• 한국방사선학회논문지
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• 제16권2호
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• pp.103-113
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• 2022

이 논문에서는 결합된 PET(fluorodeoxyglucose, ¹⁸F-FDG)와 MRI(magnetic nanoparticles, MNP) 조영제를 동시 PET-MRI 스캔에 사용하기 위한 가교제로 N-(p-maleimidophenyl) isocyanate를 사용하여 합성하는 방안을 제안하였다. 실험은 신경교종 줄기 세포 마우스 모델에서 결합 조영제(¹⁸F-FDG로 표지된 MNP)를 주입하기 전후에 PET-MRI 이미지를 획득하고 평가하였다. 획득한 각 영상에 대해 관심영역(ROI)을 설정한 후, 분할하여 병변의 면적을 계산하였을 때 PET 영상이 MRI 영상보다 더 크고 정확했다. 특히 동시 PET-MRI 영상은 주변 연조직과 함께 정확한 병변을 묘사하였다. 평균 및 표준편차 값은 조영제 주입 여부에 관계없이 PET 영상 또는 PET-MRI 동시 영상보다 MRI 단독 영상에서 더 높게 나타났다. 또한 동시 PET-MRI 영상값이 PET 영상보다 평균 및 표준편차 값이 높게 나타났다. ¹⁸F-FDG 라벨링된 MNP 조영제와 동시 PET-MRI 영상을 표적 영상으로 사용하고 ¹⁸F- FDG 조영제만을 원본 이미지로 사용했을 때의 피크 신호 대 잡음비(PSNR) 값은 모든 실험에서 유의미 하게 나타났다. 결론적으로 동시 PET-MRI 영상에서 결합된 ¹⁸F-FDG 표지 MNP 조영제가 유용함을 확인하였다. 다양한 핵종을 사용할 수 있는 SPECT-MRI 영상 연구를 통해 진단과 치료를 동시에 할 수 있는 제제를 개발하기 위해서는 향후 연구가 필요할 것이다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.1-1
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• 2011

We developed a new generalized synthetic procedure, called as "heat-up process," to produce uniform-sized nanocrystals of many transition metals and oxides without a size selection process. We were able to synthesize uniform magnetite nanocrystals as much as 1 kilogram-scale from the thermolysis of Fe-oleate complex. Clever combination of different nanoscale materials will lead to the development of multifunctional nano-biomedical platforms for simultaneous targeted delivery, fast diagnosis, and efficient therapy. In this presentation, I would like to present some of our group's recent results on the designed fabrication of multifunctional nanostructured materials based on uniform-sized magnetite nanoparticles and their medical applications. Uniform ultrasmall iron oxide nanoparticles of <3 nm were synthesized by thermal decomposition of iron-oleate complex in the presence of oleyl alcohol. These ultrasmall iron oxide nanoparticles exhibited good T1 contrast effect. In in vivo T1 weighted blood pool magnetic resonance imaging (MRI), iron oxide nanoparticles showed longer circulation time than commercial gadolinium complex, enabling high resolution imaging. We used 80 nm-sized ferrimagnetic iron oxide nanocrystals for T2 MRI contrast agent for tracking transplanted pancreatic islet cells and single-cell MR imaging. We reported on the fabrication of monodisperse magnetite nanoparticles immobilized with uniform pore-sized mesoporous silica spheres for simultaneous MRI, fluorescence imaging, and drug delivery. We synthesized hollow magnetite nanocapsules and used them for both the MRI contrast agent and magnetic guided drug delivery vehicle.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2008년도 춘계학술대회
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• pp.295-299
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• 2008

This paper discusses tests of factor effect or contrast by the use of saturated design $k^n$ factorial design. The nine nonparametric rank measures in normality test using normal probability pot are proposed. Length's PSE(Pseduo Standard Error) test [4] which relies on the concept of effect sparsity is also introduced and extended to the margin of error(ME) and Simultaneous margin of error(SME).

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(4)
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• pp.251-254
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• 2002

Currently many devices reproduce electronic images in a variety of ways. However, the colors that are reproduced are different from the original color due to the differences in the gamut between devices. In this paper, a gamut mapping method utilizing a simultaneous mapping function and a lightness rescaling is proposed. This method enhance the local-color characteristics and lightness contrast. The experimental result shows that the overall contrast and the colorfulness were increased.

• Journal of applied mathematics & informatics
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• 제3권2호
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• pp.129-148
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• 1996

This paper propose the inference mechanism for handling linear polynomial constraints called consistency checking algorithm based on the feasibility checking algorithm borrowed from linear pro-gramming. in contrast with other approaches proposed algorithm can efficiently and coherented by linear polynomial forms. The developed algorithm is successfully applied to the symbolic simulation that offers a convenient means to conduct multiple simultaneous exploration of model behaviors.

• 한국가시화정보학회지
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• 제4권2호
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• pp.69-75
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• 2006

The microbubbles were used in various fields, such as turbulent control, drag reduction, material science and life science. The X-ray PTV using X-ray micro-imaging technique was employed to mea-sure the size and velocity of micro-bubbles moving in an opaque tube simultaneously. Micro-bubbles of $10{\sim}60{\mu}m$ diameter moving upward in an opaque tube (${\phi}$=2.7mm) were tested. Due to the different refractive indices of water and air, phase contrast X-ray images clearly show the exact size and shape of over-lapped microbubbles. In all of the working fluids tested (deionized water, tap water, 0.01 and 0.10M NaCl solutions), the measured terminal velocity of the microbubbles rising through the solution was proportional to the square of the bubble diameter. The rising velocity was increased with increasing mole concentration. The microbubble can be useful as contrast agent or tracer in life science and biology. The X-ray PTV technique should be able to extract useful information on the behavior of various bio/microscale fluid flows that are not amenable to analysis using conventional methods.

• 한국의상디자인학회지
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• 제5권2호
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• pp.103-113
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• 2003

This paper analyses the geometric aspect of Sonia Delaunay′s works on the basis of design elements and principles. Geometric pattern is one of the distinct features of early 20th century avant-garde works. The significance of its pattern and colour comes from the fact that it has not only influenced the contemporary fine art but also offered the basic principle of modern costume design. In 1925 she was designing clothes which could be worn today without appearing old-fashioned. She foresaw the future trends in fashion and interior decoration. One might claim she belongs to the avant-garde even today and no less astonishing a phenomenon than she was in 1925. Sonia Delaunay′s art was one of the first expressions of abstract painting and her "simultaneous contrasts" are among the earliest example of the aesthetic. In Delaunay′s geometric abstraction it is found that the technique of "simultaneous contrasts" is exploited almost without exception. Colour as well as Collage was the favourite technique Delnaunay used in creating a distinct simultaneity. Many "inobjective" paintings as she herself called unite the rigour of simple geometric forms with an inner life and poetry which emanate from the richness of the colour, the musicality of the rhythm, the vibrant breadth of the execution.

• 복식
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• 제50권6호
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• pp.47-58
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• 2000

This paper analyses the geometric aspect of Soma Delaunay's works on the basis of design elements and principles. Geometric pattern is one of the distinct features of early 20th century avant-garde works. The significance of its pattern and colour comes from the fact that it has not only influenced the contemporary fine art but also offered the basic principle of modern costume design. In 1925 she was designing clothes which could be worn today without appearing old-fashioned. She foresaw the future trends in fashion and interior decoration, One might claim she belongs to the avant-garde even today and no less astonishing a phenomenon than she was in 1925. Soma Delaunay's art was one of the first expressions of abstract painting and her "simultaneous contrasts"are among the earliest example of the aesthete. In Delaunay's geometric abstraction it is found that the technique of"simultaneous contrasts" is exploited almost without exception. colour as well as collage was the favourite technique Delnaunay used in creating a distinct simultaneity, Many "inobjective" paintings as she herself called unite the rigour of simple geometric forms with an inner life and poetry which emanate from the richness of the colour, the musicality of the rhythm, the vibrant breadth of the execution.rant breadth of the execution.

• Journal of Pharmaceutical Investigation
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• 제36권5호
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• pp.309-314
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• 2006

The multicellular layers(MCL) of human cancer cells is a three dimensional(3D) in vitro model for human solid tumors which has been used primarily for the assessment of avascular penetration of anti-cancer drugs. For anti-cancer drugs with penetration problem, MCL represents a good experimental model that can provide clinically relevant data. Calcein-AM is a fluorescent dye that demonstrates the cellular vitality in a graded manner in cancer cell culture system. In the present study, we evaluated the use of calcein-AM for determination of anti-proliferative activity of anti-cancer agents in MCL model of DLD-1 human colorectal cancer cells. Optical sectioning of confocal imaging was compromised with photonic attenuation and penetration barrier in the deep layers of MCL. By contrast, fluorescent measurement on the cryo-sections provided a feasible alternative. Cold pre-incubation did not enhance the calcein-AM distribution to a significant degree in MCL of DLD-1 cells. However, the simultaneous determination of drug penetration and cellular vitality appeared to be possible in drug treated MCL. In conclusion, these data suggest that calcein-AM can be used for the simultaneous determination of drug-induced anti-proliferative effect and drug penetration in MCL model.

• 제어로봇시스템학회논문지
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• 제10권7호
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• pp.590-596
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• 2004

A passivity-based dynamic output feedback controller design is considered for a finite collection of non-square linear systems. Design of a single controller for a set of plants i.e. simultaneous stabilization is an important issue in the area of robust control design. We first determine a squaring gain matrix and an additional dynamics that is connected to the systems in a feedforward way, then a static passivating control law is designed. Consequently, the actual feedback controller will be the static control law combined with the feedforward dynamics. A necessary and sufficient condition for the existence of the parallel feedforward compensator is given by the static output feedback formulation. In contrast to the previous result [1], a technical condition for constructing the parallel feedforward compensator is removed by proposing a new type of the parallel compensator.