• Title/Summary/Keyword: similar materials

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Innovative Modeling of Explosive Shock Wave Assisted Drug Delivery (고에너지물질에 의한 약물 전달 시스템 연구)

  • Yoh, Jai-Ick;Kim, Ki-Hong;Lee, Kyung-Cheol;Lee, Hyun-Hee;Park, Kyoung-Jin
    • Journal of the Korean Society of Combustion
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    • v.11 no.4
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    • pp.9-13
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    • 2006
  • Recent advances in energetic materials modeling and high-resolution hydrocode simulation enable enhanced computational analysis of bio-medical treatments that utilize high-pressure shock waves. Of particular interest is in designing devices that use such technology in medical treatments. For example, the generated micro shock waves with peak pressure on orders of 10 GPa can be used for treatments such as kidney stone removal, transdermal micro-particle delivery, and cancer cell removal. In this work, we present a new computational methodology for applying the high explosive dynamics to bio-medical treatments by making use of high pressure shock physics and multi-material wave interactions. The preliminary calculations conducted by the in-house code, GIBBS2D, captures various features that are observed from the actual experiments under the similar test conditions. We expect to gain novel insights in applying explosive shock wave physics to the bio-medical science involving drug injection. Our forthcoming papers will illustrate the quantitative comparison of the modeled results against the experimental data.

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Dimensional Stability of Plastic Processing Wood Material - Compression Wood and Bentwood -

  • Hwang, Kweon-Hwan;Lee, Won-Hee
    • Journal of the Korea Furniture Society
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    • v.18 no.2
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    • pp.143-146
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    • 2007
  • This study was carried out to assess the dimensional stability of wood material treated by plastic processing for bentwood and compression wood. The evaluation method was different between two wood materials, but the treatments for them were very similar to each other. One of the main methods is heat treatment with sufficient water vapor. In bentwood, the used species were painted maple (Acer mono), bitter wood (Picrasma quassioides) and birch (Betula schmidtii). Steaming was the worst treatment method for dimensional stabilization of bentwood. The best results could be attained with PEG treatment for dimensional stabilization of bentwood. Dimensional stability of bitter wood was found to be conspicuous. However the steaming treatment at lower temperatures, i.e., about $130^{\circ}C$ was not suitable for dimensional stability of bentwood. In compression wood, the used specimen was Italian poplar wood (Populus euramericana). Two heat compressive pressing conditions, an open-press system and an air-tighten closed-press system, were used. The recovery rate was measured after boiling and/or absorbing in water to estimate the dimensional stability of heat compressed wood. The best dimensional stability of compressed wood in the air-tighten closed-press system was found to be better at $200^{\circ}C$ than $180^{\circ}C$. The best compression rate for dimensional stability was 73 percent.

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Effect of Fabric Properties used for the Loop Type Decorative Elements on the 3-dimensional Shape

  • Ko, Youngmin;Kim, Jongjun
    • Journal of Fashion Business
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    • v.17 no.3
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    • pp.30-47
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    • 2013
  • In the modern fashion industry, efficiency has been increasing thanks to development of computer graphics, IT technology, and digitalization. Unlike the past when fashion design heavily depended on handwork, digitalization of fashion industry makes fabrication time shorter and enables designers to adopt comprehensive expression, generating high value-added product. The Apparel CAD, an example of the digitalized fashion industry, has been developed from 2D system into a system providing 3D simulation. Digital clothing can be determined as an activity of designers using the tool in order to fabricate pattern and simulate its designed clothes in the virtual space of computer. In this study, physical properties of eight materials, which can be utilized on a par with current fashion trend, have been specified. For more sophisticated investigation, external appearance of the material was investigated by 3D scanning. In order to examine the physical properties of fabric specimens, KES(Kawabata Evaluation System) measurements and other physical property measurements were made. With the results, virtual material and clothes were simulated via CLO 3D, one of 3D apparel CAD systems. Then, virtual fabrics and clothes of similar types were generated and analyzed.

Trace Metals in Surface Seawaters and Mussels around the Dokdo, Korea

  • Kim, Kyung-Tae;Kim, Eun-Soo;Lee, Soo-Hyung;Cho, Sung-Rok
    • Ocean and Polar Research
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    • v.24 no.4
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    • pp.399-406
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    • 2002
  • Trace metals were investigated for the surface seawaters and mussels collected in adjacent sea to the Dokdo during 1999-2000. This study reports the temporal and spatial distributions of trace metals in seawaters and mussels of the Dokdo coastal areas. Clean technique for trace metal analyses was employed in all manipulations including the sampling and pretreatment procedures. The concentrations of dissolved Cu, Cd and Pb in the surface seawaters were similar to those of the previous data in the East Sea. Contents of particulate Al, Fe, Mn and Co were influenced by input of detrital materials from the Dokdo. The average EFs of particulate metals were to the order of Cd > Zn > Pb > Cu > Ni > Mn > Co > Fe, and the high values in Cd and Zn may be closely related to the preferential uptake of biogenic particles. With the exception of Cd, all metal contents in the mussels were in the same ranges with those from other world coastal areas. The Cd accumulation factor of mussel/seawater in this study was abnormally much higher than previous data from the Korean coasts.

A Comparison of Patient Controlled Analgesia and P.R.N. Intramuscular Injection for Postoperative Pain Control in Children and Adolescents (소아환자의 수술후 P.R.N. 근주와 PCA의 제통효과의 비교)

  • Lee, Kang-Chang
    • The Korean Journal of Pain
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    • v.11 no.1
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    • pp.69-73
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    • 1998
  • Background: The postoperative pain in children and adolescents is most commonly managed by intramuscular injections of NSAIDs or opioids. This approach may result in fluctuating plasma drug levels and cycles of pain, comfort, and sedation. Patient-controlled analgesia(PCA) is a method of analgesia administration that consists of a computer-driven pump with a button that the patient may press to administer a small dose of analgesic drug. Materials & Methods: Forty ASA physical status 1 or 2 children and adolescents were divided into two groups. In the PRN group, patients received intramuscularly diclofenac(Valentac$^{(R)}$) on a p.r.n. basis. The PCA group patients received a mixture of nalbuphine and ketorolac by WalkMed$^{(R)}$PCA infusor. Analgesic efficacy was evaluated with NRS(numerical rating scale) and Faces Pain Rating Scale. The side effects were evaluated. Results: The patients of PCA group had less pain than those of PRN group. Complications were similar in both group. Conclusions: PCA with nalbuphine and ketorolac is a safe and effective methods of pain relief in children and adolescents after surgery, and is better accepted than intramuscular injections.

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FGM micro-gripper under electrostatic and intermolecular Van-der Waals forces using modified couple stress theory

  • Jahangiri, Reza;Jahangiri, Hadi;Khezerloo, Hamed
    • Steel and Composite Structures
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    • v.18 no.6
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    • pp.1541-1555
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    • 2015
  • In this paper mechanical behavior of the functional gradient materials (FGM) micro-gripper under thermal load and DC voltage is numerically investigated taking into account the effect of intermolecular forces. In contrary to the similar previous works, which have been conducted for homogenous material, here, the FGM material has been implemented. It is assumed that the FGM micro-gripper is made of metal and ceramic and that material properties are changed continuously along the beam thickness according to a given function. The nonlinear governing equations of the static and dynamic deflection of microbeams have been derived using the coupled stress theory. The equations have been solved using the Galerkin based step-by-step linearization method (SSLM). The solution procedure has been evaluated against available data of literature showing good agreement. A parametric study has been conducted, focusing on the combined effects of important parameters included DC voltage, temperature variation, geometrical dimensions and ceramic volume concentration on the dynamic response and stability of the FGM micro-gripper.

Profile of Colorectal Polyps: a Retrospective Study from King Fahad Hospital, Madinah, Saudi Arabia

  • Albasri, Abdulkader;Yosef, Hala;Hussainy, Akbar;Bukhari, Saud;Alhujaily, Ahmed
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2669-2673
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    • 2014
  • Aim: To evaluate the predominant colorectal polyps in the Almadinah region of Saudi Arabia. Materials and Methods: In this iretrospective study, we analyzed pathology reports of colonoscopies performed in King Fahad Hospital, Madinah, Saudi Arabia during the period 2006 to 2013. Data based on patient age, gender, size, site and type of polyps and the degree of dysplasia were analyzed by software SPSS 17 and compared with other published studies from different geographic regions of the world. Results: During these years, 224 patients had colonic polyps, of whom 149 (66.5%) were men and 75 (33.5%) were women. The most common types of polyps were adenomatous (166), followed by hyperplastic polyps (24), juvenile (18), inflammatory (13), lipomatous (2) and one patient with Peutz-Jegher polyps. Tubulovillous adenoma was the commonest adenomatous polyp (102), followed by tubular (41) and villous (23) types. The sigmoid colon was the most commonly involved region (36.6%). Dysplasia was significantly associated with female patients who had large size tubulovillous polyps located in the left colon. Conclusions: The type and distribution of colorectal polyps in Saudi Arabia is very similar to Western countries. Patient gender, and size, histological type and location of polyps are closely related to dysplastic change in colonic polyps.

Prognostic Significance of Peripheral Blood Flow Cytometry Parameters in Patients with Non-Metastatic Breast Cancer

  • Engin, Huseyin;Bilir, Cemil;Tekin, Ishak Ozel
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7645-7649
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    • 2013
  • Background: Immune functions and their relation to prognosis in breast cancer patients have become areas of great interest in recent years. Correlations between survival outcomes and peripheral blood flow cytometry parameters are therefore of interest. Here we focused on patients with non-metastatic breast cancer (BC). Materials and Methods: A total of 29 patients with pathological confirmed breast carcinoma and flow cytometry data were assessed for overall survival (OS) and progression free survival (PFS). Results: The median age of the patients was 54 years (range, 29-83). Multivariate analysis revealed that OS was significantly associated with absolute cytotoxic T cell count (95%CI, coef 2.26, p=0.035), tumor size (95%CI, coef -14.5, p 0.004), chemotherapy (95%CI, coef 12.9, p 0.0001), MFI of CD4 (95%CI, coef -5.1, P 0.04), MFI of HLA DR (95%CI, coef -5.9, p 0.008) and tumor grade (95%CI, coef -13, P 0.049) with R-Sq(adj)=67%. Similar findings were obtained for PFS. Conclusions: OS and PFS were significantly associated with tumor grade, tumor size, chemotherapy, MFI of CD4, HLA DR and absolute cytotoxic T cell count. The study revealed that MFI of basic CD markers and absolute cytotoxic T cell number may be a prognostic factors in women with non-metastatic BC.

Estimating dehalogenation reactivity of nanoscale zero-valent iron by simple colorimetric assay by way of 4-chlorophenol reduction

  • Mines, Paul D.;Kaarsholm, Kamilla M.S.;Droumpali, Ariadni;Andersen, Henrik R.;Hwang, Yuhoon
    • Environmental Engineering Research
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    • v.25 no.2
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    • pp.197-204
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    • 2020
  • A number of different nanoscale zero-valent iron (nZVI) materials have been prepared and compared depending on the desired properties for the particular application, but different physicochemical properties of this prepared nZVI make it difficult to universally compare and standardize them to the same scale. In this study, we aimed to demonstrate a simple microplate-based colorimetric assay using 4-chlorophenol as an indicator with respect to the remediation of real treatment targets, such as trichloroethylene (TCE), 1,1,1-trichloroethane (TCA), and atrazine. Effect of nickel contents on 4-chlorophenol reduction was successfully investigated by the miniaturized colorimetric assay. In the same manner, the effect of nickel contents on dehalogenation of TCE, TCA, and atrazine was investigated and the pseudo-first-order kinetic constants were compared with the results for 4-chlorophenol. The similar pattern could be observed between 4-chlorophenol reduction obtained by colorimetric assay and TCE, TCA, atrazine reduction obtained by a traditional chromatographic method. The reaction kinetics does not match perfectly, but the degree of reaction can be estimated. Therefore, the colorimetric assay can be a useful and simple screening tool to determine nZVI reactivity toward halogenated organics before it is applied to a particular remediation site.

A Study on the Characteristics of Microemulsion Containing Isoflavone (이소플라본을 함유한 마이크로에멀젼의 물성 연구)

  • Jeong, Noh-Hee;Moon, Young-Jin;Lee, Hyang-Woo;Kim, Hong-Soo
    • Journal of the Korean Applied Science and Technology
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    • v.19 no.1
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    • pp.56-62
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    • 2002
  • Microemulsion is stable to aggregation, sedimentation, fusion and has $3nm{\sim}200nm$ of particle size which is transparent and semitransparent. The isoflavone as a derivatives of Flavone is colorless crystalline compounds. It has similar basic structure to steroid materials which is hormone that acts to skin physiological phenomenon. On this study, we tried to search and demonstrate system content rate of dermal translocation system for cosmetics using O/W type microemulsion containing isoflavone. We manufactured O/W microemulsions by phase inversion emulsification method. It's was found that POE(20) monostearate with HLB value 14 caused microemulsion to be formed, which had $4nm{\sim}18nm$ of average diameter and $3nm{\sim}33nm$ of particle size distribution. Apparent viscosities of the microemulsions have increased in proportion to add surfactant dose.