• Earthquakes and Structures
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• v.9 no.1
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• pp.173-194
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• 2015

Site response analysis is an important topic in earthquake engineering. A time-domain numerical method called as one-dimensional (1D) finite element artificial boundary method is proposed to simulate the homogeneous plane elastic wave propagation in a layered half space subjected to the obliquely incident plane body wave. In this method, an exact artificial boundary condition combining the absorbing boundary condition with the inputting boundary condition is developed to model the wave absorption and input effects of the truncated half space under layer system. The spatially two-dimensional (2D) problem consisting of the layer system with the artificial boundary condition is transformed equivalently into a 1D one along the vertical direction according to Snell's law. The resulting 1D problem is solved by the finite element method with a new explicit time integration algorithm. The 1D finite element artificial boundary method is verified by analyzing two engineering sites in time domain and by comparing with the frequency-domain transfer matrix method with fast Fourier transform.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2003.03a
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• pp.110-117
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• 2003

The result of recent seismic hazard analysis indicates that the ground motion response spectra for Korean nuclear power plant site have relatively large high frequency acceleration contents. In the ordinary seismic fragility analysis of nuclear power plant structures and equipments, the safety margin of design ground response spectrum is directly used as a response spectrum shape factor. The effects of input response spectrum shape on the floor response spectrum were investigated by performing the direct generation of floor response spectrum from the ground response spectrum. The safety margin included in the design ground response spectrum should be considered as a floor response spectrum shape factor for the seismic fragility analysis of the equipments located in a building.

• Geomechanics and Engineering
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• v.20 no.2
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• pp.131-146
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• 2020

Evaluation of earthquake impacts in settlements with a high risk of earthquake occurrence is important for the determination of site-specific dynamic soil parameters and earthquake-resistant structural planning. In this study, dynamic soil properties of Karliova (Bingol) city center, located near to the intersection point of the North Anatolian Fault Zone and the East Anatolian Fault Zone and therefore having a high earthquake risk, were investigated by one-dimensional equivalent linear site response analysis. From ground response analyses, peak ground acceleration, predominant site period, 0.2-sec and 1-sec spectral accelerations and soil amplification maps of the study area were obtained for both near-field and far-field earthquake effects. The average acceleration spectrum obtained from analysis, for a near-field earthquake scenario, was found to exceed the design spectra of the Turkish Earthquake Code and Eurocode 8. Yet, the average acceleration spectrum was found to remain below the respective design spectra of the two codes for the far-field earthquake scenario. According to both near- and far-field earthquake scenarios in the study area, the low-rise buildings with low modal vibration durations are expected to be exposed to high spectral acceleration values and high-rise buildings with high modal vibration durations will be exposed to lower spectral accelerations. While high amplification ratios are observed in the north of the study area for the near-distance earthquake scenario, high amplification ratios are observed in the south of the study area for the long-distance earthquake scenario.

• Biomolecules & Therapeutics
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• v.2 no.2
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• pp.114-119
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• 1994

[$^3$H]Ouabain binding parameters ( $K_{D}$ and $B_{max}$) to control rat ventricular strips and Langendorff preparations which were not previously exposed to ouabain were compared with those to both preparations that had been first exposed to a complete ouabain dose range of dose-response curve (10$^{-8}$ to 10$^{4}$M). In rat ventricular strips and Langendorff perfused heart preparations, cumulative dose-response curves of ouabain revealed biphasic positive inotropic effects, a "low-dose" effect and a "high-dose" effect with E $d_{50}$ values of 0.5 $\mu$M and 35 $\mu$M ouabain, respectively. The "low-dose" effect in ventricular strip disappeared or was diminished significantly when the ouabain dose-response curve was repeated after the washout of the effects of the first dose-response curve, whereas there were no significant differences in the maximal "high-dose"effect in both exposures to oubain. However, both of the control and ouabain-preexposed Langendorff perfused hearts revealed the same low-dose effects. The $K_{D}$ value for [$^3$H] ouabain binding and the ouabain binding site concentration ( $B_{max}$) estimated by [$^3$H]ouabain displacement assay in control preparations were 230 nM and 2 pmol/mg protein, respectively. [$^3$H]Ouabain binding parameters were not changed by repeated exposure to high concentrations of ouabain. These results suggest that digitalis receptor desensitization in the rat ventricular strip may due to the change of post-receptor events induced by ouabain binding to a high affinity site ($\alpha$$_2$isoform).).).).).

• Structural Engineering and Mechanics
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• v.22 no.6
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• pp.647-664
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• 2006

The main purpose of this paper is to investigate the effect of transient stochastic analysis on nonlinear response of earth and rock-fill dams to spatially varying ground motion. The dam models are analyzed by a stochastic finite element method based on the equivalent linear method which considers the nonlinear variation of soil shear moduli and damping ratio as a function of shear strain. The spatial variability of ground motion is taken into account with the incoherence, wave-passage and site response effects. Stationary as well as transient stochastic response analyses are performed for the considered dam types. A time dependent frequency response function is used throughout the study for transient stochastic responses. It is observed that stationarity is a reasonable assumption for earth and rock-fill dams to typical durations of strong shaking.

• Bulletin of the Korean Chemical Society
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• v.27 no.3
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• pp.407-412
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• 2006

Bioluminescence single-site immunometric assay for methamphetamine (MA) using the native aequorin, a photoprotein, as a signal generator was developed for the first time. MA is a potent sympathomimetic amine with stimulant effects on the central nervous system. MA abuse induces hallucinations and, thus, may cause a serious social problem. The single-site immunometric MA assay was optimized and its dose-response behavior was examined. The dose-response curve shows that the detection limit is 1.1 ${\times}$ $10^{-10}$ M and a dynamic range is four orders of magnitude with 15 $\mu$g/mL BSA-MA conjugate and 1.0 ${\times}$ $10^{-8}$ M anti-MA antibody-biotin conjugate. In order to evaluate this assay, the structurally similar compounds, amphetamine, ephedrine, norephedrine, benzphetamine and N-4-(aminobutyl)methamphetamine were examined for their crossreactivity. None of these five compounds showed any cross-reactivity. Additionally, an artificial urine solution spiked with MA was analyzed by the MA assay, and the result of the analysis demonstrated the usefulness of the present assay for the determination of MA in urine.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.73-81
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• 2024

The substantia gelatinosa (SG) within the trigeminal subnucleus caudalis (Vc) is recognized as a pivotal site of integrating and modulating afferent fibers carrying orofacial nociceptive information. Although naringenin (4',5,7-thrihydroxyflavanone), a natural bioflavonoid, has been proven to possess various biological effects in the central nervous system (CNS), the activity of naringenin at the orofacial nociceptive site has not been reported yet. In this study, we explored the influence of naringenin on GABA response in SG neurons of Vc using whole-cell patch-clamp technique. The application of GABA in a bath induced two forms of GABA responses: slow and fast. Naringenin enhanced both amplitude and area under curve (AUC) of GABA-mediated responses in 57% (12/21) of tested neurons while decreasing both parameters in 33% (7/21) of neurons. The enhancing or suppressing effect of naringenin on GABA response have been observed, with enhancement occurring when the GABA response was slow, and suppression when it was fast. Furthermore, both the enhancement of slower GABA responses and the suppression of faster GABA responses by naringenin were concentration dependent. Interestingly, the nature of GABA response was also found to be sex-dependent. A majority of SG neurons from juvenile female mice exhibited slower GABA responses, whereas those from juvenile males predominantly displayed faster GABA responses. Taken together, this study indicates that naringenin plays a partial role in modulating orofacial nociception and may hold promise as a therapeutic target for treating orofacial pain, with effects that vary according to sex.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.91-97
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• 2000

Once a response spectrum is estimated for the site, if there is a need of generating realistic earthquakes time histories considering seismic sources and path effects, one alternative is to use statistical phase characteristics based on real earthquake records other than assuming arbitrary duration and envelope curves. In this study, statistics of group delay times derived from Japanese strong earthquake data were used for phase generation to fully capture the stochastic property of earthquakes. The result shows that simulated earthquake time histories can be generated according to earthquake magnitude and distances with target response spectrum.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 1998.10a
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• pp.335-342
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• 1998

A soil-structure interaction (SSI) experiment is being conducted in a seismically active region in Hualien, Taiwan. To obtain earthquake data for quantifying SSI effects and providing a basis to benchmark analysis methods, a 1/4-th scale cylindrical concrete containment model similar in shape to that of a nuclear power plant containment was constructed in the field where both the containment model and its surrounding soil, surface and sub-surface, are extensively instrumented to record earthquake data. In between September 1993 and May 1996, fifteen earthquakes with Richter magnitudes ranging from 4.2 to 6.2 were recorded. The recorded data were analyzed to provide information on the response characteristics of the Hualien soil-structure system, the SSI effects and the ground motion characteristics. The ground response data were analyzed for their variations with depth, with distance from the model structure, and at the same depths along downhole arrays. Variations of soil stiffness and soil-structure system frequencies were also evaluated against maximum ground motion. In addition, the site soil properties were derived based on correlation analysis of the recorded data and then correlated with those from the geotechnical investigation data.

• Structural Engineering and Mechanics
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• v.43 no.5
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• pp.637-655
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• 2012

In this study, stochastic responses of a cable-stayed bridge subjected to the spatially varying earthquake ground motion are investigated by the finite element method taking into account soil-structure interaction (SSI) effects. The considered bridge in the analysis is Quincy Bay-view Bridge built on the Mississippi River in between 1983-1987 in Illinois, USA. The bridge is composed of two H-shaped concrete towers, double plane fan type cables and a composite concrete-steel girder deck. In order to determine the stochastic response of the bridge, a two-dimensional lumped masses model is considered. Incoherence, wave-passage and site response effects are taken into account for the spatially varying earthquake ground motion. Depending on variation in the earthquake motion, the response values of the cable-stayed bridge supported on firm, medium and soft foundation soil are obtained, separately. The effects of SSI on the stochastic response of the cable-stayed bridge are also investigated including foundation as a rigidly capped vertical pile groups. In this approach, piles closely grouped together beneath the towers are viewed as a single equivalent upright beam. The soil-pile interaction is linearly idealized as an upright beam on Winkler foundation model which is commonly used to study the response of single piles. A sufficient number of springs on the beam should be used along the length of the piles. The springs near the surface are usually the most important to characterize the response of the piles surrounded by the soil; thus a closer spacing may be used in that region. However, in generally springs are evenly spaced at about half the diameter of the pile. The results of the stochastic analysis with and without the SSI are compared each other while the bridge is under the sway of the spatially varying earthquake ground motion. Specifically, in case of rigid towers and soft soil condition, it is pointed out that the SSI should be significantly taken into account for the design of such bridges.