• Molecules and Cells
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• v.41 no.6
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• pp.545-552
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• 2018

Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors, including fostamatinib (R406 or R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659, have been assessed in clinical trials. Here, we report the crystal structures of SYK in complex with two newly developed inhibitors possessing 4-aminopyrido[4,3-D]pyrimidine moieties (SKI-G-618 and SKI-O-85). One SYK inhibitor (SKI-G-618) exhibited moderate inhibitory activity against SYK, whereas the other inhibitor (SKI-O-85) exhibited a low inhibitory profile against SYK. Binding mode analysis indicates that a highly potent SYK inhibitor might be developed by modifying and optimizing the functional groups that interact with Leu377, Gly378, and Val385 in the G-loop and the nearby region in SYK. In agreement with our structural analysis, one of our SYK inhibitor (SKI-G-618) shows strong inhibitory activities on the ${\beta}$-hexosaminidase release and phosphorylation of SYK/Vav in RBL-2H3 cells. Taken together, our findings have important implications for the design of high affinity SYK inhibitors.

• 한국체육학회지인문사회과학편
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• v.54 no.2
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• pp.285-297
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• 2015

This study aimed to research customer reward program factors of ski resorts in Korea through surveying the expert panel side and the customer side. This study conducted survey for 28 practicians that have been working for the department of customer reception of 6 different ski resorts all over the country and 7 faculties quited well-known in the academic circles. Delphi technique has been used to conduct survey customer reward program factors of the supplier side till the 3rd survey as the final. Based on this survey, an interview and a questionnaire survey have been used to conduct survey customer reward program factors that have been aware by the 50 customers, who have visited the ski resorts in 2014, and compared those two surveys above. In order to process the data, descriptive statistic analysis and Kendall W test have been utilized PASWWIN Ver. 18.0. The results were as follows: discount factor 8 articles, promotion factor 10 articles, package factor 5 articles, and convenience factor 6 articles have been produced as a good result.

• Steel and Composite Structures
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• v.3 no.2
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• pp.141-152
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• 2003

The ski jump in Innsbruck known for the famous annual New Year "Four-ski-jump-tournament" has been fully renewed. The original jumping tower (built for the 1976 Olympic winter games) was fully pulled down and a new landmark similar to a lighthouse has been erected located on a small hill at the border of the city. Zaha Hadid(London) won the international architectural competition for this significant building. The constructional realisation has been ordered from Aste Konstruktion and has been finally honoured with the Austrian state award for consulting 2002. After a very strict timetable the building was already handed restaurant at the top.

• Journal of Fisheries and Marine Sciences Education
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• v.29 no.3
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• pp.655-664
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• 2017

The purpose of this study was to verify the relationships among sport enjoyment, leisure satisfaction, and continuous participation intention in ski class. The study conducted a research survey through purposive sampling method. 280 questionnaires distributed and 271 were selected as final valid sample by removing 9 questionnaires that have insufficient answers. Hypothesis test on collected data was conducted by using SPSS 20.0 and AMOS 18.0 programs. The results were as followings. First, sport enjoyment factors a significant effect on psychological satisfaction, environmental satisfaction. Second, sport enjoyment factors had effect on re-participation intention, word of mouth intention. Third, leisure satisfaction had effect on re-participation intention, word of mouth intention. In addition, it had effect on continuos participation intention as the partial mediation of the leisure satisfaction.

• Korean Journal of Microbiology
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• v.28 no.2
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• pp.114-119
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• 1990

A yeast chromosomal superkiller gene (SK13) was cloned and expressed in $ski3^{-}$ Saccharomyces cerevisiae strains. The gene was fused to the structural region of E. coli lacZ gene at its C-terminus in a yeast-E. coli shuttle vector, pSR605. The fused gene complemented $ski3^{-}$ strains with SK13 activity and the quantitative level of expression was measured as determined by assaying $\beta$-galactosidase activity. The SDS-polyacrylamide gel electrophoresis and the Western blot analysis of this fused protein showed the immuno-reacted bands with a protein of the estimated molecular size (ca.250Kd).

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.187-187
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• 1994

선경인더스트리 연구소에서 개발된 100 여종의 새로운 백금착체 항암제 중 그 동안의 전임상연구를 통해 항암효과가 우수하고 안정성이 확인된 항암제인 SKI 2053R의 인체내 최대내약용량을 결정하고 부작용 및 항암효과를 평가하고 약제의 인체내 약동학적 특성을 검토하기 위해 각종 악성종양 환자들을 대상으로 제 1상 임상연구를 시행하였다. 약제의 투여는 500m1의 5% 포도당용액에 용해하여 1시간에 걸쳐 정주하였으며 병의 악화나 심한 독성이 없으면 치료를 매 4주마다 반복하였다. SKI 2053R의 초기용량은 생쥐에서의 LD$_{10}$의 1/10에 해당하는 40 mg/$m^2$로 하였고, 용량의 단계별 증가는 modified Fibonacci법에 따랐다. 각 단계별로 3명이상의 환자를 치료하여 WHO 기준상 3도 이상의 부작용이 2/6 이상에서 나타날 때의 용량을 최대내약용량으로 설정하였다.

• Korean Journal of Applied Biomechanics
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• v.17 no.3
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• pp.41-49
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• 2007

This study was to investigate the kinematical analysis using ski simulator. Twelve people(six skilled, six unskilled) participated in the experiment. Each phase of motion time was slight differences between the skilled group and the unskilled group but not significant difference in statistics. In displacement of vertical on COG(Center of Gravity), left and right down motion showed significant difference between group. In velocity of horizontal on COG, both left and right down motion showed significant difference between group, and up motion of between down motion showed significant difference. In displacement of angle on ankle, knee, hip joint almost showed significant difference between group. Almost in body position was lower skilled group than unskilled group.

• Journal of Korean Orthopaedic Sports Medicine
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• v.2 no.1
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• pp.37-43
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• 2003

Purpose: This study is to analyse the injury patterns of knee ligament and the factors influencing ligament injuries of knee, and to evaluate the changes of knee function and activity after ski injury. Materials and Methods: Thirty cases of ligament injuries of knee were studied with a questionaire, stress radiographs, magnetic resolution imaging, and physical examination. Mean age was 28.6 years old and mean follow up was 29.6 months. Clinical evaluation of Lysholm knee scoring scale was used for knee function and Tegner activity score was used for activity change after ski injury. Results: The anterior cruciate ligament (ACL) injury accompanied with medial collateral ligament(MCL) injury was most in 11 cases and isolated MCL injury was the next in 9 cases. The common types of injury mechanism were Phantom foot phenomenon (13 cases, 43$\%$) and valgus external rotation injury (12 cases, 40$\%$), which constitute 83$\%$ of all case. At the last follow up, the mean Lysholm score was 93.4 and mean Tegner activity score was 4.2. The reduced Tegner activity score after injury was 1.9. Among several injury groups, the evaluation of knee function and activity was best in the isolated MCL injury group and worst in the ACL injury accompanied with MCL injury group. The factors to influence ski injury were participation to ski class, release of binding, and skiing long time more than 2 hours. Conclusions: Lysholm score at last follow up revealed good grading, but sports activity after ski injury was reduced when compared with pre-injury state. It seems to need a active, systemic sports rehabilitation program after sports injury.

• 한국체육학회지인문사회과학편
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• v.57 no.6
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• pp.293-308
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• 2018

This study was carried out to investigate the current trends in skiing-related research from existing literature in the field of kinematics, measurement sensor and computer simulation. In the field of kinematics, research is being conducted on the mechanism of ski turn, posture analysis according to the grade and skill level of skiers, friction force of ski and snow, and air resistance. In the field of measurement sensor and computer simulation, researches are being conducted for researching and developing equipment using IMU sensor and GPS. The results of this study are as follows. First, beyond the limits of the existing kinematic analysis, it is necessary to develop measurement equipment that can analyze the entire skiing area and can be deployed with ease at the sports scene. Second, research on the accuracy of information obtained using measurement sensors and various analysis techniques based on these measures should be carried out continuously to provide data that can help the sports scene. Third, it is necessary to use computer simulation methods to clarify the injury mechanism and discover ways to prevent injuries related to skiing. Fourth, it is necessary to provide optimized ski trajectory algorithm by developing 3D ski model using computer simulation and comparing with actual skiing data.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.143.2-144
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• 2003

Joins (SKI 306X) is now clinically used for the treatment of osteoarthritis (OA). In previous reports, Joins a natural herbal product extracted from three herbs Clematis Radix. Trichosanthes Radix and Prunella Flos, was shown to have good analgesic and anti-inflammatory effects in several in vivo models. e.g., acetic acid-induced pain, carrageenan-induced paw edema and adjuvant-induced arthritis. (omitted)