• Imaging Science in Dentistry
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• v.50 no.3
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• pp.209-216
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• 2020

Purpose: In India, the age of 14 years is the legal age threshold for child labour. Therefore, in suspected instances of child labour, age assessment plays a crucial role in determining whether a violation of the law on the employment of children has occurred. The aim of this retrospective cross-sectional study was to assess the discriminatory ability of stages of cervical vertebral maturation (CVM) in predicting the legal age threshold of 14 years. Materials and Methods: Routinely taken lateral cephalograms from 408 subjects aged 10 to 18 years were evaluated retrospectively using the CVM stages described by Baccetti et al. Descriptive statistics, accuracy, sensitivity, specificity, positive and negative predictive values, and likelihood ratios were calculated for stages 2, 3, and 4 of CVM. Results: Real age increased as the CVM stage gradually increased. The results of 2×2 contingency tables showed that CVM stage 4 produced an accuracy of 71% and 73%, a false positive rate of 7% and 18%, and a post-test probability of 59% and 68% for boys and girls, respectively. Conclusion: Based on these findings, it can be concluded that the stages of CVM are of limited use for predicting the attainment of the legal age threshold of 14 years. Future studies should investigate whether combinations of skeletal and dental methods could achieve better accuracy and post-test probability.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.2
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• pp.236-243
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• 2005

Anterior openbite is defined as the lack of contacts between the functional occluding teeth on vertical line at centric occlusion and classified into functional and skeletal anterior openbite based on its causes and characteristics. In mixed dentition, habit control and the elimination of abnormal perioral muscle function and moving the vertical direction development to the sagittal direction of the mandible by the functional appliance is a goal of treatment. This study presents the effective interception of oral habit by the tongue crib and functional-fixed treatment and treatment response of openbite related to tongue thrust habit.

• Journal of KIISE:Computing Practices and Letters
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• v.11 no.3
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• pp.275-283
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• 2005

Ontologies are the core components of the Semantic Web and knowledge-based systems. But it is difficult to find useful ontologies in actual domains. In order to build useful domain ontology, the conceptualization of the domain knowledge by knowledge experts of the specific domain and the specification of conceptualized knowledge with formal languages by ontology designers are required. In addition, structured and detailed guidelines and methods should be provided to be shared by the development team members. However, existing ontology building methodologies define and describe the skeletal structure of the whole building process at the top-layer. We build a useful academic ontology that is based on the conceptual knowledge structure in the domain of philosophy, and propose a detailed methodology to build a text ontology based on Topic Maps. Our methodology consists of two phases, ontology modelling and ontology implementation. We implement a philosophy knowledge portal to support retrieving and navigating of the philosophy knowledge.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.6
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• pp.456-463
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• 2002

Distraction osteogenesis is a well-established clinical treatment for limb length discrepancy and skeletal deformities. Appropriate mechanical tension-stress is believed not to break the callus but rather to stimulate osteogenesis. In contrast to fracture healing, the mode of bone formation in distraction osteogenesis is primarily intramembranous ossification. Although the biomechanical, histological, and ultrastructural changes associated with distraction osteogenesis have been widely described, the basic biology of the process is still not well known. Moreover, the molecular mechanisms in distraction osteogenesis remain largely unclear. Recent studies have implicated the growth factor cascade is likely to play an important role in distraction. And current reserch suggested that mechanical tension-stress modulates cell shape and phenotype, and stimulates the expression of the mRNA for bone matrix proteins. This article presents the hypotheses and current research that have furthered knowledge of the molecular biology that govern distraction osteogenesis. The gene regulation of growth factors and extracellular matrix proteins during distraction osteogenesis are discussed in this article. It is believed that understanding the biomolecular mechanisms that mediate distraction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone healing.

• Journal of International Academy of Physical Therapy Research
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• v.11 no.2
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• pp.2052-2059
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• 2020

Background: Kinesiology taping (KT) is a method that helps immediately increase muscle activation, strength and joint stability by being attached to various skeletal muscles and structures of the body. Objectives: To investigate the effect of KT applied below the hyolaryngeal complex on the movement of the hyolaryngeal complex during swallowing in patients with dysphagia after stroke. Design: One-group, pre-post design. Methods: Twenty individuals with dysphagia after stroke participated in this study. KT was applied to the sternum and both clavicles from the hyolaryngeal complex. We analyzed the motion of the hyolaryngeal complex during swallowing with and placebo KT and KT using the Image-J software with videofluoroscopic swallowing study. In addition, a 0-to-10 numerical rating self-report scale was used to check the required effort and resistance felt during swallowing. Results: KT condition showed that the anterior and superior movement of the hyoid bone during swallowing was significantly lower than placebo KT (P<.05, all). Also, KT condition showed that the anterior and superior movement of the larynx during swallowing was significantly lower than placebo KT (P<.05, all). In result of statistical comparison between KT group and placebo KT group, the KT group showed significantly higher self-report scale score than the placebo KT group in terms of two category; the required effort and resistance felt (P<.05, all). Conclusion: This study demonstrated that KT applied below the hyolaryngeal complex inhibits the anterior and superior movement of hyoid bone and larynx during swallowing of patients with dysphagia after stroke.

• Journal of Marine Bioscience and Biotechnology
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• v.6 no.2
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• pp.102-109
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• 2014

Cetaceans (whales, dolphins, and porpoises) are aquatic mammals that experienced drastic changes during the transition from terrestrial to aquatic environment. Morphological changes include streamlined body, alterations in the face, transformation of the forelimbs into flippers, disappearance of the hindlimbs and the acquisition of flukes on the tail. For a prolonged diving, cetaceans acquired hypoxia-resistance by developing various anatomical and physiological changes. However, molecular mechanisms underlying these adaptations are still limited. CREB-binding protein (CREBBP) is a transcriptional co-activator critical for embryonic development, growth control, metabolic homeostasis and responses to hypoxia. Natural selection analysis of five cetacean CREBBPs compared with those from 15 terrestrial relatives revealed strong purifying selection, supporting the importance of its role in mammals. However, prediction for amino acid changes that elicit functional difference of CREBBP identified three cetacean specific changes localized within a region required for interaction with SRCAP and in proximal regions to KIX domain of CREBBP. Mutations in CREBBP or SRCAP are known to cause craniofacial and skeletal defects in human, and KIX domain of CREBBP serves as a docking site for transcription factors including c-Myb, an essential regulator of haematopoiesis. In these respects, our study provides interesting insights into the functional adaptation of cetacean CREBBP for aquatic lifestyle.

• Molecules and Cells
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• v.38 no.12
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• pp.1096-1104
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• 2015

Particulate $matter_{2.5}$ ($PM_{2.5}$) is notorious for its strong toxic effects on the cardiovascular, skin, nervous, and reproduction systems. However, the molecular mechanism by which $PM_{2.5}$ aggravates disease progression is poorly understood, especially in a water-soluble state. In the current study, we investigated the putative physiological effects of aqueous $PM_{2.5}$ solution on lipoprotein metabolism. Collected $PM_{2.5}$ from Seoul, Korea was dissolved in water, and the water extract (final 3 and 30 ppm) was treated to human serum lipoproteins, macrophages, and dermal cells. $PM_{2.5}$ extract resulted in degradation and aggregation of high-density lipoprotein (HDL) as well as low-density lipoprotein (LDL); apoA-I in HDL aggregated and apo-B in LDL disappeared. $PM_{2.5}$ treatment (final 30 ppm) also induced cellular uptake of oxidized LDL (oxLDL) into macrophages, especially in the presence of fructose (final 50 mM). Uptake of oxLDL along with production of reactive oxygen species was accelerated by $PM_{2.5}$ solution in a dose-dependent manner. Further, $PM_{2.5}$ solution caused cellular senescence in human dermal fibroblast cells. Microinjection of $PM_{2.5}$ solution into zebrafish embryos induced severe mortality accompanied by impairment of skeletal development. In conclusion, water extract of $PM_{2.5}$ induced oxidative stress as a precursor to cardiovascular toxicity, skin cell senescence, and embryonic toxicity via aggregation and proteolytic degradation of serum lipoproteins.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.505-510
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• 2004

In this article, we present an automated system for adjusting the 6 degree of freedom (D.O.F.) circular fixator. The system includes a scheduling software to adjust the Hexapod Circular Fixator (HCF) and an automated strut with the ability of the multiple synchronized motion and independent motion. The HCF was designed to control a 6 D.O.F. Ilizarov fixator and it's mechanism. The HCF adjustment software evaluates each value of altered length of the HCF struts to correct the complex skeletal deformity by using the X-ray data of the patient. The data of HCF adjustment software feed into the automated strut system which provides the scheduled adjustment. Then, the automated strut is synchronized by input data. Also the data of HCF adjustment software can be used to adjust HCF without automated struts. The proposed HCF system was verified by experiments.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.8
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• pp.691-701
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• 2017

The barbell squat is a fundamental physical exercise for strengthening the lower body and core muscles. It is an integral part of training and conditioning programs in sports, rehabilitation, and fitness. In this paper, we proposed a virtual test framework for squat exercises using a Smith machine to simulate joint torques and muscle forces, based on an integrated product-human model and motion synthesis algorithms. We built a muscular skeletal human model with boundary conditions modeling the interactions between the human body and a machine or the ground. To validate the model, EMG, external forces, and squat motions were captured through physical experiments by varying the foot position. A regression-based motion synthesis algorithm was developed based on the captured squat motions to generate a new motion for a given foot position. The proposed approach is expected to reduce the need for physical experiments in the development of training programs.

• Current Research on Agriculture and Life Sciences
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• v.4
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• pp.124-126
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• 1986

A teratogenecity study was carried out on SD rats administered antiemetic drug (components: diphenhydramine hydrochloride, caffeine, promethazine hydrochloride) at dose levels of 5, and 10ml/kg/day for a period of 11 days from day 7 to 17 of gestation. All of the pregnant females in each group were sacrificed on 20th day of gestation and their fetuses were examined. The incidences of external and skeletal anomalies were not significantly increased in the fetuses of any treated groups, and delayed ossification and resorptions in the treated groups were increased compared to these of the control group and mean number of corpus lutea on the treated groups were decreased compared to that of the control group.