• International Journal of Oral Biology
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• v.32 no.4
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• pp.153-160
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• 2007

The superficial dorsal horn, particularly substantia gelatinosa (SG) in the spinal cord, receives inputs from small-diameter primary afferents that predominantly convey noxious sensation. Reactive oxygen species (ROS) are toxic agents that may be involved in various neurodegenerative diseases. Recent studies indicate that ROS are also involved in persistent pain through a spinal mechanism. In the present study, whole cell patch clamp recordings were carried out on SG neurons in spinal cord slice of young rats to investigate the effects of hydrogen peroxide on neuronal excitability and excitatory synaptic transmission. In current clamp condition, tert-buthyl hydroperoxide (t-BuOOH), an ROS donor, depolarized membrane potential of SG neurons and increased the neuronal firing frequencies evoked by depolarizing current pulses. When slices were pretreated with phenyl-N-tert-buthylnitrone (PBN) or ascorbate, ROS scavengers, t-BuOOH did not induce hyperexcitability. In voltage clamp condition, t-BuOOH increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs), and monosynaptically evoked excitatory postsynaptic currents (eEPSCs) by electrical stimulation of the ipsilateral dorsal root. These data suggest that ROS generated by peripheral nerve injury can modulate the excitability of the SG neurons via pre- and postsynaptic actions.

• Journal of Periodontal and Implant Science
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• v.23 no.3
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• pp.507-516
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• 1993

The Chlorhexidine(CHX) has been a widely used adjunt in periodontal therapy due to its bactericidal effect. In spite of the effects of CHX exhibits cytotoxic to human cells and delays granulation tissue formation. Therefore, understanding the effects of CHX on fibroblast attachment and cell growth will provide the rationale for its use during healing phase of periodontal surgery. This study was undertaken to examine the effects of standardized CHX-pretreated dentin slices and direct CHX exposure on human gingival fibroblasts. The results were as follow : 1. In experiment 1, there was a significant reduction in the number of fibroblast attachment in 0.12, 1%-pretreated groups relative to the control, 0.05%-pretreated groups(P<0.05). 2. In experiment 1, the control, 0.05%-pretreated groups showed considerable attachment and typical fibroblastic morphology, but 0.12, 1%-pretreated groups showed irregular, round-up (unattached) fibroblastic morphology. 3. In experiment 2, it appeared that all experimental groups exhibits significant inhibition of cell growth when compared with the control group.

• Journal of Dental Rehabilitation and Applied Science
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• v.18 no.4
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• pp.313-320
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• 2002

The purpose of the present study was to evaluate the marginal discrepancy and topography of artificial crown on teeth extracted due to severe periodontal disease. Twenty specimens were invested into metamethylacrylate resin and cutted into vertical slices along with the long axis of tooth. The selected marginal discrepancy between the outer edge of the crown and the finishing line of abutment was examined by stereo- microscope(Olympus, PM-VSP-3, Japan) at magnification of up to 10, and the topography of finishing margin on crown was observed by stereomicroscopeat magnification of up to $70{\times}$. The results were as follows. (1) The mean marginal discrepancy between extracted tooth and artificial crown were $50.82{\mu}m$. (2) There was a considerable difference in the microstructure of finishing margins among specimens. Microscopic Structure on finishing margin showed indefinite line, poor fit (open, underextended and overextended), distorted margin, and surface roughness. This study suggested that there could be necessary to consider the response of periodontium to the emergence profile of natural tooth and precision of marginal geometry while establishing treatment planning for the reconsruction of the artificial crown.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.187-189
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• 2018

In this paper, the optimal design conditions for hardware implementation of the Secure Hash Algorithm3-512 (SHA3-512) hash function were analyzed. Five SHA3-512 hash cores with data-path of 64-bit, 320-bit, 640-bit, 960-bit, and 1600-bit were designed, and their functionality were verified by RTL simulation. Based on the results synthesized with Xilinx Virtex-5 FPGA device, we evaluated the performance of the SHA3-512 hash cores, including maximum frequency, throughput, and occupied slices. The analysis results show that the best hardware performance of SHA3-512 hash core can be achieved by designing it with 1600-bit data-path.

• The KIPS Transactions:PartD
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• v.8D no.3
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• pp.257-264
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• 2001

We developed a SIFG (Slice-based Information Graph), which modelled the information flow on program on the basis of the information flow of data tokens on data slices. Then we defied a SCM (Slice-based complexity measure), which measured the program complexity by measuring the complexity of information flow on SIFG. SCM satisfied the necessary properties for complexity measure proposed by Briand et al. SCM could measure not only the control and data flow on program but also the physical size of program unlike the existing measures.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.12
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• pp.2376-2385
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• 1994

In receiving the digital TV signal, both decoding delay and the channel hopping delay are very critical factors in applications. The intra-slice coding in the MPEG-2 SIMPLE PROFLE of No B-picture is one of the primary methods for short delay time in video decoding. It has the advantage of short decoding delay, but has the drawback of long channel hopping delay time. In this paper, we propose a method to reduce the channel delay with negligible loss in SNR performance. It is shown that dividing pictures into several regions of slices and adding some restriction in motion vector search for inter-frame coding. hence the random acess points are effectively increased. and the channel hopping delay is reduced.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1988.10a
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• pp.54-57
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• 1988

A film is fabricated by depositing several slices ultra thin films on a slide glass. The UV-absorbance outcomed on a multi-layered bulky ultra thin film with (N-docosyl pyridinium)-TCNQ (1:2) complex results tat the quantity of UV-absorbances becomes more linearly according to the number of layer becomes higher. In addition, it is found that the capacitance of this film gets smaller as the number of layer gets higher. Finally, the conductivity of this film is measured by the direction of the long axis of the TCNQ radical anion, and is resulted in a remarkably low value (about 1.66∼3.78 x 10$\^$-14/S/cm).

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2015.11a
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• pp.149-151
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• 2015

본 논문에서는 4K UHD 입력 영상에 대해 각 프레임을 다중 슬라이스로 분할하고, 이를 병렬 처리를 통해 실시간으로 부호화를 수행하는 소프트웨어 기반 HEVC 인코더의 율 제어 방법에 관한 연구이다. 이를 위하여 HEVC 가 지원하는 슬라이스를 적용하여 프레임을 독립적인 다중 슬라이스로 분할하였고, 각각의 슬라이스에 대해서는 기존에 제안된 몇 가지의 율 제어 방법을 개선하여 적용하였다. 본 논문에서는 다중 슬라이스에 각각 독립적으로 적용한 율 제어 방법에 대한 실험 결과를 통해 제안된 율 제어 방법의 안정성을 확인하고, 향후 연구로서 각 슬라이스의 출력 비트율을 예측하고 다중 슬라이스에 효과적으로 할당하는 방법과 이를 통한 주관적 화질을 향상 하는 방법에 대해 논한다.

• International Journal of Oral Biology
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• v.40 no.2
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• pp.103-109
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• 2015

Growing evidence suggests that mitochondrial reactive oxygen species (ROS) are involved in various pain states. This study was performed to investigate whether ROS-induced changes in neuronal excitability in trigeminal subnucleus caudalis are related to ROS generation in mitochondria. Confocal scanning laser microscopy was used to measure ROS-induced fluorescence intensity in live rat trigeminal caudalis slices. The ROS level increased during the perfusion of malate, a mitochondrial substrate, after loading of 2',7'-dichlorofluorescin diacetate ($H_2DCF-DA$), an indicator of the intracellular ROS; the ROS level recovered to the control condition after washout. When pre-treated with phenyl N-tert-butylnitrone (PBN) and 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (TEMPOL), malate-induced increase of ROS level was suppressed. To identify the direct relation between elevated ROS levels and mitochondria, we applied the malate after double-loading of $H_2DCF-DA$ and chloromethyl-X-rosamine (CMXRos; MitoTracker Red), which is a mitochondria-specific fluorescent probe. As a result, increase of both intracellular ROS and mitochondrial ROS were observed simultaneously. This study demonstrated that elevated ROS in trigeminal subnucleus caudalis neuron can be induced through mitochondrial-ROS pathway, primarily by the leakage of ROS from the mitochondrial electron transport chain.

• International Journal of Oral Biology
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• v.42 no.2
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• pp.55-61
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• 2017

Recent studies indicate that mitochondria are an important source of reactive oxygen species (ROS) in the spinal dorsal horn. In our previous study, application of malate, a mitochondrial electron transport complex I substrate, induced a membrane depolarization, which was inhibited by pretreatment with ROS scavengers. In the present study, we used patch clamp recording in the substantia geletinosa (SG) neurons of spinal slices, to investigate the cellular mechanism of mitochondrial ROS on neuronal excitability. DNQX (an AMPA receptor antagonist) and AP5 (an NMDA receptor antagonist) decreased the malate-induced depolarization. In an external calcium free solution and addition of tetrodotoxin (TTX) for blockade of synaptic transmission, the malate-induced depolarization remained unchanged. In the presence of DNQX, AP5 and AP3 (a group I metabotropic glutamate receptor (mGluR) antagonist), glutamate depolarized the membrane potential, which was suppressed by PBN. However, oligomycin (a mitochondrial ATP synthase inhibitor) or PPADS (a P2 receptor inhibitor) did not affect the substrates-induced depolarization. These results suggest that mitochondrial substrate-induced ROS in SG neuron directly acts on the postsynaptic neuron, therefore increasing the ion influx via glutamate receptors.