• Nuclear Medicine and Molecular Imaging
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• 제42권1호
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• pp.1-7
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• 2008

PET allows non-invasive, quantitative and repetitive imaging of biological function in living animals. Small animal PET imaging with $[^{18}F]$FDG has been successfully applied to investigation of metabolism, receptor-ligand interactions, gene expression, adoptive cell therapy and somatic gene therapy. Experimental condition of animal handling impacts on the biodistribution of $[^{18}F]$FDG in small animal study. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point. Tumor imaging in small animal with small animal $[^{18}F]$FDG PET should be considered fasting, warming, and isoflurane anesthesia level. Registered imaging with small animal PET and CT image could be useful for the detection of tumor. Small animal experimental condition of animal handling and registration method will be of most importance for small lesion detection of metastases tumor model.

• 대한의용생체공학회:의공학회지
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• 제30권1호
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• pp.1-9
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• 2009

Many types of small animal imaging modalities, like micro-CT, micro-PET, and micro-SPECT, have been recently developed worldwide. Small animal imaging systems are now recognized as indispensable tools to validate efficacy and safety of new drugs or new therapeutic methods using the animal disease models. With increasing demands for small animal imaging in biomedical research, multimodal small animal imaging systems, like micro-PET/CT or micro PET/MRI, are now also being developed. Small animal imaging with spatial resolution and sensitivity comparable to human imaging is quite challenging since laboratory small animals are much smaller than human beings. Research activities in Korea on small animal imaging systems are reviewed in this paper. In the field of micro-CT and micro-PET, many world-class technologies have been developed successfully in Korea. It is expected that the developed animal imaging system technologies can be used in the development of clinical imaging systems in Korea in the near future.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.603-603
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• 2007

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.595-595
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• 2007

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.596-596
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• 2007

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.597-597
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• 2007

• Asian-Australasian Journal of Animal Sciences
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• 제23권2호
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• pp.175-181
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• 2010

The effects of corticosterone (CORT) administration on the weight of small intestine and the expression of nutrient transporter mRNA in the small intestine of broiler chickens (Gallus gallus domesticus) were investigated. One hundred and eight sevenday-old birds were randomly divided into two equal groups comprising a control group (CTRL) and an experimental group (CORT). CTRL birds were fed a basal diet and the CORT birds were fed a basal diet containing 30 mg corticosterone/kg from d 8 to 21. At 21 d of age, average daily feed intake (ADFI), serum corticosterone level, small intestinal absolute wet weight and relative weight, and relative abundance of SGLT1, CaBP-D28k, PepT1 mRNA in the duodenum and L-FABP mRNA in the jejunum were determined. The results showed that serum corticosterone level, liver weight and small intestinal relative weight (small intestinal wet weight/body weight) of CORT chickens were about 30.15%, 26.72% and 42.20% higher, respectively, than in the CTRL group (p<0.05). CORT birds had relative mRNA abundance of CaBP-D28k and PepT1 in the duodenum, and L-FABP in the jejunum which was 1.77, 1.37 and 1.94 fold higher, respectively, than in the CTRL group (p<0.05); the relative abundance of SGLT1 was 1.67 fold higher than in the CTRL group (p = 0.097). ADFI, small intestinal wet weight and length in CORT-treated broiler chickens was about 29.11%, 31.12% and 12.35% lower, respectively, than in the CTRL group (p<0.05). In conclusion, corticosterone administration lowered the wet weight but increased the relative weight of the small intestine and the expression of intestinal nutrient transporter mRNA of broiler chickens.

• Asian-Australasian Journal of Animal Sciences
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• 제17권10호
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• pp.1360-1365
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• 2004

Using the method of 'random sampling in typical colonies of the central area of the habitat', 60 Small-tailed Han sheep were obtained in Jining city, Shangdong province. The variations of Small-tailed Han sheep at 12 structural loci encoding blood proteins were detected by several electrophoresis techniques and their gene frequencies were then estimated. The same data of four other sheep populations from Near-sea Mainland in East Asia were cited for the analysis of genetic differentiation. The average heterozygosities of five populations, namely Kharkhorin sheep, Ulaanbaatar sheep, Small-tailed Han sheep, Hu sheep and Cham Tribe sheep were 0.3447, 0.3285, 0.3157, 0.3884 and 0.2300, respectively. The coefficient of gene differentiation among four populations, Kharkhorin sheep, Ulaanbaatar sheep, Small-tailed Han sheep and Hu sheep, was 0.045557, and that between these four breeds and Cham Tribe sheep was 0.088005, indicating that the level of gene differentiation among the former four sheep populations of Mongolian group was comparatively lower than that between Cham Tribe sheep and other four sheep populations. The origin of Cham Tribe sheep deserve further research. The documentary research on the evolution of Small-tailed Han sheep and Hu sheep from Mongolian sheep was further verified by the biochemical experiments in the study. It was reasonably deduced that Hu sheep, Small Tailed Han sheep and Cham Tribe sheep were decreasingly influenced by the bloodline of Mongolian sheep.

• 대한의용생체공학회:의공학회지
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• 제32권1호
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• pp.74-78
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• 2011

Although recent studies have shown the usibility of [F-18]FDG small animal Positron Emission Tommography (PET) as a functional neuroimaging technique in behavioural small animal study, researches showing the detection power of functional changes in the brain are still limited. Thus, in the study, we performed [F-18]FDG small animal PET neuroimaging in the well-established fear behavioural experiment. Twelve rats were exposed on cat for 30 minutes after the [F-18]FDG injection. As a result, the brain activity in bilateral amygdala areas significantly increased in the fear condition. In addition, the fear condition evoked the functional activities of hypothalamus, which seemed to be related to the response to stress. These clear localization of fear related brain regions may reflect that a functional neuroimaging technique using [F-18]FDG small animal PET has functional detectibility enough to be applied in small animal behavioral research.

• 한국임상수의학회지
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• 제30권2호
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• pp.134-137
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• 2013

4개월 된 수컷 진도 견에서 좌측 후지 파행이 발생하였다. 방사선 검사에서 양측 경골 견인 골단 아래 작은 골편이 관찰되었으나, 견인 골단의 변위는 없었다. 그 후 양측 경골 조면 부위의 골밀도는 방사선 투과성에서 비투과성으로 변화하였다. 좌측 경골은 수술 후 회복되었으나, 우측 경골은 보존적 처치로 자가 치료되었다. 본 환자는 경골조면의 부분 견열골절로 진단되었으며, 이는 개에서 'Osgood-Schlatter disease'로 불려져 왔던 질환이다. 이 증례는 환자의 경골조면 부분 견열골절의 순차적인 방사선학적 영상 변화에 대한 유용한 임상적 정보를 제공할 수 있을 것으로 생각한다.