• Tribology and Lubricants
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• 제18권5호
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• pp.357-363
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• 2002

The vibration characteristics of the pad fluttering in a fluid film tilting pad journal bearing (4-pad LBP) have been investigated experimentally under the different values of oil supply flow rate, bearing load and shaft speed. The vibration characteristics of the pad fluttering are estimated by measuring the time signal of circumferential distribution of the film thickness and the cascade plot of the response of the relative displacement between the bearing and the shaft. It is shown that the vibration frequency of the pad fluttering has a sub-synchronous frequency and almost does not change by the increase of shaft speed. However the vibration amplitude is increased by the increase of shaft speed. From those experimental results, pad fluttering can be thought of as a self-excited vibration. The incipient pad fluttering velocity is increased by the increase of oil supply flow rate and by the decrease of bearing load. It is observed that the vibration amplitude of the pad fluttering can be decrease by the control of supply oil flow rate effectively. And also It is known that the outbreak of pad fluttering does not concern with the shaft vibration.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.145-145
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• 1998

In the present study, we have demonstrated that taurine could stimulate the production of nitric oxide and the activity of ERK2 (extracellular signal regulated protein kinase or pp42 MAP kinase). Nitric oxide(NO), the product of inducible nitric oxide synthase(iNOS), is known to be implicated in the metabolism of bone. ERK cascade plays a key role in the gene expression of iNOS in osteoblastic cell. We investigated whether taurine (l-20mM) could stimulate ERK2 activity, nitric oxide production, and inducible nitric oxide synthase in osteoblast-like UMR-106 cells. Nitric oxide was measured spectophotometrically as nitrite and the activation of ERK2 and iNOS was studied using Western 145 blot analysis. Taurine increased the production of nitric oxide in a dose-dependent manner and the effect was reached to a maximum at 10 mM. The activation of iNOS were consistent with NO levels. The tyrosine phosphorylation of ERK2 was increased by taurine in a time-dependent manner. The these result suggest that taurine might stimulate the production of nitric oxide in osteoblast-like cells by the activation of ERK2 and could regulate the metabolism of bone via nitric oxide.

• Journal of Ginseng Research
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• 제41권2호
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• pp.227-231
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• 2017

Background: Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22). Methods: The present study investigated the kidney-protective effects of ginsenosides Rk2 and Rh3 against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells. Results: As a result, ginsenoside Rh3 shows a stronger protective effect than that shown by Rk2. Cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38, and cleaved caspase-3 decreased after cotreatment with ginsenoside Rh3. The increase in the percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment also significantly reduced after cotreatment with ginsenoside Rh3. Conclusion: These results demonstrate that inhibition of the JNK and ERK mitogen-activated protein kinase signaling cascade plays a critical role in mediating the renoprotective effect of ginsenoside Rh3.

• 전자공학회논문지A
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• 제33A권4호
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• pp.37-46
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• 1996

In this paper, we analyzed the performance improvement of the DS-CDMA/dPSK cellular mobile communication system with CCI canceller and RAKE receiver techniques in mobile radio channel which is characterized by AWGN, Multi-user interference (mUI) and frequency-selective rayleigh fading. System capacity i.e., number of user per cell has been derived and the evaluated results are shown in figuraes as a function of PN code sequence length, number of RAKE receiver tap, BER and E$_{b}$/N$_{o}$. The voice activity factor is assumed to be 3/8 the number of sectors in a cell 3 and MUI is modeled as gaussian process. From the results, the capacity of the DS-CDMA/DPSK cellular mobile communication system is improved by adopting CCI canceller. When we adopt the RAKE receiver to mitigate the multipath fading, the error performance is improved and the amount of improvement is proportional ot the number of taps L in the case that each tap contains a signal component and the better of improvement can be obtained, the smaller of the SNR difference in each tap. The system capacity is more increased when the CCI canceller and the RAKE receiver is used in cascade.

• 한국광학회지
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• 제19권3호
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• pp.237-241
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• 2008

전자 논리회로에서 이용되는 전자신호 암호화와 같은 방법으로, 반도체 광 증폭기 XOR논리 게이트를 이용한 전광 암호화 시스템을 제안하였다. 시스템의 변수를 최적화 하고 전체 디자인 과정을 빠르게 수행하기 위해 정상상태와(steady state) 과도상태에(dynamic) 대한 전산모사가 차례로 이루어졌다. 심각한 신호 왜곡이 없이 10 Gbps 속도에서 일반적인 반도체 광 증폭기의 연속적 연결을 통해 전광 신호에 대한 암호화와 해독이 수행될 수 있음을 전산모사와 실험에 의한 결과를 통해 보여주었다.

• Journal of Electrical Engineering and Technology
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• 제12권3호
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• pp.1146-1155
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• 2017

Normally, the artificial intelligence algorithms are widely applied to the optimal controller design. Then, it is expected that the best output performance is achieved. Unfortunately, when resulting controller parameters are implemented by using the practical devices, the output performance cannot be the best as expected. Therefore, the paper presents the optimal controller design using the combination between the state-space averaging model and the adaptive Tabu search algorithm with the new criteria as two penalty conditions to handle the mentioned problem. The buck-boost converter regulated by the cascade PI controllers is used as the example power system. The results show that the output performance is better than those from the conventional design method for both input and load variations. Moreover, it is confirmed that the reported controllers can be implemented using the realistic devices without the limitation and the stable operation is also guaranteed. The results are also validated by the simulation using the topology model of MATLAB and also experimentally verified by the testing rig.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2000년도 제32회 추계학술대회 정기총회
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• pp.228-234
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• 2000

The vibration characteristics of the pad fluttering in a fluid film tilting pad journal bearing(4-pad LBP) have been investigated experimentally under the different values of oil supply flow rate, bearing load and shaft speed. The vibration characteristics of the pad fluttering are estimated by measuring the time signal of circumferential distribution of the film thickness and the cascade plot of the response of the relative displacement between the bearing and the shaft. It is shown that the vibration frequency of the pad fluttering has a sub-synchronous frequency and 31mos1 does not change by the increase of shaft speed. However the vibration amplitude is increased by the increase of shaft speed. From those experimental results, pad fluttering can be thought of as a self-excited vibration. The incipient pad fluttering velocity is increased by the increase of oil supply rate and by the decrease of bearing load. It is observed that the vibration amplitude of the pad fluttering can be decreased by the control of supply oil flow rate effectively. And also It is known that the outbreak of pad fluttering does not concern with the shaft vibration.

• International Journal of Oral Biology
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• 제46권3호
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• pp.99-104
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• 2021

Associations between periodontal infection and cardiovascular disease have been documented. Porphyromonas gingivalis is a well-established periodontal pathogen, and tissue factor (TF) is a key initiator of the coagulation cascade. In this context, P. gingivalis has been reported to enhance TF expression in human endothelial cells. The present study investigated the underlying mechanisms of TF induction by P. gingivalis in human umbilical vein endothelial cells. P. gingivalis increased TF expression in a dose- and time-dependent manner. Not only live bacteria but also glutaraldehyde-fixed bacteria increased TF expression to the same extent. However, sonicates of P. gingivalis did not induce TF expression. Cytochalasin D and SMIFH2, which are inhibitors of actin polymerization and actin nucleation, respectively, inhibited the TF expression induced by P. gingivalis. Finally, TF production was decreased or increased in the presence of various signaling inhibitors, including mitogen-activated protein kinases. These results suggest that P. gingivalis induces endothelial TF expression by a bacterial internalization-dependent mechanism and through diverse signal transduction mechanisms.

• 센서학회지
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• 제31권2호
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• pp.115-119
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• 2022

A readout circuit for a mercury-cadmium-telluride (MCT)-amplified mid-wave infrared (IR) photodetector was realized and applied to noncontact chemical agent detectors based on a quantum cascade laser (QCL). The QCL emitted 250 times for each wavelength in 0.2-㎛ steps from 8 to 12 ㎛ with a frequency of 100 kHz and duty ratio of 10%. Because of the nonconstant QCL emission power during on-duty, averaging the photodetector signals is essential. Averaging can be performed in digital back-end processing through a high-speed analog-to-digital converter (ADC) or in analog front-end processing through an integrator circuit. In addition, it should be considered that the 250 IR data points should be completely transferred to a PC during each wavelength tuning period of the QCL. To average and minimize the IR data, we designed a readout circuit using the analog front-end processing method. The proposed readout circuit consisted of a switched-capacitor integrator, voltage level shifter, relatively low-speed analog-to-digital converter, and micro-control unit. We confirmed that the MCT photodetector signal according to the QCL source can be accurately read and transferred to the PC without omissions.

• Anatomy and Cell Biology
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• 제56권4호
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• pp.421-427
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• 2023

Bladder exstrophy is a rare congenital condition of the pelvis, bladder, and lower abdomen that opens the bladder against the abdominal wall, produces aberrant growth, short penis, upward curvature during erection, wide penis, and undescended testes. Exstrophy affects 1/30,000 newborns. The bladder opens against the abdominal wall in bladder exstrophy, a rare genitourinary condition. This study is vital to provide appropriate therapy choices as a basis to improve patient outcomes. This study may explain bladder exstrophy and provide treatment. Epispadias, secretory placenta, cloacal exstrophy, and other embryonic abnormalities comprise the exstrophy-spades complex. The mesenchymal layer does not migrate from the ectoderm and endoderm layers in the first trimester, affecting the cloacal membrane. Embryological problems define the exstrophy-aspidistra complex, which resembles epimedium, classic bladder, cloacal exstrophy, and other diseases. Urogenital ventral body wall anomalies expose the bladder mucosa, causing bladder exstrophy. Genetic mutations in the Hedgehog cascade pathway, Wnt signal, FGF, BMP4, Alx4, Gli3, and ISL1 cause ventral body wall closure and urinary bladder failure. External factors such as high maternal age, smoking moms, and high maternal body mass index have also been associated to bladder exstrophy. Valproic acid increases bladder exstrophy risk; chemicals and pollutants during pregnancy may increase bladder exstrophy risk. Bladder exstrophy has no identified cause despite these risk factors. Exstrophy reconstruction seals the bladder, improves bowel function, reconstructs the vaginal region, and restores urination.