• The Journal of Internal Korean Medicine
• /
• v.27 no.1
• /
• pp.92-101
• /
• 2006

Objectives : This study was done with intend to investigate whether two oriental medical prescriptions, daecheongryong-tang (DCRT) and prescription A (P-A) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Methods : Confluent HTSE cells were metabolically radiolabeled with $^3H$-glucosamine for 24 hrs and chased for 30 min in the presence of DCRT or P-A to assess the effect of each agent on $^3H$-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of DCRT and P-A on contractility of isolated tracheal smooth muscle were investigated. Results were as follows : 1. DCRT significantly inhibited mucin release from cultured HTSE cells, with significant cytotoxicity. 2. P-A significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity. 3. DCRT inhibited Ach-induced contraction of isolated tracheal smooth muscle. 4. P-A also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusion: Results suggest that DCRT and P-A have regulating effects on mucin secretion from goblet cells. Further investigation is needed, because of the value in finding novel agents to this purpose, and these oriental medical prescriptions have potential for this role.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.27 no.4
• /
• pp.362-366
• /
• 2001

Leiomyosarcoma(LMS) is a malignant tumor from smooth muscle origin that arises most commonly in the gastrointestinal tract and uterus, but rarely in the oral and maxillofacial area which lacks smooth muscles. 63 cases of oral LMS have been reported, especially LMS that occurred in the mandibular gingiva is only 2 cases. Major symptom of oral LMS is painful or painless swelling. Besides it, oral LMS has no specific characteristics. So it is difficult to diagnose the case as LMS of the oral cavity. Certain cases report that LMS of the oral cavity was misdiagnosed as periodontitis and the patients were treated with unnecessary procedures. Conventional treatment of LMS is the radical surgical excision. LMS that is infiltrative and very malignant has poor prognosis despite of well-circumscribed boundary. LMS of the oral cavity is often recurred, has high rate of distant metastasis and 5-year-survival rate is as low as 23%. This article reports LMS of the mandibular gingiva that treated with surgical intervention, had local recurrence and metastasis to the lymph node after 16-month's follow-up examination.

• Journal of Chest Surgery
• /
• v.26 no.8
• /
• pp.654-660
• /
• 1993

The incidence of pulmonary leiomyosarcoma is very rare as a primary lung tumor. Usually, pulmonary leiomyosarcoma arise from the smooth muscle present in the bronchi or blood vessles. We had experienced two cases of primary pulmonary leiomyosarcoma. The first case was 28-year old male patient who had been in good health until admission, when he experienced an episode of dyspnea and sudden hemoptysis. The chest X-ray film revealed a large round tumor mass in left lower lobe measuring 6.5x9.5x5.3cm in dimension. On physical examination,the patient was friction rub and rales on the left lower chest and postoperative course was smooth and non-eventful. Emergency left lower lobectomy was performed due to repeated hemoptysis. Chemotheraphy was done postoperatively as an adjuvant therapy.The second case was 52-year-old man who had been well prior to admission, when recently he noticed a abrupt growing tendency of old pulmonary coin lesion in right lower lobe on routine physical examination. Since 1968, small round mass was gradually enlarged very slowly, during recent one year interval, the tumor mass was enlarged abruptly as twice in size on chest X-ray. Bronchoscopic examination revealed no specipic findings. Right lower lobectomy was performed and pathologic examination was answered as primary leiomyosarcoma without lymph node metastasis. Postoperative course was smooth, except local wound infection.

• Journal of Ocean Engineering and Technology
• /
• v.1 no.1
• /
• pp.127-137
• /
• 1987

The evaluation of the elastic-plastic fracture toughness $J_{1C}$ was performed on the center of weld metal(CWM), the heat affected zone (HAZ) and the base metal (BM) of API 5LB steel pipes welded by the high frequency electric resistance welding. The $J_{1C}$ was evaluated by the JSME R-Curve and JSME SZW methods using the smooth and side-grooved specimens. The results are as follows; (1) The $J_{1C}$ values by the SZW method are overestimated as compared with those by the R-curve method, because the micro-crack is formed as SZW increase with the deformation at SZ after initiation of the ductile crack. (2) The everage of $J_{1C}$ values by the the R-curve and the SZW methods in side-grooved specimens tended to decrease in comparison with smooth specimens 9.42% at CWM, 4.2% at HAZ, 23.2% at BM, respectively. (3) The boundary of the fatigue pre-crack, stretched zone, and dimple regions appeared more clearly in side-grooved specimens, for the slight change of SZW in the direction of the plate thickness, as compared with smooth specimens.

• Journal of Navigation and Port Research
• /
• v.28 no.6
• /
• pp.469-474
• /
• 2004

In this paper, we study the posture control of an underwater vehicle with nonholonomic constraint. Generally, systems with nonholnomic constraints cannot be stabilized to an equilibrium points by smooth state feedback control. For the nonholonomic underwater vehicle system, we applied coordinate transformation to get multi-chained system We proposed non smooth feedback controller using backstepping method for stabilizing the multi chained form system Applying inverse input transformation to the non smooth feedback controller, we can get posture controller of the underwater vehicle with nonholonomic constraint. The proposed control scheme is applied to the posture control qf an underwater vehicle and verified the effectiveness of control strategy by numerical simulation.

• Journal of Power System Engineering
• /
• v.12 no.3
• /
• pp.19-25
• /
• 2008

This paper deals with the heat transfer and pressure drop characteristics of R-290 (Propane), R-600a (Iso-butane) and R-1270 (Propylene) as an environment friendly refrigerant and R-22 as a HCFC's refrigerant for condensing. The test section is a horizontal double pipe heat exchanger. Condensing heat transfer and pressure drop measurements were Peformed for 12.70 mm micro-fin tube and compared with the results in smooth tube. The local condensing heat transfer coefficients of hydrocarbon refrigerants were superior to those of R-22 and the maximum increasing rate of heat transfer coefficient was found in R-600a. The average condensing heat transfer coefficients in hydrocarbon refrigerants showed 20 to 28% higher values than those of R-22. Hydrocarbon refrigerants have a higher pressure drop than that of R-22 with respect to refrigerant qualify and mass flux. Also, the condensing heat transfer coefficient and pressure drop of working fluids in smooth and micro-fin tube were compared. The heat transfer enhancement factor (EF) between smooth and micro-fin tube varied from 2.2 to 2.6 in all experimental conditions.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.9 no.6
• /
• pp.699-705
• /
• 1985

Heat transfer characteristics in terms of the tube wall-temperature and the enthalpy have been investigated utilizing ribbed (rifled) tubes in order to enhance heat transfer performance. Considerations were given for the cases of smooth tubes in order to compare with the case of ribbed tubes. The tilt angle of the experimental tubes are from 0.deg. to 90.deg. , in order to simulate the boiler water tubes having 15.deg.-90.deg. inclined angle in boiler nose and studded tubes (burner zones), Natural convection and forced convection (Re=1810) conditions were considered in the experiments. The experimental results for the effect for the tube inclination through a natural convection and forced convection are presented and it is shown that ribbed tubes permit an appreciable increase in heat transfer coefficients and consequently it means substantial reductions in boiler water wall tubes and heat exchanger surface areas.

• Journal of the Korean Society of Visualization
• /
• v.12 no.3
• /
• pp.15-20
• /
• 2014

Direct numerical simulation (DNS) dataset of a turbulent boundary layer (TBL) with a step change from smooth to rough surface is analyzed to examine spatially developing flow characteristics. The roughness elements are periodically arranged two-dimensional (2-D) spanwise rods with a streamwise pitch of ${\lambda}=8k$ ($=12{\theta}_{in}$), and the roughness height is $k=15{\theta}_{in}$, where ${\theta}_{in}$ is the inlet momentum thickness. The step change is introduced $80{\theta}_{in}$ downstream from the inlet. For the first time, full images from the DNS data with the step change from the smooth to rough walls is present to get some idea of the geometry of turbulent coherent structures over rough wall, especially focusing on their existence and partial dynamics over the rough wall. The results show predominance of hairpin vortices over the rough wall and their spanwise scale growth mechanism by merging.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.20 no.7
• /
• pp.2196-2204
• /
• 1996

The damage mechanism by the impact of steel ball on the soda-lime glass having a different surface roughness was investigated. An initiation and a propagation behavior of cracks formed by each impact velocity were quantitatively studied. A 4-point bending test was carried out to evaluate the remaining bending strength of a scratched soda-lime glass which impacted by the steel ball. As the surface roughness was increased, the shape of cracks became more irregular rather than those of the smooth specimens. The phenomenon of turning up in the wing of cone cracks occurred even at the lower velocity than the critical velocity caused the crushing. The threshold velocity of cracks initiation generally became lower than those of smooth specimen. An initiation and a propagation behavior of radial cracks had no relation with the direction of scratch on the surface. The remaning benidng strength of the scratched specimen according to impact velocity had no big difference compared with those of the smooth specimen.

• The Korean Journal of Physiology and Pharmacology
• /
• v.3 no.6
• /
• pp.597-603
• /
• 1999

Caldesmon (CaD), one of microfilament-associated proteins, plays a key role in microfilament assembly in mitosis. We have investigated the effects of overexpression of the high molecular weight isoform of CaD (h-CaD) on the physiology of vascular smooth muscle cells (VSMCs). Rat aortic VSMCs were stably transfected with plasmids carrying a full length human h-CaD cDNA under control of cytomegalovirus promoter. The majority of the overexpressed h-CaD appears to be localized predominantly on cytoskeleton structures as determined by detergent lysis. The overexpression of h-CaD, however, does not decrease the level of endogenous low molecular weight isoform of CaD. h-CaD overexpressing VSMCs (h-CaD/VSMCs) show a decreased growth rate than that of vector-only transfected cells when determined by $[^3H]thymidine$ uptake and cell counting after fetal bovine serum (FBS) stimulation. h-CaD/VSMCs were smaller than vector-transfected cells by 18% in cell diameter. These data suggest that overexpression of h-CaD can inhibit the poliferation and the cell volume of VSMCs stimulated by growth factors and that the gene therapy with h-CaD may be helpful to prevent the conditions associated with hypertrophy and/or hyperplasia of VSMCs after arterial injuries.