• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2005년도 생물공학의 동향(XVII)
• /
• pp.225-225
• /
• 2005

• 한국통신학회논문지
• /
• 제25권9A호
• /
• pp.1377-1386
• /
• 2000

As all delays resulting from the signaling network directly affect the response time of network management activity, all control informations have to be transported most efficiently. It is very important to know the performance of the signaling system not only because of smooth network operation but also because of efficient engineering of signaling networks. In this paper, we analyzed mean queueing delay of signaling link for ISUP signaling messages in common channel signaling system by using M[X]/G/1 and M[X]/D/1 batch arrival queueing system. This is because we modeled arrival process of the signaling messages as batch arrival process considering that many kinds of signaling messages are generated at short intervals when a call requests a connection. Analysis was carried out considering different call processing scenario based on ITU-T specification. We also described the numerical results from the different types of queueing models.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
• /
• 제3B권4호
• /
• pp.195-201
• /
• 2003

In accordance with the computerization of railway signaling systems, the interface link between signaling equipment has been replaced by a digital communication channel and the importance of this communication link has become increasingly significant. However, there are some problems with the present state of railway signaling. First, different communication protocol is applied to interfaces between signaling although they have the same functions. Next, the communication protocols currently used in the railway fields contain various illogical components such as structure, byte formation, error correction scheme and so on. To solve these matters, a new data link protocol for railway signaling systems is designed. In this paper, the structure of protocol and the results of performance analyses are presented. It will be expected to increase the safety, reliability and efficiency of maintenance of signaling systems by using the designed communication protocol for railway signaling in Korea.

• 한국정보처리학회논문지
• /
• 제4권7호
• /
• pp.1797-1803
• /
• 1997

공통선 신호방식에서 메시지처리기능은 다량의 신호트래픽을 전달지연이 없이 신호망내의 착신점으로 루팅하기 위한 기능으로써 실시간 처리가 가능 하여야 하며 데이타통신 서비스, 영상정보 서비스등 계속적으로 발생하는 다량의 트래픽에 대하여 그 처리능력이 탁월해야 한다. 본 논문에서는 다중 분산 메시지처리기 구조에서 실시간, 다량의 트래픽 처리를 위한 루팅기법을 제시하였다. 루팅은 신호링크선택코드를 이용하여 다수의 분산 메시지 처리기로 트래픽을 균등 분산하기 위한 시스템 내부 분산 루팅 기법과 신호망에서 다수의 신호루트로 신호트래픽을 분산 루팅하는 신호망 분산 루팅 기법으로 분류하였다. 이러한 루팅 기법을 적용함으로써 가용 신호루트의 고장, 비가용 신호루트의 복구와 같은 신호루트의 이상이 발생시 신호루트선택코드를 변경함으로서 신호트래픽의 효율적 루팅을 가능하게 하였다.

• 대한약리학회:학술대회논문집
• /
• 대한약리학회 2006년도 58th Annual Meeting of The Korean Society of Pharmacology
• /
• pp.41-41
• /
• 2006

• BMB Reports
• /
• 제47권10호
• /
• pp.540-545
• /
• 2014

Balanced cell growth is crucial in animal development as well as tissue homeostasis. Concerted cross-regulation of multiple signaling pathways is essential for those purposes, and the dysregulation of signaling may lead to a variety of human diseases such as cancer. The time-honored Wnt/${\beta}$-catenin and recently identified Hippo signaling pathways are evolutionarily conserved in both Drosophila and mammals, and are generally considered as having positive and negative roles in cell proliferation, respectively. While most mainstream regulators of the Wnt/${\beta}$-catenin signaling pathway have been fairly well identified, the regulators of the Hippo pathway need to be more defined. The Hippo pathway controls organ size primarily by regulating cell contact inhibition. Recently, several cross-regulations occurring between the Wnt/${\beta}$-catenin and Hippo signaling pathways were determined through biochemical and genetic approaches. In the present mini-review, we mainly discuss the signal transduction mechanism of the Hippo signaling pathway, along with cross-talk between the regulators of the Wnt/${\beta}$-catenin and Hippo signaling pathways.

• BMB Reports
• /
• 제47권7호
• /
• pp.361-368
• /
• 2014

Lipid components in biological membranes are essential for maintaining cellular function. Phosphoinositides, the phosphorylated derivatives of phosphatidylinositol (PI), regulate many critical cell processes involving membrane signaling, trafficking, and reorganization. Multiple metabolic pathways including phosphoinositide kinases and phosphatases and phospholipases tightly control spatio-temporal concentration of membrane phosphoinositides. Metabolizing enzymes responsible for PI 4,5-bisphosphate (PI(4,5)P2) production or degradation play a regulatory role in Toll-like receptor (TLR) signaling and trafficking. These enzymes include PI 4-phosphate 5-kinase, phosphatase and tensin homolog, PI 3-kinase, and phospholipase C. PI(4,5)P2 mediates the interaction with target cytosolic proteins to induce their membrane translocation, regulate vesicular trafficking, and serve as a precursor for other signaling lipids. TLR activation is important for the innate immune response and is implicated in diverse pathophysiological disorders. TLR signaling is controlled by specific interactions with distinct signaling and sorting adaptors. Importantly, TLR signaling machinery is differentially formed depending on a specific membrane compartment during signaling cascades. Although detailed mechanisms remain to be fully clarified, phosphoinositide metabolism is promising for a better understanding of such spatio-temporal regulation of TLR signaling and trafficking.

• Journal of Microbiology and Biotechnology
• /
• 제25권5호
• /
• pp.637-647
• /
• 2015

In this study, we attempted to understand signaling pathways behind lipid biosynthesis by employing a chemical genetics approach based on small molecule inhibitors. Specific signaling inhibitors of MAP kinase or modulators of cAMP signaling were selected to evaluate the functional roles of each of the key signaling pathways in three different microalgal species: Chlamydomonas reinhardtii, Chlorella vulgaris, and Haematococcus pluvialis. Our results clearly indicate that cAMP signaling pathways are indeed positively associated with microalgal lipid biosynthesis. In contrast, MAP kinase pathways in three microalgal species are all negatively implicated in both lipid and carotenoid biosynthesis.

• IMMUNE NETWORK
• /
• 제13권5호
• /
• pp.184-193
• /
• 2013

Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.

• International Journal of Safety
• /
• 제6권2호
• /
• pp.38-42
• /
• 2007

As railway signaling system is computerized, the significance on safety demonstration and assessment has been increased. Therefore, railway signaling system should reflect the needs for safety assessment technique. Various studies on safety assessment technique for railway signaling have been made in Europe and standardization of the requirements for safety acceptance has been initiated by IEC. In order to develop and establish the safety assessment techniques for railway signaling in Korea, we try to review safety assessment activities for signaling system via reviewing relevant case studies and consulting with experts. And also we propose the safety assessment activity/methodology for Korean railway signaling system.