• 환경영향평가
• /
• 제24권5호
• /
• pp.432-443
• /
• 2015

스키산업은 기후변화에 매우 민감한 산업이다. 이에 따라 세계 각국의 많은 연구자들이 기후화로 인한 스키산업의 영향을 연구해왔다. 그러나 이런 대부분의 연구들은 대부분 세계적 규모의 대형 스키장을 대상으로 진행해왔기 때문에 우리나라와 같은 소규모 스키장에 연구 결과를 적용하기는 어려웠다. 이에 국내 스키장 17곳을 대상으로 한국적 여건을 고려한 스키산업의 기후 변화 영향을 분석하고자 하였다. 그 결과, 저감 노력 하에 기후변화 추세가 완화한다면(RCP 4.5) 스키산업은 현재와 같은 수준으로 유지될 수 있을 것으로 전망되었다. 그러 현재의 기후변화 추세가 계속 지속된다면(RCP 8.5) 스키산업의 운영 어려움이 발생될 것으로 전망되었는데, 스키장 운영 최소 영업일 100일을 기준으로 했을 때, 17개 스키장 중 2030년대에 3개, 2060년대에는 12개, 2090년대에는 나머지 2개 스키장의 운영이 불가해 질 것으로 전망되었다. 이는 우리나라의 소규모 스키장 또한 해외의 대형 스키장과 마찬가지로 기후변화로 인한 운영 어려움에 노출될 것임을 뜻하며, 스키장의 운영 지속성을 확보하기 위한기술적, 운영적 차원의 적응 노력이 필요함을 시사한다.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
• /
• pp.74-74
• /
• 1993

The in vitro cytotoxicity of SKI 2053R was evaluated against human tumor cell lines along with those of cisplatin and carboplatin using MTT assay. The cell lines tested were two human lung cancer cell lines and five human stomach cancer celt lines. The level of cytotoxic effects of SKI 2053R against two human lung cancer cell lines was located between cisplatin and carboplatin. However, the cytotoxic activity of SKI 2053R against five human stomach cancer cell lines was similar to that of cisplatin. SKI 2053R is considered to be selectively cytotoxic toward human stomach cancer cell lines. We carried out pharmacokinetic and ex vivo phrmacodynamic studies of SKI 2053R in beagle dogs to predict the clinical antitumor effect of SKI2053R, comparing with those of cisplatin and carboplatin. In ex vivo pharmacodynamics which used MTT assay as bioassay on the 2 lung and 5 stomach cancer cell, mean antitumor indexes (ATIs) of SKI 2053R were highest among three compounds in both lung and stomach cancer cell lines, especially in stomach cancer cell. Much higher ATI profile and maximal inhibition rates of SKI 2053R appeared in the stomach cancer cells will give desirable advantages to clinical trial s against gastric carcinoma. The anti tumor activity and target organ toxicity of SKI 2053R were compared with those of cisplatin on stomach cancer cell line, KATO III xenografted into nude BALB/c(nu/nu) mice. All groups of cisplatin and SKI 2053R showed active tumor regression. The inhibition rates(IR) of SKI 2053R were higher than that of cisplatin on the basis of mean IR. Though the loss of body weight was observed in all groups from the first week, the SKI 2053R group recovered it soon from the third week after the initiation of treatment, maintaining the most active anti tumor activity among three groups.

• 한국의류산업학회지
• /
• 제25권2호
• /
• pp.199-209
• /
• 2023

This study identified design elements of the functions required for children's ski pants. Data for this study were collected through questionnaire surveys conducted among children's ski instructors and children's sportswear developers. Five functionalities of children's skiwear were evaluated: mobility, stability, comfort, protection, and convenience. A total of 25 functional design elements related to the patterns, design details, and physical characteristics of fabrics for ski garments, were evaluated. The results of this study are as follows. First, children's sportswear developers evaluated that the pattern elements were important. Most of the pattern design elements highly related to mobility. Children's ski instructors' appraisal was that the height of the back waist was the important feature. Second, regarding the design details, children's ski instructors evaluated the size adjustment function and ventilation system as important elements. Many design detail elements were highly related in respect of stability, comfort, protection, and convenience. Third, the physical characteristics of fabric were strongly associated with mobility, comfort, and protection. As regards the physical characteristics of fabric, children's ski instructors valued anti-fouling highly, but children's sportswear developers attached more importance to the weight of the fabric. The results of this study will be useful in designing functional ski pants for children of elementary and intermediate ski levels. Since there may be limitations related to the ski level and age of children wearing ski pants, it is suggested that follow-up studies according to various groups of the ski pant wearers should be done.

• 한국안전학회지
• /
• 제24권2호
• /
• pp.13-16
• /
• 2009

A ski lifter for winter sports is one of the necessary and familiar facilities. But recently safety concern about ski lifter has been built. The ski lifter crash in Pocheon happened recently showed an example of safety concern and frigidity for safety awareness. In this report, the cause of the ski lifter crash in Pocheon was reviewed, and some suggestions were made to prevent a similar accident base on this review.

• Toxicological Research
• /
• 제8권2호
• /
• pp.235-253
• /
• 1992

A subacute toxicity study of cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II)(SKI 2053R) was carried out to obtain information on its toxicological profiles, and to determine the maximum tolerated dose in beagle dogs. Four groups of beagle dogs (2M and 2F per group, 0,0.5,1.0,2.0mg/kg/day)were given 15 i.v. injections of SKI 2053R. In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group was treated with cisplatin(0.7mg/kg/day)according to the same treatment schedule. The dosing schedule was divided into 3 courses of 5 consecutive days with 23-day dose-free intervals between each course. After completion of the treatments, remaining dogs were necropsied under established guidelines. Three of four dogs in the high dose group and one of four dogs in the middle dose group treated with SKI 2053R died of hypovolemic shock secondary to hemorrhagic and ulcerative enterocolitis. No toxicity-related mortality occurred in the low dose group of SKI 2053R. No survivor was observed in the group of cisplatin. Clinical signs including vomiting, diarrhea, anorexia and loss body weight were apparent in dogs given either cisplatin or high and middle doses of SKI 2053R. Severe thrombocytopenia and leukocytopenia were observed in the high dose group of SKI 2053R and cisplatin-treatment group, while toxicities as bone marrow suppression were reversible. The significant elevation of serum ALP values in group of SKI 2053R(2.0 mg/kg/day and 1.0mg/kg/day) and cisplatin(0.7mg/kg/day)was observed. Slight proteinuria waa observed in high and middle dose level groups of SKI 2053R. In histopathological examinations, pathological alterations of liver, kidney and spleen were noted dose-dependantly in dogs treated with SKI 2053R, and there was no overt sign of toxicity in low dose group of SKI 2053R. Compared to SKI 2053R, more severe durg-related toxicities occurred in dogs treated with cisplatin. It waw estimated that maximum tolerated dose of SKI 2053R in this treatment schedule was 0.5~0.7mg/kg/day. In conclusion, overall toxic potential of SKI 2053R was approximately 3 times lower than that of cisplatin with respect of lethality.

• 한국수정란이식학회지
• /
• 제26권4호
• /
• pp.237-244
• /
• 2011

Ski protein is implicated in proliferation/differentiation in a variety of cells. We had previously reported that Ski protein is present in granulosa cells of atretic follicles, but not in preovulatory follicles, suggesting that Ski has a role in apoptosis of granulosa cells. The alternative fate of granulosa cells other than apoptosis is to differentiate to luteal cells, however, it is unknown whether Ski is expressed and has a role in granulosa cells undergoing luteinization. Thus, the aim of the present study was to examine whether the initiation of luteinization with luteinizing hormone (LH) directly regulates expression of Ski in the luteinized granulosa and luteal cells after ovulation by in vitro models. RT-PCR and real time PCR analysis respectively revealed that LH had no effect on c-Ski mRNA expression in the cultured granulosa cells regardless of LH treatment. Though Ski protein is absent in granulosa cells of preovulatory follicle, its mRNA (c-Ski) was expressed and the level was unchanged even after LH surge. Taken together, these results demonstrated that Ski protein expression is induced in granulosa cells upon luteinization, and suggested that its expression is regulated post-transcriptionally. Moreover, expression of mRNA of Arkadia, an E3 ubiquitin ligases, in luteinizing granulosa cells in vivo was assessed by realtime-PCR. The levels of Arkadia mRNA expression were unchanged during follicular growth and postovulatory luteinization. These findings suggest that Ski protein level may be regulated during luteinization at translational and/or post-translational level but not by Arkadia.

• Reproductive and Developmental Biology
• /
• 제35권3호
• /
• pp.341-348
• /
• 2011

Sloan-Kettering virus gene product of a cellular protooncogene c-Ski is an unique nuclear pro-oncoprotein and belongs to the Ski/Sno proto-oncogene family. Ski plays multiple roles in a variety of cell types, it can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. The aim of the present study was to locate Ski protein in rat ovaries in order to predict the possible involvement of Ski in follicular development and atresia. First, expression of c-Ski mRNA in the ovaries of adult female rats was confirmed by RT-PCR. Then, ovaries obtained on the day of estrus were subjected to immunohistochemical analysis for Ski and proliferating cell nuclear antigen (PCNA) in combination with terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL). Ski was expressed in granulosa cells that were positive for TUNEL, but negative for PCNA, regardless of the shape and size of follicles. Expression of Ski in TUNEL-positive granulosa cells, but not in PCNA-positive granulosa cells, was also verified in immature hypophysectomized rats having a single generation of developing and atretic follicles by treatment with equine chorionic gonadotropin (eCG). These results indicate that Ski is profoundly expressed in the granulosa cells of atretic follicles, but not in growing follicles, and suggest that Ski plays a role in apoptosis of granulosa cells during follicular atresia.

• 한국운동역학회지
• /
• 제24권4호
• /
• pp.425-433
• /
• 2014

The purpose of the study was to investigate the effect of CAD (Computer Aided Design) based alpine mono-ski bucket design on disabled ski athletes' kinematic characteristics. Two national team ski athletes with LW11 disabilities (Locomotion Winter Classification) category for sit ski participated in both pre and post experiment. Both of the subjects performed 3 trials of carved turn on a ski slope under two conditions. Where, subject "A" performed pre experiment with personal bucket and post experiment with the newly developed CAD based bucket whereas, Subject "B" as control subject performed both pre and post experiment with his personal bucket. For the experiment, 24 Infrared cameras were positioned on the ski slope which covered the path of the ski turn. Also, motion capture suit with reflective markers were worn by both subjects. In the result, decrement in medial/lateral displacement of COM, anterior/posterior displacement of COM, flexion/extension angle of trunk as well as velocity losing rate of COM was observed in subject "A" when using the newly developed CAD based bucket. In contrast, no larger effect on performance was observed when using personal buckets. In conclusion, the findings obtained from the study indicated effectiveness of newly developed CAD based bucket by reducing excessive movement of hip and trunk which is an important factor to perform an effective turn.

• 대한인간공학회지
• /
• 제17권1호
• /
• pp.115-123
• /
• 1998

We study the ski wear which are compared at the materials and the designes and their human physiological and phychological response during exercise in a cold and air-conditioned enviroments. Five men exercises in the experiment room with four types of ski-wears : two of one-piece and two of two-piece : two of special material and two of a normal material, respectively. We keep the environment at $-5^{\circ}C$ and speed of 3.6 mile/hr during the measurement of 13 points, which is a mean model of the Muju ski-resort at January 1996. We conclude the followings : 1. The ski-wear with special materials have higher than the normal type at mean skin temperature and rectal temperature. 2. Changes of temperature withing the clothes during the exercise is small, but the humidity within the clothes abruptly increases because of the weight loss. 3. Type A ski-wear with the special material has $295.5g/m^2hr$ weight loss, which is higher, and type D ski-wear is smaller 4. The special material shows comfortable in the thermal sensation. 5. In the design aspect of the ski-wears, the two-piece type ski-wear shows higher skin temperature and temperature & humidity within the clothes than the one-piece type due to the effect of the multiplicity.

• Biomolecules & Therapeutics
• /
• 제4권1호
• /
• pp.19-31
• /
• 1996

This study was performed to determine the subacute toxicities of SKI306X, an antiinflammatory herbal extract, in rats. SKI306X was administered orally to rats once a day for 4 weeks at doses of 0.3, 1.0, and 3.0 g/kg/ day. Each group consisted of 20 male and 20 female rats, including 5 male and 5 female rats per group for an interim study at the end of 2-week administration and for a 2-week recovery study, respectively. Throughout the study, all rats survived and no adverse clinical signs were observed. Although male rats treated with high dose (3.0 g/kg/day) of SKI306X showed slight loss of body weight (approximately 5%) in comparison with control animals during the administration period, their body weight loss was normally restored during the recovery period. No significant change was found in all hematological parameters of SKI306X-treated groups except for the decreased number of red blood cells in all female groups at the interim study. Statistically significant changes were observed in several blood enzyme levels of SKI306X-treated groups; however, most of these significant changes were within normal range and statistically significant values did not show dose-related responses. In SKI306X-treated groups, the absolute and relative weights of liver, heart, and stomach were statistically different from those of control group, but these differences disappeared at the end of recovery period and also drug-related gross and histopathological findings in these organs were not found. No other drug-related gross and histopathological findings were observed. It is concluded from the results of this study that non-toxic dose of SKI306X was estimated to be between 0.3 and 1.0 g/kg/day and the maximum tolerated dose of SKI306X was assumed to be higher than 3.0 g/kg/day.