• Title/Summary/Keyword: simple GA

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Tumor Imaging by Monoclonal Antibodies Labeled with Radioactive Metal Ions

  • Endo, K.;Sakahara, H.;Nakashima, T.;Koizumi, M.;Kunimatsu, M.;Ohta, H.;Furukawa, T.;Ohmomo, Y.;Arano, Y.;Yokoyama, A.;Okada, K.;Yoshida, O.;Hosoi, S.
    • The Korean Journal of Nuclear Medicine
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    • v.18 no.2
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    • pp.77-85
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    • 1984
  • Monoclonal antibodies have become widely investigated in the Nuclear Oncology, especially in the radioimmunosassay of tumor markers and in vivo radioimmunoimaging of cancer. However, there are numerous factors as to whether radioimmunoimaging will ultimately successful. For imaging of tumors, metallic radionuclides such as In-111, Ga-67, Tc-99m have favorable nuclear properties than widely used I-131. These radioistopes have characteristics of the useful radiation for imaging, convenient short half-lives and the simple and rapid radiolabeling of monoclonal antibodies by using bifunctional chelaing agents. The obtained chelate-tagged antibodies are quite stable both in vitro and in vivo, without interfering antibody activities and animal experiments provided a good basis for its clinical applicability for the radioimmunoimaging of cancer. Much attention has also been given to the possibility, only beginning to be exploited, of the specific treatment of malignant neoplasms with these agents. Although specific antibody has not been developed that is uniquely specific for cancer alone and there are still many questions to be answered and problems to be overcome before radioimmunoimaging can be successfully used in ptients with cancer, these methods can be applied to the coupling of monoclonal antibodies with anti-neoplastic drugs or radionuclides suitable for internal radiation therapy of cancer.

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A Study on assortment of Sim-Eui Form in Chosun Dynasty Period (조선시대 심의 유형에 관한 연구)

  • Chung Hye-Gyung;Kwon Young-Suk;Choi Eun-Joo;Moon Myeng-Ok
    • Journal of the Korean Society of Clothing and Textiles
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    • v.13 no.1 s.29
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    • pp.35-42
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    • 1989
  • The purpose of this study is to assort Sim-Eui form in Chosun Dynasty Period, so that we considered pictures of Sim-Eui in literature, portraits, and Sim-Eui. The results obtained are as follows; 1. Considering that United Sinla Period was related deeply to Tang Period, it is assumed that Sim-Eui was already transmitted in United Sinla Period. 2. Sim-Eui form was assorted roughly into two group, Straight line collar Sim-Eui (Gik-Ryeong Sim-Eui) and Sguare collar Sim-Eui (Bang-Ryeong Sim-Eui). The former was made to closs collars but not similar to carpenters sguare (Gop-Ja). The latter was made by Bek Gyum-Han at the begining, by the way it was not used widely. Then again Chun-Hu made the Sguare collar Sim-Eui in 19 c, it was used widely with Straight line collar Sim-Eui. 3. Sim-Eui in $\ulcorner$Ga-Rye-Bu-Chuei$\lrcorner$ was similar to those days Chullick, that verifies the Sim-Eui's influence on Chullick. 4. There was new simple Sim-Eui in $\ulcorner$Sa-Rye-Jip-Yo$\lrcorner$, it was similar to large sleeve's Durumagi, Heng-Eui. 5. Sim-Eui was sustituted by Gik-Ryeong Eui, Dap-Ho, Dan-Ryeong, Do-Po, Heng-Eui.

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Development of DVD Player Design for the Film Generation (영상세대를 위한 DVD 플레이어 디자인 개발)

  • Ryoo, Ga-Yong
    • The Journal of the Korea Contents Association
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    • v.9 no.11
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    • pp.120-129
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    • 2009
  • It is now the digital and multi-media era. The DVD market is growing constantly. So is the capacity and quality of DVD players, In our research, we focused on the younger generation, who are now the greatest consumers. The results helped signify the most distinctive and popularized DVD player designs that satisfy young people's entertainment needs. Our new design is a large step ahead of older ones. Previous designs were uniform and standard. This new design has distinctive features and is uniquely user-friendly. It is focused primarily on easy usability. The interface is simple and straight forward. The user can use the system easily before consulting a manual. It is consistent in internal and external software and hardware, allowing the user to easily adapt to the product. DVD players have become a necessity in the current multi-media/digital era. So products need to be geared towards being available to not just those who are technologically savvy, but also those who rely on basic user-intuition. Our design takes into account these conditions, based on our statistical research, allowing us to expect our product to be a competitive force in the DVD market.

Development of Approximate Cost Estimate Model for Aqueduct Bridges Restoration - Focusing on Comparison between Regression Analysis and Case-Based Reasoning - (수로교 개보수를 위한 개략공사비 산정 모델 개발 - 회귀분석과 사례기반추론의 비교를 중심으로 -)

  • Jeon, Geon Yeong;Cho, Jae Yong;Huh, Young
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.33 no.4
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    • pp.1693-1705
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    • 2013
  • To restore old aqueduct in Korea which is a irrigation bridge to supply water in paddy field area, it is needed to estimate approximate costs of restoration because the basic design for estimation of construction costs is often ruled out in current system. In this paper, estimating models of construction costs were developed on the basis of performance data for restoration of RC aqueduct bridges since 2003. The regression analysis (RA) model and case-based reasoning (CBR) model for the estimation of construction costs were developed respectively. Error rate of simple RA model was lower than that of multiple RA model. CBR model using genetic algorithm (GA) has been applied in the estimation of construction costs. In the model three factors like attribute weight, attribute deviation and rank of case similarity were optimized. Especially, error rate of estimated construction costs decreased since limit ranges of the attribute weights were applied. The results showed that error rates between RA model and CBR models were inconsiderable statistically. It is expected that the proposed estimating method of approximate costs of aqueduct restoration will be utilized to support quick decision making in phased rehabilitation project.

Virtual Reality Based Cultural Tourist Attractions converging with Souvenir (수베니어를 융합한 가상현실 기반의 문화 관광지 가상체험 서비스)

  • Lee, Ga-Yeon;Lee, Seok-hyun
    • Journal of Convergence for Information Technology
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    • v.7 no.3
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    • pp.111-116
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    • 2017
  • This study offers the possibility as a new product of souvenirs from cultural tourist sites with virtual reality contents, instead of a simple exhibit. Users can watch augmented reality contents on souvenirs, and use the virtual experience service of cultural tourist sites with VR viewer. It has 4K-class high-quality $360^{\circ}$ image capture to increase the immersion of users in virtual space, implement virtual reality space and intuitive UI interaction with users using IMU (Inertial Measurement Unit). It is also possible to apply various add-on functions, including 3D contents, through technical development to increase its marketability, and apply in other industries. In addition, the prototype of the souvenir and VR viewer will be made by using a 3D printer and such in order to apply the contents which will be introduced in this study. Various product expansions can be considered through consultation with the relevant companies for the use of ready-made products.

Optimum Structural Design of Sinusoidal Corrugated Web Beam Using Real-valued Genetic Algorithm (실변수 유전자 알고리즘을 이용한 사인형 주름 웨브 보의 최적구조설계)

  • Shon, Su-Deok;Lee, Seung-Jae
    • Journal of Korean Society of Steel Construction
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    • v.23 no.5
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    • pp.581-593
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    • 2011
  • The underlying advantages of using thin-walled corrugatedwebs instead of plate girders with stiffeners are the elimination of instability problems associated with buckling of the thin-walled flat plate, and elimination of the need for transverse stiffeners, which alsoresults in economic advantages. This paper focuses on two aspects related to the structural design technique forsinusoidal corrugated web steel beams, and the optimum design of the beams using real-value genetic algorithms. The structural design process and design variables used in this optimization werecomposed with EN 1993-1-5, DASt-R015 standard and Pasternak et al. (2004), and the valid design capacity of shear buckling of the standards were compared. For the optimum structural design, the objective function, presented as the fullweight of the sinusoidal corrugated web beams, and the slenderness, member forces, and maximum deflection of the beam, were considered constraints. Finally, the simple beam under the uniform load was adopted as a numerical example, and the effective probability parameters of the genetic operators were considered to find the global minimum point.

Experimental Demonstration of Enhanced Transmission Due to Impedance-matching Si3N4 Layer in Perforated Gold Film

  • Park, Myung-Soo;Yoon, Su-Jin;Hwang, Je-Hwan;Kang, Sang-Woo;Kim, Deok-kee;Ku, Zahyun;Urbas, Augustine;Lee, Sang Jun
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.359-359
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    • 2014
  • In this study, surface plasmon resonance structures for the selective and the enhanced transmission of infrared light were designed. In order to relieve the large discontinuity of refractive index between air and metal hole array, $Si_3N_4$ was used as the impedance matching layer. Experimental parameter were calculated and determined in advance by the rigorous coupled wave analysis (RCWA) simulation, and then the experiment was carried out. A 2-dimensional metal hole array structures were patterned on the size of $1{\times}1cm^2$ GaAs substrate using photolithography process, and 5 nm thick Ti, 50 nm thick Au were deposited by E-beam evaporator, respectively. Subsequently, $Si_3N_4$ films with various thicknesses (150, 350, 550, and 750 nm) were deposited by plasma enhanced chemical vapor deposition (PECVD). For the comparison, transmittance of specimens with and without $Si_3N_4$ was measured using Fourier transform infrared spectroscopy (FTIR) in the range of $2.5-15{\mu}m$. Furthermore, the surface and the cross-sectional images were collected from the specimens by scanning electron microscopy (SEM). From the results, it was demonstrated that the transmittance was enhanced up to 80% by the deposition of 750 nm $Si_3N_4$ at $6.23{\mu}m$. It has advantage of enhanced transmission despite the simple fabrication process.

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Physiochemical Properties of Binary Pluronic Systems for Reversal of Multi-drug Resistant (MDR) Cancers

  • Yun, Jung-Min;Park, Ga-Young;Kim, Ha-Hyung;Lee, Jae-Hwi;Lee, Eun-Seong;Youn, Yu-Seok;Lee, Beom-Jin;Oh, Young-Taik;Oh, Kyung-Taek
    • Journal of Pharmaceutical Investigation
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    • v.40 no.4
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    • pp.255-261
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    • 2010
  • Pluronic as pharmaceutical excipients are listed in the US and British Pharmacopoeia. In particular, Pluronics exist as different compositions and display abundant phases as self-assembling into polymeric micelles with various morphologies depending on the aqueous solvent quality, the composition of structure, and hydrophilic-lipophilic balance (HLB). Pluronics were also known as a P-gp modulator, which was exploited as a reversal molecule of multi-drug resistant (MDR) cancers. We selected a lamella forming Pluronic L92 which has high hydrophobicity and relatively long PEO block among L series of Pluronics. The dispersion of L92 showed great size particles and low stability. To increase the stability and to decrease the particle size, secondary Pluronics (F68, F88, F98, F127, P85, P105, and P123) with relatively long PEO chain were added into 0.1 wt% Pluronic L92 dispersion. The stability of binary systems was increased due to incorporated long PEO chain. Their particle sizes slightly decreased to over 200~400 nm and their solubilization capacity of binary systems didn't change except Pluronic L92/P123 mixtures. The L92/P123 systems showed ca. 100 nm sizes and lowest turbidity among the all systems. The solubilization capacity of 0.1 wt% L92/0.1 wt% P123 was slightly increased compared to 0.1 wt% L92 mono system and other binary systems. These nano-sized binary systems may have potential as alternative drug delivery systems with simple preparation method and overcome the drawbacks of mono systems such as low stability and loading capacity.

A study on the screen printing of high definition used FM screen (FM Screen을 이용한 高精細 스크린 인쇄에 관한 연구)

  • Kim, Gi-Ho;Cho, Ga-Ram;Koo, Chul-Whoi
    • Journal of the Korean Graphic Arts Communication Society
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    • v.20 no.2
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    • pp.31-43
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    • 2002
  • Screen printing is a stencil process whereby ink is transferred to the substrate through a stencil supported by a fine fabric mesh. Therefore screen had a tendency to distort and swell, as ink was deposited between the fibers, and were difficult to clean. The tow importance of stencil parameters that affect print quality are stencil thread diameter and the fabric thickness because of their influence on both ink deposit and print definition. Since screen printing inks can be formulated to adhere to almost any surface, and the printing process itself can be handled almost any substrate in a wide variety of shape, screen printing is a very versatile process. The small size pronting is reproduced image used screen printing because the surface of substrates is not suited at screen printing method. In screen printing, the need of high definition printing is gradually increasing according to developing special inks. A conventional haftone, so called AM screening, is simple and easy to implement, but the haftone dot patterns by using this method are not free for the moire fringe. This paper is used densitometry and image analysis to investigate relation with printing according to screen mesh, opening size and resolution of copy in image reproduction used FM screen. We had the good result of dot gain and tone reproduction on the screen printing of high definition using FM screen.

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The Development of a Trial Curriculum Classification and Coding System Using Group Technology

  • Lee, Sung-Youl;Yu, Hwa-Young;Ahn, Jung-A;Park, Ga-Eun;Choi, Woo-Seok
    • Journal of Engineering Education Research
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    • v.17 no.4
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    • pp.43-47
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    • 2014
  • The rapid development of science & technology and the globalization of society have accelerated the fractionation and specialization of academic disciplines. Accordingly, Korean colleges and universities are continually dropping antiquated courses to make room for new courses that better meet societal demands. With emphasis placed on providing students with a broader range of choices in terms of course selection, compulsory courses have given way to elective courses. On average, 4 year institutions of higher learning in Korea currently offer somewhere in the neighborhood of 1,000 different courses yearly. The classification of an ever growing list of courses offered and the practical use of such data would not be possible without the aid of computers. For example, if we were able to show the pre/post requisite relationship among various courses as well as the commonalities in substance among courses, such data generated regarding the interrelationship of different courses would undoubtedly greatly benefit the students, as well as the professors, during course registration. Furthermore, the GT system's relatively simple approach to course classification and coding will obviate the need for the development of a more complicated keyword based search engine, and hopefully contribute to the standardization of the course coding scheme in the future..Therefore, as a sample case project, this study will use GT to classify and code all courses offered at the College of Engineering of K University, thereby developing a system that will facilitate the scanning of relevant courses.