• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.4
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• pp.407-414
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• 2016

As wind turbines are getting larger in size with multi-MW capacity, the blades are getting longer, over 40 m, and hence the asymmetric loads produced during the rotation of the rotor blades are increasing. Some factors such as wind shear, tower shadow, and turbulence have an effect on the asymmetric loads on the blades. This paper focuses on a method of modeling the dynamic load acting on a blade because of thrust variation under wind shear. A method that uses thrust coefficient is presented. For this purpose, "wind shear coefficient of thrust variation" is defined and introduced. Further, we calculate the values of the "wind shear coefficient of thrust variation" for a 2 MW on-shore wind turbine, and analyze them for speeds below the rated wind speed. Then, we implement a dynamic model that represents the thrust variation under wind shear on a blade, using MATLAB/Simulink. It is shown that it is possible to express thrust variations on three blades under wind shear by using both thrust coefficient and "wind shear coefficient of thrust variation."

• Journal of Internet Computing and Services
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• v.12 no.4
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• pp.1-14
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• 2011

This paper analyzes the fairness and efficiency of channel sharing when heterogeneous wireless networks that have different transmission power and/or coverage coexist with the contention-based channel access protocol. First, we show that the existing CSMA (carrier sensing multiple access) protocol, that is a prevailing contention-based mechanism, results in significant unfairness of channel access because of (1) the asymmetric capability of carrier sensing and (2) the blindness of binary exponential backoff and link adaptation mechanisms to the interference-driven transmission failures. Next, we derive the feasible region of carrier sensing thresholds that assures spatial reuse and fair channel sharing simultaneously. Moreover, we establish an analytical model for per-system throughput and investigate the effect of contention window size and transmission rate on the fairness and efficiency of channel sharing. Finally, we compare the performance of several approaches for fair channel sharing via simulations under various network configurations.

• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.75-82
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• 2010

Specific diseases like cancer and acquired immune deficiency syndrome (AIDS) occur at various organs including lymphatics and spread through lymphatic system. Thus, if therapeutic agents for such diseases are more distributed or targeted to lymphatic system, we can obtain several advantages like reduction of systemic side effect and increase of efficacy. For these reasons, much interest has been focused on the nature of lymphatics and a lot of studies for lymphatic delivery of drugs have been carried out. Because lymphatics consist of single layer endothelium and have high permeability compared with blood capillaries, especially, the studies using nano-sized carriers have been performed. Polymeric nano-particle, liposome, and lipid-based vehicle have been adopted for lymphatic delivery as carriers. According to the administration route and the kind of carrier, the extent of lymphatic delivery efficiency of nano-sized carriers has been changed and influenced by several factors such as size, charge, hydrophobicity and surface feature of carrier. In this review, we summarized the key factors which affect lymphatic uptake and the major features of carriers for achieving the lymphatic delivery. Lymphatic delivery of drug using nano-sized carriers has many fold improved ability of lymphatic delivery compared with that of conventional dosage forms, but it has not shown whole lymph selectivity yet. Even though nano-sized carriers still have the potential and worth to study as lymphatic drug delivery technology as before, full understanding of delivery mechanism and influencing factors, and setting of pharmacokinetic model are required for more ideal lymphatic delivery of drug.

• Journal of Biosystems Engineering
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• v.20 no.4
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• pp.333-342
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• 1995

The resistance to air flow through fruits and vegetables in bulk was an important consideration in the design of the pressure cooling system. The amount of resistance to air flow through produce in bulk normally depended upon air flow rate, stacking depth, porosity, stacking patterns and shape and site of product. But, there was not enough information relating the effects of those factors on air flow resistance. The objectives of this study were to investigate the effect of stacking depth, stacking patterns, porosity and airflow rate on airflow resistance and to develop a statistical model to predict static pressure drop across the produce bed as a function of air flow rate, stacking depth, bed porosity, and product size. Mandarins and tomatoes were used in the experiment. The airflow rate were in the range of 0.1~1.0 ㎥/s.$m^2$, the porosity were in the range of 0.25~0.45, the depth were in the range of 0.3~0.9m and the equivalent diameters were 5.3cm and 6.3cm for mandarins, and 6.5cm and 8.5cm for tomatoes. Three methods of stacking arrangement were used i.e. cubic, square staggered, and staggered stacking arrangement. The results were summarized as follows. 1. The pressure drops across produce bed increased in proportion to stacking depth and superficial air velocity and decreased in proportion to porosity. 2. The increasing rates of pressure drop according to stacking patterns with the increase of superficial air velocity were different one another. The staggered stacking arrangement produced the highest increasing rate and the cubic stacking arrangement produced the lowest increasing rate. But it could be assumed that the stacking patterns had not influenced greatly on pressure drops if it was of equal porosity. 3. The statistical models to predict the pressure drop across produce bed as a function of superficial air velocity, stacking depth, porosity, and product diameter were developed from these experiments.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.1
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• pp.29-36
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• 2008

In this paper, the orbital forming analysis of an automotive hub bearing was studied to predict forming performances using the explicit finite element method. To find an efficient solution technique for the orbital forming, axisymmetric finite element models and 3D solid element models were solved and numerically compared. The time scaling and mass scaling techniques were introduced to reduce the excessive computational time caused by small element size in case of the explicit finite element method. It was found from the numerical simulations on the orbital forming that the axisymmetric element models showed the similar results to the 3D solid element models in forming loads whereas the deformations at the inner race of bearing were quite different. Finally the strains at the inner race of bearing and the forming forces to the peen were measured for the same product of the numerical model by test, and were compared with the 3D solid element results. It was founded that the test results were in good agreements with the numerical ones.

• Journal of Korean Society for Atmospheric Environment
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• v.14 no.5
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• pp.433-442
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• 1998

The removal procedure of particles in the atmosphere was simulated in the saturated and dry conditions to know the effect of the saturated atmosphere on the size distributions of particles. The particles were divided into 5 ranges, 0.0mm, 0.0∼0.65mm, 0.65∼2mm, 2∼10mm and more than 10mm, and the gases were classified into the smallest range for calculation. At the dry condition, particles grew only by the collision -coalescence and were removed by gravitation. The particles in the range of 2.0∼10mm fell mostly at the 30 km distance from the pollutant source because of gravitation. The particles larger than 10 pm were removed at the 10 km distance from the pollutant source because of their gravity. But the particles larger than 10pm appeared again at more than 30km distance. It is considered that they have been grown during the smaller particles had been advected and diffused at that distance, and it needed about 1 hour from the moment of release. At the saturated condition, particles grew by both the collision-coalescence and condensation. The model showed that the condensation makes more number of particles larger than 10mm and then the particles were removed due to their large gravity. Only a few particles existed at the range of 0.65∼10mm and larger thats 10mm. It is concluded that the saturated atmosphere is effective on removing PM-10.

• Journal of Pharmaceutical Investigation
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• v.35 no.1
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• pp.17-23
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• 2005

Polyethylenimine (PEI) has been used as cationic polymers for efficient gene transfer without the need for endosomolytic agents. Various kinds of PEIs with different molecular weight were tested in order to investigate the effects of the molecular weight of PEI on the transfection efficiency and cell cytotoxicity. The ${\beta}-galactosidase$ expression $(pCMV-{\beta}-gal)$ plasmid was used as a model DNA. Complex formation between PEI and pDNA was assessed by 1% agarose gel electrophoresis method. Particle size and zeta-potential of complexes were determined by electrophoretic light scattering spectrometer. In vitro transfection efficiency was assayed by measuring ${\beta}-galactosidase$ activity. Cell cytotoxicity was determined by MTT assay. Particle sizes of the complexes became smaller on increasing molecular weights of PEI and N/P ratios. Surface potential of complexes was increased as the molecular weight of PEI increased. Transfection efficiency of $pCMV-{\beta}-ga1$ on the HEK 293 cells was greatest with PEI 25 K system but having the lowest cell viability. PEI with high molecular weight showed higher transfection efficiency and cell viability than PEI with low molecular weight.

• Journal of The Korean Society of Agricultural Engineers
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• v.48 no.7
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• pp.3-14
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• 2006

The objective of this study was to develop a GIS-based decision support system (GIS-USLE system) to estimate soil erosion and evaluate its effect on concentrated upland plots in Godang district, Korea. This system was developed for the ArcView environment using A VENUE script. Three modules were used in the GIS-USLE system, namely pre-processing, the USLE factors calculator module, and post-processing. This system benefits from a user friendly environment that allows users with limited computer knowledge to use it. This system was applied to 1,285 individual upland plots ranging from 0.005 to 1.347 ha in size with an average slope steepness of 14 %. The rainfall distributions were estimated using the three methods, namely Mononobe and Yen-Chow with Triangle and with Trapezoid type, and then used to calculate the rainfall erosivity factor. The soil erosion amounts from the 1,285 individual plots in the study area by 2 year return period with a 24h maximum rainfall amount of 154.6 mm were estimated at 5 tons/ha on average. Slope appeared to be the most important factor affecting soil erosion estimation, as expected. The prototype model was applied to the project area, and the results appeared to support the practical applications. By examining many fields simultaneously, this system can easily provide fast estimation of soil erosion and thus reveal the spatial pattern of erosion from fields in a region. This study will help estimate and evaluate soil erosion in concentrated upland districts and identify the best management practices.

• YAKHAK HOEJI
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• v.49 no.4
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• pp.323-329
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• 2005

Antimicrobial peptides are evolutionary ancient weapons for animal and plant species to depend themselves against infectious microbes. In the present study, we investigated if an antimicrobial peptide was produced from Coptidis Rhizoma. For the determination, protein substance from the medicinal plant was isolated by various preparations. Among the preparations, the protein portion dissolved in phosphate-buffered saline solution (CRP-DS) that contained the most amount of protein $(90\%)$ resulted in maximal inhibition of Candida albicans which causes local and systemic infections. Analyses by gel-electrophoresis and gel-permeation chromatography showed the CRP-DS formed a single band of approximately 11.8 KDa as molecular size. Antifungal activity of the CRP-DS was almost equivalent to antifungal activity by fluconazole, resulting in MIC (minimal inhibitory concentration) of approximately $50{\mu}g/ml$. The antifungal activity was a dose-dependent. The antifungal activity appeared to be inactivated by heat-treatment and ionic strength, respectively. In a murine model, the CRP-DS enhanced resistance of mice against disseminated candidiasis. The HPLC analysis demonstrated maximum $4\%$ of berberine as residual content in the CRP-DS preparation resulted in no influence on the antifungal activity. In addition, protein portion isolated from Phellodendri Cortex producing the alkaloid component like Coptidis Rhizoma had no such anticandidal effect. These results indicate that the protein substance from Coptidis Rhizoma was responsible for the antifungal activity.

• Journal of Korea Water Resources Association
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• v.48 no.8
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• pp.625-634
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• 2015

The diverse patterns of separation zone according to the marked bed discordance by dredging at confluence in addition to the confluence angle of tributary and discharge ratio between tributary and main channels have been analyzed by CCHE2D model simulation. The separation zone is defined by inside of zero velocity boundary at down-stream of confluence. The separation zone dose not formed at the $30^{\circ}$ of confluence angle of tributary. The size of separation zone increases as the discharge ratio and confluence angle increase in general. The separation zone decreases as the dredging depth increases which shows the relative momentum reduction compared by the flow volume increasing by dredging at confluence. The contraction factor with the variation of confluence angle and discharge ratio has been investigated and confirmed the corresponding conveyance decreasing results in backwater effect. The regression equation of shape factor with confluence angle and discharge and dredging depth ratios has been suggested.