• Proceedings of the SCSK Conference
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.700-718
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• 2003

Fructan, a polysaccharide existing in plants or produced by microorganisms, is a sugar polymer of fructose with $\beta$-2,6 linkages. In this study, we investigated some cosmeceutical properties of Fructan such as moisturizing effect, cell proliferation effect, anti-inflammation effect and cell cytotoxicity. Zymomonas mobilis, a microorganism producing Fructan, was cultured in a medium containing 10％ sucrose and 2％ yeast extract as main components for 24 hours at 37$^{\circ}C$ and pH 7. Fructan was obtained by precipitation from the cultured medium by adding alcohol (alcohol ratio of 1:3) after removing the enzyme by centrifuging. Fructan exhibited almost same moisturizing effect as hyaluronic acid and cell proliferation effect on human fibroblast and keratinocyte as well. Moreover, on cell proliferation test on bio-artificial skin constructed by 3-dimensional(3-D) culture after inducing primary skin inflammation with 0.5％ sodium lauryl sulfate (SLS), the 3-D artificial skin treated with 0.01 mg/ml, 0.05mg/ml of Fructan exhibited higher cell proliferation than the 3-D artificial skin treated with SLS only. On anti-inflammation test on 3-D artificial skin evaluated by measuring secreted quantity of interleukin-1$\alpha$ (IL-1$\alpha$) which is a pre-inflammatory mediator induced by SLS, the quantity of IL-1$\alpha$on the 3-D artificial skin treated with 0.01 mg/ml, 0.05mg/ml of Fructan was less than the one on the 3-D artificial skin treated with SLS only. As a result of these studies, Fructan has anti-inflammation effect against inflammatory reaction by a skin irritant as well as cell proliferation effect in bio-artificial skin. Fructan was also evaluated as a safe material without any toxicity in safety tests using fibroblasts and animals.

• Journal of Food Hygiene and Safety
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• 제27권2호
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• pp.188-193
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• 2012

This study was designed to evaluate to acute oral toxicity and skin irritation of Chrysanthemum dye in Sprague-Dawley (SD) rats. SD rats were orally treated with Chrysanthemum dye at a dose of 0, 1 and 2 ml/kg body weight. After oral administration, the rats were observed for 14days. In primary skin irritation test, SD rats were dermally treated with Chrysanthemum dye and observed for 3 days. To ensure the safety of Chrysanthemum dye such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the histopathological test, the mortality and skin irritation. As a result, no significant differences were found in body weight, feed intake and histopathological test between control and Chrysanthemum dye treated group. In the result of skin irritation test, Chrysanthemum dye did not induce erythema and edema after topical application. Primary irritation index was "0" in the test. Therefore, it is suggested that Chrysanthemum dye has no effect on acute toxicity and side effect in SD rats and is non-irritant material based on the score "0" of primary irritation index.

• Journal of Life Science
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• 제29권4호
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• pp.442-446
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• 2019

We recently reported the characteristics of Chrysanthemum boreale MAKINO essential oil (CBMEO) at different harvesting stages and its in vitro antioxidant, whitening, skin regeneration, and antiwrinkle properties. In the present study, we investigated the effectiveness of cosmetic creams containing 0.1% of CBMEO in terms of wrinkle reduction and safety. The participants were 22 women aged 42 to 60 y with natural wrinkles. All the participants applied the CBMEO-containing cream to the eye area for 8 weeks. Visual observations of the skin by a dermatologist were used to assess the safety of the product, and improvements in skin wrinkles (roughness) were analyzed using a skin visiometer. Neither the CBMEO-containing cream nor the placebo caused abnormal reactions, such as erythema or allergies, during the test period. The CBMEO-containing cream-exposed test regions showed a greater reduction in the roughness index as compared with those of the placebo-exposed control regions. The R1, R2, and R3 indices showed a statistically significant decrease in the test regions as compared with the placebo control regions after using the cream for 2 weeks (p<0.05). Therefore, this study demonstrated that CBMEO-containing cosmetics are safe for human use and that they have skin wrinkle improvement properties. In the future, CBMEO may be a promising product for use in the development of functional anti-wrinkle cosmetics.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• 제32권3호
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• pp.23-36
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• 2019

Objectives : The purpose of this study is to confirm the efficacy and safety of "Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans" on dry skin due to mild atopic dermatitis. Methods : A total of 24 patients who visited Semyung Oriental Medical Center from November 1st, 2018 to December 20th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans. For 4 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase in treatment group in baseline, 2 weeks and 4 weeks. 2. In the primary endpoint, Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 4 weeks. 3. In the secondary endpoint, Skin pH showed a statistically significant decrease in treatment group between baseline and 4 weeks. 4. To evaluate the safety of the products for the human body, Adverse events, SCORAD Index Assessment were conducted; There were no severe adverse events during this study. And SCORAD Index showed a statistically significant decrease in treatment group in baseline, 2 weeks and 4 weeks. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that "Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans" should be effective for dry skin due to mild atopic dermatitis.

• Steel and Composite Structures
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• 제37권4호
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• pp.431-446
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• 2020

This paper presents the flexural performance of double skin composite beams (DSCBs) at different Arctic low temperatures. 12 DSCBs were prepared and tested under two-point loading at different Arctic low temperatures of 20, -30, -50, and -70℃. The studied parameters include low-temperature level (T), steel-faceplate thickness (t), shear span ratio (λ), and spacing of headed studs (S). The experimental investigations under two-point loading tests showed that flexural failure occurred to all DSCBs, even including the specimen designed with the small λ ratio of 2.9. The ultimate strength behaviours of DSCBs were improved due to the improved mechanical properties of constructional materials and the confinement on shear connectors. The DSCB subjected to two-point loading and low temperatures exhibits a five-stage working mechanism. The stiffness and strength indexes of DSCBs increase linearly with temperature and t value increasing, while decreasing as shear span ratio boosts. In the contrast, the change of S value from 150 to 200 mm has little effect on the ultimate strength behavior of DSCB.

• Proceedings of KOSOMES biannual meeting
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• 해양환경안전학회 2009년도 춘계학술발표회
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• pp.63-68
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• 2009

The marine leisure activities are increasing due to the formation of people's values which pursuit the better life quality and various life styles with the growth of economy and operation the system of five working days per week. Among the various marine leisure activities, skin scuba diving is the most prevalent activity, even though it doesn't have proper institutional system in relation to the activity, Thus, this paper studies the status of various institutional systems and problems and examines the ways of improving.

• The Journal of Industrial Distribution & Business
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• 제10권12호
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• pp.15-23
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• 2019

Purpose : We will develop the distribution method of wide oil extract technology to develop repellent using this technology and study mosquito repellent persistence. Research design, data and methodology : A positive control group containing purified water, ethanol and picaridin was prepared, and the experimental control group was prepared in the same proportion as the positive control group, and 0.6% of broad oil was added. The results were summarized using the calculation method according to the avoidance effect and statistically tested by t-test using the excel statistics program. Results : Experiments on skin surface area and voice control of participants showed that men had 8.9% wider skin surface area than women, and voice control tests showed that women were bitten by mosquitoes five times more than men. Both the positive and the experimental control groups had a valid duration of up to three hours, but from the time of five hours, the positive control group had 77% and the experimental control had 90%, indicating a difference of 14.4% over the positive control group. Conclusions : The mosquito repellents developed in this study on the basis of safety and continuity are cost-effective in terms of mosquito repellent, and in addition fragrance, odor removal, perfume, ink, skin care and massage effect.

• The Journal of the Korea institute of electronic communication sciences
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• 제9권12호
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• pp.1427-1434
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• 2014

Among the medical devices, medical treatments inflicting physical energy from the outside of the body to the inside or using the energy from the devices which take advantages of chemical changes of the human body require a high degree of reliability and safety. In particular, the medical treatment on the most exposed skin to the external surface in all parts of the human body will be very important. In this perspective, when you undergo skin treatment, you need to reduce all risks and to maximize the effect of treatment equipment. Therefore, the development of equipment which guarantees high therapeutic efficacy and safety is essential.

• Steel and Composite Structures
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• 제26권6호
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• pp.759-769
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• 2018

This paper studies shear and tensile behaviors of headed stud connectors in double skin composite (DSC) structure. Firstly, 11 push-out tests and 11 tensile tests were performed to investigate the ultimate shear and tensile behaviors of headed stud in DSC shear wall, respectively. The main parameters investigated in this test program were height and layout of headed stud connectors. The test results reported the representative failure modes of headed studs in DSC structures subjected to shear and tension. The shear-slip and tension-elongation behaviors of headed studs in DSC structures were also reported. Influences of different parameters on these shear-slip and tension-elongation behaviors of headed studs were discussed and analyzed. Analytical models were also developed to predict the ultimate shear and tensile resistances of headed stud connectors in DSC shear walls. The developed analytical model incorporated the influence of the dense layout of headed studs in DSC shear walls. The validations of analytical predictions against 22 test results confirmed the accuracy of developed analytical models.

• Steel and Composite Structures
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• 제37권5호
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• pp.517-532
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• 2020

This paper firstly developed a new type of Double Skin Composite (DSC) beams using novel enhanced C-channels (ECs). The shear behaviour of novel ECs was firstly studied through two push-out tests. Eleven full-scale DSC beams with ECs (DSCB-ECs) were tested under four-point loading to study their ultimate strength behaviours, and the studied parameters were thickness of steel faceplate, spacing of ECs, shear span, and strength of concrete core. Test results showed that all the DSCB-ECs failed in flexure-governed mode, which confirmed the effective bonding of ECs. The working mechanisms of DSCB-ECs with different parameters were reported, analysed and discussed. The load-deflection (or strain) behaviour of DSCB-ECs were also detailed reported. The effects of studied parameters on ultimate strength behaviour of DSCB-ECs have been discussed and analysed. Including the experimental studies, this paper also developed theoretical models to predict the initial stiffness, elastic stiffness, cracking, yielding, and ultimate loads of DSCB-ECs. Validations of predictions against 11 test results proved the reasonable estimations of the developed theoretical models on those stiffness and strength indexes. Finally, conclusions were given based on these tests and analysis.