• Asian-Australasian Journal of Animal Sciences
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• 제10권3호
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• pp.318-323
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• 1997

In order to assess the effect of solar exposure on pulmonary functions and evaporative losses from skin and pulmonary surfaces, in six healthy Sahiwal (S) and six Sahiwal ${\times}$ Holstein ($S{\times}H$) cattle were exposed to direct sun during summer. Breed differences were observed during exposure. Increase in sweating rate was higher in crossbreds (222%) than in Sahiwal (125%). Pre-exposure (ambient temperature, $32.6{\pm}0.85^\circ}C$, solar radiation, $0.9cal\;cm^{-2}min^{-1}$) evaporative loss from skin accounted for about 90% of the losses and remaining losses were contributed by pulmonary surfaces in Sahiwal. The contribution of evaporation through skin increased to 92% (ambient temperature $39.4{\pm}0.68^\circ}C$, solar radiation, $1.35cal\;cm^{-2}min^{-1}$). In crossbreds 80% of the evaporative losses were through skin before exposure which increased to 87% after exposure to solar radiations. Rectal temperature increase was higher in crossbreds ($1.5^{\circ}C$) than in Sahiwal ($0.8^{\circ}C$). With the increase in pulmonary evaporative losses, respiratory frequency increased to 2 fold in Sahiwal and pulmonary ventilation increased 1.6 times the resting value in Sahiwal due to solar exposure. In $S{\times}H$ crossbreds the respiratory frequency increased 3.5 times and pulmonary ventilation increased only to 1.8 times due to decrease in tidal volume. There was about 2 fold increase in alveolar ventilation in both the breeds, the increase in dead space ventilation was more in crossbreds than in Sahiwal. Behavioral symptoms exhibited by animals after exposure were profuse salivation, open mouth panting, tongue protrusion and general restlessness.

• 한국지하수토양환경학회지:지하수토양환경
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• 제12권1호
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• pp.64-72
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• 2007

토양매체중의 오염물질들은 다양한 경로를 통해 인체나 생태계에 노출되어 위해성 문제를 유발하고 있다. 토양위해성평가(Soil Risk Assessment)는 토양오염물질로 인한 악영향의 개연성을 정량적으로 평가하는 과정으로, 유해성 확인(Hazard Identification), 용량-반응평가(Dose-Response Assessment), 노출평가(Exposure Assessment), 그리고 위해도 결정(Risk Characterization)의 4가지 단계적 과정으로 이루어진다. 이중 노출평가과정에서 매우 중요하게 작용하는 노출인자(Exposure Factor)는 토양오염물질의 인체노출량을 산정하는데 필수적인 요소로, 미국, 유럽국가 등 선진국에서는 나라별 상황에 적절한 노출인자를 사용하고 있으나, 우리나라는 아직 국내에 적용하기 적합한 노출 인자에 대한 연구가 매우 부족한 실정이다. 본 연구에서는 토양오염 위해성평가를 위한 국가별 노출인자를 비교분석하고, 이를 토대로 국내상황에 적용가능한 노출인자를 제시하였다. 국가별 노출인자 연구는 미국 Environmental Protection Agency, 영국 Environmental Agency, 네덜란드 RIVM, 호주, 그리고 독일에서 적용되고 있는 노출인자값에 대해 노출인자별로 총괄적인 비교분석을 수행하였다. 또한 국가별 비교분석연구와 국내에서 제시된 노출인자 자료를 종합하여, 국내자료가 없는 경우 외국에서 보편적으로 적용하고 있는 인자값을 국내 적용 타당성을 고려하여 제시하였다. 본 연구에서 고려된 노출인자 조사항목은 평균수명, 노출기간, 노출빈도, 체중, 체표면적(또는 노출체표면적), 피부흡수계수(Skin Absorption Factor), 토양-피부간 흡착계수(Soil-Skin Adherence Factor), 음용수 섭취량, 호흡률, 토양 섭취량 그리고 농작물 섭취량 등이다. 본 연구는 오염토양의 위해성평가를 수행할 때 국내 상황을 고려한 노출평가에 필요한 기반연구가 될 것이다.

• 한국환경보건학회지
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• 제41권6호
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• pp.412-424
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• 2015

Objectives: An ultra dry air environment of nearly ${\leq}2%$ RH is often required in lithium battery factories. The objective of this study is to evaluate the subjective eye, pulmonary, nose, and skin symptoms of workers exposed to ultra-low relative humidity and thionyl chloride. Methods: We recruited 274 workers using a self-reported questionnaire in March 2014. Those who worked in ultra-low relative humidity and with thionyl chloride were identified and their prevalence of symptoms was compared with that of other workers. We excluded white collar workers, researchers and other workers who were exposed to various hazard factors, and finally included 164 workers. Results: There were significant differences in the rate of self-reported eye and skin symptoms between exposure group_1 and exposure group_2. Exposure group_2 experienced more frequent eye, and skin symptoms. Multinomial logistic regression analysis for experience of dry eye symptoms and skin symptoms in exposure group_2 showed that dry eye symptoms (odds ratio [OR], 6.33, 95% confidence interval [CI], 2.19-18.24, p<0.001), and itchiness (OR, 6.45, 95% CI, 1.94-21.43, p<0.01) were the significant variables. The complaints of workers experiencing ultra-low relative humidity and thionyl chloride were high compared with other workers. Conclusion: These findings suggest that exposure to ultra-low relative humidity and thionyl chloride may be associated with more frequent eye and skin symptoms than exposure to ultra-low relative humidity alone. The current precautions to protect workers from the adverse effects of ultra-low relative humidity and thionyl chloride appear to be insufficient, indicating that additional management plans to reduce symptoms should be considered.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1201-1207
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• 2016

Background: Excessive exposure to the sun during childhood is strongly associated with the development of skin cancer in the future. The only way to prevent the development of skin cancer is to protect against ultraviolet radiation, which can be achieved through strategic awareness during childhood and adolescence. Objective. The aim of this work was to evaluate the impact of educational activities for rural and urban students to promote the use of sunscreens and prevent skin cancer. Materials and Methods: This study was carried out with students (9-12 years) of rural (n=70) and urban (n=70) schools in Rio Grande do Sul state, Brazil. The educational interventions were lectures and games. The impact of this strategy was evaluated through the application of a questionnaire before and after the interventions. Results: Before the intervention, it was found around 50% of rural and urban students were not aware of the damage caused by sun exposure, often exposing themselves to UV radiation without use sunscreen ( ~ 25 %) and at the most critical times of the day/year. After the lectures we observed an improvement in the behavior of the students with regard to sun exposure and knowledge about skin cancer. Conclusions: The results of this study emphasize the importance of prevention strategies for skin cancer and promoting the use of sunscreens based educational strategies. The interventions were of great value in relation to disseminating knowledge on the subject.

• Toxicological Research
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• 제30권4호
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• pp.251-260
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• 2014

The number of farmers who have suffered from non-fatal acute pesticide poisoning has been reported to vary from 5.7% to 86.7% in South Korea since 1975. Absorption through the skin is the main route of exposure to pesticides for farmers who operate with them. Several in vitro tests using the skins of humans or animal and in vivo tests using laboratory animals are introduced for the assessment of human dermal absorption level of pesticides. The objective of this study is to evaluate and compare international guidelines and strategies of dermal absorption assessments and to propose unique approaches for applications into pesticide registration process in our situation. Until present in our situation, pesticide exposure level to operator is determined just using default value of 10 as for skin absorption ratio because of data shortage. Dermal absorption tests are requested to get exposure level of pesticides and to ultimately know the safety of pesticides for operators through the comparison with the value of AOEL. When the exposure level is higher than AOEL, the pesticide cannot be approved. We reviewed the skin absorption test guidelines recommended by OECD, EFSA and EPA. The EPA recommends assessment of skin absorption of pesticides for humans through the TPA which includes all the results of in vitro human and animal and animal in vivo skin absorption studies. OECD and EFSA, employ a tiered approach, which the requirement of further study depends on the results of the former stage study. OECD guidelines accept the analysis of pesticide level absorbed through skin without radioisotope when the recovery using the non-labeled method is within 80~120%. Various factors are reviewed in this study, including the origin of skin (gender, animal species and sites of skin), thickness, temperature and, etc., which can influence the integrity of results.

• Tribology and Lubricants
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• 제30권1호
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• pp.36-45
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• 2014

Understanding steel/skin contact phenomena is important for the study of object manipulation in robotics and has been a topic of great interest. In this study, pig skin was taken as a surrogate model for human skin, and its adhesive, friction, and deformation behaviors were measured under various exposure times to air. Indentation, friction, and scratch tests were performed at $25^{\circ}C$ and 45% relative humidity. The influences of adhesion and deformation on the coefficient of friction were characterized; the pig skin was found to be sensitive to the sliding velocity and normal load under the controlled experimental conditions.

• 한국산업보건학회지
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• 제22권2호
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• pp.100-106
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• 2012

Objectives: Diazinon is an insecticide which acts as a contact stomach and respiratory poison, and used throughout the world to control a wide range of sucking and chewing insects and mites on a range of crops. In this study, the airborne diazinon levels were measured for farmers, pest control operaters, landscapers, and agricultural chemicals sellers, and an assessment of the health risk to the workers was presented. The exposure scenario was based on the route of inhalation and skin absorption. The "OSHA Method No. 62" was used to sample and measure the airborne diazinon levels. The skin wipe method was applied to measure the level of the diazinone exposure through the skin. For the determination of exposure scenario, the exposure factors were surveyed for the daily average inhalation rate and the exposure period and frequency and time of diazinone as well as the body weight and lifetime of the workers. The median values of exposure frequency and exposure time were selected after evaluating the validity of those. Methods: The highest level of the diazinon exposure in the air was $107.21ug/m^3$ in farmers, followed by $93.53ug/m^3$ in landscapers, at $31.40ug/m^3$ in pest control operators, and $1.04ug/m^3$ in agricultural chemical seller. The amount of skin absorption was the highest in farmers at 63.39 ug/day, followed by landscapers at 10.47 ng/day, pest control operaters at 4.26 ng/day, and agricultural chemicals sellers at 0.34 ng/day. The hazardous indices calculated using toxicological reference value were 2.79 for pest control operaters, 0.41 for landscapers, 0.07 for agricultural chemicals sellers, and 0.06 for farmers. Conclusions: While the farmers were exposed to the high levels of diazinon through the air and skin, the pest control operaters, landscapers and agricultural chemicals sellers have more the diazinon hazards than the farmer based on the risk assessment in this study.

• Toxicological Research
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• 제16권1호
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• pp.89-94
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• 2000

Alpha-hydroxy acid(AHA) are used in cosmetic products as a pH adjuster, mild exfoliant and humectant-skin conditioner. Cosmetics containing higher concentration (30%) and lower pH (3.0) of AHA can cause side effects if it is applied without the prescription. For providing information on the safety of AHA and on human risk assessments we studied skin irritation effect of glycolic acid, one of the most commonly used AHA in guinea pigs. The skin irritation by glycolic acid was increased in a dose(10% to 70%), acidity (pH 2.5 to 5.5.) and length of exposure dependent manner (for up to 14 days), respectively. The combination treatment with UVB (0.4 or 3.0 J/$cm^2$) increased glycolic acid-induced skin irritation. Histological examination showed that hyperplasia of non-inflammatory cells in the epidermis of skin treated with high dose of glycolic acid (pH 3.0). There results show that glycolic acid increased skin irritation in a dose, length of exposure and pH dependent manner, respectively, in guinea pig, and the combination with UVB increased glycolic acid-induced skin irritation. The cell proliferation of non-inflammatory cell may be involved in high doses of glycolic acid-induced skin irritation. Long-term application of more than 30% of glycolic acid (pH 3.0) may cause skin irritation.

• 한국안전학회지
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• 제24권6호
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• pp.72-78
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• 2009

차량수리작업장에 일반적으로 사용하고 있는 HDI의 노출은 직업성 천식을 발생시키는 주요 원인이 된다. 비록 피부나 눈의 오염이 흡수경로로 고려되고 있음에도 불구하고 이들의 폭로에 관한 작업장의 노출허용 기준이 규정되어 있지 않으므로 많은 실험 자료들이 제공되어져야 한다. 따라서 이 연구는 피부, 눈 그리고 호흡보호구와 눈보호구의 표면에 대한 HDI의 오염정도를 확인하였으며, 손잡이, 작업대 그리고 분사건과 같이 다양한 오염표면이 있다는 것도 명확히 하였다. 상대적으로 짧은 시간의 분사임에도 불구하고 목, 이마, 손등, 팔과 손목 등에서 채취한 시료의 많은 부분(47~80%)이 HDI오염에 양성이었다. 분사실 내부에서의 오염정도는 좋지 못한 작업여건이나 보호경과 같은 부적절한 개인보호구 때문에 분사실 외부의 오염정도보다 일반적으로 높다. 경험이 있는 페인트 공보다 초보자들의 폭로수준이 높은 것은 안전이나 보건의식의 결여 때문인 것으로 사료되고, 보호구내부의 오염 정도는 호흡기관, 피부 및 눈의 잠재적인 노출을 야기할 것이다. 작업자 14명중에서 4명의 눈물시료로부터 HDI양성반응을 보였으며, 이것은 부적절한 눈 보호구에 의한 것으로 나타났다. 호흡기의 과민반응을 포함한 건강징후에 관여되는 피부와 눈의 노출 잠재성을 고려해볼 때 실질적 자료는 작업자들의 근무여건개선, 적절한 보호구의 선택과 사용 그리고 관리의 중요성을 잘 보여 주고 있다.

• 한국재료학회지
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• 제33권3호
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• pp.87-94
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• 2023

Exposure to ultraviolet (UV) light is often associated with skin damage, sometimes very serious, and in recent times has received particular attention as a health risk. As a result, the proper use of sunscreen has long been recommended to protect against skin damage. The continued increase in the use of sunscreen may be linked to increased information about the risk of melanoma and non-melanoma skin cancer caused by prolonged exposure to ultraviolet rays. Natural and harmless materials that block and prevent UV light have emerged as essential household items in the field of skin beauty. New materials need to be considered and evaluated in relation to ultraviolet rays and their harmful effects. This study aims to explain the effect of UV exposure on human skin, the classification of sunscreens, the application of zeolite, nano clay, and LDH in sunscreen formulations, as well as the regulation of this service in various countries around the world.