• YAKHAK HOEJI
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• v.44 no.3
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• pp.251-256
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• 2000

Sterically stabilized liposomes (SSL) composed of distearoylphosphatidylcholine, cholesterol, dicetylphosphate and distearoylphosphatiodylethanolamine-N-poly(ethyleneglycol) 2000 (DSPE-PEG 2000) were made by reverse phase evaporation method to prolong biological half-life and decrease toxic side effect of drug. Streptozocin (572), a water-soluble antitumor agent with short half-life, was selected as a model drug. The size of SSL was controlled by polycarbonate extrusion to 100 nm which is adequate size for long circulation in plasma. The release rate of drugs from SSL in PBS was evaluated. And the stability of STZ-containing liposomes against drug leakage into rat plasma was evaluated in order to investigate the interaction of liposome and plasma protein. Incorporation of DSPE-PEG 2000 into conventional liposomes significantly decreased the drug leakage into rat plasma.

• Journal of Technology Innovation
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• v.10 no.2
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• pp.69-90
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• 2002

This paper investigates the determinants of the firm's decision to carry out innovative activities in terms of the resource-based view(RBV) in strategic management. Two types of resources are distinguished: tangible(financial autonomy, firm size, capital intensity) and intangible(human resource, entrepreneurship, and commercial resource). R&D intensity and patent statistics are used as proxies for innovative activity. Specific hypotheses about their effect on the probability of a firm carrying out innovative activities are derived and tested on a sample of 337 listed firms in Korean manufacturing industry for the year 1999, using the logistic regression model. Empirical findings suggest that firm size and human resource are the main determinants of firm's internal innovative activities. The results show that the hypotheses concerning financial autonomy, debt ratio, capital intensity, entrepreneurship, and commercial resource are rejected.

• Transactions of the Korean Society of Automotive Engineers
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• v.9 no.4
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• pp.18-26
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• 2001

OSKA engine was developed to remove the dense core of injection sprays. The engine uses impinging spray on a small pip, which spray after impinging is broken into smaller drops and disperses into fee space in chamber. In this paper the pip size is analyzed to give more dispersion of spray and fuel vapor. The gas phase is modelled by the Eulerian continuum conservation equations of mass, momentum, energy and fuel vapour fraction. The liquid phase is modelled following the discrete droplet model approach in Lagrangian form, and the droplet wall interaction is modelled as a function of the velocity normal to impaction lands. The droplet distributions, vapor fractions and gas flows are analyzed for various injection pressure cases. Numerical results indicate that the land diameter of 5.6mm has the best performance of spray dynamics and vaporization in the test sizes.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2003.10a
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• pp.63-70
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• 2003

This study investigates the seismic responses of two structures connected by sky-bridges equipped with viscoelastic dampers (VED) in the bridge-building connections. The applicability of the method is verified first by computing RMS responses of two-degrees-of-freedom systems subjected to white noise ground excitation. Then model structures with various number of stories are analyzed using EL CENTRO earthquake excitation to observe the effect of the varying size of VED on reduction of responses. According to the analysis results, there exists a proper size of VED which minimizes the structural responses. It is also observed that the effectiveness of VED increases as the difference of natural frequencies between the two connected structures increases.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.336-337
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• 2006

During sintering of cemented carbides abnormal grain growth is often observed but cannot be understood from the classical LSW-theory. A model based on 2-D nucleation of new crystalline layers and a grain-size distribution function is formulated and the equations are solved numerically. Experimental studies and computer simulations show that the initial grain size distribution has a strong effect on the grain growth behavior. For example, a fine-grained powder can grow past a coarser powder.

• Advances in aircraft and spacecraft science
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• v.7 no.2
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• pp.169-186
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• 2020

Based upon differential quadrature method (DQM) and nonlocal strain gradient theory (NSGT), mechanical-hygro-thermal vibrational analyzes of shear deformable porous functionally graded (FG) nanoplate on visco-elastic medium has been performed. The presented formulation incorporates two scale factors for examining vibrational behaviors of nano-dimension plates more accurately. The material properties for FG plate are porosity-dependent and defined employing a modified power-law form. It is supposed that the nano-size plate is exposed to hygro-thermal and variable compressive mechanical loadings. The governing equations achieved by Hamilton's principle are solved implementing DQM. Presented results indicate the prominence of moisture/temperature variation, damping factor, material gradient index, nonlocal coefficient, strain gradient coefficient and porosities on vibrational frequencies of FG nano-size plate.

• Steel and Composite Structures
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• v.38 no.2
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• pp.213-221
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• 2021

The objective of this paper is to study the deformation in a homogeneous isotropic thermoelastic solid using modified couple stress theory subjected to ramp-type thermal source with two temperature. The advantage of this theory is the involvement of only one material length scale parameter which can determine the size effects. Laplace and Fourier transform technique is applied to obtain the solutions of the governing equations. The components of displacement, conductive temperature, stress components and couple stress are obtained in the transformed domain. A numerical inversion technique has been used to obtain the solutions in the physical domain. The effect of two temperature is depicted graphically on the resulted quantities. Numerical results show that the proposed model can capture the size effects of microstructures.

• Geomechanics and Engineering
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• v.36 no.1
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• pp.83-97
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• 2024

It is important to make reasonable prediction about the long-term deformation of high rockfill geostructures. However, the deformation is usually underestimated using the rockfill parameters obtained from laboratory tests due to different size effects, which make it necessary to identify parameters from in-situ monitoring data. This paper proposes a novel hybrid back-analysis method with a modified objective function defined for the time-dependent back-analysis problem. The method consists of two stages. In the first stage, an improved weighted average method is proposed to quickly narrow the search region; while in the second stage, an adaptive response surface method is proposed to iteratively search for the satisfactory solution, with a technique that can adaptively consider the translation, contraction or expansion of the exploration region. The accuracy and computational efficiency of the proposed hybrid back-analysis method is demonstrated by back-analyzing the long-term deformation of two high embankments constructed for airport runways, with the rockfills being modeled by a rheological model considering the influence of stress states on the creep behavior.

• Journal of the Korean Geotechnical Society
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• v.20 no.1
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• pp.131-139
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• 2004

When calculating bearing capacity and settlement of actual foundation from plate test result fur design and construction of shallow foundation, scale effect should be considered. But, adequate guide and test result of scale effect were not prepared yet in Korea. So, to analyze the relations of bearing capacity and settlement as the difference of loading plate sizes, model test and field loading test were performed with different loading plate on weathered-granite layer. Model tests were conducted with water content, compaction number, saturated unit weight and plate size(Dl5, 25cm) in soil-box$(2,000\times 2,000\times 1,000mm)$ formed soil layer. Field loading tests were carried out with diameters of loading plate$(D15, 25, 30, 40, 75\times 75, 140\times 210cm)$ on the same soil condition. Finally, we presented the prediction formula of bearing and settlement for computating scale offset in design of shallow foundation through result analysis of load test and numerical simulation on weathered soil and rock.

• Journal of Family Relations
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• v.22 no.4
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• pp.31-52
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• 2018

Objectives: The purpose of this study is to examine whether the maternal and paternal value of children mediates the relationship between the marital relationship satisfaction and the parental sense of competence in the longitudinal dyadic approach. Method: The data were obtained from the Panel Study on Korean Children (PSKC) conducted by the Korea Institute of Child Care and Education. Using the Actor-Partner Interdependence Model（APIM), the author analyzed three waves (from 5th to 7th year) of the data, and the sample size was 1,773. The average age was 34.79 for mothers, and 37.26 for fathers. Their average length of marriage was 95.3 months, and their children were 51.03 months old on average. Results: The marital relationship satisfaction influenced the parental sense of competence with both the actor effect and the partner effect of mothers and fathers. The marital relationship satisfaction also influenced the value of children, with the actor effect from both mothers and fathers and with the partner effect only from mothers. The value of children influenced the parental sense of competence with the actor effect only from mothers and fathers. Also, the value of children mediated the relationship between the marital relationship satisfaction and the parental sense of competence with the actor effect from both mothers and fathers. For the partner effect, only the mediation path from fathers' marital relationship satisfaction to mothers' value of children to mothers' parental sense of competence was significant. Conclusions: These results suggest the importance of highlighting the marital relationship satisfaction and the value of children to improve the parental sense of competence.