• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.437-445
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• 2018

In this study, we analyzed two components, sulforaphane and PF-3758309 to prove that the mixed composition of them has more effective antioxidant and whitening functions compared to each component. We analyzed the cellular toxicity of each component and also the mixed composition to find the safe concentration level for cell viability. From the single component treatment, we discovered that sulforaphane was safe up to $10{\mu}M$, and PF-3758309 up to 100 nM. Combination treatment of $10{\mu}M$ sulforaphane and 1 nM PF-3758309 did not affect the cell viability. The LPS-stimulated NO generation was significantly reduced by the mixed composition of sulforaphane and PF-3758309. Melanogenesis by ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH) was also inhibited by the mixed composition. In order to confirm the possibility as the cosmetic material, we carried out clinical studies for the mixed composition samples. Skin safety evaluation using patch test was judged to be unstimulated, skin whitening effect was increased, and melanin deposition was suppressed by treatment of mixed composition samples. These results provide us with the opportunity for applying it into the development of new functional cosmetics.

• The Korean Journal of Pesticide Science
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• v.14 no.4
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• pp.478-489
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• 2010

Penthiopyrad is a fungicide agent in types of pyrazole which is showing the effect of prevention in fungal disease and powdery mildew. In order to register this new pesticide, reports of acute toxicity and chronic toxicity by animal study were examined to set acceptable daily intake to evaluate hazards of consumers. Acute toxicity was low in toxic, and it did not have the effect of acute dermal toxicity, acute eye irritation, or skin sensitization. As the result of the study in chronic toxicity, the common effect of chemical appeared in the liver and thyroid which was proven as a toxic effect. Two-generation reproduction toxicity, genotoxicity, and prenatal development toxicity were not proven. As the result of carcinogenic study, increase of thyiroid follicular adenoma in the rat and the frequency of liver hepatocellar adenoma in mice were also increased. However, it was decided that the threshold value on the effect in chemicals could be controlled through study liver enzyme induction. Therefore, the ADI for penthiopyrad is 0.081 mg/kg/ bw/day, based on the NOAEL of 8.10 mg/kg bw/day of twelve-months dogs study and applying an uncertainty factor of 100.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.3
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• pp.421-435
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• 2017

Recently, due to the saturation of ground structures and the overpopulation of pipeline facilities requires to development of underground structures as an alternative to ground structures. Thus, mechanized tunnel construction of the shield TBM method has been increasing in order to prevent vibration and noise problems in construction of the NATM tunnel for the urban infrastructure construction. Tunnel construction plan for the tunnel line should be formed in a sharp curve to avoid building foundation and underground structures and it is inevitable to develop a shield TBM technology that suits the sharp curve tunnel construction. Therefore, this study is about the structural stability technology of the articulation jack, shield jack and skin plate for the shield TBM thrust in case of the mechanized tunnel construction that is a straight and sharp curve line. The construction case study and shield TBM operation principle are examined and analyzed by the theoretical approach. The torque of the cutter head, the thrust of the articulation jack and the shield jack, the amount of over cutting for curve is important respectively in shield TBM construction of straight and sharp curve line. In addition, it is very important to secure the stability of the skin plate structure to ensure the safety of the inside worker. This study examines the general structure and construction of the equipment, experimental simulation was carried out through numerical analysis to examine the main factors and structural stability of the skin plate structure. The structural stability of the skin plate was evaluated and optimizes the shape by comparing the loads of the articulation jack by selecting the virtual soil to be applied in a straight and sharp curve line construction. Since the present structure and operation method of the shield TBM type in domestic constructions are very similar, this study will help to develop the localized shield TBM technology for the new equipment and the vulnerability and stability review.

• Journal of the Korea Safety Management & Science
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• v.15 no.3
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• pp.83-91
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• 2013

The purpose of this study was to compare the exposure levels to emotional labor, occupational and socio-psychological stress, and fatigue for workers engaged in the fields of beauty business (make-up, skin, nail, and hair). For this purpose, a survey was carried out and a statistical analysis was performed for 813 persons As a result, emotional labor was found to be linked with 3 factors of emotional control, emotional dissonance, and positive emotional expression. The exposure level of emotional control was found to be high in the area of hair care and that of positive emotional expression was high in the area of nail care. Based on evaluation of Occupational Stress Scale(KOSS), the stress were found to be highest among workers engaged in the field of make-up and lowest among those in the field of nail. The exposure level of psychosocial stress was found to be the highest in the area of make-up and the lowest in the area of nail care. The exposure level of fatigue was found to be the highest in the area of make-up and the lowest in the area of nail care, showing a difference in the exposure level of stress by area of beauty business. The study confirmed that there is a difference in the exposure level related to emotional labor, job stress, psychosocial stress, and fatigue by area of beauty business.

• Archives of Plastic Surgery
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• v.46 no.6
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• pp.525-534
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• 2019

Background In microtia patients with bilateral hearing impairment, hearing improvement is crucial for language development and performance. External auditory canal reconstruction (EACR) has been performed to improve hearing, but often results in complications. We performed transcutaneous bone conduction implant (TBCI) surgery in these patients. This study aimed to evaluate the safety and efficacy of TBCI surgery. Methods A retrospective review was performed of five patients who underwent auricular reconstruction and TBCI surgery and 12 patients who underwent EACR between March 2007 and August 2018. Hearing improvement was measured based on the air-bone gap values using pure-tone audiometry over a 6-week postoperative period. We reviewed other studies on hearing improvement using EACR and compared the findings with our results. The surgical techniques for TBCI were reviewed through case analyses. Results Postoperative hearing outcomes showed a significant improvement, with a mean gain of 34.1 dB in the TBCI cohort and 14.1 dB in the EACR cohort. Both gains were statistically significant; however, the TBCI cohort showed much larger gains. Only three of the 12 patients who underwent EACR achieved hearing gains of more than 20 dB, which is consistent with previous studies. All patients who underwent TBCI surgery demonstrated hearing gains of more than 20 dB and experienced no device-related complications. Conclusions TBCI is a safe and effective method of promoting hearing gains in microtia patients with bilateral hearing impairment. TBCI surgery provided better hearing outcomes than EACR and could be performed along with various auricular reconstruction techniques using virgin mastoid skin.

• Archives of Plastic Surgery
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• v.41 no.6
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• pp.740-747
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• 2014

Background Autologous fat graft has become a useful technique for correction of acquired contour deformity in reconstructed breasts. However, there remains controversial regarding the efficacy and safety of the practice for reconstructive breast surgery. Methods A retrospective review was performed on 102 patients who had secondary fat grafting after breast reconstruction. Fat harvest, refinement and injection were done by Coleman's technique. All patients were followed up postoperatively within 1 month and after 6 months including physical examination and ultrasonography. In 38 patients, the reabsorption rate was calculated by serial changes of thickness between skin and pectoral fascia in the ultrasonic finding. Locoregional recurrence rate was compared with control group of 449 patients who had breast reconstruction without fat graft in the same time period. Results Average 49.3 mL fat was injected into each breast. The most common location of fat graft was upper pole, followed by axilla, lower and medial breasts. During 28.7 months of average follow-up period, 2.9% of total patients had symptoms of palpable mass on fat graft side and ultrasonography identified fat necrosis and cyst formation in 17.6% of the patients. Calculated fat reabsorption rate was 32.9%. Locoregional recurrence was occurred in 1 patient (0.9%) and the rate was not different significantly with control group (2%). Conclusions Although further studies are required to provide surgeons with definitive guidelines for the implementation of fat grafting, we propose autologous fat graft is an efficient and safe technique for secondary breast reconstruction.

• Journal of Acupuncture Research
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• v.28 no.2
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• pp.49-55
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• 2011

Objectives : This study was to develop programmable and rechargeable electronic moxibustion device as an interdisciplinary research focusing on traditional Korean medicine. Methods : This device deployed several advances on safety and conveniences with the advantage of programmable heat stimulation, heating material and recharging method. The gradient of heat stimulation was programmed with the reference of previous studies and own measurements. The heat curve reached its efficacious stimulus temperature after three minutes, and maintained until 13 minutes with $42^{\circ}C$. We also incorporated feedback from field hospital experiences with the help of hospital staffs. Results : This device can prevent damages from skin burn and fire accidents, and control the smoke, smell and residue of moxa itself. Conclusions : This study will contribute for the development and improvement of efficacious and safe treatment methods for the traditional Korean medicine.

• The Journal of Korean Physical Therapy
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• v.18 no.3
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• pp.79-87
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• 2006

Purpose: The present study purposed to examine induced characteristic or erythema and safety by medium wave ultra violet(UVB) lamp. Methods: We compared sunshine and UVB lamp using spectroradiometer and UV radiometer. For measuring sunshine irradiation, we used spectoradiometer and detected from 8 to 18 o'clock every each hour on the beach, playground and rooftop of a 5 story building. The subjects for erythema examination were 5 healthy subjects who have no pathologic history of photosensitivity reaction, psoriasis and vitiligo. They were exposed to UVB radiation at the abdominal area for 2 hours and after irradiation, we observed the change of skin color every 12 hours over a period of 1 week. Results: Between sunshine and UVB lamp, sunshine had higher data on the chromaticity coordinates, dominant and peak wavelength, bandwidth and purity than the UVB lamp but on the color temperature, brightness the UVB lamp had higher data than the sunshine. In comparison of sunshine and UVB lamp, UVB lamp irradiated constantly such as $3.9-4.4{\mu}W/cm^2$ at a distance of 100cm between bed and lamp which was same as early morning irradiation on the sunshine. The erythema didn't appear to any subject. Conclusion: This results suggest that the UVB lamp has lower irradiance as much as early sunshine. Therefore the UVB lamp had no influence of inducing erythema at a distance of 100cm between bed and lamp.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.4
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• pp.365-370
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• 2012

International Organization for Standardization has recently published ISO 12215-5 which is the small craft-hull construction and scantling. According to ISO 12215-5 AnnexB, the scantling determination can be accomplished by drop test for craft with a length $L_H$ of 2.5m up to 6m and single-skin construction. The current method, however, of visual test has the issue where it is difficult to make an objective evaluation of ship body strength. In this study, in order to develop an evaluation system that can make a quantitative evaluation of the drop test of leisure boats, the domestic/foreign regulations on drop test of leisure boats are analyzed and the drop test evaluation system is designed, and the system applicability is reviewed through 5-meter level aluminum ship, and the issues incurred by the state of the ship and the posture while dropping were checked.

• Fisheries and Aquatic Sciences
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• v.14 no.3
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• pp.168-173
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• 2011

The purpose of this study was to obtain a fraction with high antioxidative activity from second rockfish gelatin hydrolysates (SRSGHs), which were hydrolyzed with Alcalase and Flavourzyme through ultrafiltration membranes with serial digestions for 1 and 2 h, respectively, and to investigate the feasibility of this fraction as a potential functional food ingredient. Among various fractions that were ultrafiltered from the SRSGH with four types of membrane (1, 5, 10, and 30 kDa), the SRSGH-III fraction, which permeated the 10 kDa membrane but not the 5 kDa membrane, showed the highest antioxidant activity (protection factor=5.13) and angiotensin-I-converting enzyme-inhibiting activity ($IC_{50}$=0.82 mg/mL). These results suggest that the SRSGH-III fraction from the SRSGH can be used as a functional food ingredient. However, further studies examining its antioxidant activity in vivo as well as the different antioxidant mechanisms are needed.