• Journal of Microbiology and Biotechnology
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• 제30권1호
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• pp.85-92
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• 2020

One of the omega-3 essential fatty acids, docosahexaenoic acid (DHA), is a significant constituent of the cell membrane and the precursor of several potent lipid mediators. These mediators are considered to be important in preventing or treating several diseases. Resolvin D5, an oxidized lipid mediator derived from DHA, has been known to exert anti-inflammatory effects. However, the detailed mechanism underlying these effects has not yet been elucidated in human monocytic THP-1 cells. In the present study, we investigated the effects of resolvin D5 on inflammation-related signaling pathways, including the extracellular signal-regulated kinase (ERK)-nuclear factor (NF)-κB signaling pathway. Resolvin D5 downregulated the production of interleukin (IL)-6 and chemokine (C-C motif) ligand 5 (CCL5). Additionally, these inhibitory effects were found to be modulated by mitogen-activated protein kinase (MAPK) and NF-κB in lipopolysaccharide (LPS)-treated THP-1 cells. Resolvin D5 inhibited the LPS-stimulated phosphorylation of ERK and translocation of p65 and p50 into the nucleus, resulting in the inhibition of IL-6 and CCL5 production. These results revealed that resolvin D5 exerts anti-inflammatory effects in LPS-treated THP-1 cells by regulating the phosphorylation of ERK and nuclear translocation of NF-κB.

• 조명전기설비학회논문지
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• 제17권4호
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• pp.64-73
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• 2003

빌딩자동제어시스템은 여러 서브시스템의 통합을 통한 고도의 서비스 제공, 관리비의 절감 등을 효과적으로 실현할 수 있다. 통합운전의 전제조건은 표준 프로토콜을 가진 개방형 네트워크를 이용하여 합리적인 네트워크 설계에 있다. 따라서 본 논문에서는 BAS에 가장 걸림돌이 되었던 화재경보시스템(소방법 명칭)을 ANSI/FIA 709.1인 LonTalk 프로토콜을 이용하여 BAS에서의 통합을 위한 개념적인 새로운 설계방안을 제시하였다. 기존 시스템에서 사용되는 중계기를 대체하는 지능형제어모듈을 개발하고 이를 이용하여 개방된 지능형 화재경보시스템의 설계방안을 제안한 것이다. 이는 오보률의 저감 실현은 물론 빌딩의 통합운전에도 크게 기여할 것으로 판단된다.

• IMMUNE NETWORK
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• 제1권3호
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• pp.196-202
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• 2001

Backgorund: WEHI-231 B cell line is a representative model for $IgM^+$ mature B cells. To understand the signaling differences between mature and immature B cells, we compared the responsiveness of WEHI-231 and Bal 17 B cell lines to BCR cross-linking. Methods: The extents of tyrosine phosphorylation, ligand-induced internalization, and activation-induced cell death upon BCR cross-linking were compared in two cell lines. Results: Despite a higher expression of BCR, cross-linking of BCR on WEHI-231 cell evoked a weaker level of tyrosine phosphorylation and BCR endocytosis than Bal 17 cells. Furthermore, the endocytosed BCR could not enter the lysosomal compartment and stayed as peripheral spots in WEHI-231 cells. Conclusion: WEHI-231 cell showed preferred BCR-mediated signaling pathways leading to a reduced capability of antigen presentation as well as the enhanced apoptosis in comparision with Bal 17 cells. These results might reflect the signaling differences between mature and immature B cells.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1998년도 하계종합학술대회논문집
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• pp.74-77
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• 1998

We consider connection-oriented wireless cellular networks. These networks employ dedicated radio channels for the transmission of signaling information. A forward signaling channel is a common signaling channel assigned to carry the multiplexed stream of paging and channel allocation(virtual circuit allocation) packets from a base station to mobile stations. The delay levels experienced by paging and channel allocation packets have serious effect on the utilization level of the limited radio channel capacity. While a slotted mode operation is used to reduce the power consumption level at mobile stations, it may induce an increase in packet delay levels. In this paper, we thus consider a multiplexing scheme for paging and channel allocation packets under which slots are dynamically allocated for the paging packet transmission. For this dynamic scheme, we develop an analytical method for deriving the delay characteristics exhibited by paging and channel allocation packets, and investigate the effect of network parameters on the delay level by using this method.

• IMMUNE NETWORK
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• 제9권2호
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• pp.53-57
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• 2009

Engagement of the immunoreceptors initiates signaling cascades resulting in lymphocyte activation and differentiation to effector cells, which are essential for the elimination of pathogens from the body. For the transduction of these immunoreceptor-mediated signals, several linker proteins termed transmembrane adaptor proteins (TRAPs) were shown to be required. TRAPs serve as platforms for the assembly and membrane targeting of the specific signaling proteins. Among seven TRAPs identified so far, LAT and LIME were shown to act as a positive regulator in TCR-mediated signaling pathways. In this review, we will discuss the functions of LAT and LIME in modulating T cell development, activation and differentiation.

• BMB Reports
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• 제50권9호
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• pp.437-444
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• 2017

Different types of eukaryotic cells may adopt seemingly distinct modes of directional cell migration. However, several core aspects are regarded common whether the movement is either ameoboidal or mesenchymal. The region of cells facing the attractive signal is often termed leading edge where lamellipodial structures dominates and the other end of the cell called rear end is often mediating cytoskeletal F-actin contraction involving Myosin-II. Dynamic remodeling of cell-to-matrix adhesion involving integrin is also evident in many types of migrating cells. All these three aspects of cell migration are significantly affected by signaling networks of TorC2, TorC1, and PP2A/B56. Here we review the current views of the mechanistic understanding of these regulatory signaling networks and how these networks affect eukaryotic cell migration.

• IMMUNE NETWORK
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• 제11권4호
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• pp.223-226
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• 2011

Although exercise-induced growth factors such as Insulin-like growth factor-I (IGF-I) are known to affect various aspects of physiology in skeletal muscle cells, the molecular mechanism by which IGF-I modulates anti-inflammatory effects in these cells is presently unknown. Here, we showed that IGF-I stimulation suppresses the expression of toll-like receptor 4 (TLR4), a key innate immune receptor. A pharmacological inhibitor study further showed that PI3K/Akt signaling pathway is required for IGF-I-mediated negative regulation of TLR4 expression. Furthermore, IGF-I treatment reduced the expression of various NF-${\kappa}B$-target genes such as TNF-${\alpha}$ and IL-6. Taken together, these findings indicate that the anti-inflammatory effect of exercise may be due, at least in part, to IGF-I-induced suppression of TLR4 and subsequent downregulation of the TLR4-dependent inflammatory signaling pathway.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2005년도 추계학술대회 논문집
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• pp.1016-1020
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• 2005

The real-time monitoring and controlling between the interior and the field signaling security devices is a necessity for the train safety in terms of the train operating plan. The type wiring lower the safety level of signaling security device, because too much wiring makes the maintenance more difficult and it might be have a problem of an induction field and contact. It also need high cost. The single network communication(Fieldbus) does not need that much wiring, and the maintenance will be easier. It also guarantee the high level of stability.

• 한국산업정보학회논문지
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• 제17권1호
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• pp.31-38
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• 2012

Next generation cellular applications and smart phone usage generate very heavy wireless data traffic. It becomes ineluctable for mobile network operators to have multiple core network entities such as Serving Gateway and Packet Data Network Gateway in 4G-LTE to share this high traffic generated. A typical configuration consists of multiple serving gateways behind a load-balancer which would determine which serving gateway would service a end-users'request. Such hardware is expensive, has a rigid policy set, and is a single point of failure. Another perspective of today's increasingly high data traffic is that besides it is being widely accepted that the high bandwidth L TE provides is creating bottlenecks for service providers by the increasing user bandwidth demands without creating any corresponding revenue improvements, a hidden problem that is also passively advancing on the newly emerging 4G-LTE that may need more immediate attention is the network signaling traffic, also known as the control-plane traffic that is generated by the applications developed for smartphones and tablets. With this as starting point, in this paper, we propose a solution, by a new approach considering OpenFlow switch connected to a controller, which gains flexibility in policy, costs less, and has the potential to be more robust to failure with future generations of switches. This also solves the problem of scaling the control-plane traffic that is imperative to preserve revenue and ensure customer satisfaction. Thus, with the proposed architecture with OpenFlow, mobile network operators could manipulate the traffic generated by the control-plane signaling separated from the data-plane, besides also reducing the cost in installing multiple core-network entities.

• 대한한의학회지
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• 제45권1호
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• pp.114-125
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• 2024

Objectives: Network pharmacology is an analysis method that explores drug-centered efficacy and mechanism by constructing a compound-target-disease network based on system biology, and is attracting attention as a methodology for studying herbal medicine that has the characteristics for multi-compound therapeutics. Thus, we investigated the potential functions and pathways of Myrrha on Allergic Rhinitis (AR) via network pharmacology analysis and molecular docking. Methods: Using public databases and PubChem database, compounds of Myrrha and their target genes were collected. The putative target genes of Myrrha and known target genes of AR were compared and found the correlation. Then, the network was constructed using STRING database, and functional enrichment analysis was conducted based on the Gene Ontology (GO) Biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways. Binding-Docking stimulation was performed using CB-Dock. Results: The result showed that total 3 compounds and 55 related genes were gathered from Myrrha. 33 genes were interacted with AR gene set, suggesting that the effects of Myrrha are closely related to AR. Target genes of Myrrha are considerably associated with various pathways including 'Fc epsilon RI signaling pathway' and 'JAK-STAT signaling pathway'. As a result of blinding docking, AKT1, which is involved in both mechanisms, had high binding energies for abietic acid and dehydroabietic acid, which are components of Myrrha. Conclusion: Through a network pharmacological method, Myrrha was predicted to have high relevance with AR by regulating AKT1. This study could be used as a basis for studying therapeutic effects of Myrrha on AR.