• The Journal of Korean Medicine
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• v.37 no.2
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• pp.53-61
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• 2016

Objectives: Considering high prevalence of myopia in Asian countries, social cost paid for myopia may gradually increase in Korea. However, studies for developing myopia treatment are deficient. The study was to evaluate whether the periocular acupressure with a medical massager is effective for suppressing myopia progression. Methods: This study was an investigator-sponsored, prospective, open-labeled, and superiority pre and post single-armed study. 14 myopia children aged 7-12 years wore a medical massager for 15 minutes to stimulate periocular acupoints. For 24 weeks, the participants used the device twice a day. Based on prior studies, the refraction change of naturally proceeded myopia was set as -0.38 D. The axial length change of naturally proceeded myopia was set as 0.228 mm. To assess the safety, we performed vital sign check, physical examination, visual acuity test, slit lamp examination, IOP measurement, and fundus examination. Results: The refraction and axial length of the participants increased. For 24 weeks, the change in refraction was -0.38 D at the right eye and -0.40 D at the left. The change in axial length was 0.21 mm at the right and 0.22 mm at the left. In the safety assessment, any adverse event did not occur. Conclusions: There was no significant difference between the control group and the intervention group. The effect of growth may have more contributed to our result than that of acupressure. Based on our result, a full-scale study will not be conducted.

• Journal of Korean Society of Steel Construction
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• v.19 no.2
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• pp.147-160
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• 2007

In this paper, we described the aeroelastic full-bridge model tests that were conducted to investigate the effect of alternative temporary stabilizing measures for thecable-stayed bridge during construction to ensure aerodynamic stability in the event of a typhoon or similar disasters. The effect of alternative temporary stabilizing measures was investigated through various configurations on two cable-stayed bridges with a main span of 475 m and 230 m, respectively. To investigate the bridge's aerodynamic behaviour and dynamic wind force during construction, the deflections at the end of the cantilever, the accelerations atthe top of the pylon and the moments at the lower part of the pylon were measured. As the result, the system with two sets of vertical cables per cantilever seemed to be the overall most effective solution, but the system with single vertical cable may also work. The combined system using the caisson support and vertical cables and the system with two sets of inclined cables per cantilever on the same anchor block may also be a solution. The inclined cables from the caisson to the girder were effective for some early stages of erecting the deck.

• Journal of Society of Preventive Korean Medicine
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• v.19 no.3
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• pp.91-102
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• 2015

Objective : The purpose of this study is to find out the possibility of application to herbal medicine's report form for adverse drug reaction (ADR) by reviewing and analyzing Asian countries's ADR report forms. Method : We investigated, compared, and analyzed ADR report forms (ADR-RF) of Asian countries's ADR institutions (ACAI), such as, Korea institute of drug safety & risk management and Dongguk university Ilsan oriental hospital (DUIOH) in Korea, national center for ADR monintoring (NCAM) in China, pharmaceuticals and medical devices agency (PMDA) in Japan, Ministry of Health and Welfare (MOHW) in Taiwan, and drug office, department of health, the government of the Hong Kong special administrative region (GHKSAR) in Hong Kong. Results : ADR-RF for ACAI included common contents, such as, patients information (name(initial), gender, age, weight), adverse event (AE)'s report information (Recognition and report for AE occurrence, first or follow up report, Severe AE), the detailed information of AE (the title of AE, onset & closing date of AE symptoms, the progress & results detailed test of AE), the information of AE's medicine (the types of medicine, product name, ingredient name, suspected or combination drug, single dose & frequency, dosage form, administration route, dealing for AE-suspected medicine), and AE reporter's information (reporter's information, institution's information). Taiwan had ADR-RF and the department exclusively for herbal medicine (HM), but others (except DUIOH) had not only no ADR report form but also contents for HM. Conclusion : ADR-RF for HM have to include the common contents of ACAI at least, as well as HM information related to ADR, such as the title, composition and types of HM, history related to HM's ADR, and the contents of drug-induced liver injury and so on. In addition, the main department of government for HM's ADR will be needed.

• Information Systems Review
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• v.12 no.3
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• pp.1-17
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• 2010

IT Systems based on Global Single Instance (GSI) can manage a corporation's internal information, resources and assets effectively and raise business efficiency through consolidation of their business process and productivity. But, It has also dangerous factor that IT system fault failure can cause a state of paralysis of a business itself, followed by huge loss of money. Many of studies have been conducted about fault-tolerance based on using redundant component. The concept of fault tolerance is rather simple but, designing and adopting fault-tolerance system is not easy due to uncertainty of a type and frequency of faults. So, Operational fault management that working after developed IT system is important more and more along with technical fault management. This study proposes the fault management process that including a pre-estimation method using TRM (Technical Reference Model) check point and event rule engine. And also proposes a effect of fault-free process through built fault management system to representative company of Hi-tech industry. After adopting fault-free process, a number of failure decreased by 46%, a failure time decreased by 56% and the Opportunity loss costs decreased by 77%.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.1
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• pp.79-84
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• 2013

DC/DC switching power converters are commonly used to generate a regulated DC output voltage with high efficiency. The DC/DC converter is composed of a PWM-IC (pulse width modulation-integrated circuit) controller, a MOSFET (metal-oxide semiconductor field effect transistor), inductor, capacitor, etc. It is shown that the variation of threshold voltage and the offset voltage in the electrical characteristics of PWM-IC increase by radiation effects in TID (Total Ionizing Dose) testing at the low energy ${\gamma}$ rays using $^{60}Co$, and 4 heavy ions applied for SEL (Single Event Latch-up) make the PWM pulse unstable. Also, the output waveform for the given input in the DC/DC converter is observed by the simulation program with integrated circuit emphasis (SPICE). TID testing on PWM-IC is accomplished up to the total dose of 30 krad, and the cross section($cm^2$) versus LET($MeV/mg/cm^2$) in the PWM operation is studied at SEL testing after implementation of the controller board.

• Journal of The Korean Society of Clinical Toxicology
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• v.14 no.2
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• pp.100-106
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• 2016

Purpose: Beta blocker (BB) has been prescribed for anxiety and panic disorder. Patients intoxicated by psychiatric drugs have often been exposed to BB. Moreover, BB overdose has adverse effects including cardiovascular effects, which can be life-threatening. This study was conducted to identify the characteristics of BB intoxication with psychiatric drugs and the adverse effects on the cardiovascular system. Methods: A single center, retrospective study was performed from January 2010 to December 2015. A total of 4,192 patients visited the emergency department (ED) with intoxication, and 69 with BB intoxication were enrolled. Results: Overall, 64 patients (92.8%) of enrolled patients were intoxicated with drugs prescribed for the purpose of psychiatric disorders. Propranolol was the most common BB (62 cases, 96.2%), and the median dose was 140.0 mg (25%-75% 80.0-260.0). Twenty-four patients (37.5%) had experienced cardiovascular events, and these patients tended to have decreased mentality, hypotension and coingestion with quetiapine. An initial mean arterial pressure (MAP) below 65 mmHg (odds ratio 10.069, 95% confidence interval 1.572-64.481, p=0.015) was identified as a factor of cardiovascular event upon multiple logistic regression analysis. Conclusion: Initial MAP below 65 mmHg was a factor of cardiovascular adverse effect in patients of BB intoxication with psychiatric drugs.

• Journal of Plant Biotechnology
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• v.37 no.3
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• pp.275-282
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• 2010

Chloroplast transformation in higher plants offers many attractive advantages over nuclear transformation, including a high-level accumulation of foreign proteins, multi-gene expression in single transformation event via transgene stacking in operons and no position effect due to site-specific integration of transgenes by homologous recombination. Most importantly, chloroplast transgenic plants are eco-friendly because their transgenes are maternally inheritance in most crop plants. However, chloroplast transformation system has limited success in crops alike nuclear transformation. In the past two decades, great progress has been made to overcome the limitations of chloroplast transformation, thus expending chloroplast bioreactor to several important crops including soybean, carrot, lettuce, and oilseed. Therefore, it has become possible that chloroplast transformation of crops can be used not only for the improvement of agronomic traits, but also for the production of vaccines and high valuable therapeutic proteins in pharmaceutical industry.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.2
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• pp.35-41
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• 2011

This work investigates the potential of in-cylinder thermal stratification and fuel stratification for extending the operating ranges in HCCI engines, and the coupling between thermal stratification and fuel stratification. Computational results areemployed. The computations were conducted using both a custom multi-zone version and the standard single-zone version of the Senkin application of the CHEMKINII kinetics rate code, and kinetic mechanism for di-methyl ether (DME). This study shows that the potential of thermal stratification and fuels stratification for extending the high-load operating limit by a staged combustion event with reduced pressure-rise rates is very large. It was also found that those stratification offers good potential to extend low-load limit by a same mechanism in high-load. However, a combination of thermal stratification and fuel stratification is not more effective than above stratification techniques for extending the operating ranges showing similar results of fuel stratification. Sufficient condition for combustion (enough temperature for) turns misfire in low-load limit to operate engines, which also leads to knock in high-load limit abruptly due to the too high temperature with high. DME shows a potential for maximizing effect of stratification to lower pressure-rise rate due to the characteristics of low-temperature heat release.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.11
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• pp.981-987
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• 2014

DC/DC switching power converters are commonly used to generate a regulated DC output voltage with high efficiency. The DC/DC converter is composed of a MOSFET (metal-oxide semiconductor field effect transistor), a PWM-IC (pulse width modulation-integrated circuit) controller, inductor, capacitor, etc. It is shown that the variation of threshold voltage and the breakdown voltage in the electrical characteristics of MOSFET occurs by radiation effects in TID (Total Ionizing Dose) testing at the low energy ${\gamma}$ rays using $^{60}Co$, and 5 heavy ions make the gate of MOSFET broken in SEGR (Single Event Gate Rupture) testing. TID testing on MOSFET is accomplished up to the total dose of 40 krad, and the cross section($cm^2$) versus LET(MeV/mg/$cm^2$) in the MOSFET operation is studied at SEGR testing after implementation of the controller board.

• Korean Journal of Occupational Health Nursing
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• v.26 no.4
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• pp.218-226
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• 2017

Purpose: The study aimed to determine the impact of post-traumatic stress and ways of stress coping on problem drinking in firefighters. Methods: Data were collected from May 11 to June 11, 2015, in fire brigades across South Korea. Participants were 183 male firefighters who used self-report questionnaires containing questions from the Impact of Event Scale-Revised (IES-R), Ways of Coping Checklist (WCC), and Alcohol Use Disorders Identification Test (AUDIT). Data were analyzed using $x^2$ test, t-test, and logistic regression with the SPSS/WIN 21.0 program. Results: The prevalence of PTSD among firefighters was 36.7% and that of problem drinking was 39.3%. Firefighters with single (OR=0.23, 95% CI=0.038~1.321) and married status (OR=0.46, 95% CI=0.069~3.040) were less likely to have problem drinking than those who were divorced or bereavement. Those with invasion symptoms (OR=1.17, 95% CI=1.031~1.327) and hyperarousal symptoms (OR=0.85, 95% CI=0.722~0.989) were more likely to have problem drinking than those with avoidance symptoms. Conclusion: Post-traumatic stress symptom was a major risk factor that increased problem drinking, and married status reduced problem drinking. There is a need to develop post-traumatic stress symptom management program and early education content for symptom management.