• Journal of Ginseng Research
• /
• 제46권5호
• /
• pp.657-665
• /
• 2022

Background: Sarcopenia is a new and emerging risk factor aggravating the quality of life of elderly population. Because Korean Red Ginseng (RG) is known to have a great effect on relieving fatigue and enhancing physical performance, it is invaluable to examine its potential as an anti-sarcopenic drug. Methods: Anti-sarcopenic effect of non-saponin fraction of Korean Red Ginseng (RGNS) was evaluated in C2C12 myoblasts treated with C2-ceramide to induce senescence phenotypes, and 22-month-old mice fed with chow diet containing 2% RGNS (w/w) for 4 further months. Results: The RGNS treatment significantly alleviated cellular senescence indicated by intracellular lipid accumulation, increased amount of lysosomal β-galactosidase, and reduced proliferative capacity in C2C12 myoblasts. This effect was not observed with saponin fraction. In an aged mouse, the 4-month-RGNS diet significantly improved aging-associated loss of muscle mass and strength, assessed by the weights of hindlimb skeletal muscles such as tibialis anterior (TA), extensor digitorum longus (EDL), gastrocnemius (GN) and soleus (SOL), and the cross-sectional area (CSA) of SOL muscle, and the behaviors in grip strength and hanging wire tests, respectively. During the same period, an aging-associated shift of fast-to slow-twitch muscle in SOL muscle was also retarded by the RGNS treatment. Conclusions: These findings suggested that the long-term diet of RGNS significantly prevented aging-associated muscle atrophy and reduced physical performance, and thus RGNS has a strong potential to be developed as a drug that prevents or improves sarcopenia.

• Nutritional Sciences
• /
• 제9권2호
• /
• pp.112-116
• /
• 2006

This study investigated the effect of physical training on the utilization and recuperation of stored fuel with exercise in rats. For physical training, animals were exercised on treadmill for 30 minutes everyday. Forty eight rats were given either a physical training or no training for 4 weeks and were then subdivided into 3 groups: before-exercise (BE); during-exercise (DE); after-exercise (AE). The DE group was exercised on treadmill for 1 hour just before being sacrificed Animals in the AE group were allowed to take a rest for 2 hours after being exercised like the DE group. Glucose and free fatty acids were compared in plasma. Glycogen and triglycerides were compared in liver and skeletal muscle. Protein were compared in plasma, liver and skeletal muscle of rats. Plasma glucose levels of trained group were not significantly different from those of non-trained group. Muscle glycogen levels of trained group were significantly higher than those of non-trained group. Liver glycogen level of trained group was also significantly higher than that of non-trained group in DE while was not significantly different from those of non-trained group in BE and AF. Plasma free fatty acid levels of trained group were significantly higher than those of non-trained group in BE and AE. Muscle triglyceride levels of trained group tended to be higher than those of non-trained group in BE and DE and significantly higher than those of non-trained group in AF. Plasma and muscle protein levels of trained group were not significantly different from those of non-trained group. liver protein levels of trained group were not significantly different from those of non-trained group in BE and DE but were significantly higher than that of non-trained group in AE. Thus, it is suggested that an even moderate physical training may delay the onset of fatigue and improve exercise performance by facilitating the mobilization and oxidation of fat and conserving limited carbohydrate store.

• 대한한의학회지
• /
• 제37권2호
• /
• pp.76-84
• /
• 2016

Objectives: We evaluated the anti-fatigue effects of Rh2-enriched Korean ginseng (Ginseng Rh2+) using a forced exercise-induced chronic fatigue mouse model. Methods: ICR male mice were subjected to running wheel for 1 h, 5 days/week during 4 weeks, and running velocity was gradually increased. Each running session was followed by oral administration of distilled water, Ginseng Rh2+ (150 or 300 mg/kg), or N-acetyl-L-cysteine (NAC, 100 mg/kg) 1 h later. The exercise tolerance and forced swimming test were performed to evaluate the fatigue condition. Results: Chronic forced exercise reduced the physical activity, as evidenced by the behavioral tests, which were notably ameliorated by Ginseng Rh2+ treatment. Ginseng Rh2+ treatment also attenuated the alterations of energy metabolism and oxidative stress in skeletal muscle tissues and/or sera, including malondialdehyde (MDA), lactate concentration and its related factors (lactate dehydrogenase, blood urea nitrogen, and glucose levels). Conclusion: These findings strongly suggest that Ginseng Rh2+ exerts a potent anti-fatigue effect through modulation of energy metabolism and oxidative response.

• BMB Reports
• /
• 제47권2호
• /
• pp.69-79
• /
• 2014

$Ca^{2+}$ release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled $Ca^{2+}$ influx into cells is store-operated $Ca^{2+}$ entry (SOCE), which is activated by the reduction of $Ca^{2+}$ concentration in the lumen of endoplasmic or sarcoplasmic reticulum (ER/SR). Although SOCE is pronounced in non-excitable cells, accumulating evidences highlight its presence and important roles in skeletal muscle and heart. Recent discovery of STIM proteins as ER/SR $Ca^{2+}$ sensors and Orai proteins as $Ca^{2+}$ channel pore forming unit expedited the mechanistic understanding of this pathway. This review focuses on current advances of SOCE components, regulation and physiologic and pathophysiologic roles in muscles. The specific property and the dysfunction of this pathway in muscle diseases, and new directions for future research in this rapidly growing field are discussed.

• 로봇학회논문지
• /
• 제12권3호
• /
• pp.270-278
• /
• 2017

The electrical muscle stimulator (EMS) based human machine interface (HMI) free to mechanical constraint and muscle fatigue problems are proposed for force feedback in a virtual reality. The device was designed to provide force feedback up to 4.8 N and 2.6 N each to the thumb and forefingers. The main objective of the HMI is to make unnecessary mechanical structures to attach on the hand or fingers. It employs custom EMSs and an interface arranged in the forearm. In this work, major muscle groups such as extensor pollicis brevis (EPB), extensor indicis proprius (EIP), flexor pollicis longus (FPL) and flexor digitorum profundus (FDP) are selected for efficient force feedback and controlled individually. For this, a human muscular-skeletal analysis was performed and verified. The validity of the proposed multi-channel EMS based HMI was evaluated thorough various experiments with ten human subjects, interacting with a virtual environment.

• 한국운동역학회지
• /
• 제14권3호
• /
• pp.271-284
• /
• 2004

The purpose of this study was to analyse the EMG activity of selected muscles with balance taping treatment and blood fatigue makers which accumulated during exercise of progressive maximal intensity. Ten male college students who did not experience any cardiovascular and musculo-skeletal disease were participated in this study. Balance taping were applied to rectus femoris, vastus medialis, vastus lateralis, biceps femoris, semitendinous, semimembranous, and around knee joint. Isokinetic knee joint flexion/extension force, EMG activity, lactate and ammonia as blood fatigue makers during progressive maximal intensity exercise were measured for with/without applying balance taping. The results indicated that although flexion force of total work at $60^{\circ}/sec$ with taping was increased applied taping did not affect to the aerobic exercise ability parameters. Lactate level as blood fatigue makers during progressive maximal intensity exercise after taping was decreased but the ammonia level did not change with same treatment. In isokinetic knee joint test at the angular velocity of $60^{\circ}/sec$, $180^{\circ}/sec$, and $240^{\circ}/sec$ the taping treatment did not affect to any selected muscle EMG activities except maximal EMG of vastus lateralis at $240^{\circ}/sec$.

• 대한물리치료과학회지
• /
• 제2권1호
• /
• pp.393-404
• /
• 1995

The purpose of this review was to examine the clinical characteristics of patients who had a diagnosis of Myofascial Pain Syndrome(MPS). Myofascial pain is a painful condition of skeletal muscle characterized by the presence of one or more trigger points. A trigger point(TrP) is a focus of hyperirritability in a tissues. Of the patients with MPS, 21(44.7 %) were male and 26(55.3 %) were female. The mean duration of MPS was 9.6 months for males and 11.3 months for females. Trigger points with associated referred patterns of pain were found in muscles of the post neck(trapezius, infrasupinatus) and in quadratus lumborum muscle. Patients reported increased fatigue(87.2 %), tingling sensation(66.0 %), numbness(66.0 %), tension(55.3 %), anxiety(44.7 %), headache (59.6 %), pilomotor activation(59.6 %).

• 대한물리치료과학회지
• /
• 제19권4호
• /
• pp.53-59
• /
• 2012

Background : The purpose of the study was: to investigate muscle activation of upper arm according mouse shape. Methods : Twenty person(mean age : 23. 7) who have healthy condition was participated this study, we collected data of muscle activation using by EMG from upper trapezius(Tr), deltoid middle fiber(De), extensor digitorum(Ed), first dorsal interosseous(Di) during participants was performed click and drag according various mouse. Mouse shape was divided 4 level as follow shape 1 was very small, 2 was small, 3 was moderate, 4 was large. Data was analyzed ANOVA, independent t-test using by SPSS ver18.0. Results : There was significantly difference of muscle activation among each muscle according mouse shape in drag and click. In shape 1, 4, there was significantly difference of muscle activation of Tr, De, Ed between drag and click except Di. In shape 2, 4, there was significantly difference of muscle activation of all muscle between drag and click. Conclusion : We knew that extensor digitroum showed more higher muscle activation than other muscle in drag, first dorsal interoseous showed more higher muscle activation that other muscle in click. We suggest that mouse shape was very important factor in order to prevent skeletal muscular disorder for computer user, and mouse shape can reduce muscle fatigue during computer work.

• 근관절건강학회지
• /
• 제17권1호
• /
• pp.79-88
• /
• 2010

Purpose: The purpose of this study was to analyze the published research in the Journal of Muscle and Joint Health and to suggest the future perspectives. Methods: In this study, we reviewed the contents of 195 articles published in this journal from the first issue of the year 1994 to 2007. Results: The majority of subjects were adult, mostly with arthritis. The position of the authors was mostly professor (73.3%). Most of studies did not clearly describe about ethical consideration. The data collection was mostly conducted in the hospital (53.8%) or community (36.9%), with the questionnaire (62.6%). The types of research design were correlational study (36.4%), experimental study (31.8%), survey (18.5%), and qualitative research (4.6%). Physical variables included pain, fatigue, activities of daily living, joint flexibility, muscle strength, etc., psychosocial variables were measured by self-efficacy, depression, quality of life, etc., and cognitive variables by knowledge, education, etc. The most utilized nursing intervention for experimental study were exercise, self-help, and education. Conclusion: Further research is needed to extend the target population research design from multidisciplinary perspectives.

• 한국응용과학기술학회지
• /
• 제36권4호
• /
• pp.1164-1171
• /
• 2019

Dietary supplements derived from natural sources are an essential factor in optimizing athletic performance. It has been proposed that the extract of Momordica charantia (M. charantia) that is known as a bitter melon can be potentially used as a novel supplement for health promotion. This pilot study aimed to examine the effects of the M. charantia extract when administered in the form of a sports drink, and we evaluated changes in body composition and metabolic factors in tennis players after 4-week consumption of the extract. Eight male college tennis players were instructed to consume an M. charantia extract 6 times per day (3 in the morning and 3 in the afternoon, and the total daily intake was 600 ml). Collected data were analyzed using paired t-tests to examine the changes over time after consumption of the M. charantia extract. The results revealed a significant increase in the trunk muscle mass, basal metabolic rate, and daily calorie intake (p < 0.05). Levels of protein, minerals, and total body water showed an increased tendency (not statistically significant), whereas intracellular water and extracellular water showed a decreased trend. Furthermore, fat-free mass, skeletal muscle mass, and muscle mass showed an increased tendency. In conclusion, consumption of the M. charantia extract caused an increase in parameters related to protein, muscle mass, and metabolism. It seems that follow-up studies related to fatigue, inflammation, and stress hormones related to the M. charantia extract consumption would be needed.