• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.2
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• pp.106-113
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• 2018

The Intense acoustic wave generated by the jet flame at the lift-off causes the vehicle to vibrate in the form of acoustic loads. The DSM-II(Distributing Source Method-II), which is a representative empirical acoustic loads prediction method, is a method of distributing a noise source along a jet flame axis and has advantages in calculation cost and accuracy. However, due to the limitation of the distributing method, there is a limit to accurately reflect the various launch pad configurations. In this study, acoustic loads prediction method which can freely distribute noise sources is studied. by introducing NURBS(Non-Uniform Rational B-Spline) modeling into empirical prediction method. For the verification of the newly introduced analytical technique of the NURBS, the acoustic loads prediction for the Epsilon rocket's low-noise launch pad shape was performed and the results of the analysis were compared with the existing prediction methods and experimental results.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.95-101
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• 2007

Recently, small-animal imaging technology has been rapidly developed for longitudinal screening of laboratory animals such as mice and rats. One of newly developed imaging modalities for small animals is an x-ray micro-CT (computed tomography). We have developed two types of x-ray micro-CT systems for small animal imaging. Both systems use flat-panel x-ray detectors and micro-focus x-ray sources to obtain high spatial resolution of $10{\mu}m$. In spite of the relatively large field-of-view (FOV) of flat-panel detectors, the spatial resolution in the whole-body imaging of rats should be sacrificed down to the order of $100{\mu}m$ due to the limited number of x-ray detector pixels. Though the spatial resolution of cone-beam CTs can be improved by moving an object toward an x-ray source, the FOV should be reduced and the object size is also limited. To overcome the limitation of the object size and resolution, we introduce zoom-in micro-tomography for high-resolution imaging of a local region-of-interest (ROI) inside a large object. For zoom-in imaging, we use two kinds of projection data in combination, one from a full FOV scan of the whole object and the other from a limited FOV scan of the ROI. Both of our micro-CT systems have zoom-in micro-tomography capability. One of both is a micro-CT system with a fixed gantry mounted with an x-ray source and a detector. An imaged object is laid on a rotating table between a source and a detector. The other micro-CT system has a rotating gantry with a fixed object table, which makes whole scans without rotating an object. In this paper, we report the results of in vivo small animal study using the developed micro-CTs.

• Journal of Korean Society on Water Environment
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• v.20 no.5
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• pp.397-408
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• 2004

Due to the growing impact of non-point source pollution and limitation of water treatment technology, a new policy of water quality management, called a source protection, is now becoming more important in drinking water supply. The source protection means that the public agency purchases the pollution sensitive area, such as riparian zone, and prohibit locations of point and non-point sources. Many studies have reported that this new policy is more economical in drinking water supply than the conventional one. However, it is very difficult to determine location and size of the pollution sensitive zone in the watershed. In this paper, we presented the scientific criteria for the priority of the pollution sensitive zone, along with a case study of the upstream watershed of the Paldang Reservoir, Han River. This study includes applications of the analytical hierarchy process(AHP) and a watershed-based land prioritization(WLP) model. After major criteria affecting water quality were selected, the AHP and geographic analysis were performed. The WLP model allowed us to include both quantity and quality criteria, using AHP as the multi-criteria method in making decision and reflecting local characteristics and various needs. By adding a travel-time function, which represents the prototype effectively, the results secured adaptability and scientific objectivity as well. As such, the WLP model appeared to provide reasonable criteria in determining the prioritization of land acquisition. If the tested data are used with a validated travel-time and AHP method is applied after further discussion among experts in such field, highly reliable results can be obtained.

• The Journal of the Acoustical Society of Korea
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• v.36 no.1
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• pp.23-29
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• 2017

A concept of a VSA (Virtual Source Array) is the method for an acoustic spatio-temporal focus at a selected location in the outbound direction with respect to the VSA without the need of a probe source as combines a TRP (Time-Reversal Processing) and time-delay and beam-steering. However, in TRP using the VSA concept, it is limited to the critical angle and the short distances relevant to the VSA. In this paper, the waveguide invariant theory is applied to the VSA concept to refocus the received field at ranges greater other than the critical angle and the short ranges by shifting the focused field. The suggested method is verified via numerical simulation, and the results show that the robust acoustic focusing is achieved on the selected location regardless of the limitation on the conventional VSA concept.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.11
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• pp.1038-1043
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• 2015

When the study on the relationship between the Head-of-Bed (HOB) angle and ventilator-associated pneumonia is performed, the fact that the HOB angle can only be measured intermittently imposes a significant limitation on the study. Therefore, there has been demand for the development of a device that can measure the HOB angle continuously. In this paper, we propose the rapid prototyping of an HOB measurement system using open-source hardware and software. The proposed system helps to maintain the HOB angle at a particular angle by displaying the angle and helps the medical study of pneumonia patients by enabling continuous data acquisition. Firstly, we eliminate the process of making an MCU board by utilizing an open-source hardware mbed LPC1768. Secondly, we reduce the software development time by using libraries and hence enabling the easy use of peripherals. Thirdly, for rapid prototyping, we build the enclosure of the proposed system using a 3D printer. The proposed system can be attached and detached to and from a bed. Therefore, we can attach it to the bed of a patient for whom measurement of the HOB angle is necessary. Finally, we check the measurement performance and the validity of the proposed system through an experiment utilizing an incremental encoder.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.5
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• pp.193-208
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• 2022

In this study, we proposed a mathematical model that can explain the source of the observed variability of repeated measurement data collected in Korean medicine clinical practice, and conducted a pilot analysis to infer the source of these variability based on our model. Mathematical model was constructed by dividing the observed variations into three components: common time-dependent variations, signal shift, and measurement error. To show the applicability of our model in real data, we analyzed 20 repeated measurement data of Korean clinical indicators in graduate students of Pusan National University Graduate School of Korean Medicine. We showed how to infer each source of variations based on our model and also showed the limitation of inference given the acquired the dataset. On the basis of objective recognition of these source of the variability, we hope that quantitative investigations on these sources for each Korean medicine clinical indicator are made in the future, so that they can be used in the clinical and educational areas of Korean medicine.

• The Journal of the Acoustical Society of Korea
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• v.43 no.2
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• pp.178-183
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• 2024

This study introduces an enhanced sound source localization technique, bolstered by a data-driven deep learning approach, to improve the precision and accuracy of direction of arrival estimation. Focused on refining Time Difference Of Arrival (TDOA) based sound source localization, the research hinges on accurately estimating TDOA from cross-correlation functions. Accurately estimating the TDOA still remains a limitation in this research field because the measured value from actual microphones are mixed with a lot of noise. Additionally, the digitization process of acoustic signals introduces quantization errors, associated with the sampling frequency of the measurement system, that limit the precision of TDOA estimation. A deep learning-based approach is designed to overcome these limitations in TDOA accuracy and precision. To validate the method, we conduct comprehensive evaluations using both two and three-microphone array configurations. Moreover, the feasibility and real-world applicability of the suggested method are further substantiated through experiments conducted in an anechoic chamber.

• Reproductive and Developmental Biology
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• v.34 no.3
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• pp.143-151
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• 2010

Pluripotency of human embryonic stem cell (hESC) is one of the most valuable ability of hESCs for applying cell therapy field, but also showing side effect, for example teratoma formation. When transplant multipotent stem cell, such as mesnchymal stem cell (MSC) which retains similar differentiation ability, they do not form teratoma in vivo, but there exist limitation of cellular source supply. Accordingly, differentiation of hESC into MSC will be promising cellular source with strong points of both hESC and MSC line. In this study, we described the derivation of MSC like cell population from feeder free cultured hESC (hESC-MSC) using direct differentiation system. Cells population, hESC-MSC and bone marrow derived MSC (BM-MSC) retained similar characteristics in vitro, such as morphology, MSC specific marker expression and differentiation capacity. At the point of differentiation of both cell populations, differentiation rate was slower in hESC-MSC than BM-MSC. As these reason, to verify differentially expressed molecular condition of both cell population which bring out different differentiation rate, we compare the molecular condition of hESC-MSC and BM-MSC using 2-D proteomic analysis tool. In the proteomic analysis, we identified 49 differentially expressed proteins in hESC-MSC and BM-MSC, and they involved in different biological process such as positive regulation of molecular function, biological process, cellular metabolic process, nitrogen compound metabolic process, macromolecule metabolic process, metabolic process, molecular function, and positive regulation of molecular function and regulation of ubiquitin protein ligase activity during mitotic cell cycle, cellular response to stress, and RNA localization. As the related function of differentially expressed proteins, we sought to these proteins were key regulators which contribute to their differentiation rate, developmental process and cell proliferation. Our results suggest that the expressions of these proteins between the hESC-MSC and BM-MSC, could give to us further evidence for hESC differentiation into the mesenchymal stem cell is associated with a differentiation factor. As the initial step to understand fundamental difference of hESC-MSC and BM-MSC, we sought to investigate different protein expression profile. And the grafting of hESC differentiation into MSC and their comparative proteomic analysis will be positively contribute to cell therapy without cellular source limitation, also with exact background of their molecular condition.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1036-1041
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• 2003

Non-destruction examinations are required in medical sciences and various engineering now. We wish to emulate the examinations in very simplified experiments. It is an educational program. We show a neural network analysis to predict the locations of a sound-source or a body irradiated by sound-waves in audio-region. The sound is an interest flux, and it enables to clear local-structures in a non-transparent space. However, the sound-propagation equations are not solved easily, therefore, we consider to adopt multi-layer neural-networks instead of the direct solutions. We used detected intensities and coordinates for input data and teaching data. A neural network learned them. The neural-network analysis decomposed the distance of 50cm. The resolution is rather rough; however, it is caused by the limitation of our equipments. Since there is no problem in the neural network processing, if we could revise experiments, then, progress of the resolution would be got. Thus, the proposed method functioned as an educational and simplified non-destruction examination.

• The Journal of the Acoustical Society of Korea
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• v.34 no.5
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• pp.351-359
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• 2015

Typical underwater acoustic transducers detect only the magnitude of an acoustic pressure and they have the limitation of not being able to recognize the direction of the sound signal. Hence, the authors of this paper proposed a new vector sensor structure based on Tonpilz transducers that could detect both the magnitude and the direction of a sound pressure. In the proposed structure, the piezoceramic ring was divided into four segments, and proper combination of the output voltages of the segments in response to the external sound pressure could provide the information on the orientation of the sound source. In this paper, a Tonpilz transducer has been fabricated to have the proposed structure and its characteristics has been measured to confirm the validity of the proposed structure.