• Biomolecules & Therapeutics
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• 제22권1호
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• pp.73-77
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• 2014

The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed using Franz diffusion cells along with rat dorsal skin, and the effect of drug concentration and the addition of pectin on skin deposition profiles of RP was observed. The skin distribution of RP increased in a concentration dependent manner and the formulations containing 0.5 and 1 mg of pectin demonstrated significantly increased RP distributions in the epidermis. Furthermore, it was found that skin distribution of RP could be further improved by combined use of pectin and ascorbyl palmitate (AP), due largely to their anti-oxidative effect. These results clearly demonstrate that the skin deposition properties of RP can be improved by stabilizing RP with pectin. Therefore, it is strongly suggested that pectin could be used in the pharmaceutical and cosmetic formulations as an efficient stabilizing agent and as skin penetration modulator.

• Journal of Ginseng Research
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• 제42권4호
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• pp.512-523
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• 2018

Background: 20(S)-Protopanaxadiol (20S-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal antiaging activity. However, because of its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20S-PPD. Methods: MEs and MEHs were formulated and evaluated for their particle size distribution, morphology, drug loading capacity, and stability. Then, the deposition profiles of the selected 20S-PPD-loaded MEH formulation were studied using a hairless mouse skin model and Strat-M membrane as an artificial skin model. Results: A Carbopol-based MEH system of 20S-PPD was successfully prepared with a mean droplet size of 110 nm and narrow size distribution. The formulation was stable for 56 d, and its viscosity was high enough for its topical application. It significantly enhanced the in vitro and in vivo skin deposition of 20S-PPD with no influence on its systemic absorption in hairless mice. Notably, it was found that the Strat-M membrane provided skin deposition data well correlated to those obtained from the in vitro and in vivo mouse skin studies on 20S-PPD (correlation coefficient $r^2=0.929-0.947$). Conclusion: The MEH formulation developed in this study could serve as an effective topical delivery system for poorly soluble ginsenosides and their deglycosylated metabolites, including 20S-PPD.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.457-468
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• 2003

Active ingredients have been around in cosmetics for a long time but have they really resulted in active cosmetic products\ulcorner In order to achieve this, the right active needs to be delivered to the right location at the right concentration for the correct period of time. And the extent (and therefore the concentration) of this delivery depends on the formulation. From a rather theoretical approach based on the polarity of the active ingredient, the stratum corneum and the oil phase, the Relative Polarity Index was established that enables the selection of a suitable emollient for ensuring skin penetration of the active ingredient. Practical examples subsequently show the validity of this approach that demonstrates that one can regulate the delivery of an active molecule (and therefore the efficacy of a cosmetic formulation) by selection and control of the emollient system. Cosmetic formulations are generally quite complex mixtures and subsequent experiments using different emulsifier systems indicated that this component of a cosmetic formulation could also have an impact on steering the active ingredient to the right layer of the skin, although it is too early to be able to derive general rules from this.

• Archives of Plastic Surgery
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• 제44권4호
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• pp.313-318
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• 2017

Background Jeju Island is geographically and socioeconomically distinct from the mainland of South Korea. Thus, the presentation and management of non-melanocytic skin cancers (NMSC) of the head and neck may differ from those in other regions of the country. We compared the clinical characteristics and treatment modalities of NMSC on Jeju Island with the findings of similar regional studies. Methods Patient data, including age, sex, diagnosis, tumor site, treatment, and recurrence, were obtained from the medical and pathology records of patients diagnosed with NMSC between January 2010 and June 2015. Results In total, 190 patients (57 men) with a mean age of 75 years (range, 42-97) were assessed. Overall, 203 NMSCs were diagnosed, including 123 basal cell carcinomas and 80 squamous cell carcinomas. The tumor sites included the nose, cheeks, periorbital area, and lips (n=55, 54, 25, and 20, respectively). We identified 92 T1-stage and 60 T2-stage tumors, and 120 cases were treated with wide surgical resection and 17 cases were treated with radiation therapy at the medical center. Of the 120 cases treated surgically, 69 required reconstructive surgery using a local skin flap, 22 required full-thickness skin grafting, and 12 underwent primary closure. Basal and squamous cell carcinomas recurred in 2 and 1 cases, respectively. Conclusions Compared to the reports from other regions, the average patient age was 10 years higher, with a marked female preponderance. While the proportion of squamous cell carcinoma was higher than in other regions, the tumor distribution and surgical management profiles were similar.

• Journal of applied mathematics & informatics
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• 제25권1_2호
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• pp.67-83
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• 2007

The characteristics of steady two-dimensional laminar boundary layer flow of a viscous and incompressible fluid past a moving wedge with suction or injection are theoretically investigated. The transformed boundary layer equations are solved numerically using an implicit finite-difference scheme known as the Keller-box method. The effects of Falkner-Skan power-law parameter (m), suction/injection parameter ($f_0$) and the ratio of free stream velocity to boundary velocity parameter (${\lambda}$) are discussed in detail. The numerical results for velocity distribution and skin friction coefficient are given for several values of these parameters. Comparisons with the existing results obtained by other researchers under certain conditions are made. The critical values of $f_0$, m and ${\lambda}$ are obtained numerically and their significance on the skin friction and velocity profiles is discussed. The numerical evidence would seem to indicate the onset of reverse flow as it has been found by Riley and Weidman in 1989 for the Falkner-Skan equation for flow past an impermeable stretching boundary.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제11권1호
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• pp.57-70
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• 2007

The effects of variable viscosity, blowing or suction on mixed convection flow of a viscous incompressible fluid past a semi-infinite horizontal flat plate aligned parallel to a uniform free stream in the presence of the wall temperature distribution inversely proportional to the square root of the distance from the leading edge have been investigated. The equations governing the flow are transformed into a system of coupled non-linear ordinary differential equations by using similarity variables. The similarity equations have been solved numerically. The effect of the viscosity temperature parameter, the buoyancy parameter and the blowing or suction parameter on the velocity and temperature profiles as well as on the skin-friction coefficient and the Nusselt number are discussed.

• Journal of Mechanical Science and Technology
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• 제18권1호
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• pp.153-166
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• 2004

This paper presents a comparative study of a fully coupled, upwind, compressible Navier-Stokes code with three two-equation models and the Baldwin-Lomax algebraic model in predicting transonic/supersonic flow. The k-$\varepsilon$ turbulence model of Abe performed well in predicting the pressure distributions and the velocity profiles near the flow separation over the axisymmetric bump, even though there were some discrepancies with the experimental data in the shear-stress distributions. Additionally, it is noted that this model has y$\^$*/ in damping functions instead of y$\^$＋/. The turbulence model of Abe and Wilcox showed better agreements in skin friction coefficient distribution with the experimental data than the other models did for a supersonic compression ramp problem. Wilcox's model seems to be more reliable than the other models in terms of numerical stability. The two-equation models revealed that the redevelopment of the boundary layer was somewhat slow downstream of the reattachment portion.

• 대한기계학회논문집
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• 제19권1호
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• pp.240-250
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• 1995

A CPM (computational preston tube method) was developed to measure wall shear stress in a transitional boundary layer on a flat plate using Preston tubes. Correlation for the displacement factor of Preston tubes was improved for a CPM to be used in the transitional boundary layer. The distribution of skin-friction coefficient was reasonably predicted in the uniform free stream of 3.1% turbulence intensity. Reasonable and accurate estimation of displacement factor of Preston tubes was found to be of crucial importance for the CPM, especially in the laminar boundary layer. The mean velocity profiles of the boundary layer on the plate were also measured and presented.

• 한국게임학회 논문지
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• 제9권5호
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• pp.137-144
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• 2009

이 논문은 피하산란의 정도가 다를 것으로 예상되는 얼굴의 6개의 부위를 촬영하여 각각의 산란특성을 추출하고 렌더링에 반영하여 얼굴의 사실감 있는 표현이 가능한 방법을 제안한다. 각 부위별 산란이미지는 프로젝터로부터 피부에 입사된 단위광선이 내부 산란을 거쳐 밖으로 드러나는 모양을 여러 노출로 촬영하여 HDR 이미지로 합성하고, 비선형 최소제곱합의 해법 중 Sequential Quadratic Programming을 이용하여 광선의 입사지점을 지나는 단면이 이루는 곡선에 '가우스 함수의 선형결합'을 적합한다. 가우스 함수는 산란곡선을 잘 근사하면서 필터로서 적용이 쉬운 장점을 가진다. 우리는 최소제곱합의 해가 지역 해에 빠지는 않도록 유전알고리듬을 이용해 초기 값을 설정한다. 근사된 식의 각 가우스 항은 얼굴에 입사되는 복사조도를 렌더링한 텍스처에 가우스 필터로 적용되어 피하산란효과를 표현. 이 논문에서는 최대 12회의 가우스 필터링을 효율적으로 처리하기 위해 쿠다의 병렬처리능력를 활용하였다.

• 한국의학물리학회지:의학물리
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• 제7권2호
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• pp.57-65
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• 1996

피부 T 세포림프종에 대하여 4MeV 의 전자선으로 전 피부 방사선 조사를 시행하였다. 피부전체의 균일한 선량분포를 위하여 스탠포드대학의 방법으로 알려져 있는 six dual field 기법을 사용하였다. SSD 는 390cm로 하였으며 방사선 조사시의 gantry 의 각은 환자의 중심을 지나는 수평축에 대하여 상ㆍ하로 14$^{\circ}$가 되도록 하였다. 전자콘을 설치해야만 전자선 조사가 가능하므로 최대의 전자콘인 25$\times$25cm콘을 사용하였다. 치료면에서의 선량분포의 균일성을 확인하기 위하여 치료면에 90$\times$180cm의 폴리스틸렌을 설치하고 Famer type ion chamber와 측정용 필름을 사용하여 측정하였다. 그 결과 치료면에서 10% 정도의 균일함을 보였다. 환자의 자세를 하루에 세가지씩 이틀에 걸쳐 여섯가지 자세를 한 주기로 치료를 시행하였다. 선량이 부족한 정수리, 회음부, 발바닥 등은 따로 추가의 방사선을 조사하였다. 렌즈와 손톱, 발톱은 차폐물을 제작하여 차폐하였다.