• 대한한의학방제학회지
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• 제29권3호
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• pp.119-125
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• 2021

Obejectives : The purpose of this study is to find out the efficacy of pacemaker potentials of interstitial Cells of Cajal (ICC) by Fermented Lotus Root (FLR) in small intestine. Methods : Enzyme digestions were used to separate the ICC. Using electrophysiological methods, pacemaker potentials were measured and intestinal transit rates (ITR) experiments were conducted to identify in vivo gastrointestinal motility. Results : 1. FLR (0.5-10 mg/ml) caused membrane depolarization by electrophysiological methods. 2. In the case of pretreatment with a Ca²⁺ free solution and thapsigargin, the pacemaker potential disappeared and in this case, FLR did not have a membrane depolarization reaction. 3. Lowering the concentration of extracellular Na⁺ concentration stoped the pacemaker potentials and inhibited the reaction caused by FLR. Flufenamic acid also inhibited the reaction by FLR. 4. In mice, ITR was increased by FLR. Conclusions : This study shows that FLR can control ICC by an internal/external Ca²⁺ and Na⁺. It also shows that FLR can be a good candidate for gastrointestinal motility medication development.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제36권5호
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• pp.219-223
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• 2014

During surgical procedures, unexpected material, including surgical instruments and tissue segments, may get lost in the surgical field. Most of these should be immediately removed to prevent further complications, such as vital organ irritation, infection, and inflammatory pseudo-tumor formation. However, it is not always easy to define the exact location of the foreign body, especially if the item is very small and/or it is embedded in the soft tissue of the head and neck region. Intraoperative real-time radiological imaging with C-arm fluoroscopy can be useful to trace the three-dimensional location of small and embedded foreign bodies in the oral and maxillofacial area. We describe an unusual case of an embedded micro-screw in the intrinsic tongue muscle that had been dropped into the sublingual space during a lower alveolar bone graft procedure. The lost foreign body was accurately identified with C-arm fluoroscopy and safely removed without any further complications.

• 제어로봇시스템학회논문지
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• 제22권10호
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• pp.839-846
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• 2016

Bin picking is a task of picking a small object from a bin. For accurate bin picking, the 3D pose information, position, and orientation of a small object is required because the object is mixed with other objects of the same type in the bin. Using this 3D pose information, a robotic gripper can pick an object using exact distance and orientation measurements. In this paper, we propose a 3D vision technique for accurate measurement of 3D position and orientation of small objects, on which a paper label is stuck to the surface. We use a maximally stable extremal regions (MSERs) algorithm to detect the label areas in a left bin image acquired from a stereo camera. In each label area, image features are detected and their correlation with a right image is determined by a stereo vision technique. Then, the 3D position and orientation of the objects are measured accurately using a transformation from the camera coordinate system to the new label coordinate system. For stable measurement during a bin picking task, the pose information is filtered by averaging at fixed time intervals. Our experimental results indicate that the proposed technique yields pose accuracy between 0.4~0.5mm in positional measurements and $0.2-0.6^{\circ}$ in angle measurements.

• Clinical Pain
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• 제19권2호
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• pp.120-123
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• 2020

Rapidly destructive arthrosis is a rare syndrome characterized by narrowing of the joint space and rapid joint destruction within 6~12 months. A 62-year-old woman with anaplastic lymphoma kinase rearranged non-small-cell lung cancer presented with both knee pain and varus deformity. She was treated with crizotinib 500 mg/day for more than 2 years, with partial tumor response. Initial plain radiography showed Kellgren and Lawrence (K-L) grade 1. After 10 months, varus deformity was worsened and plain radiography aggravated to K-L grade 4 despite conservative treatment including activity modification. Diffuse synovitis with massive joint effusion and destruction of anterior cruciate ligament, medial meniscus, medial collateral ligament, and lateral collateral ligament were shown in magnetic resonance imaging. The patient was diagnosed with rapidly destructive arthrosis of knee and underwent a both total knee arthroplasty.

• 시스템엔지니어링학술지
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• 제10권1호
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• pp.33-41
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• 2014

New design concept of Reactor Coolant System (RCS) including a reactor assembly for the SMR is introduced in this work. An exploration of new type of reactor that is advanced from proposed SMRs is performed by using systems engineering approach. In this point of view project structured on three main phases; needs analysis (NA), concept exploration (CE), and concept definition (CD). Main objectives as an output of the CE stage are a small size, low cost, shortening the schedule, and enhancing safety. The SMRs usually have a small size requirement. In order to meet the size requirement and to achieve a productivity, in other words, easiness to manufacture, this paper suggests an integrated PWR design concept through researching predecessors. Although the integrated PWR concept provides many advantages, it has disadvantages that composite of maintenance and a low availability problem. Therefore, this paper comes up with a run-to-fail design concept based on modular design to address the maintenance problem and to maximize the availability of SMRs as well as to be compatible with the overall-SMRs including Barge Mounted(BM)type.

• Nuclear Engineering and Technology
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• 제53권11호
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• pp.3580-3596
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• 2021

An integral test facility, PILLAR, was commissioned, aiming to provide valuable experimental results which can be referenced by system and component designers and used for the performance demonstration of liquid-metal-cooled, passive small modular reactors (SMRs) toward their licensing. The setup was conceptualized by a scaling analysis which allows the vertical arrangements to be conserved from its prototypic reactor, scaled uniformly in the radial direction achieving a flow area reduction of 1/200. Its final design includes several heater rods which simulate the reactor core, and a single heat exchanger representing the steam generators in the prototype. The system behaviors were characterized by its data acquisition system implementing various instruments. In this paper, we present not only a detailed description of the facility components, but also selected experimental results of both steady-state and transient cases. The obtained steady-state test results were utilized for the benchmark of a system code, achieving a capability of accurate simulations with ±3% of maximum deviations. It was followed by qualitative comparisons on the transient test results which indicate that the integral system behaviors in passive LBE-cooled systems are able to be predicted by the code.

• Journal of Mechanical Science and Technology
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• 제20권6호
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• pp.882-895
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• 2006

Surface and interfacial waves in two superposed horizontal inviscid fluids of finite depths are studied. The flow is induced by translating a vertical rigid plate with a prescribed velocity. Analytical solutions that accurately predict the motion of the free surface and the interface are obtained by using a small-Froude-number approximation. Three different velocities of the plate are considered, while flows induced by any arbitrary motion of the plate can be easily analyzed by a linear superposition of the solutions obtained. It is shown that pinching of the upper layer can occur for a sufficiently thin upper layer, which leads to its rupture into small segments. Other interesting phenomena, such as primary and secondary wiggles generated on the interface near the wavemaker, are discussed.

• 대한한의학방제학회지
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• 제28권1호
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• pp.81-90
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• 2020

Objectives : This study was conducted to investigate the effects of major constituents of Epimedium koreanum Nakai (Icariin, epimedium A, epimedium B, and epimedium C) on melanin synthesis. Methods : We measured melanin contents, tyrosinase activity, and expression of Rab27a in B16F10 cells cultured with Epimedium koreanum Nakai ethanol extract (EKN) and their major constituents. After treatment with H89 and dibutyryl cAMP, which inhibit or promote the activation of PKA, we observed changes in melanin synthesis and tyrosinase activity stimulated by EKN. Results : Among them, EKN and icariin enhanced tyrosinase activity and melanin contents. We confirmed that EKN augmented melanin synthesis via cAMP/PKA pathway. Icariin-induced tyrosinase activity and melanin content were attenuated by PKA inhibitor H89, while melanogenic effect of icariin was further augmented by cAMP analog, dbc AMP. However, icariin did not affect the expression of small GTPase Rab27a involved in melanosome transport. Conclusions : These results suggest that icariin promotes melanogenesis through cAMP/PKA pathway but does not affect small GTPase Rab27a.

• 정보저장시스템학회논문집
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• 제9권2호
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• pp.62-66
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• 2013

For the production method, stamp base is increasing the market share. But also, by the manufacturing method, stiffness of the stamp base is small. Many studies have been carried out in order to increase the stiffness of the stamp base. In this study, we optimally designed according to the position of bolting using a screening method in order to increase the stiffness base. After establishing a simulation model, the maximum deformation and frequency of the first mode based having relevance with stiffness of the base, were optimized. There for, it was possible to expect of increasing the stiffness of the stamp base.

• Journal of Mechanical Science and Technology
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• 제18권4호
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• pp.573-581
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• 2004

A self-contained wall climbing robot, called MRWALLSPECT (Multi-functional Robot for WALL inSPECTion) II, is developed. It is designed for scanning external surfaces of gas or oil tanks with small curvature in order to find defects. The robot contains all the components for navigation in itself without any external tether cable. Although it takes the basic structure of the sliding body mechanism, the robot has its original characteristic features in the kinematic design with closed link mechanism, which is enabled by adopting a simple and robust gait pattern mimicking a biological system. By employing the proposed link mechanism, the number of actuators is reduced and high force-to-weight ratio is achieved. This paper describes its mechanism design and the overall features including hardware and software components. Also, the preliminary results of experiments are given for evaluating its performances.