• Title/Summary/Keyword: size dependent effect

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Formulation of Liposome for Topical Delivery of Arbutin

  • Wen, Ai-Hua;Choi, Min-Koo;Kim, Dae-Duk
    • Archives of Pharmacal Research
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    • v.29 no.12
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    • pp.1187-1192
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    • 2006
  • The aims of this study were to encapsulate arbutin (AR) in liposome to enhance the skin-whitening activity, and to investigate the effect of liposome formulation on the entrapment efficiency (EE%), skin permeation rate and skin deposition. The liposomes were prepared by a film dispersion method with several different formulations and were separated from the solution by using the gel-filtration method. The physical (size distribution, morphology) and chemical (drug entrapment efficiency, hairless mouse skin permeation and deposition) properties of liposomes were characterized. The entrapment efficiency in all liposome formulations varied between 4.35% and 17.63%, and was dependent on the lipid content. The particle sizes of liposomes were in the range of $179.9{\sim}212.8\;nm$ in all liposome formulations. Although the permeation rate of AR in the liposome formulations decreased compared with AR solution, the deposition amount of AR in the epidermis/dermis layers increased in AR liposomal formulation. These results suggest that liposomal formulation could enhance the skin deposition of hydrophilic skin-whitening agents, thereby enhancing their activities.

Ocean Current Power Farm Interaction Study (해양 조류발전단지 간섭 연구)

  • Jo, Chul-Hee;Yim, Jin-Young;Chae, Kwang-Su;Park, Ro-Sik
    • Journal of Ocean Engineering and Technology
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    • v.23 no.1
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    • pp.109-113
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    • 2009
  • Several tidal current power plants are being planned and constructed in Korea utilizing the strong tidal currents along the west and south coasts. A tidal current reaches 9.7 m on the west coast; there are few potential regions for tidal current power generation. The construction of a dam to store water can prevent the circulation of water, causing a great environmental impact on the coast and estuary. The tidal barrage could produce a large amount of power, but it should be carefully considered. The purpose of developing renewable energies is to minimize the environmental impact and to maximize the utilization of clean energy. To produce a great quantity of power, tidal current farms require the placement of numerous units in the ocean. The power generation is very dependent on the size of the rotor and the incoming flow velocity. Also, the interactions between devices contribute greatly to the production of power. The efficiency of a power farm is estimated to determine the production rate. This paper introduces 3 D interaction problems between rotating rotors, considering the axial, transverse, and diagonal distances between horizontal axis tidal current devices.

Effects of Inclusions on Fracture Toughness for 1%CrMoV Rotor Steel (1%CrMoV 로터강의 파괴인성에 미치는 개제물의 영향)

  • Jeong, Sun-Eok
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.24 no.9 s.180
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    • pp.2319-2325
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    • 2000
  • This thesis studied that seven kinds of residual elements(inclusions) had influenced on fracture toughness($K_{IC}$) obtained by Begley-Logsdon and Rolfe-Novak model equation using tensile an d impact test data of I%CrMoV HP(high pressure) rotor steel. $K_{IC}$ design curve of ASME and fracture surface by SEM were also considered, obtained results are summarized as follows $K_{IC}$ was linearly increased with increase of temperature, effect of the inclusions was significantly over FATT. $K_{IC}$ at lower shelf temperature was quantitatively related to yield strength and was agreed well with Begley's equation. It was difficult to determine $K_{IC}$ because of specimen size and tester capacity at upper shelf temperature, but for this view point Rolfe-Novak's equation was useful. The degree of brittle fracture was dependent on FATT fundamentally, adding S, Sb to matrix decreased impact energy and adding Cu, As increased yield(tensile) strength, and the influence of the others minority inclusion was comparatively insignificant.

Effect Analysis of Factors on Satisfaction of Fundamental Education for Major Course Learning (전공기초교육 프로그램 만족도에 영향을 미치는 변인 분석)

  • Kim, Jin Young;Oh, Jong Wook;Kang, Dae Wook
    • Journal of Engineering Education Research
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    • v.15 no.6
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    • pp.80-85
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    • 2012
  • This study investigates significant factors regarding college freshman engineering students and analyses each factors influence on student satisfaction in the College of Engineering core curriculum. We carried out a survey targeting 505 students who completed their fundamental education for major course learning in the 2011 academic year while attending one college in Gwangju and ruled out inadequate respondents. A total sample size 437 students were analyzed. The seven independent variables are academic fees, academic term period, academic environment of the classroom, learning material content, time of lecture, student sincerity and student need for the program. The dependent variable is fundamental education satisfaction level. As a result of multiple regression analysis, the following factors were found to be significant in the following order: learning material content, time of lecture, student sincerity, student need for the program, academic fees and academic environment of the classroom. On the other side academic term period was not significant. For improving fundamental education satisfaction, there is a need for prudent consideration regarding learning material development and lecture times. Also further investigation should take place for policies necessary for increasing learner motivation and sincerity, and expand appropriate conditions for learners to become self-aware of the education they need within their major.

Molecular Characterization of a Novel Putative Partitivirus Infecting Cytospora sacchari, a Plant Pathogenic Fungus

  • Peyambari, Mahtab;Habibi, Mina Koohi;Fotouhifar, Khalil-Berdi;Dizadji, Akbar;Roossinck, Marilyn J.
    • The Plant Pathology Journal
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    • v.30 no.2
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    • pp.151-158
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    • 2014
  • Three double-stranded RNAs (dsRNAs), approximately 1.85, 1.65 and 1.27 kb in size, were detected in an isolate of Cytospora sacchari from Iran. Partial nucleotide sequence revealed a 1,284 bp segment containing one ORF that potentially encodes a 405 aa protein. This protein contains conserved motifs related to RNA dependent RNA polymerases (RdRp) that showed similarity to RdRps of partitiviruses. The results indicate that these dsRNAs represent a novel Partitivirus that we tentatively designate Cytospora sacchari partitivirus (CsPV). Treatment of the fungal strain by cyclohexamide and also hyphal tip culture had no effect on removing the putative virus. Phylogenetic analysis of putative RdRp of CsPV and other partitiviruses places CsPV as a member of the genus Partitivirus in the family Partitiviridae, and clustering with Aspergillus ochraceous virus 1.

An Experimental Study on the Thermal Performance Measurement of Large Diameter Borehole Heat Exchanger(LD-BHE) for Tripe-U Pipes Spacer Apply (3중관용 스페이서를 적용한 대구경 지중열교환기의 성능측정에 관한 연구)

  • Lee, Sang-Hoon;Park, Jong-Woo;Lim, Kyoung-Bin
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.11a
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    • pp.581-586
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    • 2009
  • Knowledge of ground thermal properties is most important for the proper design of large scale BHE(borehole heat exchanger) systems. The type, pipe size and thermal performance of the BHE is highly dependent on the ground source heatpump system-efficiency and instruction cost. Thermal response tests with mobile measurement devices were developed primarily for insitu determination of design data for large diameter BHE for triple-U spacer apply. The main purpose has been to determine insitu values of effective ground thermal conductivity and thermal resistance, including the effect of ground-water flow and natural convection in the boreholes. The test rig is set up on a some trailer, and contains a circulation pump, a inline heater, temperature sensors, flow meter, power analysis meter and a data logger for recording the temperature, fluid flow data. A constant heat power is injected into the borehole through the tripl-U pipes system of test rig and the resulting temperature change in the borehole is recorded. The recorded temperature data are analysed with a line-source model, which gives the effective insitu values of rock thermal conductivity and borehole thermal resistance of large diameter BHE for spacer apply.

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A Study on the Properties of AZO Films Surface-annealed by RF Magnetron Sputtering and Electron Beam Radiation (전자빔 조사에 의해 표면열처리된 AZO 박막의 물성변화에 관한 연구)

  • Shin, Chang-Ho;Jeong, Cheol-Woo;Kim, Yu-Sung;Chae, Ju-Hyun;Kim, Daeil
    • Journal of the Korean Society for Heat Treatment
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    • v.23 no.4
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    • pp.205-209
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    • 2010
  • Transparent and conductive AZO films were deposited on the glass by using radio frequency (RF) magnetron sputtering with intense electron radiation, simultaneously. After deposition, the effect of electron radiation energy on the optical and electrical properties of AZO was investigated. In XRD measurements, the films irradiated with intense electron beam show the larger grain size than that of the films prepared without electron radiation. Sheet resistance was also dependent on the electron radiation energy, while the optical transmittance in visible wavelength region was not affected seriously by electron radiation. X-.ray diffraction, UV-Vis spectrophotometer and four point probes were used to observe the crystallization, optical transmittance and sheet resistance, respectively.

Statistical Review for USNCAP on SUV & Pick-up, Part 1: Frontal Crash Test (SUV & 트럭 차종의 USNCAP 통계분석, Part 1: 정면충돌)

  • Beom, Hyenkyun;Kim, Joseph;Cho, Kisoon;Yi, Hoki
    • Transactions of the Korean Society of Automotive Engineers
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    • v.23 no.4
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    • pp.420-427
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    • 2015
  • This paper statistically reviewed for the USNCAP frontal crash test results carried out by NHTSA. Vehicle samples were selected on total 20 vehicles which were included on 15 vehicles for MPV&SUV and 5 Pickup. The results was summarized as followings. The performance for the driver was better than the passenger's in the average sense. There exist distinctions between the driver and the passenger on the USNCAP front test procedure, for example dummy size, seating position and airbag style. Therefore these differences originated in the statistical results. Main effect was Neck injury for crash performance on both dummies on the average value. Root cause of neck injury was different for each dummy, ie, the driver caused from Nte & Ntf, but the passenger did absolutely Nte mode. Reliability evaluated from the standard deviation was highly dependent upon chest injury on the driver and neck injury on the passenger. Restraint system was also summarized.

The Production of Hydrophobic Surfaces by the Adsorption of Perfluorocarboxylic Acids onto Metal Oxides (금속 산화물에 플루오르화 카르복시산을 흡착시킨 소수성 표면의 제조)

  • Ha, Ki Ryong;Lee, Myunghee;Chung, Chinkap
    • Applied Chemistry for Engineering
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    • v.16 no.4
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    • pp.542-548
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    • 2005
  • The self-assembled monolayers (SAMs) of perfluorocarboxylic acids were fabricated on several metal oxide powders. Perfluorododecanoic acid and perfluorooctadecanoic acid were used to study the effect of chain length on SAM. Alumina, Tantalia, Titania, and Zirconia were the metal powders used. The formation of the SAMs was confirmed by DRIFT(Diffuse Reflectance Infrared Fourier Transform) spectroscopy. Since the perfluorohydrocarbons are well known for their hydrophobicity, the resulting monolayers are also expected to have high hydrophobicity. The quality of DRIFT spectra of SAMs was dependent on the powder size as well as the element of metal oxides.

Sterilization of Bacteria, Yeast, and Bacterial Endospores by Atmospheric-Pressure Cold Plasma using Helium and Oxygen

  • Lee Kye-Nam;Paek Kwang-Hyun;Ju Won-Tae;Lee Yeon-Hee
    • Journal of Microbiology
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    • v.44 no.3
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    • pp.269-275
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    • 2006
  • Atmospheric-pressure cold plasma (APCP) using helium/oxygen was developed and tested as a suitable sterilization method in a clinical environment. The sterilizing effect of this method is not due to UV light, which is known to be the major sterilization factor of APCP, but instead results from the action of reactive oxygen radicals. Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae deposited on a nitrocellulose filter membrane or Bacillus subtilis spores deposited on polypropylene plates were exposed to helium/oxygen plasma generated with AC input power at 10 kHz, 6 kV. After Plasma treatment, nitrocellulose filter membranes were overlaid on fresh solid media and CFUs were counted after incubation overnight. D-values were 18 sec for E. coli, 19 sec for S. aureus, 1 min 55 sec for S. cerevisiae, and 14 min for B. subtilis spores. D-values of bacteria and yeast were dependent on the initial inoculation concentration, while the D-value of B. subtilis spores showed no correlation. When treated cells were observed with a scanning electron microscope, E. coli was more heavily damaged than S. aureus, S. cevevisiae exhibited peeling, and B. subtilis spores exhibited shrunken morphology. Results showed that APCP using helium/oxygen has many advantages as a sterilization method, especially in a clinical environment with conditions such as stable temperature, unlimited sample size, and no harmful gas production.