• Journal of Korean Public Health Nursing
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• v.26 no.1
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• pp.28-37
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• 2012

Purpose: The aim of this study was to examine BMI, body fat mass, percent body fat, waist-hip ratio, soft lean mass, skeletal muscle mass, and fat free mass, and to determine the association between dietary behavior and exercise and body composition among students at women's colleges, and decide on the relationships among them. Method: This study employed a cross-sectional study design and a convenient sampling method. Ultimately, a total of 404 students participated in the study, which was conducted from September 1 to December 22, 2009. Measurements administered were comprised of dietary behavior and a questionnaire on exercise. The SPSS Win 18.0 statistics program was used for analysis of final data. Results: Major findings are as follows: 9.9% of participants showed a high BMI, and more than 56% and 38% of participants showed a high percent body fat and waist-hip ratio, respectively. Dietary behavior showed a significant negative association with percent body fat (r=-0.110, p=0.027) and waist-hip ratio (r=-0.118, p=0.018). Compared with the non-regular exercise group, the regular exercise group showed a high level of soft, lean mass (t=4.15, p<0.001), skeletal muscle mass (t=3.13, p=0.002), and fat free mass (t=4.00, p<0.001). Conclusion: For maintenance of proper body composition, health promotion programs for management of dietary behavior and regular exercise for students at women's colleges should be developed.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.4
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• pp.427-436
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• 2018

The objective of this study was to analyze the concurrent treatment effects of ursolic acid (UA) and low-intensity treadmill exercise and to confirm the effectiveness of UA as an exercise mimetic to safely improve muscle atrophy-related diseases using Sprague-Dawley (SD) rats with skeletal muscle atrophy. Significant muscle atrophy was induced in male SD rats through hind limb immobilization using casting for 10 days. The muscle atrophy-induced SD rats were group into four: SED, sedentary; UA, daily intraperitoneal UA injection, 5 mg/kg; EX, low-intensity (10-12 m/min, $0^{\circ}$ grade) treadmill exercise; and UEX, daily intraperitoneal UA injection, 5 mg/kg, and low-intensity (10-12 m/min, $0^{\circ}$ grade) treadmill exercise. After 8 weeks of treatment, endurance capacity was analyzed using a treadmill, and tissues were extracted for analysis of visceral fat mass, body weight, muscle mass, expression of muscle atrophy- and hypertrophy-related genes, and endurance capacity. Although the effects of body weight gain control, muscle mass increase, and endurance capacity improvement were inadequate in the UA group, significant results were confirmed in the UEX group. The UEX group had significantly reduced body weight and visceral fat, significantly improved mass of tibialis anterior and gastrocnemius muscles, and significantly decreased atrophy-related gene expression of MuRF1 and atrogin-1, but did not have significant change in hypertrophy-related gene expression of Akt and mTOR. The endurance capacity was significantly improved in the EX and UEX groups. These data suggest that concurrent treatment with low-intensity exercise and UA is effective for atrophy-related physical dysfunctions.

• BMB Reports
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• v.55 no.2
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• pp.104-109
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• 2022

Skeletal myogenesis is essential to keep muscle mass and integrity, and impaired myogenesis is closely related to the etiology of muscle wasting. Recently, miR-141-3p has been shown to be induced under various conditions associated with muscle wasting, such as aging, oxidative stress, and mitochondrial dysfunction. However, the functional significance and mechanism of miR-141-3p in myogenic differentiation have not been explored to date. In this study, we investigated the roles of miR-141-3p on CFL2 expression, proliferation, and myogenic differentiation in C2C12 myoblasts. MiR-141-3p appeared to target the 3'UTR of CFL2 directly and suppressed the expression of CFL2, an essential factor for actin filament (F-actin) dynamics. Transfection of miR-141-3p mimic in myoblasts increased F-actin formation and augmented nuclear Yes-associated protein (YAP), a key component of mechanotransduction. Furthermore, miR-141-3p mimic increased myoblast proliferation and promoted cell cycle progression throughout the S and G2/M phases. Consequently, miR-141-3p mimic led to significant suppressions of myogenic factors expression, such as MyoD, MyoG, and MyHC, and hindered the myogenic differentiation of myoblasts. Thus, this study reveals the crucial role of miR-141-3p in myogenic differentiation via CFL2-YAP-mediated mechanotransduction and provides implications of miRNA-mediated myogenic regulation in skeletal muscle homeostasis.

• International journal of advanced smart convergence
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• v.12 no.1
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• pp.184-192
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• 2023

The purpose of this study was to compare and analyze the body composition, muscle circumference, and muscle activity of men in their 30s and 50s when the resistance exercise program was applied for 12 weeks, and to provide basic data for the preparation of the resistance exercise program for middle-aged men before entering old age. Nine men in their 30s and eleven 11 men in their 50s participated in the moderate intensity resistance exercise program for 12 weeks. Two weeks before the experiment, body composition, muscle circumference, and EMG were pre-tested, and then body composition and muscle circumference were additionally measured at the 8th week. Body composition, muscle circumference, and EMG were measured within 2 weeks after the 12 week exercise program. The measured data were compared and analyzed by Mixed design two-way ANOVA, and the following results were obtained. The body composition showed a significant difference only in the skeletal muscle mass, and it increased in the 30s group at 8 weeks. Muscle circumference did not show significant difference according to group and time. Muscle activity showed a significant difference according to group and time, and pectoralis major and triceps brachii showed a significant decrease to 30s group. The pectoralis major was higher in the 30s group at all times. In summary, when applying a 12-week resistance exercise program for young men and middle-aged men, the effect of improving muscle strength may appear similar, but they are not consistent, and it is thought that gradual changes in training variables are needed to improve muscle mass.

• Korean Journal of Community Nutrition
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• v.21 no.4
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• pp.378-385
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• 2016

Objectives: This study was conducted to investigate the association between sarcopenia and sarcopenic obesity and cardiovascular disease risk in Korean postmenopausal women. Methods: We analyzed data of 2,019 postmenopausal women aged 50-64 years who participated in the Korea National Health and Nutrition Examination Survey in 2008-2011 and were free of cardiovascular disease history. Blood pressure, height, and weight were measured. We analyzed the serum concentrations of glucose, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglyceride levels. Waist circumference was used to measure obesity. Appendicular skeletal muscle mass was measured by dual-energy X-ray absorptiometry. Sarcopenia was defined as the appendicular skeletal muscle mass/body weight<1 standard deviation below the gender-specific means for healthy young adults. The estimated 10-year risk of cardiovascular disease risk was calculated by Pooled Cohort Equation. Subjects were classified as non-sarcopenia, sarcopenia, or sarcopenic obesity based on status of waist circumference and appendicular skeletal muscle mass. Results: The prevalence of sarcopenia and sarcopenic obesity was 16.3% (n=317) and 18.3% (n=369), respectively. The 10-year risk of cardiovascular disease risk in the sarcopenic obesity group was higher ($3.82{\pm}0.22%$) than the normal group ($2.73{\pm}0.09%$) and sarcopenia group ($3.17{\pm}0.22%$) (p < 0.000). The odd ratios (ORs) for the ${\geq}7.5%$ 10-year risk of cardiovascular disease risk were significantly higher in the sarcopenic obesity group (OR 3.609, 95% CI: 2.030-6.417) compared to the sarcopenia group (OR 2.799, 95% CI: 1.463-5.352) (p for trend < 0.000) after adjusting for independent variables (i.e., exercise, period of menopausal, alcohol use disorders identification test (AUDIT) score, income, education level, calorie intake, %fat intake and hormonal replacement therapy). Conclusions: Sarcopenia and sarcopenic obesity appear to be associated with higher risk factors predicting the 10-year risks of cardiovascular disease risk in postmenopausal women. These findings imply that maintaining normal weight and muscle mass may be important for cardiovascular disease risk prevention in postmenopausal women.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.4
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• pp.173-181
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• 2019

PURPOSE: This study examined the necessity of a musculoskeletal injury-prevention program for automobile parts manufacturing workers by assessing the body composition, muscle strength, and posture according to sex and age. METHODS: Two hundred eighty-two workers (men, 218; women, 64; mean age, 38.97 years; and mean work tenure, 10.29 years) participated in this study. They completed a questionnaire on their general characteristics, excluding personal identification codes. The participants were evaluated for body composition, muscle strength, and posture using InBody, a hand dynamometer, and the Image J program through photography, respectively. An independent t-test and one-way analysis of the variance were used for the comparisons according to sex and age, respectively. RESULTS: Significant sex-related differences in muscle strength and grip force were observed (p<.05). In addition, the left-side pelvic inclination was significantly higher in the female participants than in the male participants (p<.05). Significant age-related differences in the skeletal muscle mass and muscle strength were observed around 40 years (p<.05). Significant correlations were observed among the body composition (skeletal muscle and body fat masses), muscle strength, and posture (pelvic inclination; p<.01). CONCLUSION: Significant differences in pelvic inclination by sex and muscle strength by age were found, even in healthy workers. Additional posture and muscle strength measurements will be needed for workers who participate in the musculoskeletal injury prevention program because they are exposed to an incorrect posture for many hours or in many repetitive tasks.

• Journal of Korean Medicine for Obesity Research
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• v.16 no.2
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• pp.109-115
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• 2016

Objectives: The all anti-obesity drugs currently approved by the US Food and Drug Administration work by reducing energy intake. In fact, no approved drug targets energy expenditure. In Korean medicine, it is known to Qi or Yang invigorating therapy could increase energy metabolism. Aconitum carmichaeli Debx (ACD) is a Yang invigorating herb, often used for treat obesity in Korean medicine. In the present study, the authors investigated the regulatory effects of ACD in energy metabolism and mitochondrial biogenesis in C2C12 skeletal muscle cells. Methods: The water extract of ACD (0.2, 0.5 and 1.0 mg/ml) were treated in differentiated C2C12 cells. The protein or mRNA levels of target genes were analyzed and mitochondrial mass were investigated. Results: ACD activated the expressions of peroxisome proliferator-activated receptor gamma coactivator 1-alpha ($PGC-1{\alpha}$), nuclear respiratory factor 1 and TFAM and increased mitochondrial mass. ACD also increased adenosin monophosphate-activated protein kinase (AMPK), and acetyl-CoA carboxylase. Conclusions: This study suggests that ACD has the potential to increase energy metabolism and mitochondrial biogenesis by activating AMPK and $PGC1{\alpha}$.

• Physical Therapy Rehabilitation Science
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• v.10 no.3
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• pp.320-327
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• 2021

Objective: The community has implemented a variety of exercise programs for the elderly population. However, studies comparing changes in the cardiovascular system through body composition and blood analysis after applying aqua aerobic exercise are insufficient. The purpose of this study was to investigate the effect of a 12 weeks aqua exercise on body composition and cardiovascular index in elderly women. Design: Non-equivalence pre-post design. Methods: Thirty elderly women were assigned to aquarobic group(n=15) and control group(n=15). The aquarobic exercise was 60 minutes per every session, 2times per week, for 12weeks. Weight, skeletal muscle mass, body fat percentage, total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured before and after the exercise program. Paired and independent t-tests were performed using SPSS program. Results: The result showed was weight(p<0.05), body fat percentage(p<0.05), total cholesterol(p<0.05), triglyceride(p<0.05), HDL cholesterol(p<0.05), and LDL cholesterol(p<0.05) were significantly decreased and skeletal muscle mass(p>0.05) was not significantly increased after aquatic exercise program. Conclusions: According to the study result, aqua exercise program made a positive effect in the improvement of obesity and cardiovascular function in elderly women. Therefore, we suggest that you actively consider implementing the Aquarobic exercise program when operating the community health promotion program in the future. In addition, in future studies, comparative studies according to various ages and genders and studies on the effects of aqua aerobic exercise as a community exercise program for chronically illness patients are needed.

• Korean Journal of Exercise Nutrition
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• v.16 no.2
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• pp.65-71
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• 2012

Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.

• Journal of The Korean Society of Integrative Medicine
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• v.8 no.3
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• pp.11-20
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• 2020

Purpose : The purpose of this study was to determine the correlation between smartphone use, body composition, posture and muscle properties of elementary school students. Methods : A total of 22 healthy elementary school students in Daejeon, South Korea, participated in this study with informed consent. Smartphone use was evaluated with Smartphone addiction self-report scale (S-scale) for youth. Body composition (BMI, percent body fat, body fat mass, and skeletal muscle mass) was measured using Inbody. To assess posture, forward head posture and round shoulder posture were measured using Dartfish motion analysis. Muscle properties (muscle tone, stiffness, and elasticity) were measured on the upper trapezius, splenius capitis and sternocleidomastoid muscles using Myoton. To investigate the correlation between the main variables, Pearson correlation analysis was performed. Results : Disturbance of adaptive function, which is one of sub-component of S-scale, had a weak positive correlations with BMI (r=.538, p<.01), and body fat mass (r=.453, p<.05). However, scores of S-scale showed no correlation with posture and muscle properties. The correlation between posture and muscle properties was analyzed, and round shoulder posture revealed a weak positive correlation with respect to stiffness (r=.418, p<.05) and elasticity (r=.502, p<.05) of the sternocleidomastoid muscle. Conclusion : Scores of S-scale demonstrated a weak correlation with body composition (BMI) among elementary school students, whereas S-scale scores were not correlated with the posture and muscle properties. Further research is needed to identify and focus on potential high-risk user groups of elementary students who are more dependent upon smartphones.