• Earthquakes and Structures
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• v.2 no.4
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• pp.357-376
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• 2011

Ground motion models predict the mean and standard deviation of the logarithm of spectral acceleration, as a function of predictor variables such as earthquake magnitude, distance and site condition. Such models have been developed for a variety of seismic environments throughout the world. Some calculations, such as the Conditional Mean Spectrum calculation, use this information but additionally require knowledge of correlation coefficients between logarithmic spectral acceleration values at multiple periods. Such correlation predictions have, to date, been developed primarily from data recorded in the Western United States from active shallow crustal earthquakes. This paper describes results from a study of spectral acceleration correlations from Japanese earthquake ground motion data that includes both crustal and subduction zone earthquakes. Comparisons are made between estimated correlations for Japanese response spectral ordinates and correlation estimates developed from Western United States ground motion data. The effect of ground motion model, earthquake source mechanism, seismic zone, site conditions, and source to site distance on estimated correlations is evaluated and discussed. Confidence intervals on these correlation estimates are introduced, to aid in identifying statistically significant differences in correlations among the factors considered. Observed general trends in correlation are similar to previous studies, with the exception of correlation of spectral accelerations between orthogonal components, which is seen to be higher here than previously observed. Some differences in correlations between earthquake source zones and earthquake mechanisms are observed, and so tables of correlations coefficients for each specific case are provided.

• Journal of the Korean Geotechnical Society
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• v.34 no.11
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• pp.71-80
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• 2018

In this study, the seismic response of cut-and-cover box tunnels is evaluated from pseudo-static analyses and the fragility curves are derived. A series of site profiles were used to evaluate the effect of soil conditions. A total of 20 ground motions were used. The fragility curves were developed as functions of peak ground acceleration for three damage states, which are minor, moderate, and extensive states. The damage indices, defined as the ratio of the elastic moment to the yield moment, correlated to three damage states, were used. The curves are shown to greatly depend on the site profile. The curves are further compared to those derived in previous studies. The widely used empirically derived curves are shown not to account for the site effects, and therefore underestimate the response for soft sites.

• The Korean Journal of Pain
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• v.20 no.2
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• pp.92-99
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• 2007

Background: A correlation between a T-type voltage activated calcium channel (VACC) and pain mechanism has not yet been established. The purpose of this study is to find out the effect of ethosuximide and mibefradil, representative selective T-type VACC blockers on postoperative pain using an incisional pain model of rats. Methods: After performing a plantar incision, rats were stabilized on plastic mesh for 2 hours. Then, the rats were injected with ethosuximide or mibefradil, intraperitoneally and intrathecally. The level of withdrawal threshold to the von Frey filament near the incision site was determined and the dose response curves were obtained. Results: After an intraperitoneal ethosuximide or mibefradil injection, the dose-response curve showed a dose-dependent increase of the threshold in a withdrawal reaction. After an intrathecal injection of ethosuximide, the threshold of a withdrawal reaction to mechanical stimulation increased and the increase was dose-dependent. After an intrathecal injection of mibefradil, no change occurred in either the threshold of a withdrawal reaction to mechanical stimulation or a dose-response curve. Conclusions: The T-type VACC blockers in a rat model of postoperative pain showed the antihyperalgesic effect. This effect might be due to blockade of T-type VACC, which was distributed in the peripheral nociceptors or at the supraspinal level. Further studies of the effect of T-type VACC on a pain transmission mechanism at the spinal cord level would be needed.

• Restorative Dentistry and Endodontics
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• v.43 no.4
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• pp.36.1-36.12
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• 2018

Objectives: Direct pulp capping is a treatment for mechanically exposed pulp in which a biocompatible capping material is used to preserve pulpal vitality. Biocompatibility tests in animal studies have used a variety of experimental protocols, particularly with regard to the exposure site. In this study, pulp exposure on the occlusal and mesial surfaces of molar teeth was investigated in a rat model. Materials and Methods: A total of 58 maxillary first molars of Wistar rats were used. Forty molars were mechanically exposed and randomly assigned according to 3 factors: 1) the exposure site (occlusal or mesial), 2) the pulp-capping material (ProRoot White MTA or Bio-MA), and 3) 2 follow-up periods (1 day or 7 days) (n = 5 each). The pulp of 6 intact molars served as negative controls. The pulp of 12 molars was exposed without a capping material (n = 3 per exposure site for each period) and served as positive controls. Inflammatory cell infiltration and reparative dentin formation were histologically evaluated at 1 and 7 days using grading scores. Results: At 1 day, localized mild inflammation was detected in most teeth in all experimental groups. At 7 days, continuous/discontinuous calcified bridges were formed at exposure sites with no or few inflammatory cells. No significant differences in pulpal response according to the exposure site or calcium-silicate cement were observed. Conclusions: The location of the exposure site had no effect on rat pulpal healing. However, mesial exposures could be performed easily, with more consistent results. The pulpal responses were not significantly different between the 2 capping materials.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 1999.04a
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• pp.57-60
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• 1999

Amplification factor spectrum using the observed strong ground motions database in the Korean Peninsula has been obtained and compared with Standard Rpectrum which wa suggested by United States Nuclear Regulatory Committee. The observed ground motions from the Yongwol and the Kyoungju Earthquakes respectively which are supposed to represent domestic seismotectonic characteristics such as seismic source attenuation of the propagation meium and site specific effect are used for the analysis of amplification factor spectrum,. The database are slightly different from the those of the second study. Amplification factors have been calculated by comparing the observed peak ground motions with results from responses to the observed horizontal na vertical ground motions. The comparison have shown that the amplification factors resultant from this study exceeds those of Standard Response Spectrum The results suggest that the characteristics of seismic strong ground motion which are supposed to represent the domestic seismotectonic characteristics differs from those of Standard Response Spectrum especially at higher frequencies. The results from the 2nd study are similar to those of 1st analysis.

• Bulletin of the Korean Chemical Society
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• v.24 no.8
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• pp.1188-1192
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• 2003

In order to study the role of residue in the active site of glutathione S-transferase (GST), Tyr 108 residue in human GST P1-1 was replaced with alanine, phenylalanine and tryptophan by site-directed mutagenesis to obtain mutants Y108A, Y108F and Y108W. These three mutant enzymes were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized GSH. The substitutions of Tyr108 significantly affected $K_m^{CDNB}$ and $K_m^{ETA}$, whereas scarcely affected $K_m^{GSH}$. The substitutions of Tyr108 also significantly affected $I_{50}$ of ETA, an electrophilic substrate-like compound. The effect of these substitutions on kinetic parameters and the response to inhibition suggests that tyrosine 108 in hGST P1-1 contributes to the binding of the electrophilic substrate and a major determinant in the binding of CDNB is the aromatic ring of Tyr108, not its hydroxyl group.

• Knowledge Management Research
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• v.14 no.4
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• pp.1-17
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• 2013

As online communities proliferate, online news sites have received great attention in news media research. Although most of the online news sites provide contents for free, some have adopted the Pay-What-You-Want (PWYW) model by offering a voluntary payment option to the readers. In this study, we investigate the factors which influence subscribers' voluntary payment behavior on an online news site. Drawing upon both the Stimulus-Organism-Response (SOR) framework and the Elaboration Likelihood Model (ELM), we hypothesize that appreciation has a direct effect on the subscribers' voluntary payment behavior, whereas central factors (positive emotional content, cognitive content) and peripheral factors (news sharing, news article length) of the news articles have indirect impacts on voluntary payment behavior through the enhanced appreciation. Based on an empirical analysis of 172 news articles from the Korean online news site that adopted the PWYW pricing model (i.e., Ohmynews.com), we find that appreciation plays a critical role in voluntary payment behavior and that peripheral factors have significant impacts on appreciation. However, the impacts of central factors on appreciation are not found. By identifying influencing factors of subscribers' voluntary payment behavior on online news sites for the first time, this paper suggests a prospective alternative profit model for online news providers faced with fierce competition.

• Bulletin of the Korean Chemical Society
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• v.24 no.1
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• pp.70-74
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• 2003

The heterogeneous bioluminescence immunoassay for digoxin was developed using photoprotein, native aequorin as a label and the site-directed immobilization technique based on avidin/biotin interaction. Aequorin is a bioluminescence protein, originally isolated from the jellyfish Aequoria Victoria and an attractive label in analytical applications because of sensitive detection due to virtually no background bioluminescent signal. Digoxin is a cardioactive drug, and its therapeutic level in serum is at low concentration with very narrow therapeutic index. The aequorin-digoxigenin conjugates were synthesized by the N-hydroxysuccinimide ester method and characterized in terms of bioluminescent residual activity. The resulting dose-response curve shows that the detection limit is $1.0\;{\times}\;10^{-10}\;M$ and a dynamic range is three orders of magnitude, which was obtained by $1.0\;{times}\;10^{-10}\;M$ conjugate and 0.9 μg/mL anti-digoxin antibody. Three structurally similar molecules to digoxin were examined for their cross-reactivity. None of these three compounds showed any crossreactivity with digoxin antibody employed in this study. Standard amounts of digoxin corresponding to the therapeutic range were spiked into the each serum solution. Study of the serum matrix effect indicated that correlation coefficient shows good agreement between luminescence light intensity between in buffer and in serum.

• Geomechanics and Engineering
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• v.15 no.2
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• pp.775-781
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• 2018

Shake table tests were conducted on scaled tunnel model to investigate the mechanism and effect of seismic loadings on horseshoe scaled tunnel model in ground fissure site. Key technical details of the experimental test were set up, including similarity relations, boundary conditions, sensor layout, modelling methods were presented. Synthetic waves and El Centro waves were adopted as the input earthquake waves. Results measured from hanging wall and foot wall were compared and analyzed. It is found that the seismic loadings increased the subsidence of hanging wall and lead to the appearance and propagation of cracks. The values of acceleration, earth pressure and strain were greater in the hanging wall than those in the foot wall. The tunnel exhibited the greatest earth pressure on right and left arches, however, the earth pressure on the crown of arch is the second largest and the inverted arch has the least earth pressure in the same tunnel section. Therefore, the effect of the hanging wall on the seismic performance of metro tunnel in earth fissure ground should be considered in the seismic design.

• Journal of Korean Society on Water Environment
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• v.21 no.6
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• pp.609-616
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• 2005

A high ammonia nitrogen ($NH_3-N$) concentration has been recursively observed every winter season in Geum River, which hindered chemical treatment processes at a water treatment plant. A flushing discharge from Daecheong Dam was often considered to dilute $NH_3-N$, but information on the quantitative effect of flushing on the downstream water quality was limited. In this study, the impact of a short-term reservoir flushing on the downstream water quality was investigated through field experiments and unsteady water quality modeling. On November 22, 2003, the reservoir discharge was increased from $30m^3/sec$ to $200m^3/sec$ within 6 hours for the purpose of the experiment. The results showed that flushing flow tends to reduce downstream $NH_3-N$ concentrations considerably, but the effectiveness was limited by flushing amount and time. An unsteady river water quality model was applied to simulate the changes of nitrogen concentrations in response to reservoir flushing. The model showed very good performance in predicting the travel time of flushing flow and the effect of flushing discharge on the reduction of downstream $NH_3-N$ concentrations at Maepo and Geumnam site, but a significant discrepancy was observed at Gongju site.