• 한국동물학회지
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• 제33권4호
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• pp.454-460
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• 1990

Acrylamide의 신경독성에 대해 조사하기 위하여 초기운동실조증이 유도된 생쥐의 신경계에 대한 Acrylamide의 영향을 관찰한 결과, 중추 및 말초신경조직에 있어서의 손상이 보여 척수의 전반적 공포현상, 신경원 및 신경교의 세포손상 그리고 말초신경섬유의 퇴행현상들이 보였다. 또한 이들에 대한 미세구조적 관찰에 의하여 신경원에서의 비정상적 미토콘드리아 및 척수전근 섬유에서의 수초의 균혈화 현상등이 야기됨을 알았으며 좌골신경에서의 수초의 부분적 붕괴 및 축삭형질내의 퇴행현상들도 보였다. 위와 같은 실험결과는 Acrylamide로 인한 중독의 영향이 말초신경장애의 증상으로 나타나나 최초의 신경독성효과는 중추 및 말초신경계에 대해 거의 유사한 시기에 작용함을 시사한다.

• International Journal of Industrial Entomology and Biomaterials
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• 제10권2호
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• pp.143-145
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• 2005

Lamerin breed of the silkworm, Bombyx mori L. for Northeastern India hosts a vertically transmitted microsporidian parasite for generations, which does not harm significantly the cocoon production. The transversally infected progenies do not exhibit marked external sign or symptom. The microspordian causes inapparent infection and over $(80\%)$ of the infected progeny survives and spin cocoons. There is possibility of co-existence between the breed and the associated micosporidian parasite. To evaluate the impact of the microsporidian on breed the present study was conducted in respect of tranovarial transmitted (observed as T1), secondarily infected (observed as T2) and healthy silkworm (observed as T3). The larval and pupal mortality was $12\%$ and $6\%$ in T1 and $10\%$ and $3\%$ in T2 batch, while in case of T3 batch there was no mortality. Significant changes were also observed in single cocoon weight, single shell weight, denier, reelibility, raw silk recovery $\%$ and neetness. There is no significant impact of the infection on the fecundity and hatchability. The hatchability of the eggs laid by healthy or infected moths are equall as much as control but the progeny had the infection transmitted from the parent.

• Nuclear Engineering and Technology
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• 제50권5호
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• pp.788-793
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• 2018

High-density spent fuel (SF) storage racks have been installed to increase SF pool capacity. In these SF racks, neutron absorber materials were placed between fuel assemblies allowing the storage of fuel assemblies in close proximity to one another. The purpose of the neutron absorber materials is to preclude neutronic coupling between adjacent fuel assemblies and to maintain the fuel in a subcritical storage condition. METAMIC neutron absorber has been used in high-density storage racks. But, neutron absorber materials can be subject to severe conditions including long-term exposure to gamma radiation and neutron radiation. Recently, some of them have experienced degradation, such as white spots on the surface. Under these conditions, the material must continue to serve its intended function of absorbing neutrons. For the first time in Korea, this article uses a neutron attenuation test to examine the performance of METAMIC surveillance coupons. Also, scanning electron microscope analysis was carried out to verify the white spots that were detected on the surface of METAMIC. In the neutron attenuation test, there was no significant sign of boron loss in most of the METAMIC coupons, but the coupon with white spots had relatively less B-10 content than the others. In the scanning electron microscope analysis, corrosion material was detected in all METAMIC coupons. Especially, it was confirmed that the coupon with white spots contains much more corrosion material than the others.

• Geomechanics and Engineering
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• 제20권5호
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• pp.399-410
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• 2020

Cavities often develop behind the vault during the construction of double-arch tunnels, generally in the form of various defects. The study evaluates the impact of cavities behind the vault on the mechanical and failure behaviors of double-arch tunnels. Cavities of the same sizes are introduced at the vault and the shoulder close to the central wall of double-arch tunnels. Physical model tests are performed to investigate the liner stress variation, the earth pressure distribution and the process of progressive failure. Results reveal that the presence of cavities behind the liner causes the re-distribution of the earth pressure and induces stress concentration near the boundaries of cavities, which results in the bending moments in the liner inside the cavity to reverse sign from compression to tension. The liner near the invert becomes the weak region and stress concentration points are created in the outer fiber of the liner at the bottom of the sidewall and central wall. It is suggested that grouting into the foundation soils and backfilling injection should be carried out to ensure the tunnel safety. Changes in the location of cavities significantly impact the failure pattern of the liner close to the vault, e.g., cracks appear in the outer fiber of the liner inside the cavity when a cavity is located at the shoulder close to the central wall, which is different from the case that the cavity locates at the vault, whereas changes in the location of cavities have a little influence on the liner at the bottom of the double-arch tunnels.

• Journal of Chest Surgery
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• 제30권11호
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• pp.1136-1138
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• 1997

승모판막 폐쇄부전증으로 승모판막 치환술을 받은 45세 남자가 확장성 심근증으로 심장이식수술을 받았다. 환자는 수술전 면역억제를 위하여 cyclosporine 400 mg, Immuran 250 mg과 Solumedrol 500 mg을 투약하였 다 술후 cyclosporine을 2 mg/kg/day로 정주했는데 술후 8시간이 지나도 혼수상태가 지속되어 cyclosporine을 1 mg/kg/day로 감량하였다. 당시 혈장내 cyclosporine농도는 345$\mu\textrm{g}$/L, 크레아티닌 수치는 1.8 mg/dl였으며 마그 네슘 수치는 정상수준이 였다. 환자의 의식은 술후 31시간째 완전히 회복되었으나 술후 36시간경부터 전신근 력약화, 초조감, 환청 및 환각을 호소하였다. 신경증상들은 술후 4일째 정상으로 회복되었으며, 환자는 술후 28일째 퇴원하였고 12개월째 후유증은 보이지 않고 있다.

• 대한본초학회지
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• 제34권3호
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• pp.31-36
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• 2019

Objectives : In this animal study, we performed the single oral dose toxicity test of Standardized Cornus officinalis Sieb. et Zucc. and Psoralea corylifolia L. 30% ethanol extract (SCP) in Sprague-Dawley (SD) rats owing to aims for verifying approximate lethal dose (ALD). Methods : According to OECD guidelines for the testing of chemicals section 4 health effects test No. 420 acute oral toxicity study - fixed dose procedure (17 December 2001), single oral dose toxicity test was performed. Animals were divided into two groups: Group 1, vehicle-treated rats (Control); Group 2, SCP 5000 mg/kg treated rats. SCP is composed of two medicinal herbs: Cornus officinalis Sieb. et Zucc. (650 g) and Psoralea corylifolia L. (350 g) in 30% ethanol. SCP was once orally administered to female and male SD rats at dose levels of 5000 mg/kg. Animals were monitored on the mortality, clinical signs, body weight changes and necropsy findings for 14 days. Results : After single oral treatment of SCP, we could not find any mortality up to 5000 mg/kg. Compared with the control group, there were also no significant differences in clinical sign, weight change, weight gain and gross abnormalities in SCP 5000 mg/kg-treated group. Conclusions : Taken together, these results suggest that the ALD of SCP in both female and male SD rats were considered as over 5000 mg/kg. Results from this study provide scientific evidence for the safety of SCP.

• Archives of Plastic Surgery
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• 제37권3호
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• pp.285-288
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• 2010

Purpose: Dermatofibrosarcoma protuberans is a rare tumor, accounting for 0.1% of all malignant tumors. Although metastasis is very uncommon, local recurrence occur frequently. Dermatofibrosarcoma protuberans occurring in children is even more rare; this is the first case report of congenital dermatofibrosarcoma protuberans in Korea. Methods: The patient is a 14-month-old male infant with a lesion that was first thought to be a birthmark. The lesion grew larger, and a punch biopsy revealed dermatofibrosarcoma protuberans. A wide local excision was performed with a 2 cm peripheral resection margin beyond the gross tumor lesion. Deep fascia and a portion of muscle underneath the central part of the lesion were also taken. The surgical defect was covered by a split-thickness skin graft. Results: There has been no clinical sign of recurrence over one year after the surgery. Conclusion: A patient with congenital dermatofibrosarcoma protuberans detected at an early stage underwent a wide local excision of the tumor after accurate diagnosis was carried out by biopsy and immunohistochemical studies. There was no clinical evidence of tumor recurrence during over a 1-year follow-up.

• 간호행정학회지
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• 제12권3호
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• pp.444-453
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• 2006

Purpose: The purpose of the study was to identify critical indicators for the development of efficient patient classification system in a emergency room. Method: This study involved following five steps. Step 1. Selection of the lists direct nursing services in the ER. Step 2. Measurement of the time of direct nursing services from Aug. 31st to Nov. 30th, 2005. Step 3. Classification of the patients according to the nursing care time. Step 4. The determination the critical indicators for different patient classes. Result: Determinate indicators were as follow: 3 items in the first group (vital sign checking, IV route starting, blood sampling), 3 items in the second group (vital sign checking, fluid infusion, blood sampling), 9 items in the third group (I/O checking, $O_{2}$ inhalation, suction, fluid infusion, IV bolus, Central catheter preparation & management, blood sampling, intubation preparation & management, postmortem management), 7 items in the fourth group (EKG monitoring, BP monitoring, $O_{2}$ inhalation, fluid infusion, using the specific drugs, CPR, postmortem management). Conclusion: This study can help future studies which measure nursing services standard time or assigns value to emergency nursing services.

• 한국동물생명공학회지
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• 제35권1호
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• pp.50-57
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• 2020

The objective of this research work was to know ovarian dynamics and pregnancy rate of cyclic Murrah buffalo cows with induced estrus by administration of prostaglandin F2α (PGF2α) and timed artificial insemination (TAI) with frozen thawed semen. A total of 31 female buffaloes were selected for the study. The buffalos having matured CL observed by ultrasonography were given one intra muscular injection of cloprostenol 500 ㎍ and TAI was performed using frozen thawed semen of Indian Murrah buffalo bull. Results showed that 90.32% (significantly, at p < 0.05) cows explore the sign of heat after injection of PG and 67.85% (significantly, at p < 0.05) cows were become pregnant out of 28 inseminated (TAI) cows. In the 28 inseminated (TAI) cows, average number of smaller and larger size of follicles were non-significantly (p > 0.05) higher at day 3 post PG injection, but the medium size of follicles was nonsignificantly (p > 0.05) higher at PG injection. At day 3 post PG injection the diameter of follicles was significantly (p < 0.05) higher, but the diameter of CL was significantly (p < 0.01) lower compared at PG injection. At PG injection the diameter of largest follicle was non-significantly differences (p > 0.05) in between pregnant and non-pregnant cows. But at day 3 post PG injection it was significantly (p < 0.01) higher in pregnant cows compared to non-pregnant cows. The number of small, medium, and large follicles at PG injection and at day 3 post PG injection were non-significantly (p > 0.05) difference in between pregnant and non-pregnant buffalo cows. Finally, it is concluded that the CL was effectively regresses and induced the sign of heat in buffalo cows and after AI the cows were become pregnant with significant rate. The study will help to the veterinarian and researcher to know the efficacy of PG injection and AI for reproductive efficiency in buffalo cows.

• 대한소아치과학회지
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• 제30권3호
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• pp.385-390
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• 2003

청소년기에는 두개악안면부위의 외상성 손상이 흔하다. 그러나 상아질, 백악질, 치수를 포함하는 치아파절로 정의되는 치근파절은 비교적 드물다. 치근파절에 대하여 취 할 수 있는 적절한 조치는 파절편의 치관부위를 재위치시키고, $2{\sim}3$달간 레진강선 고정술을 시행하는 것이다. 치수괴사나 치근흡수의 징후가 나타날때까지 근관치료를 보류해야 하는데 대부분의 증례에서 파절편의 치근부위는 그 생활력을 유지하기 때문이다. 본 증례의 10세 4개월된 남아는 상악영구중절치의 치근파절을 주소로 연세대학교 치과병원에 내원하였으며, 그후 7년동안 동일부위에 2번의 반복적인 외상이 있었으나 파절편 치관부의 재위치, 레진 강선 고정술, 근관치료 시행 후 임상적으로 방사선학적으로 비교적 양호한 치료결과를 얻었기에 보고하는 바이다.