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Radical Oncological Surgery and Adjuvan Therapy in Non-Small Cell Lung Cancer Patients over 70 years of Age

  • Demirci, Nilgun Yilmaz;Ulger, Sukran;Yilmaz, Ulku;Aydogdu, Koray;Yilmaz, Aydin;Erdogan, Yurdanur
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.11
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    • pp.4711-4714
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    • 2015
  • Background: The incidence of lung cancer increases with age. Approximately 50% of non-small cell lung cancer (NSCLC) patients are over 70 years old. Because of the increasing elderly population, treatment approaches in this age group continue to be studied similar to groups of young people. Materials and Methods: In the current study, 26 patients who underwent radical surgery and adjuvan chemoradiation at Ataturk Chest Diseases and Chest Surgery Training and Research Hospital were evaluated retrospectively. Results: Of 21 patients (81%) were male and the average age was 74.4. Lobectomy was performed in 18 cases, pneumonectomy in 3, sleeve lobectomy in 3 and bilobectomy in 2. There was no perioperative or early period mortality. Overall survival was 24.5 months. Conclusions: From our study, lung cancer surgery and adjuvant therapy can be performed safely with low morbidity in the elderly.

Optimization of Predictors of Ewing Sarcoma Cause-specific Survival: A Population Study

  • Cheung, Min Rex
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.10
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    • pp.4143-4145
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    • 2014
  • Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) Ewing sarcoma (ES) outcome data. The aim of this study was to identify and optimize ES-specific survival prediction models and sources of survival disparities. Materials and Methods: This study analyzed socio-economic, staging and treatment factors available in the SEER database for ES. 1844 patients diagnosed between 1973-2009 were used for this study. For the risk modeling, each factor was fitted by a Generalized Linear Model to predict the outcome (bone and joint specific death, yes/no). The area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. Results: The mean follow up time (S.D.) was 74.48 (89.66) months. 36% of the patients were female. The mean (S.D.) age was 18.7 (12) years. The SEER staging has the highest ROC (S.D.) area of 0.616 (0.032) among the factors tested. We simplified the 4-layered risk levels (local, regional, distant, un-staged) to a simpler non-metastatic (I and II) versus metastatic (III) versus un-staged model. The ROC area (S.D.) of the 3-tiered model was 0.612 (0.008). Several other biologic factors were also predictive of ES-specific survival, but not the socio-economic factors tested here. Conclusions: ROC analysis measured and optimized the performance of ES survival prediction models. Optimized models will provide a more efficient way to stratify patients for clinical trials.

Salivary Gland Tumors: A Clinicopathologic Study of 366 Cases in Southern Iran

  • Jaafari-Ashkavandi, Zohreh;Ashraf, Mohammad-Javad;Moshaverinia, Maryam
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.27-30
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    • 2013
  • Background: Salivary gland tumors (SGT) are one of the most complex human neoplasms, demonstrating variations in their clinicopathological profile related to racial and geographic differences. Few studies with large samples have been reported in Iran. We here investigated a large group of patients in southern Iran. Materials and Methods: In this retrospective study, all cases of primary epithelial salivary gland tumors, which had been recorded in a 5 years period from 2005-2009, were enrolled. Clinical data such as histopathologic type and site of the lesion as well as patients' age and gender were analyzed. Results: Data of 366 cases of SGTs were recorded. Pleomorphic adenoma (80.2%) and adenoid cystic carcinoma (46.6%) were the most common benign and malignant neoplasms. Male to female ratio (M/F) and the mean age of patients were 1:1.05 and 37.7 for benign tumors while they were 1.2:1 and 50.6 for malignant tumors, respectively. Parotid and minor salivary glands were involved more frequently. Conclusions: Although the salivary gland tumours encountered were similar in most of their characteristics to those reported in other countries, some differences such as relative frequency and age and gender prevalence were discovered. These findings should help surgeons and pathologists for more accurate diagnosis, management and treatment.

Does Microinvasive Adenocarcinoma of Cervix Have Poorer Treatment Outcomes than Microinvasive Squamous Cell Carcinoma?

  • Ruengkhachorn, Irene;Hanamornroongruang, Suchanan;Leelaphatanadit, Chairat;Sangkarat, Suthi
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.8
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    • pp.4013-4017
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    • 2016
  • Background: To compare the pathological findings and oncologic outcomes of stage IA cervical carcinoma patients, between adenocarcinoma and squamous cell carcinoma cases. Materials and Methods: A total of 151 medical records of stage IA cervical carcinoma patients undergoing primary surgical treatment during 2006-2013 were reviewed. Information from pathological diagnosis and recurrence rates were compared with descriptive statistical analysis. The Kaplan-Meier method and Cox proportional hazards model were used for survival analysis. Results: The median age was 48.9 years. There was no significant difference in rates of lymph node, parametrium, uterine, vaginal, or ovarian metastasis, when comparing adenocarcinoma with squamous cell carcinoma. Overall recurrence rates of adenocarcinoma (5.7%) and squamous cell carcinoma (2.6%) were not statistically significant different, even when stratified by stage. When comparing progression free survival with squamous cell carcinoma, adenocarcinoma had an HR of 0.448 (0.073-2.746), p=0.386. Conclusions: Microinvasive adenocarcinoma of cervix has similar rate of extracervical involvement and oncologic outcomes to squamous cell carcinoma.

Multi-Termination Technique for the Measurement of Characteristic Impedance and Propagation Constant of Sound Absorbing Materials Using an Impedance Tube

  • Lee, Jong-Hwa;Ih, Jeong-Guon
    • The Journal of the Acoustical Society of Korea
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    • v.25 no.2E
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    • pp.79-84
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    • 2006
  • Acoustic characteristics of a sound absorbing material can be identified, if the characteristic impedance and propagation constants are known, which have generally been determined experimentally. One easy method determining these two essential parameters is to measure the one dimensional wave characteristics in the impedance tube. In th udy, the effects of backing conditions on the impedance tube measurement have been examined using several pairs of generally used end conditions. The results showed that the measured values are similar for most pairs of end conditions: however, it was observed that the measured characteristic impedance for different thickness did not agree well for some pairs. In this work, the multi termination method, using three or more known backing con ns, was suggested to reduce such random errors, which are mostly caused by the test procedure. Employing three terminations as a set, comprised of a rigid end, an end with porous material, and an end with a backing cavity, it was demonstrated that improved measured results could be obtained for an open cell PU foam varying widely with three different thicknesses.

A Study on Texture Suited for the Acryl Knitted Jacket of Women in the Middle Age (중년 여성용 아크릴 니트 재킷에 적합한 조직에 관한 연구)

  • Choi, Jin-Hee
    • The Research Journal of the Costume Culture
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    • v.17 no.1
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    • pp.15-27
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    • 2009
  • The purpose of this study was to find texture which suitable for the acryl knitted jacket of women in the middle age. The study was carried out 2 parts. The first part was to choose the pattern fitted in the body shape of women in the middle age, and the second part was wearing test with 3 different textured acryl knitted jacket(half milano, milano, jacquard). The usable data of the test were coded for further statistical analysis including descriptive statistics (frequency and one way-ANOVA test, Student-Newman-Keuls Multiple Range Test) by using SPSSWIN 12.0. The results were as follows: It was found that first evaluation for the appearance test on fitness, pattern B(Brand: Morado) were better than the rest of them(pattern A: Trieste, pattern C: Escalier). It was found that second evaluation for the test, jacket with jacquard were better than the rest of them. Acryl knitted Jacket of women in the middle age should made of jacquard. Therefore it should be designed as possible as considering the physical characteristics of knitted materials. It was found that third evaluation for the test, it was opposite results that a general knitted fabric pattern was made smaller than a woven jacket. So, it was necessary that the acryl knitted jacket of women in the middle age follow a similar site tolerance such as a woven jacket. This result was due to a radical change of a middle age women's body shape.

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Transition process and Architectural composition of Prime Jurisdiction office in Joseon Dynasty (조선시대 의금부(義禁府) 청사(廳舍)의 변화 과정과 건축 공간 구성)

  • Bae, Chang-Hyun
    • Journal of architectural history
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    • v.29 no.5
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    • pp.29-40
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    • 2020
  • Ui-Gum-Bu(義禁府) is regarded as a key organization that reflects the power of the royal authority, mainly because it directly obeys the king's command and retains the power to punish or pardon government officials for severe crimes such as treason or significant breach of Confucian ethics. For this reason, Ui-Gum-Bu held a higher place in the organizational hierarchy of the government than other similar offices such as Hyung-Jo(刑曹), Sa-Heon-Bu(司憲府) and P o-Do-Cheong(捕盜廳). This characteristic of Ui-Gum-Bu is also evident in the architectural style and composition of the office building. The figures of the Ui-Gum-Bu office is depicted in detail in the paintings listed in 『Gum-Oh-Gye-Cheop(金吾契帖』, a record of Ui-Gum-Bu office meetings, and descriptions in the code book 『Gum-Oh-Hun-Rog(金吾契帖)』, both written in 18th century. The purpose of this study is to reveal the overall transition process of the Ui-Gum-Bu office building from the beginning until its demolition in the early 20th century. Based on research materials of 18th century, its architectural composition and characteristics will be dealt in detail.

Histochemical and Ultrastructural Study on the Digestive Tract of a Land Snail Nesiohelix samarangae (동양달팽이의 소화관에 대한 조직화학적 및 미세구조적 연구)

  • 정계헌;이용석
    • The Korean Journal of Malacology
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    • v.14 no.2
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    • pp.131-147
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    • 1998
  • A histochemical and ultrastructural study on the epithelia of some selected digestive tracks such as esophagus, crop, intestine of a land snail N. samarangae was carried out during the period of June 1997 to may 1998. The epithelium of digestive tract are simple columnar epithelium and consisted of five types of columnar cells. Type 1 cell which is majority in number has a brush border with microvilli on the free surface of the cell and contains numerous secretory granules supposed to be neutral mucopolysaccharide. Type 2 cell, elongated conical in shape, is rarely found in the epithelium. This cell also has a brush border with microvilli on its free surface and contains well developed rough surfaced endoplasmic reticulum, Golgi bodies, and secretory granules in various electron densities. This cell seems to produce both of acid and neutral mucopolysaccharides. Type 3 cell, which is morphologically similar to the Type 1 cell, has microvilli and cilia on the free surface and exists in group only in the limited regions of the intestine. Type 4 cell, typical goblet cell containing secretory granules in high electron density. Type 5 cell rarely found in the digestive tract. This cell contain inconspicuous materials.

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Corrosion Assessment by Using Risk-Based Inspection Method for Petrochemical Plant - Practical Experience

  • Choi, Song-Chun;Song, Ki-Hun
    • Corrosion Science and Technology
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    • v.8 no.3
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    • pp.119-125
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    • 2009
  • Corrosion assessment has a number of uses but the use considered here is as a precursor to Risk-Based Inspection (RBI) planning. Systematic methods consisting of technical modules of RBI program were used to assess the effect of specific corrosion mechanism on the probability of failure in equipments of petrochemical plants. Especially in part of the damage and corrosion assessment, screening step involved evaluating the combinations of process conditions and construction materials for each equipment item in order to determine which damage mechanisms are potentially active. For general internal corrosion, either API 510 or API 570 was applied as the damage rate in the calculation to determine the remaining life and inspection frequency. In some cases, a measured rate of corrosion may not be available. The technical modules of RBI program employ default values for corrosion, typically derived from published data or from experience with similar processes, for use until inspection results are available. This paper describes the case study of corrosion and damage assessment by using RBI methodology in petrochemical plant. Specifically, this paper reports the methodology and the results of its application to the petrochemical units using the $KGS-RBI^{TM}$ program, developed by the Korea Gas Safety Corporation to suit Korean situation in conformity with API 581 Codes.

Nonlinear large deformation dynamic analysis of electroactive polymer actuators

  • Moghadam, Amir Ali Amiri;Kouzani, Abbas;Zamani, Reza;Magniez, Kevin;Kaynak, Akif
    • Smart Structures and Systems
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    • v.15 no.6
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    • pp.1601-1623
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    • 2015
  • Electroactive polymers have attracted considerable attention in recent years due to their sensing and actuating properties which make them a material of choice for a wide range of applications including sensors, biomimetic robots, and biomedical micro devices. This paper presents an effective modeling strategy for nonlinear large deformation (small strains and moderate rotations) dynamic analysis of polymer actuators. Considering that the complicated electro-chemo-mechanical dynamics of these actuators is a drawback for their application in functional devices, establishing a mathematical model which can effectively predict the actuator's dynamic behavior can be of paramount importance. To effectively predict the actuator's dynamic behavior, a comprehensive mathematical model is proposed correlating the input voltage and the output bending displacement of polymer actuators. The proposed model, which is based on the rigid finite element (RFE) method, consists of two parts, namely electrical and mechanical models. The former is comprised of a ladder network of discrete resistive-capacitive components similar to the network used to model transmission lines, while the latter describes the actuator as a system of rigid links connected by spring-damping elements (sdes). Both electrical and mechanical components are validated through experimental results.