• Journal of the Korea Academia-Industrial cooperation Society
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• 제13권9호
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• pp.4171-4176
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• 2012

The conventional block systems for railway signaling currently in operation in Korea have not been electrified or integrated and therefore there have been difficulties in terms of construction and maintenance. Two independent systems have been installed for ABS and LEU of ATP system (for speeded-up lines), although they deal with the same signaling information at the same location in order to control the trains. In these conventional ABS and LEU, a number of duplicate modules are installed in each device including lamp detection units and power supply units and it results increased manufacturing costs and maintenance efforts. This paper deals with the prototype development of integrated electronic block system with CPU-based digital control methods in order to overcome the limitations of the conventional ABS. The suggested system is the integration of the conventional ABS with LEU of ATP and it is also applicable for the non-ATP sections as well.

• Journal of The Korean Society For Urban Railway
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• 제6권4호
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• pp.427-436
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• 2018

HADAX is a serial communication converter of train control computer. It is connected with various signal equipments such as wayside signal equipments, station signal equipments, train control computers, and transmits control information and signal condition information for train control. And transmits information to several electronic interlocking devices through a splitter interface. Since HADAX interfaces with many signaling devices through serial communication, frequent communication connection faults necessitate improvement of performance such as dual system configuration, integration of external splitter, and multi-channelization of communication card. The improved HADAX device should have compatibility with the dimensions of existing enclosure and enclosure, and verify the performance of dual system and splitter integration. Therefore, we verified the performance of HADAX through the route control test, dual system test, and multi-channel communication test with splitter integrated connection by connecting with the existing signal equipment.

• Restorative Dentistry and Endodontics
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• 제37권3호
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• pp.142-148
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• 2012

Objectives: We analyzed gene-expression profiles after 14 day odontogenic induction of human dental pulp cells (DPCs) using a DNA microarray and sought candidate genes possibly associated with mineralization. Materials and Methods: Induced human dental pulp cells were obtained by culturing DPCs in odontogenic induction medium (OM) for 14 day. Cells exposed to normal culture medium were used as controls. Total RNA was extracted from cells and analyzed by microarray analysis and the key results were confirmed selectively by reverse-transcriptase polymerase chain reaction (RT-PCR). We also performed a gene set enrichment analysis (GSEA) of the microarray data. Results: Six hundred and five genes among the 47,320 probes on the BeadChip differed by a factor of more than two-fold in the induced cells. Of these, 217 genes were upregulated, and 388 were down-regulated. GSEA revealed that in the induced cells, genes implicated in Apoptosis and Signaling by wingless MMTV integration (Wnt) were significantly upregulated. Conclusions: Genes implicated in Apoptosis and Signaling by Wnt are highly connected to the differentiation of dental pulp cells into odontoblast.

• Journal of Communications and Networks
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• 제2권1호
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• pp.35-45
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• 2000

this paper presents the concept of "mobile ATM', a proposal for third-generation (3G) mobile communication network infrastructure capable of supporting flexible evolution of radio technologies from today's cellular and data services towards future wireless multimedia services. Mobile ATM provides generic mobility management and QoS-based transport capabilities suitable for integration of multiple radio access technologies including cellular voice. wireless data, and future broadband wireless services. The architecture of a mobile ATM network is outlined in terms of the newly-defined "W-UNI" interface at the radio link and "M-UNI"and "M-UNI" interface which supports unified access for WATM and non-ATM mobile terminals through corresponding interworking functions (IWF) is explained. leading to an understanding of how different radio access technologies are supported by the same ATM-based core network infrastructure. Generic mechanisms for handoff and location management within the core mobile network are discussed. and related protocol extensions over the "W-UNI" and "M-UNI/NNI"interfaces are proposed. the issue of "crossover switch (COS)" selection in mobile ATM is considered, and a unified handoff signaling syntax which supports flexibility in COS selection is described. Typical signaling sequences for call connection and handoff using the proposed protocols are outlined. Experimental results form a proof-of-concept mobile ATM network prototype are presented in conclusion.

• BMB Reports
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• 제35권1호
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• pp.7-18
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• 2002

The major function of the thymus is to eliminate developing thymocytes that are potentially useless or autoreactive, and select only those that bear functional T cell antigen receptors (TCRs) through fastidious screening. It is believed that glucocorticoids (GCs) are at least in part responsible for cell death during death by neglect. In this review, we will mainly cover the topic of the GC-induced apoptosis of developing thymocytes. We will also discuss how thymocytes that are fated to die by GCs can be rescued from GC-induced apoptosis in. response to a variety of signals with antagonizing properties for GC receptor (GR) signaling. Currently, a lot of evidence supports the notion that the decision is made as a result of the integration of the multiple signal transduction networks that are triggered by GR, TCR, and Notch. A few candidate molecules at the converging point of these multiple signaling pathyways will be discussed. We will particularly describe the role of the SRG3 protein as a potent modulator of GC-induced apoptosis in the crosstalk.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• 제22권12호
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• pp.115-121
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• 2008

The communication-based train control (CBTC) technology is a kind of railway signaling technologies and is to control the train operation through communication. A project adopting the CBTC technology is in progress and its object is to develop interoperable and interchangeable subsystems. Thus the purpose of this paper is on how to develop the required subsystems and integrate them successfully without sufficient design information at the system level. Accordingly this project shall require the integration and test at the system level. In order to do so, a top-level system specification shall be needed, which is not available in the current phase of the project. The main objective of the test and evaluation activities is to see whether the developed system meets the system specification. In this paper, we describe how the test and evaluation can be carried out based on the subsystems design specifications, considering the system architecture and the operation concept of the existing system as well.

• Proceedings of the Korean Information Science Society Conference
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• 한국정보과학회 2007년도 가을 학술발표논문집 Vol.34 No.2 (B)
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• pp.22-27
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• 2007

Phosphorylation is one of the most important post translational modifications which regulate the activity of proteins. The problem of predicting phosphorylation sites is the first step of understanding various biological processes that initiate the actual function of proteins in each signaling pathway. Although many prediction methods using single or multiple features extracted from protein sequences have been proposed, systematic data integration approach has not been applied in order to improve the accuracy of predicting general phosphorylation sites. In this paper, we propose an optimal way of integrating multiple features in the framework of multiple kernel learning. We optimally combine seven kernels extracted from sequence, physico-chemical properties, pairwise alignment, and structural information. Using the data set of Phospho. ELM, the accuracy evaluated by 5-fold cross-validation reaches 85% for serine, 85% for threonine, and 81% for tyrosine. Our computational experiments show significant improvement in the performance of prediction relative to a single feature, or to the combined feature with equal weights. Moreover, our systematic integration method significantly improves the prediction preformance compared with the previous well-known methods.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제7권3호
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• pp.461-467
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• 2003

This paper proposes the method of mobility implementation for location searching in the intelligence wireless ATM networks that expand and apply standard broadband signaling capabilities, and analyze the performance based on the numerical algorithm. The existing B-ISDN UNI protocol stack demands the location search mechanism to determine the location of mobile terminal in the wireless ATM networks because it use single protocol through the fixed PTP interface or PTM interface that don't support terminal mobility. The proposed method make possible the dynamic mobility at a part of wireless access by minimizing the signaling load without a falling-off in system performance by using the intelligence network technology according to the expansion of ATM and B-ISDN signaling integration based on the fixed networks. We implemented the performance analysis by MFC modeling based on numerical algorithm, and realized the efficiency of expenses by carrying out the comparative signaling performance evaluation to measure the relative gains of location search service in the intelligence wireless ATM system. The obtained results have the flexibility to operate in the public B-ISDN network environment without a change of existing B-ISDN/ATM NNI signaling reference to support the wireless ATM access system, and can easily expand to correspond to terminal mobility and various multimedia services in the next broadband PCS.

• Applied Chemistry for Engineering
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• 제32권6호
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• pp.647-652
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• 2021

In this study, Saussurea Lappa roots were extracted using ethanol and n-hexane, and also the effects on proliferation of human hair dermal papilla cells and fibroblast and related signaling pathway were evaluated. 3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide (MTT) assay was conducted for cell proliferation effect of Saussurea Lappa root extract, and extracellular signal-related kinase (ERK), serine/threonine protein kinase (Akt), wingless-related integration site (Wnt)/𝛽-catenin signaling pathway, and 5𝛼-reductase expression through western blot analysis were measured. Saussurea Lappa root extract significantly increased human hair dermal papilla cells and propagation of fibroblast, promoted phosphorylation of ERK and Akt that get involved in cell proliferation. Additionally, Saussurea Lappa root extract significantly decreased promotion of Akt phosphorylation and cell proliferation by MEK/ERK inhibitor PD98059 and PI3K/Akt inhibitor LY294002. Also, Saussurea Lappa root extract induced intranuclear 𝛽-catenin accumulation by promoting phosphorylation of 𝛽-catenin (Ser552, 675) through phosphorylation of GSK-3𝛽 (Ser9), and suppressed activation of 5𝛼-reductase type I and II. Overall, Saussurea Lappa root induces cell proliferation through vitalization of ERK and Akt route of human hair dermal papilla cells and fibroblast and apoptosis defense mechanism, and can be helpful in hair loss prevention and hair growth by vitalizing the 𝛽-catenin signaling pathway and inhibiting activation of 5𝛼-reductase, which can be used as a potential hair care products.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제2권4호
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• pp.171-183
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• 2008

Nowadays, wireless packet data services are provided over Wireless MAN (WMAN) at a high data service rate, while 3G cellular networks provide wide-area coverage at a low data service rate. The integration of mobile WiMAX and 3G networks is essential, to serve users requiring both high-speed wireless access as well as wide-area connectivity. In this paper, we propose a cross-layer optimization scheme for a vertical handover between mobile WiMAX and 3G cellular networks. More specifically, L2 (layer 2) and L3 (layer 3) signaling messages for a vertical handover are analyzed and reordered/combined, to optimize the handover procedure. Extensive simulations using ns-2 demonstrate that the proposed scheme enhances the performance of a vertical handover between mobile WiMAX and 3G networks: low handover latency, high TCP throughput, and low UDP packet loss ratio.