• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.32 no.8
• /
• pp.612-620
• /
• 2008

New alternative refrigerants have been developed due to the ozone layer depletion and global warming. For this reason, carbon dioxide is believed to be a promising refrigerant for use in air conditioners and heat pumps. Evaporative heat transfer characteristics and pressure drop of $CO_2$ with outer diameter of 5 mm in inclined ($45^{\circ}$) smooth and micro-fin tubes have been investigated by the experiments with respect to several test conditions such as mass fluxes, heat fluxes, evaporation temperatures in this study. The inclined ($45^{\circ}$) smooth and micro-fin tubes with length of 1.44 m were installed to measure the evaporative heat transfer coefficients of $CO_2$ and heat was supplied to the refrigerant by direct heating method where the test tube was uniformly heated by electricity. The tests were conducted at mass fluxes from 212 to $656\;kg/m^2s$, heat fluxes from 15 to $60\;kW/m^2$ and evaporation temperatures from -10 to $20^{\circ}C$. The heat transfer coefficients of $CO_2$ are slightly increased with increasing mass flux, and the heat transfer characteristics in the inclined ($45^{\circ}$) tubes are enhanced about $5{\sim}10%$ compared with those in horizontal or vertical tubes.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.23 no.10
• /
• pp.670-677
• /
• 2011

Direct numerical simulation are performed in order to investigate the effect of the circular cylinder shape on the forced convection around a circular cylinder at the Reynolds number of 300 and Prandtl number of 0.71. Three-dimensional characteristics of fluid flow and heat transfer around the smooth, wavy and torsional cylinders are investigated. A wavy cylinder has the sinusoidal variation in the cross sectional area along the spanwise direction with the wave length of ${\pi}/3$ and wavy amplitude of 0.1. A torsional cylinder has the twisted elliptic cross section with a torsional period of ${\pi}/2$ and an axis ratio of 1.35 corresponding to the major axis of 1.15 and the minor axis of 0.85. The value of time-and surface-averaged drag coefficient for the smooth cylinder is similar to that for the wavy cylinder, but larger than that for the torsional cylinder. The time and surface-averaged lift coefficient for the smooth cylinder is larger than that for the wavy and torsional cylinders. The time-averaged local heat transfer rate for the wavy and torsional cylinders shows different distribution along the circumferential direction, compared to that for the smooth cylinder because of the shape change in the spanwise direction for the cases of the wavy and torsional cylinders.

• Proceedings of the Ginseng society Conference
• /
• 1980.09a
• /
• pp.71-76
• /
• 1980

Aortic strips were prepared from rabbits, and the tensions were maintained by administration of norepinephrine into the incubation chamber. The application of diol or triol induced relaxation of the aortic strip, as indicated by the decreased aortic tension. Triol, in a concentration of $30\;mg\%\;causes\;approximately\;50\%$ of muscle relaxation, whereas a similar degree of relaxation is induced by $50\;mg\%$ of diol. This indicates that both triol and diol cause relaxation of the aorta, but that triol is about $170\%$ more potent than diol. It is well established that blood-vessel smooth-muscle tone is regulated by the available intracellular $Ca^{++}$ concentration, which in turn is profoundly influenced by interaction of the cellular membrane and sarcoplasmic reticulum in the smooth muscle. Thus, any agent which modifies the smooth-muscle tone is expected to interfere with the $Ca^{++}$ binding or uptake of sarcolemma and sarcoplasmic reticulum. In the following experiments sarcoplasmic reticulum and sarcolemma were prepared from the ventricle of rabbit heart, and the active $Ca^{++}$ uptake by these cellular components was measured employing $Ca^{45}$ in the presence of triol and diol. It was found that the active $Ca^{++}$ uptake in the presence of ATP by sarcoplasmic reticulum was inhibited by both triol and diol. Panaxatriol, in a concentration of $80\;mg\;\%,$ inhibited $Ca^{++}$ uptake by $30\%,$ whereas panaxatriol in the same concentration inhibited uptake by $20\%.$ It is clear that triol is a more potent inhibitor of active $Ca^{++}$ transport in sarcoplasmic reticulum than diol. The $Ca^{++}$ binding of the cellular membrane was also studied employing Ca45 and milipore techniques. It was found that triol in a concentration of $80\;mg\;\%,$ decreased $Ca^{++}$ binding by $29\%.$ Diol in the same concentration decreased the binding by $17\%.$ It is clear that both triol and diol inhibit $Ca^{++}$ binding to the cellular membrane, but triol is approximately $180\%$ more potent than diol.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.28 no.4
• /
• pp.668-672
• /
• 2001

The purpose of study was to measure the interrater reliability of the caries diagnostic instrument, Diagnodent(KaVo, Germany), using a new laser fluorescence technique. Occlusal surfaces and smooth surfaces of one hundred extracted human premolars and molars were examined by four dentists. Pearson correlation coeffcients were 0703 to 0.870 for occlusal surfaces and 0.764 to 0.932 for smooth surfaces (P<0.01, all). Reliability coefficients which were calculated by intraclass correlation coefficients were 0.9450 for occlusal surfaces and 0.9605 for smooth surfaces. Therefore, the interrater reliability of caries diagnosis by Diagnodent is very high, and the rater training would be necessary more for occlusal surfaces than for smooth surfaces.

• The Korean Journal of Physiology
• /
• v.29 no.1
• /
• pp.61-67
• /
• 1995

The extract of Ginkgo bibloba (EGb) is a complex mixture of natural products from the Ginkgo leaves and clinically used for the treatment of cerebral and peripheral circulatory disturbances due to its combined activity of several vasoactive principles. In this study we investigated the action of EGb and its mechanism in isolated rabbit corporal smooth muscle to evaluate the possibility of using this material as a pharmacoerecting agent. Strips of rabbit corpus cavernosum were mounted in organ chambers to measure isometric tension. EGb began to exert an relaxing effect at 1 mg/ml in the submaximally precontracted muscle strips with phenylephrine $(PHE,\;5{\times}10^{-6}\;M)$; causing concentration-dependent relaxation with maximal effect at $3{\sim}5\;mg/ml$. That relaxation was partially inhibited by removal of the smooth muscle endothelium or by pretreatment with a NO scavenger, pyrogallol $(10^{-4}\;M)$ or the guanylate cyclase inhibitor, methylene blue $(10^{-4}\;M)$. Pretreatment with EGb (3 mg/ml) inhibited PHE- $(5{\times}10^{-6}\;M)$ or KCI- (20 and 40 mM) induced contraction of muscle strip. In calcium-free high potassium solution EGb depressed the basal tone of the depolarized muscle strip and inhibited calcium-induced contraction when $CaCl_2$ $(10^{-4}\;M)$ was added. These results suggest that EGb relaxes rabbit corpus cavernosal smooth muscle through multiple action mechanisms that include increasing the release of nitric oxide from the corporal sinusoidal endothelium, sequestration of intracytosolic calcium, and maybe a hyperpolarizing action.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.31 no.7A
• /
• pp.659-665
• /
• 2006

When using the Mobile IP which is the representative technology to secure the mobility in general IP networks, the packet loss during the handover is inescapable. To remedy the packet loss problem, the smooth handover was introduced. However, the smooth handover causes the packets sequence disruption during the packet forwarding procedure and it may result in the degradation of the network performance. The same problem also occurs in the WiBro (High-speed Portable Internet) system that is the next generation portable IP service system. The WiBro system, which provides the high speed data service just like xDSL and leased line in wired internet, aims to guarantee the portability, mobility, and the differentiated service based on IEEE 802.16. So, the handover mechanisms that solve the problems of packet loss and packet sequence distribution are required in the WiBro system. In this paper, we propose the handover mechanism and the packet sequence control algorithm that provide the reliability and the differentiated service for the unicast service in the WiBro system.

• The Korean Journal of Physiology and Pharmacology
• /
• v.2 no.3
• /
• pp.361-368
• /
• 1998

The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of prostaglandin $E_2$ ($PGE_2$) on the contractile and electrical activities of antral smooth muscles in guinea-pig stomach, using an intracellular recording technique. To elucidate the underlying mechanism for its effect on contractility, ionic currents were also measured using a whole-cell patch clamp method. The basal tone by $PGE_2$ was variable, whereas the magnitude of phasic contractions was reduced ($19.0{\pm}2.1%$, n=19). The resting membrane potentials were hyperpolarized ($-4.4{\pm}0.5%$ mV, n=10), and plateau potentials were lowered ($-2.9{\pm}0.5%$ mV, n=10). In most cases, however, the initial peak potentials of slow waves were depolarized more by $PGE_2$ than those of control. The frequency of the slows wave was increased from $5.7{\pm}0.2$ cycles/min to $6.5{\pm}0.2$ (n=22). Voltage-operated $Ca^{2+}$ currents were decreased by $PGE_2$ (n=5). Voltage-operated $K^+$ currents, both Ca-dependent and Ca-independent, were increased (n=5). These results suggest that $PGE_2$ plays an important role in the modulation of gastric smooth muscle activities, and its inhibitory effects on the contractility and activities of slow waves are resulted from both decrease of $Ca^{2+}$ currents and increase of $K^+$ currents.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.6
• /
• pp.437-446
• /
• 2012

Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by recurrent episodes of colonic inflammation and tissue degeneration in human or animal models. The contractile force generated by the smooth muscle is significantly attenuated, resulting in altered motility leading to diarrhea or constipation in IBD. The aim of this study is to clarify the altered contractility of circular and longitudinal smooth muscle layers in proximal colon of trinitrobenzen sulfonic acid (TNBS)-induced colitis mouse. Colitis was induced by direct injection of TNBS (120 mg/kg, 50% ethanol) in proximal colon of ICR mouse using a 30 G needle anesthetized with ketamin (50 mg/kg), whereas animals in the control group were injected of 50% ethanol alone. In TNBS-induced colitis, the wall of the proximal colon is diffusely thickened with loss of haustration, and showed mucosal and mucular edema with inflammatory infiltration. The colonic inflammation is significantly induced the reduction of colonic contractile activity including spontaneous contractile activity, depolarization-induced contractility, and muscarinic acetylcholine receptor-mediated contractile response in circular muscle layer compared to the longitudinal muscle layer. The inward rectification of currents, especially, important to $Ca^{2+}$ and $Na^+$ influx-induced depolarization and contraction, was markedly reduced in the TNBS-induced colitis compared to the control. The muscarinic acetylcholine-mediated contractile responses were significantly attenuated in the circular and longitudinal smooth muscle strips induced by the reduction of membrane expression of canonical transient receptor potential (TRPC) channel isoforms from the proximal colon of the TNBS-induced colitis mouse than the control.

• The Korean Journal of Physiology and Pharmacology
• /
• v.15 no.5
• /
• pp.267-272
• /
• 2011

A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes. In the present study, we investigated the pharmacological characterization of the 5-HT-induced contractile response in longitudinal smooth muscle isolated from the feline ileum. Addition of 5-HT into muscle chambers enhanced the basal tone and spontaneous activity in a concentration-dependent manner. The neurotoxin tetrodotoxin did not alter the 5-HT-induced contraction of the longitudinal muscles. Neither atropine nor guanethidine affected the contraction. The 5-HT agonists, 5-methylserotonin hydrochloride and mosapride, also evoked concentration-dependent contractions. The 5-HT-induced contraction was enhanced by the $5HT_2$ receptor antagonist ketanserin and the $5-HT_3$ receptor antagonist ondansetron but was inhibited by the 5-$HT_1$ receptor antagonist methysergide and 5-$HT_4$ receptor antagonist GR113808. These results indicate that 5-$HT_1$ and 5-$HT_4$ receptors may mediate the contraction of the 5-HT-induced response and 5-$HT_2$ and 5-$HT_3$ receptors may mediate 5-HT-induced relaxation in feline ileal longitudinal smooth muscles.

• The Korean Journal of Physiology and Pharmacology
• /
• v.12 no.1
• /
• pp.31-35
• /
• 2008

Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase $A_2$, has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. $Ca^{2+}$ influx was shown to be augmented in atherosclerotic artery which might be responsible for abnormal vascular reactivity. However, the mechanism underlying $Ca^{2+}$ influx change in atherosclerotic artery remains undetermined. The purpose of the present study was to examine the effects of LPC on L-type $Ca^{2+}$ current $(I_{Ca(L)})$ activity and to elucidate the mechanism of LPC-induced change of $I_{Ca(L)}$ in rabbit portal vein smooth muscle cells using whole cell patch clamp. Extracellular application of LPC increased $I_{Ca(L)}$ through whole test potentials, and this effect was readily reversed by washout. Steady state voltage dependency of activation or inactivation properties of $I_{Ca(L)}$ was not significantly changed by LPC. Staurosporine (100 nM) or chelerythrine $(3{\mu}M)$, which is a potent inhibitor of PKC, significantly decreased basal $I_{Ca(L)}$, and LPC-induced increase of $I_{Ca(L)}$ was significantly suppressed in the presence of PKC inhibitors. On the other hand, application of PMA, an activator of PKC, increased basal $I_{Ca(L)}$ significantly, and LPC-induced enhancement of $I_{Ca(L)}$ was abolished by pretreatment of the cells with PMA. These findings suggest that LPC increased $I_{Ca(L)}$ in vascular smooth muscle cells by a pathway that involves PKC, and that LPC-induced increase of $I_{Ca(L)}$ might be, at least in part, responsible for increased $Ca^{2+}$ influx in atherosclerotic artery.