• 한국소성가공학회:학술대회논문집
• /
• 한국소성가공학회 1998년도 춘계학술대회논문집
• /
• pp.53-57
• /
• 1998

In order to investigate the effects of the variables during the stamping process upon the side wall curl behavior, experiments and finite element analyses were done using a 90 degree draw-bending test. The variables considered were the die radius, the forming speed, the restraint force, the lubrication and the sheet grade. The experiments and simulation conditions were selected according to the design of experiment (DOE) approach. The effects of the restraint force, the lubrication and the forming speed were the same for both high strength and mild steels, but the effects of the die radius on the side wall curl were dependent on the magnitude of the die radius and the sheet grade. A straight side wall was observed for both high strength and mild steels when the die radius was about 2∼3 times of the sheet thickness. It was recommended that the restraint force, the forming speed and the friction be increased in order to reduce the side wall curl.

• Journal of Digestive Cancer Research
• /
• 제3권2호
• /
• pp.76-81
• /
• 2015

Gastrointestinal side effects including nausea and vomiting, diarrhea, constipation, oral mucositis and colitis, and hepatotoxicity are common occurrence during chemotherapy. Often they result in unplanned admission and interruption of scheduled therapy. Additionally they have a negative influence on patient's therapeutic outcome and quality of life. The assessment of gastrointestinal side effects is dependent on clinician assignment of a grade established by the National Cancer Institute Common Terminology Criteria for Adverse Events. Continued interest of gastrointestinal side effects has allowed identifying patients at higher risk and providing effective treatments to relieve painful symptom. Finally, proper prevention and management of chemotherapy-induced gastrointestinal side effects will be needed to improve patient's survival and quality of life.

• Ocean Systems Engineering
• /
• 제3권4호
• /
• pp.275-294
• /
• 2013

Side-by-side offloading operations are widely utilized in engineering practice. The hydrodynamic interactions between two vessels play a crucial role in safe operation. This study focuses on the coupled effects between two floating bodies positioned side-by-side as a shuttle tanker-FPSO (floating production, storage and offloading) system. Several wave directions with different side-by-side distances are studied in order to obtain the variation tendency of the horizontal hydrodynamic coefficients, motion responses and mean drift forces. It is obtained that the coupled hydrodynamics between two vessels is evidently distinguished from the single body case with shielding and exaggerating effects, especially for sway and yaw directions. The resonance frequency and the peak amplitude are closely related with side-by-side separation distance. In addition, the horizontal hydrodynamics of the shuttle tanker is more susceptible to coupled effects in beam waves. It is suggested to expand the gap distance reasonably in order to reduce the coupled drift forces effectively. Attention should also be paid to the second peaks caused by hydrodynamic coupling. Since the horizontal mean drift forces are the most mainly concerned forces to be counteracted in dynamic positioning (DP) system and mooring system, prudent prediction is beneficial in saving consumed power of DP system and reducing tension of mooring lines.

• Journal of Information Display
• /
• 제13권3호
• /
• pp.125-130
• /
• 2012

In this paper, a new precharging method without any side effects is proposed to overcome image degradation caused by insufficient charging times. This work explains why the precharging method can compensate for short charging times. However, side effects of the precharging method in the form of horizontal line artifacts are addressed, wherein line artifact-compensating precharging (LCP) is presented to mitigate the side effects. Behavioral modeling is employed to investigate the side effects by estimating transient responses of a liquid crystal display. The LCP proves that it can dramatically reduce line artifacts caused by precharging because the brightness difference of adjacent pixels does not exceed 1.0.

• 한방안이비인후피부과학회지
• /
• 제24권1호
• /
• pp.181-191
• /
• 2011

Backgrounds : Pompholyx is a distinctive reaction pattern presenting as symmetric vesicular hand and foot dermatitis. Other than acute symptoms like itching and vesicles, chronic changes with scaling, fissure and pain may follow. As patients are treated by steroid for a long period, it tends to present side effects after quitting steroid treatment. Objectives : This study was carried out to investigate the effect of carbon arc lamp therapy and oriental medical therapy that venesection therapy, ointments and herbal medicine on chronic plantar pompholyx including steroids side effects. Methods : We treated one case of chronic plantar pompholyx which had continued about 10 years, including steroids side effects with venesection therapy, carbon arc lamp therapy, ointments and herbal medicine. To evaluate the results of this treatment, we categorized symptoms into six items which are vesicles, itching, fissures, pain, erosions and scales. Results : Except mild itching, vesicles and scales in a small area, all the symptoms were subsided. Conclusions : It is considered that various kinds of oriental medical therapy including carbon arc lamp therapy could replace steroid therapy which has many side effects.

• 대한기계학회논문집B
• /
• 제27권5호
• /
• pp.596-603
• /
• 2003

Present study has been conducted to see the relative effects of adding N: to fuel-side and air-side on flame structure, soot formation and NOx emissions. Experiments were carried out to ascertain to what degree chemical kinetics and/or molecular transport effects can explain the differences in soot formation and NOx emission by studying laminar diffusion flames. Direct photograph was taken to see the flame structure. CARS techniques was used to get the flame temperature profiles. And spatial distribution of soot could be obtained by PLII method. CHEMKIN code was also used to estimate the global residence time to predict NOx emissions at each condition. Results from these studies indicate that fuel-side dilution is more effective than air-side dilution in view of NOx emissions. However, air-side dilution shows greater effectiveness over fuel-side dilution in soot formation. And turbulent mixing and heat transfer problems were thought to be considered in practical applications.

• 대한소아치과학회지
• /
• 제47권2호
• /
• pp.109-119
• /
• 2020

이 후향적 연구는 chloral hydrate, hydroxyzine 및 N₂O/O₂ 조합을 이용한 진정 치료를 시행한 149명 환아의 188회 진정 치료의 효과와 부작용에 대해 알아보고, 효과와 부작용에 영향을 미칠 수 있는 요소를 확인하고자 하였다. 진정 치료의 효과는 Houpt 분류법을 이용하여 측정하였고, excellent와 good의 경우 효과적으로 분류하였다. 진정 치료 시간을 15분 간격으로 나누어 효과와 부작용을 분석한 결과, 치료 시간이 증가할수록 효과는 감소하고 부작용은 증가하는 것으로 나타났다. 60분 동안의 진정 치료 효과는 57.4% 이었으며, 전체 부작용 발생률은 18.1%이었다. 진정 치료의 효과는 Body mass index(BMI)가 증가할수록 증가하였으며, 술식 시작 시 진정이 되어있는 경우 진정 치료 효과가 높은 것으로 나타났다. 부작용은 나이가 증가할수록 증가하였다. 진정 치료가 2회로 나누어 시행되었을 때, 진정 치료의 횟수는 효과와 부작용에 영향을 미치지 않았다. 진정 치료 시간을 무리하게 연장하는 것은 효과 감소와 부작용 증가를 불러일으킬 수 있으므로 진정 치료를 2회에 나누어 시행하는 것이 필요할 것으로 생각된다. 또한 BMI, 술식 시작 시 진정 여부 및 나이와 같은 진정 효과를 감소시키고 부작용을 증가시키는 요소에 대한 충분한 고려가 선행된 후 진정 치료를 시행하여야 할 것으로 생각된다.

• 한국컴퓨터정보학회논문지
• /
• 제21권1호
• /
• pp.115-123
• /
• 2016

In this study, we collect various side effect pairs which are appeared frequently at many drugs, and select side effect pairs that have higher severity. For every selected side effect pair, we extract common genetic networks which are shared by side effects' genes and drugs' target genes based on PPI(Protein-Protein Interaction) network. For this work, firstly, we gather drug related data, side effect data and PPI data. Secondly, for extracting common genetic network, we find shortest paths between drug target genes and side effect genes based on PPI network, and integrate these shortest paths. Thirdly, we develop a classification model which uses this common genetic network as a classifier. We calculate similarity score between the common genetic network and genetic network of a drug for classifying the drug. Lastly, we validate our classification model by means of AUC(Area Under the Curve) value.

• 동의생리병리학회지
• /
• 제19권4호
• /
• pp.945-949
• /
• 2005

The objective of this study is to investigate the inhibitor effects of an traditional oriental herb, Sophora flavescens on the pancreatic & cardiac side effects of chemotherapy were studied by using Bl6-BL6 melanoma-injected C57BL6 mouse tumor model. In this study, the effects of an traditional oriental herb, Sophora flavescens, on the side effects of chemotherapy were studied using B16 melanoma-injected C57BL6 mouse tumor model. Anticancer drugs widely used in clinical situation. Sophora flavescen has significant effect on the reduction of the side effects of chemotherapy. Water extract of Sophora flavescens significantly inhibited cisplatin-induced increase of amylase (AMY) which is a good indicator of pancreatic toxicity. Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effect. Theses results suggest a possibility that Sophora flavescens extract can be used for cancer patients for the reduction of the side effects and improving the quality of life during chemotherapy of cancer patients.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권13호
• /
• pp.5433-5436
• /
• 2014

Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.