changes for Priority Assessment in the Korea Risk Information Surveillance System (K-RISS))

  • 진현정;허성윤;이헌주;장보윤
    • 한국환경보건학회지
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    • 제50권2호
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    • pp.125-137
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    • 2024
  • Background: The Korea Risk Information Surveillance System (K-RISS) was developed to enable the early detection of food and drug safety-related issues. Its goal is to deliver real-time risk indicators generated from ongoing food and drug risk monitoring. However, the existing K-RISS system suffers under several limitations. Objectives: This study aims to augment K-RISS with more detailed indicators and establish a severity standard that takes into account structural changes in the daily time series of K-RISS values. Methods: First, a Delphi survey was conducted to derive the required weights. Second, a control chart, commonly used in statistical process controls, was utilized to detect outliers and establish caution, attention, and serious levels for K-RISS values. Furthermore, Bai and Perron's method was employed to determine structural changes in K-RISS time series. Results: The study incorporated 'closeness to life' and 'sustainability' indicators into K-RISS. It obtained the necessary weights through a survey of experts for integrating variables, combining indicators by data source, and aggregating sub K-RISS values. We defined caution, attention, and serious levels for both average and maximum values of daily K-RISS. Furthermore, when structural changes were detected, leading to significant variations in daily K-RISS values according to different periods, the study systematically verified these changes and derived respective severity levels for each period. Conclusions: This study enhances the existing K-RISS system and introduces more advanced indicators. K-RISS is now more comprehensively equipped to serve as a risk warning index. The study has paved the way for an objective determination of whether the food safety risk index surpasses predefined thresholds through the application of severity levels.

국내 유통 벌꿀의 안정동위원소 비율에 관한 연구 (A Study on Stable Isotope Ratio of Circulated Honey in Korea)

  • 조윤제;김재영;장문익;강경모;박용춘;강일현;도정아;권기성;오재호
    • 한국식품과학회지
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    • 제44권4호
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    • pp.401-410
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    • 2012
  • 본 연구는 국내 및 국외에서 생산된 다양한 벌꿀에 대한 탄소, 수소 및 산소의 안정동위원소 비율을 분석하고, 국내 유통 벌꿀의 순수 여부 등 과학적 벌꿀 관리를 위한 기초 자료를 마련하고자 수행되었다. 이를 위한 분석은 국내에서 생산 유통 중인 국내산 및 수입산 모든 벌꿀을 대상으로 하여 동위원소 비율 양상을 조사하였다. 탄소 동위원소 비율은 $C_3$ 식물군이 -27- -21‰, $C_4$ 식물군이 -19‰ 이상인 것으로 크게 양분되는 현상을 보였다. 수입산의 경우 탄소 동위원소 비율은 모두 -27- -23‰의 범위를 나타내어 수거된 제품은 모두 $C_3$ 식물군의 밀원에서 생산되어진 것으로 판단되었다. 수소 및 산소 동위원소 비율은 국내산의 경우, 각각의 밀원에 따라 결과 값의 범위가 넓어 차이가 뚜렷하지 않은 결과를 나타내었다. 또한 원산지에 따른 지역별 양상도 뚜렷한 차이가 나타나지 않았다. 수입산은 위도 차이가 넓은 지역에서는 차이가 보이나 위도 위치가 좁은 지역에서는 구분이 어려웠다. F/G 비율과 탄소 동위원소 비율을 비교 분석한 결과, 국내산은 밀감꽃을 제외한 $C_3$ 그룹이 1.3 이상으로 나타났고 $C_4$ 그룹은 1.3 이하를 나타내었다. 수입산은 다양한 밀원(초본류 및 목본류)을 가지는 경우, $C_3$ 그룹의 경우에도 1.3 이하의 경향을 나타내어 구분에 어려움이 있었다. 결론적으로 국내 유통 벌꿀의 순수 여부 판단에 탄소 동위원소 비율이 활용 가능하며, 보다 정확한 결과를 도출하기 위해 보완적으로 F/G 비율 결과를 병행하여 사용할 수 있을 것으로 판단된다.

국내 가공식품의 포장 재질, 형태 및 다양한 특징 분석 연구 (Analytical Survey on the Package Source, Components, and Various Characteristics of Processed Foods in Korea)

  • 송현주;장윤지;박세종;최재천;한재준
    • 한국포장학회지
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    • 제23권3호
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    • pp.173-181
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    • 2017
  • 본 연구에서는 한국의 가공식품 포장 특징(재질, 형태 등)을 분석하기 위해 다소비 식품에서 가공식품만을 대상으로 하여 품목별 소매점 매출액 순위에 따라 구성하였고, 이를 품목별 포장 형태, 품목별 포장 재질, 포장 형태별 포장 재질로 나누어 분석하였다. 또한, 품목별, 포장 형태별, 포장 재질별 접촉 비율과 두께를 측정하고 분석하였다. 국내 유통 중인 가공식품의 포장 재질별 사용 실태 조사 결과, 폴리에틸렌(PE, 43.61%), 폴리프로필렌(PP, 17.75%), 폴리에틸렌 테레프탈레이트(PET, 12.05%), 알루미늄(9.08%) 순으로 사용 빈도가 높아, 합성수지제를 가장 많이 사용하나 전반적으로 다양한 포장 재질을 사용하고 있는 것으로 조사되었다. 가공식품의 포장 형태별 사용 실태를 조사한 결과, EU 기준에 따른 포장 형태 총 21가지로 분류되었고, 가장 많이 쓰이는 포장 형태는 유연 포장재/봉투/파우치(38.96%)로 조사되었다. 본 연구는 가공식품 포장 재질, 포장 형태, 포장재 두께, 포장재와 식품의 접촉 비율 등의 구체적이고 방대한 양의 정보를 정리하여 국내의 가공식품 포장 현황을 반영한 조사로써, 향후 국내 식품포장 현황 분석 연구에 있어 기초 자료를 제공하는 데에 도움이 될 것으로 기대된다.

특정의약품의 자가투약행위에 관한 연구 (A Study on Self-medication Beharior of Four Cautious Drugs.)

  • 황미숙
    • 보건교육건강증진학회지
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    • 제4권2호
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    • pp.46-70
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    • 1987
  • The survey with questionnaire were conducted to grasp the actual condition of four cautious drugs-antibiotics, sedative hypnctics, mincr tranquilizer, analeptics-self -medication behavior through drugstore use and to analyze the primary factors connected with it. The following six objectives were established. 1) To catch the reason why the man who medicate himself buy four cautious drugs at a drugstore, and to know the choice motive of each drug purchased. 2) To grasp the distribution of four cautious drug taken by the man who medicate himself and to analyse the reason of taking the drug. 3) To find out whether the buyer has taken the same drug past and to know the duration and the frequency. 4) To grasp the degree of recognition about four cautious drugs and the attitude toward continuous taking them. 5) To analyze the degree of recognition about the influence on human body and the attitude of medication behavior. 6) To know "the experience of side-effects" and to grasp the kind of the side-effects. The data were collected from 15 drugstores with 677 respondents in seoul from August 17 to september 21, 1987. The following results were obtained. 1) The reasons for drugstore use were first, "for easy access and convenience" (53.7%) second, "for the slightness of illness" (19.9%) third "for the cheap price" (13.2%). According to that result, the factor of "the easy access of drugstore" was most influential. In case of the poor, the factor "for the cheap price "was revealed second (37.3%). And "for the slightness of illness" was second reason in the medically insured (22. 9%), "for the cheap price" was second reason in the others (29%). 2) The kind of drugs purchased were antibiotics (62.8%), analeptics(17.2%), minor tranquilizer(13.3%) and sedative hypnotics (6.7%) on the whole. In teenagers, besides antibiotics the percentage of taking analepits came second (42.4%) and it was revealed that the percentage of sedative hypnotics, minor tranquilizer increase with age. But in proportion to the increase of age, the taking of analeptis decreased. 3) The choice motives of each drug purchased were all different. In case of antibiotics "recommendation of pharmacist" was 39.6%, sedative hypnotics "recommendation of pharmacist" and "my own judgement", 28.9%, respectively, minor tranquilizer "my own judgement", 35.2%. and in case of analeptics "my oun judgement" was most common with 53.5%. 4) The reasons for taking drugs were as follows. antibiotics was taken for the inflammation mitigation of a wound and a swelling (38.5%), sedative hypnotics for the removal of insomnia (97.5%), minor tranquilizer because of restlessness and qloominess(39.3%), and analeptics for the shortening of sleeping hours (35.1%). 5) Those experienced in taking four cautious drugs were 78.2% on the average. It was revealed that antibiotics use duration was "from one week to one month" (38.9%), the frequency was "rarely" (62.1%), sedative hypnotics and minor tranquilizer; "More than three years", (35.7%, 30.4%), respectively, "Somtimes", (43.8%, 35%), respectively. analeptics ; "from one year to three years", (27.6%), "Sometimes", (42.7%). 6) In regard to the source of information in taking drugs, 35.3 percent of male were relied on "recommendation of pharmacist", 32.6 percent of female "my own judgement", There was a difference between below the middle school graduates and over the high school graduates Thease were relied on "recommendation of pharmacist" first, those "my own judgement" first. And "my own judgement" was the first source of specialist(40%), labours(41.4%), salesman(43.5%), and jobless men(36.8%), "recommendation of ralatives on friends" was the first source of students (30.4%), "recommendation of pharmacist" was the first soure of teachers, administrative office workers (39%) and housewives (40.7%). 7) The degree of recognition about four cautious drugs was as follows. "know a little" was (43.0%), "don't know" (30.2%), "know" (26.8%), respectively. In regard to the attitude toward continuous taking them, it was revealed that "I will take it according to circumstamces" was first (56.2%), " I will not take it as possible" was first(56.2%), "I dont know well" (12.9%), "I will take it continuously" (8.3%). 8) About the influence on human body, "if proper, it is effect" was common attitude toward antibiotics (43.6%), "Probably bad influence on the health" was first toward the other drugs (46.2%), In terms of the degree of observance to taking-time and dose of drugs, "suitably" was first (37.3%), "relatively correctly" second (27%), "correctly" (17%). 9) The percentage of four cautious drugs side-effects was 27.5 on the average. The kind of side-effects were eruption and urticaria (28.5%), heart acceleration and so forth. (25.4%), headache and Giddiness, dyspepsia (23%), respectively.

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Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study

  • Roy, Nabarun;Davis, Sangeetha;Narayanankutty, Arunaksharan;Nazeem, PA;Babu, TD;Abida, PS;Valsala, PA;Raghavamenon, Achuthan C
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권6호
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    • pp.2883-2888
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    • 2016
  • Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant source garlic. Materials and Methods: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They were docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness. Results: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions. Conclusions: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic.

Hypericum source of natural antimicrobials

  • Mukherjee, Pulok K.;Wahile, Atul;Ahamed, KFH Nazeer;Rajan, S.
    • Advances in Traditional Medicine
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    • 제3권3호
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    • pp.111-122
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    • 2003
  • Plants of the genus Hypericum (Family - Hypericaceae) are herbs, shrubs or small trees and are distributed chiefly in the temperate regions of the world. About 400 different species of Hypericum are available throughout the globe and 20 species occur in India, including a few cultivated in gardens. Almost all plants of the genus Hypericum are widely used in folk medicine. Several potent phytoconstituents from different Hypericum species have led to the isolation of antibacterial, antifungal and cytotoxic compounds. With the development of resistance and cross resistance with different microorganisms and the evolution of so many deadly diseases the screening and evaluation of the phytoconstituents so much so the development of varied phytoconstituents for the drug development for these deadly diseases is utmost essential in every aspects. The present review on the antimicrobial use of different Hypericum reports the findings from and extensive literature search on the Hypericum species around the globe that have been assessed for antimicrobial and antiviral activity. An attempt has been made through this review to summarize the information in this aspect in order to highlight the promising species of this genus which are worthy for further investigation as leads for drug development. Over 31 different Hypericum species have been reported to possess such activities with their varied number of phytoconstituents. Sixteen different constituents of six different classes of phytoconstituents have been reported to be present in different varieties of Hypericum, which may be considered responsible for this activity.