• Journal of Radiation Protection and Research
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• v.31 no.2
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• pp.69-89
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• 2006

Biological mechanisms for ionizing radiation effects are different at low doses than at high doses. Radiation hormesis involves low-dose-induced protection and high-dose-induced harm. The protective component is associated with a reduction in the incidence of cancer below the spontaneous frequency, brought about by activation of defensive and repair processes. The Linear No-Threshold (LNT) hypothesis advocated by the International Commission on Radiological Protection (ICRP) and the Biological Effects of ionizing Radiation (BEIR) Report VII for cancer risk estimations Ignores hormesis and the presence of a threshold. Cancer incidences significantly less than expected have been found in a large number of epidemiological studies including, airline flight personnel, inhabitants of high radiation backgrounds, shipyard workers, nuclear site workers in scores of locations throughout the world, nuclear power utility workers, plutonium workers, military nuclear test site Participants, Japanese A-bomb survivors, residents contaminated by major nuclear accidents, residents of Taiwan living in $^{60}Co$ contaminated buildings, fluoroscopy and mammography patients, radium dial painters, and those exposed to indoor radon. Significantly increased cancer was not found at doses <200 $mSv^*$. Evidence for radiation hormesis was seen in both sexes for acute or chronic exposures, low or high LET radiations, external whole- or partial body exposures, and for internal radionuclides. The ubiquitous nature of the Healthy Worker Effect (HWE)-like responses in cellular, animal and epidemiological studies negates the HWE as an explanation for radiation hormesis. The LNT hypothesis is wrong and does not represent the true nature of the dose-response relationship, since low doses or dose-rates commonly result in thresholds and reduce cancer incidences below the spontaneous rate. Radiation protection organizations should seriously consider the cost and health implications of radiation hormesis.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.79-79
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• 1995

Although synthetic antisense oligodeoxynucleotides (ODNs) have been used to dissect gene function in vitro, technical difficulties of targeted delivery prevented the use of this approach for investigating the effect of gene products in vivo. Here we report the use of local delivery of antisense transforming growth factor-${\beta}$l (TGF-${\beta}$1) oligonucleotides to decrease the fibrosis in the skin wound. Adult wounds heal with scar-tissue formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. We reasoned that strategy emptying antisense TGF-${\beta}$1 ODNs complementary to TGF-${\beta}$1 mRNA might decrease the scarring in dermal wound of mouse. To evaluate this concept, we tested the effects of antisense ODNs targeted to TGF-${\beta}$1 mRNA by topical application of the chemical on the skin wound. Phosphorothioate antisense ODNs was employed to retard their degradation. When antisense TGF-${\beta}$1 ODNs were applied into the wound site, there was a maked reduction of scar compared with control wound site, These effects of antisense TGF-${\beta}$1 ODNs on the scar formation were associated with decreased expression of TGF-${\beta}$1 gene. However sense TGF-${\beta}$l ODNs had no effect on expression of TGF-${\beta}$1 gene. Also, control wounds healed with excessive fibrosis, whereas the antisense treated wounds healed with less fibrosis. In conclusion, our results indicate that antisense TGF-${\beta}$1 ODNs could be used for amelioating scar formation during wound healing.

• Journal of Ginseng Research
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• v.43 no.2
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• pp.319-325
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• 2019

Background: Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. We previously showed that Korean Red Ginseng (KRG) inhibited the expression of cyclooxygenase-2 (COX-2) by hypoxia via peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$). The aim of the current study was to evaluate the possibility of ginsenoside Rf as an active ingredient of KRG in the inhibition of hypoxia-induced COX-2 via $PPAR{\gamma}$. Methods: The effects of ginsenoside Rf on the upregulation of COX-2 by hypoxia and its antimigration effects were evaluated in A549 cells. Docking of ginsenoside Rf was performed with the $PPAR{\gamma}$ structure using Surflex-Dock in Sybyl-X 2.1.1. Results: $PPAR{\gamma}$ protein levels and peroxisome proliferator response element promoter activities were promoted by ginsenoside Rf. Inhibition of COX-2 expression by ginsenoside Rf was blocked by the $PPAR{\gamma}-specific$ inhibitor, T0070907. The $PPAR{\gamma}$ inhibitor also blocked the ability of ginsenoside Rf to suppress cell migration under hypoxia. The docking simulation results indicate that ginsenoside Rf binds to the active site of $PPAR{\gamma}$. Conclusions: Our results demonstrate that ginsenoside Rf inhibits hypoxia induced-COX-2 expression and cellular migration, which are dependent on $PPAR{\gamma}$ activation. These results suggest that ginsenoside Rf has an antiinflammatory effect under hypoxic conditions. Moreover, docking analysis of ginsenoside Rf into the active site of $PPAR{\gamma}$ suggests that the compound binds to $PPAR{\gamma}$ in a position similar to that of known agonists.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.440-447
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• 2000

In order to evaluate the cost effectiveness of seismic isolation for bridges in low and moderate seismic region, a method of calculation minimum life-cycle cost of seismic-isolated bridges under specific acceleration level and soil condition is developed. Input ground motion is modeled as spectral density function compatible with response spectrum for combination of acceleration coefficient and site coefficient. Failure probability is calculated by spectrum analysis based on random vibration theories to simplify repetitive calculations in the minimization procedure. Ductility of piers and its effects on cost effectiveness are considered by stochastic linearization method. Cost function and cost effectiveness index are defined by taking into consideration the characteristics of seismic isolated bridges. Limit states for calculation of failure probability are defined on superstructure, isolator and pier, respectively. The results of example design and analysis show that seismic isolation is more cost-effective in low and moderate seismic region than in high seismic region.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2001.10a
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• pp.220-226
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• 2001

It is important to estimate exactly wave forces acting on various types of offshore structures under the severe environmental conditions in the ocean site. This paper presents an easy experimental method which deals with transient waves. The proposed scheme made it possible to generate breaking waves at any position in the wave tank by changing the maximum slope of the component waves. The theoretical and experimental methods were investigated by generating concentrated waves which acted on a single and multiple cylinders. The waves forces increased rapidly when the models encountered breaking waves. The theoretical results underestimates the forces due to breaking waves. Therefore, the effects due to breaking waves should be considered carefully in the design process of a structure under the influence of breaking waves.

• Journal of Environmental Science International
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• v.3 no.4
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• pp.333-348
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• 1994

The groundwater levels at 11 sites and the vertical variations o( the water Quality at 1 site were measured to study the characteristic of the groundwater level fluctuation of Cheju Island. The results of the measurements for the groundwater levels were as follows; In the eastern part, inculding Kimnyong, Jongdal and Sungsan, a sinusoidal fluctuation of groundwater levels occurred in response to oceanic tides. The tidal effect on the groundwater level was reduced depending upon the distance from seashore. But time lag showed that the trend is reversed. However, in the Samyang, Kosan and Shinhyo areas show that the groundwater level was directly influenced by the amount of precipitation. Especially, Shinhyo area which southern part in Cheju was affected the most and show upper parabasal groundwater level. In Susan- I which eastern part in Cheju, well rovealed that water Quality changed with the period of a tide. Salinity at the lim, bellow the natural groundwater level, was approched to the brackish groundwater(1000ppm).

• Journal of Ocean Engineering and Technology
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• v.15 no.4
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• pp.8-13
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• 2001

It is important to estimate exactly wave forces acting on various types of offshore structures under the severe environmental conditions in the ocean site. This paper presents an easy experimental method which deals with transient waves. The proposed scheme made it possible to generate breaking waves at any position in the wave tank by changing the maximum slope of the component waves. The theoretical and experimental methods were investigated by generating concentrated waves which acted on a single and multiple cylinders. The waves forces increased rapidly when the models encountered breaking waves. The theoretical results underestimates the forces due to breaking waves. Therefore, the effects due to breaking waves should be considered carefully in the design process of a structure under the influence of breaking waves.

• Wind and Structures
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• v.21 no.5
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• pp.505-521
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• 2015

A general approach of aerodynamic optimization of tall buildings is presented in this paper, focusing on how to best compromise wind issues with other design aspects in the most efficient manner. The given approach is reinforced by establishing an empirical method that can quickly assess the across-wind loads and accelerations as a function of building frequencies, building dimensions, aspect ratios, depth-to-width ratios, and site exposures. Effects of corner modifications, including chamfered corner and recessed corner, can also be assessed in early design stages. Further, to assess the effectiveness of optimization by tapering, stepping or twisting building elevations, the authors introduce a method that takes use of sectional aerodynamic data derived from a simple wind tunnel pressure testing to estimate reductions on overall wind loads and accelerations for various optimization options, including tapering, stepping, twisting and/or their combinations. The advantage of the method is to considerably reduce the amount of wind tunnel testing efforts and speed up the process in finding the optimized building configurations.

• Bulletin of the Korean Chemical Society
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• v.33 no.4
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• pp.1285-1289
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• 2012

RAP80 plays a key role in DNA damage responses by recognizing K63-linked polyubiquitin moieties through its two ubiquitin-interacting motif (UIM) domains. The linker between the two UIMs possesses a phosphorylation site, but the relationship between phosphorylation and polyubiquitin recognition remains elusive. We investigated the interaction between a phosphorylation-mimic RAP80 mutant S101E and linear polyubiquitins, structurally equivalent to the K63-linked ones, using isothermal titration calorimetry (ITC). ITC analysis revealed differential binding affinities for linear tetraubiquitin by otherwise equivalent UIMs in S101E. Mutational analysis supported such differential polyubiquitin recognition by S101E. Our results suggest a potential crosstalk between polyubiquitin recognition and phosphorylation in RAP80.

• Earthquakes and Structures
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• v.26 no.3
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• pp.191-201
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• 2024

A comprehensive probabilistic seismic hazard analysis was carried out in Istanbul to examine the seismotectonic features of the region. The results showed that earthquakes can trigger one another, resulting in the grouping of earthquakes in both time and space. The hazard analysis utilized the Poisson model and a conventional integration technique to generate the hazard curve, which shows the likelihood of ground motion surpassing specific values over a given period. Additionally, the study evaluated the impact of seismic hazard on the structural integrity of an existing masonry tower by simulating its seismic response under different ground motion intensities. The study's results emphasize the importance of considering the seismotectonic characteristics of an area when assessing seismic hazard and the structural performance of buildings in seismic-prone regions.