• The Journal of Internal Korean Medicine
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• v.38 no.3
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• pp.353-366
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• 2017

Objective: This study aimed to use a mouse model to evaluate the effects of Gwaruhaengryeon-hwan (GHH) on chronic obstructive pulmonary disease (COPD) and particulate matter induced lung injury. Materials and Methods: The study was carried out in two ways (in vitro, in vivo). In vitro RAW 264.7 cells (mouse macrophage) were used and analyzed by flow cytometry, ELISA. In vivo lipopolysaccharide (LPS) and cigarette smoke solution (CSS), or coal, fly ash, diesel exhaust particle (CFD) challenged mice were used and its BALF was analyzed by ELISA, lung tissue by real-time PCR. Results: In vitro, GHH maintained an 80-100% rate of viability. So cytotoxicity was not shown. In the ELISA analysis with RAW 264.7 cells, GHH significantly decreased NO over $30{\mu}g/ml$. In the ELISA analysis, GHH significantly decreased $TNF-{\alpha}$, IL-6 over $300{\mu}g/ml$. In the COPD model, the GHH 200 mg/kg dosage group, the application of GHH significantly decreased the increasing of neutrophils, $TNF-{\alpha}$, IL-17A, MIP2, CXCL-1 in BALF, $TNF-{\alpha}$, $IL-1{\beta}$ mRNA expression in lung tissue and histological lung injury. In the CFD induced lung injury model, the GHH 200 mg/kg dosage group, the application of GHH significantly decreased the increase of neutrophils, $TNF-{\alpha}$, IL-17A, MIP2, CXCL-1 in BALF, MUC5AC, $TGF-{\beta}$ mRNA expression in lung tissue and histological lung injury. Conclusion: This study suggests the usability of GHH for COPD patients by controlling lung tissue injury.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.3
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• pp.375-388
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• 2017

In order to solve the traffic congest and environmental issues, small-cross section tunnel for small car only is increasing, but there is not standard for installation of disaster prevention facility. In this study, in order to investigate the behavioral characteristics of thermal environment and smoke in a small cross section tunnels with a large port exhaust ventilation system, the A86, the U-Smartway and the Seobu moterawy tunnel, Temperature and CO concentration in case of fire according to cross sectional area, heat release rate and exhaust air flow rate were analyzed by numerical analysis and the results were as follows. As the cross-sectional area of the tunnel decreases, the temperature of the fire zone increases and the rate of temperature rise is not significantly affected by heat release rate. However, there is a difference depending on the change of the exhaust air flow rate. In the case of applying the exhaust air flow rate $Q_3+2.5Ar$ of the large port exhaust ventilation system, the temperature of the fire zone was 7.1 times for A86 ($Ar=25.3m^2$) and 5.4 time for U-smartway ($Ar=37.32m^2$) by Seobu moterway tunnel ($Ar=46.67m^2$). The CO concentration of fire zone also showed the same tendency. The A86 tunnels were 10.7 times and the U-Smartways were 9.5 times more than the Seobu moterway. Therefore, in the case of a small section tunnel, the thermal environment and noxious gas concentration due to the reduction of the cross-sectional area are expected to increase significantly more than the cross-sectional reduction rate.

• Fire Science and Engineering
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• v.28 no.3
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• pp.43-48
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• 2014

The purpose of this study is to analyze the flame propagation speed, radiation range, diffusion pattern and combustion completion time of a fire by filling a divided space with single combustible substance. It was found that the flame propagation speed was the fastest (0.2 s) for kerosene and the lowest (82.1 s) for alcohol. In the case of paint thinner, it took 19.0 s for the flame to reach its peak at the fastest speed after ignition while in the case of alcohol, it took 138.6 s for the flame to reach its peak at the lowest speed. In the case of the combustion of 200 ml of flammable liquids, the combustion completion time was 79.9 s for paint thinner, which is the shortest, 135 s for gasoline, 170 s for kerosene, 231.4 s for diesel and 337.0 s for alcohol. In addition, when flammable liquids are combusted, the lower part of the flame is governed by laminar flow pattern and the upper part of the flame showed turbulence pattern. In the case of a test performed for bean oil, it could be seen that if the fire source was removed, the flame was automatically extinguished without further combustion and that white smoke was generated due to incomplete combustion.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.8
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• pp.1023-1032
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• 2003

The effect of local forcing on the separated flow over a backward-facing step is investigated through hot-wire measurements and flow visualization with multi-smoke wires. The boundary layer upstream of the separation point is laminar and the Reynolds number based on the free stream velocity and the step height is 13800. The local forcing is given from a slit located at the step edge and the forcing signal is always defined when the wind tunnel is in operation. In case of single frequency forcing, the streamwise velocity and the reattachment length are measured under forcing with various forcing frequencies. For the range of 0.010〈S $t_{\theta}$〈0.013, the forcing frequency component of the streamwise velocity fluctuation grows exponentially and is saturated at x/h = 0.75 , while its subharmonic component grows following the fundamental and is saturated at x/h = 2.0. However, the saturated value of the subharmonic is much lower than that of the fundamental. It is observed that the vortex formation is inhibited by the forcing at S $t_{\theta}$ = 0.019 . For double frequency forcing, natural instability frequency is adopted as a fundamental frequency and its subharmonic is superposed on it. The fundamental frequency component of the streamwise velocity grows exponentially and is saturated at 0.5 < x/ｈ < 0.75, while its subharmonic component grows following the fundamental and is saturated at x/ｈ= 1.5 . Furthermore, the saturated value of the subharmonic component is much higher than that for the single frequency forcing and is nearly the same or higher than that of the fundamental. It is observed that the subharmonic component does not grow for the narrow range of the initial phase difference. This means that there is a range of the initial phase difference where the vortex parring cannot be enhanced or amplified by double frequency forcing. In addition, this effect of the initial phase difference on the development of the shear layer and the distribution of the reattachment length shows a similar trend. From these observations, it can be inferred that the development of the shear layer and the reattachment length are closely related to the vortex paring.

• Fire Science and Engineering
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• v.30 no.2
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• pp.68-74
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• 2016

In semi-transverse ventilation system applied for road tunnel, adjustment of the port opening ratio is an essential part for uniform airflow rate per unit length over the entire tunnel. However, it has not been considered decently throughout the design process and operating of the tunnel. Therefore, in this study, we developed a program for the calculation of the opening size ratio of supply or exhaust port in transverse ventilation system and carried out the research to present a management plan for the port. In supply duct system, the opening size of the port had a tendency to increase and then decrease later when it gradually becomes closer toward the bulkhead at the beginning of the duct the minimum opening degree is to appeared as 56%. In the exhaust system, port size is the smallest at the beginning of duct as 15%, has shown a tendency to increase towards the bulk head. As results of estimating the air flow rate for 300 m intervals, the exhaust flow rate in the center of tunnel appeared to be extremely low as 8.1% and 12.5% when port size is constant and is adjusted supply type. Thus, even if the normal ventilation efficiency is declines, yet it is highly recommend adjusting the port size in order to obtain a uniform flow rate at fire accidents.

• Safety and Health at Work
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• v.6 no.2
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• pp.85-89
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• 2015

Background: The study was designed to assess the changes in working conditions through a comparative analysis of the characteristics of working conditions in 2006 and 2010. Methods: We performed a comparative analysis of the data related to the first Korean Working Conditions Survey (KWCS) and the second KWCS in the categories of demographic characteristics, quality of labor, exposure to hazards, and health problems. Results: From our analysis of the demographic characteristics, we saw an increase in labor force participation rate of women and elderly people. As a result of the investigation with regards to working hours, the ratio of employees who worked for ${\geq}49$ hours per week was decreased and the ratio of employees who worked for ${\geq}40h/wk$ increased. As for exposure to hazards, exposure to tobacco smoke notably decreased in 2010 compared with 2006. With regards to health problems, there was a sharp increase in the number of people who complained of muscle pain in their arms and legs. Conclusion: KWCS data included many aspects of working conditions as a nationwide sample. In addition, because this is a periodic nationwide survey, the labor force, working hours, harmful factor exposure, and the change in health problems characteristics according to the flow of time could be investigated. The information comparing the main results of the first survey conducted in 2006 and the second survey conducted in 2010 obtained through this study can be used as an important base material for the establishment of the national policy.

• Structural Monitoring and Maintenance
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• v.5 no.3
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• pp.363-377
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• 2018

The proper functioning of critical points on transport infrastructure is decisive for the entire network. Tunnels and bridges certainly belong to the critical points of the surface transport network, both road and rail. Risk management should be a holistic and dynamic process throughout the entire life cycle. However, the level of risk is usually determined only during the design stage mainly due to the fact that it is a time-consuming and costly process. This paper presents a simplified quantitative risk analysis method that can be used any time during the decades of a tunnel's lifetime and can estimate the changing risks on a continuous basis and thus uncover hidden safety threats. The presented method is a decision support system for tunnel managers designed to preserve or even increase tunnel safety. The CAPITA method is a deterministic scenario-oriented risk analysis approach for assessment of mortality risks in road tunnels in case of the most dangerous situation - a fire. It is implemented through an advanced risk analysis CAPITA SW. Both, the method as well as the resulting software were developed by the authors' team. Unlike existing analyzes requiring specialized microsimulation tools for traffic flow, smoke propagation and evacuation modeling, the CAPITA contains comprehensive database with the results of thousands of simulations performed in advance for various combinations of variables. This approach significantly simplifies the overall complexity and thus enhances the usability of the resulting risk analysis. Additionally, it provides the decision makers with holistic view by providing not only on the expected risk but also on the risk's sensitivity to different variables. This allows the tunnel manager or another decision maker to estimate the primary change of risk whenever traffic conditions in the tunnel change and to see the dependencies to particular input variables.

• Journal of the Korea Computer Graphics Society
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• v.24 no.4
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• pp.21-27
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• 2018

In this paper, we propose a real-time interaction method using user's mouth wind in mobile device. In mobile and virtual reality, user interaction technology is important, but various user interface methods is still lacking. Most of the interaction technologies are hand touch screen touch or motion recognition. In this study, we propose an interface technology that can interact with real time using user's mouth wind. The direction of the wind is determined by using the angle and the position between the user and the mobile device, and the size of the wind is calculated by using the magnitude of user's mouth wind. To show the superiority of the proposed technique, we show the result of visualizing the flow of the vector field in real time by integrating the mouth-wind interface into the Navier-Stokes equations. We show the results of the paper on mobile devices, but can be applied in the Agumented reality(AR) and Virtual reality(VR) fields requiring interface technology.

• Journal of Korean Tunnelling and Underground Space Association
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• v.7 no.1
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• pp.13-25
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• 2005

In general, tunnel ventilation is analyzed with the assumption of equal vehicular speed for both directions in bidirectional traffic tunnels. This practice is likely to result in minimizing the piston effects and cannot take into consideration the effects of real situations, since in most cases, speeds of vehicles moving in opposite directions are not equal. Therefore, The ultimate goal of this study is to review the effects of unequal vehicular speeds on the planning of local bidirectional tunnel ventilation. To apply unequal vehicular speed for the bidirectional tunnel ventilation plan, the following requirements are necessary; (1) Adoption of strict smoke concentration standards for 'free-flow & congested' traffic conditions, (2) Selection of an appropriate ratio of heavy directional traffic volume, and (3) Selection of reasonable stepwised magnitude of speed difference. Based on the importance of research topic, this study aims at comparing the differences of the capacity of ventilation equipment for the cases with equal and unequal vehicular speeds in local bidirectional tunnels.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2207-2212
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• 2012

Overexpression of DNA methyltransferase 1 (DNMT1) has been detected in many cancers. Tobacco exposure is known to induce genetic and epigenetic changes in the pathogenesis of malignancy. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important carcinogen present in tobacco smoke; however the detailed molecular mechanism of how NNK induces esophageal carcinogenesis is still unclear. We found that DNMT1 was overexpressed in ESCC tissues compared with paired non-cancerous tissues, the overexpression being correlated with smoking status and low expression of $RAR{\beta}$. The latter could be upregulated by NNK treatment in Het-1A cells, and the increased DNMT1 expression level reflected promoter hypermethylation and downregulation of retinoic acid receptor ${\beta}$($RAR{\beta}$). RNA interference mediated knockdown of DNMT1 resulted in promoter demethylation and upregulation of $RAR{\beta}$ in KYSE30 and TE-1 cells. 3-(4,5-Dimethyl-thiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometric analysis demonstrated that NNK treatment in Het-1A cells could enhance cell proliferation and inhibit cell apoptosis in a dose-dependent manner. In conclusion, DNMT1 overexpression is correlated with smoking status and low expression of $RAR{\beta}$ in esophageal SCC patients. NNK could induce $RAR{\beta}$ promoter hypermethylation through upregulation of DNMT1 in esophageal squamous epithelial cells, finally leading to enhancement of cell proliferation and inhibition of apoptosis.