• 대한지역사회영양학회지
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• 제13권6호
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• pp.912-921
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• 2008

This study was performed to examine if the effects of collagen supplementation from pork skin could improve the sex steroid hormone, serum lipid and skin crack in Korean middle-aged women. Middle-aged women (40-55 years) who were not diagnosed with any type of disease were included in this study and thirty subjects were randomly assigned to a control group (n = 15) or a collagen supplemented group (n = 15). The collagen supplemented group ingested collagen flour 2 g, 3 times a day for 12 weeks. We measured serum collagen, estrogen, estradiol, estriol, progesterone, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol concentration. The collagen supplementation group had significantly increased serum collagen (p < 0.05) compared with the control group. In addition, skin crack was improved. But, there were no differences for sex steroid hormone and lipid profile in control and collagen supplemented groups. The result of the present study demonstrated that supplementation of 6 g collagen per day for 12 weeks can give beneficial effects on skin crack reduction and serum collagen concentration.

• 보건교육건강증진학회지
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• 제15권1호
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• pp.1-30
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• 1998

A study on skin care was conducted in order to develop proper skin care program and disseminate the Information to the consumers. The study was performed from October 2, 1997 though April 30 1997 by using questionnaires. The subjects were 1,793 from lug cities of Seoul, Pusan and, and 800 from medium and small cities of Kyongsan, Kimchon, Mokpo and KimHae cities. All subjects were females over 20 years. 1. 64.3% of the subjects said that they chose the massage packs after considering their skin condition. 55.1% of the subjects said that they did not know the side effects of the massage packs. 2. 53.3% of the subjects reported that they knew the cause of acne. and 73.3% of the respondents reported that they knew the nature of their body classified by oriental medicine. 3. The average knowledge and attitude was 10.61 :t3.46%( who it is converted to percent, it is 53.1%). The upper limit was 18.9% and lower limit was 19.0%. 4. The factors which are under the influence on knowledge of skin care were the times of massage, education level, the height of subjects, disease of skin, age, the degree of fatty body, the hour of make-up(R2=0.137). 5. The factors which are under the influence on the times of massage were education level, the experience of skin side effect, the status of physic8I health and the birth place of the subjects(R2=0.139). 6. The main factors which had significant effect on the status of face skin health were the status of physical health, economic status, age, the side effect of skin cosmetic, and the hour of make-up(R2=0.140). 7. Finally, it is recommended that training package on side effect of cosmetics, massage, physical characteristics and proper way of make-ups, and the public should be educated on the above mentioned areas.

• 한국응용과학기술학회지
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• 제37권1호
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• pp.66-75
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• 2020

Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. and wished to examine closely effect that Polygonum multiflorum isolated PM-E and PM-70M orally adminstration used to atopy dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. This study was investigated the anti-allergic effect of PM-E and PM-70M on BMAC induced atopic dermatitis in NC/Nga mice. We summerized as the follow. PM-E and PM-70M significantly reduced the skin number of total cell number, CD4⁺ and CD11b⁺/Gr-1 cell compared with positive control and decreased the invasion of CD4⁺ cell in dorsal skin tissue compared with positive control group by using immunohistochemical staining and chemokine such as eotaxin and CCR3 compared with positive control group. PM-E and PM-70M markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin. Taken together, these findings suggested that PM-E and PM-70M has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.

• 한방안이비인후피부과학회지
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• 제20권2호통권33호
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• pp.10-35
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• 2007

Objectives : To investigate the effects of Ohbaesangami (OBSGM) on mucosa and skin diseases, anti-microbial and anti-inflammatory tests were performed using several in vitro test models. Results : In anti-microbial test, OBSGM showed the slight inhibitory effect against Propionibacterium acnes (P. acnes) and Staphylococcus aureus (S. aureus). In anti-oxidant test, OBSGM showed the potent radical scavenging activity. In anti-inflammatory test, OBSGM weakly inhibited the lipopolysaccharide (LPS)-induced nitric oxide(NO) release from the RAW 264.7 macrophage cells. OBSGM also inhibited the LPS-induced $interleukin-1{\beta}(IL-1{\beta})$ and cyclooxygenase-2 (COX-2) expressions. The inhibitory effects of OBSGM on macrophage activation was via the inhibition of $NF-{\kappa}B$, evidenced by transient transfection assay. Furthermore, OBSGM markedly inhibited the activation of Jun-N-terminal kinase (JNK) and p38 MAP kinase in RAW 264.7 cells. In skin wrinkle formation assay, OBSGM strongly inhibited collagnease and elastase, whose activities are tightly related with the wrinkle formation. In addition, OBSGM inhibited the activities of MMP-1, MMP-2 on the mRNA levels in RAW 264.7 cells. However, OBSGM did not show an inhibitory potential on tyrosinase activity and melanin synthesis, indicating that it could not be applicable for skin whitening. Conclusion : These results suggest that the anti-inflammatory effect of OBSGM may be due to its inhibitory potentials on the macrophage activation. And, the anti-wrinkle effects of OBSGM may be due to its inhibitory potential on the collagnease and elastase activities. Therefore, OBSGM could be applicable for the treatment of mucosa and skin diseases.

• 한국실내디자인학회논문집
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• 제13권4호
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• pp.110-117
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• 2004

Recently the hospitals or clinics tend to get out of the functional and technological aspect so as to gradually emphasize service for patients. While qualitative rather than quantitative alteration is noticeable, the scale of clinics is getting larger. Especially, the opulence resulted from economic, social and cultural development has enabled more people to visit dermatology or plastic surgery besides treatment for disease. Responding to this tendency, dermatology is focusing on skin beauty, plastic operation, controlling obesity, etc. for women rather than ordinary treatment. Thus, dermatology is in need of space for skin control as well as ordinary treatment, which raises the immediate necessity of new plan for space and interior environment. In order to meet such necessity of dermatology, it is required to fully study and consider the plan for interior space. First, the purpose, scope and method of research will be defined in the introduction. Second, the concept of clinic as well at the characteristic of dermatology will be studied by theoretical investigation. Third, the general concept of dermatology will be analyzed by examining the characteristic of each room in dermatology, the moving line of nurses and patients, the color of dermatology and the design factor of finishing materials through general investigation on dermatology. Fourth, in order to look into the general case of dermatology, the object of examination will be selected for examination through literature and visiting. After examining data, the result will be analyzed and evaluated to prepare the ground for interior plan of dermatology.

• 한국생활과학회지
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• 제18권2호
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• pp.501-507
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• 2009

Atopic dermatitis is one of the most common skin disease in children and a characteristic chronically recurrent form of dermatitis with a hereditary tendency, affecting infants and may extend to the childhood or th the adult age. Environmental factors, stress, and foodstuffs such as milk, egg may cause atopic dermatitis. Nc/Nga mice were used as an animal model for human atopic dermatitis. The divided by 4group such as normal group, BMAC group, FK506 group, MR group for this study raised in conventional conditions. To investigate effect of Chamomile German on atopic dermatitis in NC/Nga mice, the serum IgE and IgG1 level were measured while the severity degree of the skin lesion was examined by the naked eyes of two volunteers who were unaware of the treatment status. The results were the followings. 1. The score on the severity degree of skin dermatitis in FK 506 and MR group was lower than that in control group. 2. The serum IgE level in control group was higher 25% than that in normal group. 3. The serum level of IgE in FK506 and MR group compares to control group was decreased. 4. The serum IgG1 level was decreased more than 3.5 times in FK506 compared to control group while MR group had significantly less the serum IgG1 than control group. From the above results, treatment of Chamomile German oil had the effect on atopic dermatitis in NC/Nga mice. If scientific researches on aroma oil are performed in various way, aroma oil will be used to cure skin dermatitis as a alternative therapy in the future.

• 대한화장품학회지
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• 제31권3호
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• pp.279-283
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• 2005

일부 도시 중년여성을 대상으로 안면부위별 피부상태를 파악하고자 비침습적 측정방법을 이용하여 유 수분, 멜라닌 홍반 정도를 관찰하였고, 주관적으로 자각하는 유 수분 유형을 조사하여 객관적 측정값들과의 관련성을 보고자 하였다. 안면부위별 측정 결과, 수분량은 눈가>이마>볼, 유분량은 이마>눈가>볼 부위 순이었으며, 홍반지수는 이마>볼>눈가, 멜라닌지수는 눈가>이마>볼 부위 순이었다. 객관적 유분 측정값과 주관적으로 자각하는 유분유형은 일치성을 나타내었다. 유분량 홍반지수, 멜라닌지수의 각 측정값들은 유의한 양의 상관관계를 보였다.

• Journal of Applied Biological Chemistry
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• 제66권
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• pp.416-423
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• 2023

무화과는 잎, 뿌리, 줄기, 라텍스 외에 열매 자체에서도 각각 항산화, 미백, 항염증, 항균 효능이 보고된다. 본 연구팀에서는 천연물 기반 화장품 소재 개발을 위해 무화과 열매 l atex에 존재하는 ficin 효소의 피부 활성 뿐만 아니라 열매를 70% 에탄올로 추출한 추출물의 미백 기능에 대해 연구 결과를 도출하여 화장품 원료로 직접 사용하고있다. 그러나 새로운 공융용매 추출법 개발 수요와 이를 활용한 피부 염증 완화 및 건선 조절기능에 대한 연구는 거의 없다. 따라서 본 연구에서는 공융용매 추출법을 적용한 무화과 열매 추출 및 분획물들에 피부 염증 조절 및 건선에 대한 유효성 평가를 수행하였다. 먼저, 무화과 열매를 최적의 공융용매 조건으로 추출한 후 n-hexane, dichloromethane, ethyl acetate. butanol로 분획한 분획물의 피부염증 조절 기능을 비교하였다. 먼저, 분획물의 항산화 활성과 RAW264.7 세포주에서 nitric oxide 생성 억제를 확인하였다. 또한 RT-PCR을 이용해 전염증성 사이토카인 mRNA 발현 조절을 관찰한 결과, 여러 분획물 중 hexane, dichloromethane, ethyl acetate와 같은 비극성 용매에서 TNF-α, IL-1α, IL-1β 등 염증성 사이토카인 mRNA 발현이 억제되었다. 뿐만 아니라 HaCaT 각질형성세포 모델에서 TNF-α 로 염증반응을 유도한 후 분획물의 항염증 활성을 비교한 결과 hexane, dichloromethane, ethyl acetate 분획에서 높은 활성을 확인하였다. 마지막으로 in vitro 인간 건선 세포모델에서 chemokine CC motif ligand 20(CCL20) 발현을 확인한 결과 유의성 있게 mRNA 발현 이 억제되었다. 따라서, 공융용매 추출 후 무화과 열매 분획물 중 hexane, dichloromethane, ethyl acetate 분획에서 높은 항염증 활성 및 CCL20 케모카인 조절 기능이 확인되었다. 이런 결과들은 무화과 열매 추출물의 항염증 활성과 함께 인체적용시험을 통해 피부진정 효과가 검증된다면 향후 뛰어난 피부 진정 천연 화장품 소재로 개발될 가능성이 높다고 사료된다.

• 식품과학과 산업
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• 제54권4호
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• pp.278-292
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• 2021

Fermented milk including yogurt, which has a long tradition of thousands of years, was first established in Korea in 1919, and the current market size has grown to over 90 billion dollars. Fermented milk, which began in the early days of liquid yogurt, appeared on the market as spoonable and drinking yogurt. Fermented milk began with research on intestinal health functions and lactobacilli, and gradually developed into various disease prevention studies such as gastrointestinal health, immunity improvement, skin beauty, and prevention of dementia. As a simple meal, it has a nutrient function element, which serves as a meal replacement, and is expanding its range from general foods to special-purpose foods and dietary supplements. Fierce market competition is taking place, and as a result, the domestic fermented milk market is developing through the development of various products for differentiation.

• 보건교육건강증진학회지
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• 제22권4호
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• pp.245-256
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• 2005

The purpose of this study is to research the situation and related knowledge and behavior of Korean beauty artists on their musculoskeletal disorders and the factors on them. It was researched by questionnaire from March 1 to May 31, 2003, and the subjects were 984 of beauty artists who were working as hair designers, skin care specialists, and make-up artists over 1 year in big cities including Seoul, Daegu, Busan and Gwangju. The analyzation was done by frequency, percentage, $x^2-test$, t-test. The results can be summarized as follows; 1. As for their degree of pain according to part of their body, the highest was shoulder as 88.3%, and next were neck(cervical region) as 83.2%, waist as 77.6%, and wrist(hand) as 71.8%, in order. 2. The level of knowledge on the muscloskeletal disorder was 65.6 points on the basis 100points. As for their level of protective behavior and knowledge on the disorders of musculoskeletal system according to their educational experience, the higher educational level they had the higher knowledge level they showed, as 42.6% of 'high', 30.4% of 'medium', and 27.0% of low; and as for degree of performing the protective behavior, they showed the higher protective behavior level when they had the higher educational level. 3. As for their level of knowledge on disorders of musculoskeletal system according to their general uniqueness as beauty artists, they showed statistical significance on the field of their marriage status, educational degree, specialized field, and numbers of customers they manage; and as for the degree of their protective behavior, they showed statistical significance in the field of age, marriage status, specialized field, and rank in their jobs. 4. The level of protecting behavior on the muscloskeletal disorder was 57.4 points on the basis 100points. As for their degree of pain on each part of their body according to their protective behavior and knowledge on musculoskeletal system, it had statistical significance on their elbows and hips, and the less pain they showed when the higher knowledge they had; it had statistical significance on their neck(cervical region), shoulders, backs, waists, knees and ankles(feet) according their protective behavior, and the less pain they showed when the higher level of protective behavior they did.