• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.104-117
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• 2009

Objective : Melanin is one of the most important facor in skin color. Melanin protects human skin from ultraviolet radiation otherwise it causes melanin pigmentation. So this experiment is carried out for test whether Scutellaria baicalensis Georgi(SBG) inhibits melanin synthesis and tyrosinase activity in mouse B16 melanoma cells. Method : The melanin synthesis inhibition effects of SBG were examined by in vitro melanin production assay. We assessed inhibitory effects of SBG on melanin contents from B16F1 melanoma cell, on tyrosinase activity(cell and cell free system), effect of SBG on the expression tyrosinase, Microphthalmia-associated Transcription Factor(MITF), Extracellular signal-regulated Kinase(ERK). Result : SBG inhibited melanin synthesis induced $\alpha$-MSH($\alpha$-Melanin Stimulating Hormone) in B16F1. SBG inhibited tyrosinase activity and expression. And SBG down-regulates MITF and stimulated ERK activation in B16F1. Conclusion : According to above results, SBG was improved its suppression effect to the inhibition of melanin synthesis, tyrosinase activation, and tyrosinase promotor activation. So SBG is considered to be used for an strong source of skin whitening effect.

• The Journal of the Acoustical Society of Korea
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• v.43 no.1
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• pp.9-18
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• 2024

The importance of active sonar systems is emerging due to the quietness of underwater targets and the increase in ambient noise due to the increase in maritime traffic. However, the low signal-to-noise ratio of the echo signal due to multipath propagation of the signal, various clutter, ambient noise and reverberation makes it difficult to identify underwater targets using active sonar. Attempts have been made to apply data-based methods such as machine learning or deep learning to improve the performance of underwater target recognition systems, but it is difficult to collect enough data for training due to the nature of sonar datasets. Methods based on mathematical modeling have been mainly used to compensate for insufficient active sonar data. However, methodologies based on mathematical modeling have limitations in accurately simulating complex underwater phenomena. Therefore, in this paper, we propose a sonar signal synthesis method based on a deep neural network. In order to apply the neural network model to the field of sonar signal synthesis, the proposed method appropriately corrects the attention-based encoder and decoder to the sonar signal, which is the main module of the Tacotron model mainly used in the field of speech synthesis. It is possible to synthesize a signal more similar to the actual signal by training the proposed model using the dataset collected by arranging a simulated target in an actual marine environment. In order to verify the performance of the proposed method, Perceptual evaluation of audio quality test was conducted and within score difference -2.3 was shown compared to actual signal in a total of four different environments. These results prove that the active sonar signal generated by the proposed method approximates the actual signal.

• Smart Structures and Systems
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• v.8 no.3
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• pp.303-320
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• 2011

Comparing to active damage monitoring, impact localization on composite by using time reversal focusing method has several difficulties. First, the transfer function of the actuator-sensor path is difficult to be obtained because of the limitation that no impact experiment is permitted to perform on the real structure and the difficulty to model it because the performance of real aircraft composite is much more complicated comparing to metal structure. Second, the position of impact is unknown and can not be controlled as the excitation signal used in the active monitoring. This makes it not applicable to compare the difference between the excitation and the focused signal. Another difficulty is that impact signal is frequency broadband, giving rise to the difficulty to process virtual synthesis because of the highly dispersion nature of frequency broadband Lamb wave in plate-like structure. Aiming at developing a practical method for on-line localization of impact on aircraft composite structure which can take advantage of time reversal focusing and does not rely on the transfer function, a PZT sensor array based phase synthesis time reversal impact imaging method is proposed. The complex Shannon wavelet transform is presented to extract the frequency narrow-band signals from the impact responded signals of PZT sensors. A phase synthesis process of the frequency narrow-band signals is implemented to search the time reversal focusing position on the structure which represents the impact position. Evaluation experiments on a carbon fiber composite structure show that the proposed method realizes the impact imaging and localization with an error less than 1.5 cm. Discussion of the influence of velocity errors and measurement noise is also given in detail.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.3
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• pp.407-416
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• 2021

An active phased array antennas can not only electrically steer the beam by controlling the weighting of the excitation signal, but can also form a pattern null in the direction of the interference source. The weight of the excitation signal to steer the main beam can be easily calculated based on the position of the radiating element. In addition, the weight of the excited signal for pattern null formation can also be calculated by setting the required radiation pattern and using WLSM(Weighted Least Squares Method). However, in a general wireless communication network environment, the location of the interference source is unknown. Therefore, an adaptive pattern null synthesis is needed. In this paper, it was confirmed that pattern null synthesis according to the required radiation characteristic was possible. And based on this, adaptive pattern null synthesis into the direction of an interference source was studied using a binary search algorithm based on observation area. As a result of conducting a simulation based on the presented technique, it was confirmed that adaptive pattern null forming into the direction of an interference is possible in efficient way.

• YAKHAK HOEJI
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• v.41 no.5
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• pp.588-594
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• 1997

N-(tert-Butoxycarbonyl)-O-(dicyanoethylthiophosphono)-L-tyrosine(7), the key intermediate for the synthesis of thiophosphotyrosine-containing peptide derivat ives, was prepared. For the phosphorylation, we used t-Boc-tyrosine and phosphoramidite in the presence of 1H-tetrazol. For the protection of thiophosphate moiety, cyanoethyl protecting group was used. Thiophosphotyrosine-containing peptides could be used as tools for the elucidation of mechanism of signal transduction pathway and also prepared as PTK inhibitors, PTPase inhibitors and cytosolic protein binding blockers. It may be contributed for the development of potential anticancer agents.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.30A no.6
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• pp.49-57
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• 1993

In the paper, we describe the design of a pipelined datapath synthesis system for DSP applications. Taking SFG (Signal Flow Graph) in schematic as inputs, the system generates pipelined datapaths automatically through scheduling and module allocation processes. For efficient hardware synthesis, scheduling and module allocation algorithms are proposed. The proposed scheduling algorithm is of iterative/constructive nature, where the measure of equi-distribution of operations to partitions is adopted as the objective function. Module allocation is performed to reduce the interconnection cost from the initial allocation. In the experiment, we compare the results with those of other systems and show the effectiveness of the proposed algorithms.

• Journal of KIISE:Computer Systems and Theory
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• v.27 no.2
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• pp.216-226
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• 2000

This paper presents a new method to synthesize timed asynchronous circuits directly from the specification without generating a state graph. The synthesis procedure begins with a deterministic signal transition graph specification with timing constraints. First, a timing analysis extracts the timed concurrency and timed causality relations between any two signal transitions. Then, a hazard-free implementation under the timing constraints is synthesized by constructing a precedence graph and finding paths in the graph. The major result of this work is that the method does not suffer from the state explosion problem, achieves significant reductions in synthesis time, and generates circuits that have nearly the same area as compared to previous methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.3
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• pp.612-621
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• 1996

In this paper, we propose the low sidelobe digital FIR doppler filter bank synthesis algorithm through the Gradient Descent method and it can be practially appliable to coherent pulse doppler radar signal processing. This algorithm shows the appropriate calculation of tap coefficients or zeros for FIR transversal fiter which has been employed in radar signal processor. The span of the filters in the filter bank be selected at the desired position the designer want to locate, and the lower sidelobe level that has equal ripple property is achieved than one for which the conventional weithtedwindow is used. Especially, when we implemented filter zeros as design parameters it is possible to make null filter gain at zero frequency intensionally that would be very efficient for the eliminatio of ground clutter. For the example of 10 tap filter synthesis, when filter coefficients or zeros are selected as design parameters the corresponding sidelobelevel is reducedto -70db or -100db respectively and it has good convergent characteristics to the desired sidelobe reference value. The accuracy ofapproach to the reference value and the speed of convergence that show the performance measure of this algorithm are tuned out with some superiority and the fact that the bandwidth of filter appears small with respect to one which is made by conventional weighted window method is convinced. Since the filter which is synthesized by this algorithm can remove the clutter without loss of target signal it strongly contributes performance improvement with which detection capability would be concerned.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2005.11a
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• pp.282-285
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• 2005

This paper discusses the interactive system for smart home environments. In order to realize this, the main emphasis of the paper lies on the description of the multiple signal processing on the basis of the technologies such as fingerprint recognition, video signal processing, speech recognition and synthesis. For essential modules of the interactive system, we adopted the motion detector based on the changes of brightness in pixels as well as the fingerprint identification for adapting home environments to the inhabitants. In addition, the real-time speech recognizer based on the HM-Net(Hidden Markov Network) and the speech synthesis were incorporated into the overall system for interaction between user and system. In experimental evaluation, the results showed that the proposed system was easy to use because the system was able to give special services for specific users in smart home environments, even though the performance of the speech recognizer was not better than the simulation results owing to the noisy environments.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.10
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• pp.966-980
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• 2011

Radar receiving echo signal provides target information - range, velocity and position by signal magnitude and Doppler shift, which are determined by target reflection characteristics and target maneuver. Target angle error is extracted from the magnitude ratio of difference channel to sum channel. In this paper, we introduce a radar Return Signal Simulation Equipment(RSSE) which is implemented for the purpose of performance analysis and evaluation of phased array multi-function radar(MFR). It generates multi-target environment with jamming signals using MC-DDS (Multi-Channel Direct Digital Synthesis), and has scalability by using the efficient hardware configuration. The performance of the developed RSSE has been evaluated under various test environments. Especially, we proved that required target detection performance is achieved by RSP(Radar Signal Processor) interfaced RSSE configuration.