• BMB Reports
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• v.44 no.8
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• pp.497-505
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• 2011

Reactive oxygen species (ROS), which include superoxide anions and peroxides, induce oxidative stress, contributing to the initiation and progression of cardiovascular diseases involving atherosclerosis. The endogenous and exogenous factors hypercholesterolemia, hyperglycemia, hypertension, and shear stress induce various enzyme systems such as nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, and lipoxygenase in vascular and immune cells, which generate ROS. Besides inducing oxidative stress, ROS mediate signaling pathways involved in monocyte adhesion and infiltration, platelet activation, and smooth muscle cell migration. A number of antioxidant enzymes (e.g., superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins) regulate ROS in vascular and immune cells. Atherosclerosis results from a local imbalance between ROS production and these antioxidant enzymes. In this review, we will discuss 1) oxidative stress and atherosclerosis, 2) ROS-dependent atherogenic signaling in endothelial cells, macrophages, and vascular smooth muscle cells, 3) roles of peroxidases in atherosclerosis, and 4) antioxidant drugs and therapeutic perspectives.

• Journal of applied mathematics & informatics
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• v.10 no.1_2
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• pp.261-275
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• 2002

Let T be a local strongly accretive operator from a real uniformly smooth Banach space X into itself. It is proved that Ishikawa iterative schemes with errors converge strongly to a unique solution of the equations T$\_$x/ = f and x + T$\_$x/ = f, respectively, and are almost T$\_$b/-stable. The related results deal with the strong convergence and almost T$\_$b/-stability of Ishikawa iterative schemes with errors for local strongly pseudocontractive operators.

• Journal of Advanced Marine Engineering and Technology
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• v.27 no.5
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• pp.600-608
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• 2003

This Paper describes a detailed experimental investigation of heat transfer in a reciprocating smooth rectangular duct having only the bottom wall heated with reference to the design of a piston for a marine propulsive diesel engine The Parametric test matrix involves Reynolds number and reciprocating radius, respectively, in the range of 1.280∼4.100, and 7∼15 cm with five different reciprocating frequency tested. namely. 1.7, 2.2, and 2.6 Hz. The effects of three different hemi-triangular wavy type tapers on the heat transfer in the reciprocating rectangular channel using the air as a working fluid were check out. The present work confirms that the Nusselt number in the channel with the triangular wavy type taper is lower than without the triangular wavy type taper.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.6
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• pp.1990-2001
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• 1991

The fatigue life and crack penetration behavior of high strength steel have been studied in detail both experimentally and analytically. The fatigue crack shape of a smooth specimen is almost semicircular, while a specimen with stress concentration becomes semielliptical according to stress concentration shape. The aspect ratio of smooth specimens calculated using the Newman-Raju's formular is smaller than the value obtained from the experiment. On the other hand, the aspect ratio of the stress concentration specimen shows a good agreement with experimental results. It is found that the crack growth behavior on the back surface after the penetration is unique and can be divided into three stages ; rapid growth region, constant growth region and acceleration growth region. By using the K value suggested in this study, the particular crack growth behavior and crack shape can be estimated quantitatively.

• Transactions of the Korean Society of Mechanical Engineers
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• v.7 no.1
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• pp.28-35
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• 1983

Quantitative analysis have been carried out on the micro-cracks on the surface and into the depth of unnotched smooth mild steel specimen under cyclic stains by rotating bending fatigue tests. Some of the results are; (1) Cracks initiate at the early stage of fatigue life N$_{I}$/ N$_{f}$=10 to 20%, and propagate during the rest of fatigue life. (2) Coalescence of highly crowded small fatigue cracks of random distribution seems to induce the final fracture at higher stress level. (3) The curves of crack initiation and the equal crack length on the graph of stress versus number of cycles are parallel to the S-N curve. (3) The curves of crack initiation and the equal crack length on the graph of stress versus number of cycles are parallel to the S-N curve. (4) The distributions of micro-surface crack length and depth show the composite Weibull distributions which are approximated to two straight lines separated by the value of transient region between stage I and stage II crack.k.k.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1460-1465
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• 2004

Flow patterns around a rotating circular cylinder having square dimpled surface were visualized by the hydrogen bubble technique at velocity ratios from a=0 to 4.8 and Reynolds number of $Re=1.0{\times}10^{4}$. The wake region of the cylinder was reduced as the velocity ratios increase and was smaller than that of the smooth cylinder without dimples at the same velocity ratio. The hydrodynamic characteristics on the cylinder was investigated by measuring of lift and drag at velocity ratios from a=0 to 4.1 and Reynolds number from $Re=1.2{\times}10^{4}$ to $Re=2.0{\times}10^{4}$. As the velocity ratios increase, the average lift and drag coefficients were increased and at the same velocity ratio, the average lift was larger but the average drag was smaller than that of the smooth cylinder.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.2
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• pp.67-79
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• 1998

Inthe study, a method to evaluate the door closing sound has been developed. Based on the factor analysis, various adjective pairs which describe meaning of the door impact sound have been differentiated. This approach, called Semantic difference(SD) method, was originally developed in linguistics research on order to compare diverse mother tongue. This paper introduces at first how the door sound os generated and transmitted. After that, a factor analysis which is a tool of SD method is implemented to door closing sound for 12 domestic and 1 foreign car models. During investigation, the examined models are categorized into small, medium and luxurious size automobiles. The adjective pairs which attritbute to the door quality have been factorized into three group : expensive/ smooth, powerful/ heavy, and modern/dull. It turns out that the first factor : expensive/ smooth plays the most important role in door closing sound quality.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.4
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• pp.486-492
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• 2004

Flow patterns around a rotating circular cylinder having square dimpled surface were visualized by the hydrogen bubble technique at velocity ratios from a=0 to 4.8 and Reynolds number of Re=1.0${\times}$10$^4$. The wake region of the cylinder was reduced as the velocity ratios increase and was smaller than that of the smooth cylinder without dimples at the same velocity ratio. The hydrodynamic characteristics on the cylinder was investigated by measuring of lift and drag at velocity ratios from a=0 to 4.1 and Reynolds number from Re=1.2${\times}$10$^4$ to Re=2.0${\times}$10$^4$. As the velocity ratios increase, the average lift and drag coefficients were increased and at the same velocity ratio, the average lift was larger but the average drag was smaller than that of the smooth cylinder.

• Biomolecules & Therapeutics
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• v.13 no.3
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• pp.181-184
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• 2005

The solution-phase combinatorial synthesis of iminodiacetic acid triamide libraries linked to 1-(4-chlorobenzhydryl)piperazine has been reported. Ten mixture libraries, each containing 5 components, were synthesized in 4 steps from N-BOC-iminodiacetic acid anhydride. Antibradykinin effects of the mixture and individual libraries were compared using guinea-pig ileum smooth muscle. The changes in the inhibition were also observed by testing the combination of two different compounds from the same library. We found out the correlation between the inhibition of mixtures and that of individual libraries. It is possible to choose the mixtures with relatively high inhibitory effects to find out the most effective individual compound for further synthesis.

• The Journal of Internal Korean Medicine
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• v.17 no.1
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• pp.193-203
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• 1996

These studies were carried out to investigate the effect of Insameumja water extract on the inhibitory contractile action of acetylcholine in guinea pig. The results of these studies were as follows; 1. Contractile force of acetylcholine from trachea smooth muscle in guinea pig was significantly inhibited by Insameumja. 2. Dose-response of acetylcholine pretreated Insameumja in guinea pig was not significantly changed. 3. Inhibitory contractile action of acetylcholine pretreated propranolol in guinea pig was decreased. 4. Inhibitory contractile action of acetylcholine pretreated indomethacin was significantly changed by Insameumja. 5. Inhibitory contractile action of acetylcholine pretreated methylene blue was not significantly changed by Insameumja.