• 생물정신의학
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• 제8권2호
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• pp.271-275
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• 2001

60세 남자 환자로 좌측 정중 전두엽과 양측 기저절 경색 후 발생한 과잉성욕 증상과 강박 증상을 주소로 내원하였다. 환자는 뇌졸중 후에 발생한 운동 기능 장애는 시간이 경과하면서 호전되어 발병 1개월 이내에 거의 정상화된 반면 과잉성욕 증상과 강박 증상은 호전되지 않았다. 환자에게 과잉성욕 증상과 강박 증상을 목표로 fluvoxamine과 perphenazine을 처방하였으며 치료 시작 후 2개월이 경과하면서 환자의 과잉성욕 증상과 강박 증상은 서서히 사라졌다. 이 증례는 기저절-시상전두엽 회로가 성적 행동과 강박 증상의 조절에 있어 중요한 역할을 하고 있음을 시사한다고 할 수 있다. 과잉성욕 증상은 임상에서 간과하기 쉽고 또한 일반적으로 성적 활동에 대한 변화는 환자들 스스로 보고하지 않는 경향이 많다. 따라서 뇌졸중 환자, 특히 정중 전두엽이나 기저절 병변을 동반한 환자들의 경우에는 비록 그 병변이 측두엽 침범이 없거나 Kluver-Bucy syndrome의 전형적인 증상을 보이지 않는다 할 지라도 성욕등 성적 활동에 대한 체계적인 조사가 필요할 것으로 생각된다. 또한 과잉성욕 증상과 강박 증상을 함께 가지고 있는 경우 선택적인 세로토닌 재흡수 억제제의 사용이 두 증상 모두를 효과적으로 치료하는 데에 도움이 될 수 있을 것이다.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2014년도 추계학술대회 및 정기총회
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• pp.15-15
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• 2014

Fusarium graminearum (teleomorph Gibberella zeae) is an important plant pathogen that causes head blight of major cereal crops such as wheat, barley, and rice, as well as causing ear and stalk rot on maize worldwide. Plant diseases caused by this fungus lead to severe yield losses and accumulation of harmful mycotoxins in infected cereals [1]. Fungi utilize spore production as a mean to rapidly avoid unfavorable environmental conditions and to amplify their population. Spores are produced sexually and asexually and their production is precisely controlled. Upstream developmental activators consist of fluffy genes have been known to orchestrate early induction of condiogenesis in a model filamentous fungus Aspergillus nidulans. To understand the molecular mechanisms underlying conidiogenesis in F. graminearum, we characterized functions of the F. graminearum fluffy gene homologs [2]. We found that FlbD is conserved regulatory function for conidiogenesis in both A. nidulans and F. graminearum among five fluffy gene homologs. flbD deletion abolished conidia and perithecia production, suggesting that FlbD have global roles in hyphal differentiation processes in F. graminearum. We further identified and functionally characterized the ortholog of AbaA, which is involved in differentiation from vegetative hyphae to conidia and known to be absent in F. graminearum [3]. Deletion of abaA did not affect vegetative growth, sexual development, or virulence, but conidium production was completely abolished and thin hyphae grew from abnormally shaped phialides in abaA deletion mutants. Overexpression of abaA resulted in pleiotropic defects such as impaired sexual and asexual development, retarded conidium germination, and reduced trichothecene production. AbaA localized to the nuclei of phialides and terminal cells of mature conidia. Successful interspecies complementation using A. nidulans AbaA and the conserved AbaA-WetA pathway demonstrated that the molecular mechanisms responsible for AbaA activity are conserved in F. graminearum as they are in A. nidulans. F. graminearum ortholog of Aspergillus nidulans wetA has been shown to be involved in conidiogenesis and conidium maturation [4]. Deletion of F. graminearum wetA did not alter mycelial growth, sexual development, or virulence, but the wetA deletion mutants produced longer conidia with fewer septa, and the conidia were sensitive to acute stresses, such as oxidative stress and heat stress. Furthermore, the survival rate of aged conidia from the F. graminearum wetA deletion mutants was reduced. The wetA deletion resulted in vigorous generation of single-celled conidia through autophagy-dependent microcycle conidiation, indicating that WetA functions to maintain conidia dormancy by suppressing microcycle conidiation in F. graminearum. In A. nidulans, FlbB physically interacts with FlbD and FlbE, and the resulting FlbB/FlbE and FlbB/FlbD complexes induce the expression of flbD and brlA, respectively. BrlA is an activator of the AbaA-WetA pathway. AbaA and WetA are required for phialide formation and conidia maturation, respectively [5]. In F. graminearum, the AbaA-WetA pathway is similar to that of A. nidulans, except a brlA ortholog does not exist. Amongst the fluffy genes, only fgflbD has a conserved role for regulation of the AbaA-WetA pathway.

• Journal of Gastric Cancer
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• 제9권3호
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• pp.117-127
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• 2009

목적: 의료진은 암 환자들에게 적절한 건강 관련 정보를 제공함으로써 암 환자들이 자신의 질병과 치료에 대한 불확실한 상황을 극복하여 스스로 건강을 관리하는 것을 도울 수 있다. 효과적으로 정보를 제공하기 위해서는 환자가 실제 알고자 하는 정보 내용을 파악하는 것이 필요하다. 본 연구에서는 위암 수술 후 환자의 정보 요구 경향을 확인하고자 하였다. 대상 및 방법: 위암 수술 후 환자로, 2008년 11월 18일 삼성서울병원 위암센터에서 주관한 '위암 환자의 날' 행사에 참여한 대상자에게 설문지를 배부하여 직접 작성하도록 하였고, 수집된 190명의 설문지를 분석하였다. 설문 도구는 검사, 치료, 예후, 추후 관리, 성 생활, 위암 관련 정보 영역과 7개의 단일 문항의 총 37개 문항으로 구성되었다. 결과: 정보 요구는 예후, 치료 기간 동안 스스로 할 수 있는 건강 관리 방법, 추후 관리, 위암 관련 정보, 치료, 검사 등의 순으로 높게 나타났다. 문항별로 살펴보면, 예후, 식이, 치료 중의 건강 관리와 관련한 문항에서 높은 정보 요구를 보였다. 대상자의 연령이 젊을수록 검사, 치료, 성 생활, 위암 관련 정보 영역의 정보 요구가 높았다. 결론: 기존에 축적된 병원의 치료 결과 및 예후 자료에 근거한 객관적인 예후 관련 정보를 교육 프로그램에 반영하고 암 환자 및 보호자가 이해하기 쉽도록, 그리고 치료 과정에 적극적으로 참여할 수 있도록 적절한 정보를 전달하여야 할 것이다.

• 대한간호학회지
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• 제13권2호
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• pp.44-57
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• 1983

The explosion of the aging population is changing the social environment of today's older people. Traditionally in Korea, a large percentage(over 90%) of elderly parents have lived with their married first son. But today, the number of elderly who live with their married sons has decreased(65.6%) The number of those who live in a different situation such as with their married daughter, unmarried offspring, with a spouse or alone has increased (34.4%) We can expect that the number of the elderly who have to live in institution will increase. The objective of this investigation was to determine differences in the number of health Complaints of older people according to their living situation with a view to planning more effective health care. The sample consisted of 231 persons over 65 years of age, 60 living in an Old Age Home ana 171 living in their own home in Kwangju. Data were gathered from July 9 to 26, 1983 by nursing students using a Questionnaire which was a modified form of the Cornell Medical Index. The data were categorized according to the subjects, living, sex, educational level, previous occupation, hobbies and sexual activity. The date were analyzed for statistical significant differences using F and X²tests. findings included the following: 1. There was a higher number of health complaints from persons who live in the institution than those living at home, but the difference was not significant. 2. The highest number of health Complaints were from persons who live alone, followed by those living with their daughters, and then by those living in the institution. Persons who live with their sons had the least Complaints. The difference in the number of Complaints accord-ing to with whom they were living was significant. 3. Women had signincantly more Complaints than men. Persons who were not living with their spouses had significantly more complaints than those living with their spouses.4. The higher eductional level the persons had, the less health Complaints they had. The number of Complaints accoraing to educational level was significantly different. 5. The highest number of health complaints were from persons who had involved in Commerce and industry, followed by those in Agriculture. Persons who were civil servant had the least 6. There were more complains from persons who had no hobby than those with hobbies. The complaints. The difference was significant. difference was significant. 7. Persons who said they were sexually inactive had significantly more complaints than those who said they were sexually active. As age increased, sexual activity significantly decreased. Those who lived with their spouse were significantly more sexually active. 8. The highest number of Somatic Complaints were eye fatigue, followed by nocturnal frequency, lumbago, cramps in extremities, vertigo, stiffness in Shoulder, tinnitus, common cold and constipation. The order of Psychic Complaints from higher to lower were anger. sensitivity, anxiety, depression and loneliness. 9. This group of Elderly persons said they valued Health the most, followed by Harmony, Religion, Money and Honor.

• 동의생리병리학회지
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• 제33권2호
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• pp.89-101
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• 2019

In recent times, the number of men with late-onset hypogonadism has increased, and interest on this topic has also increased. This study was conducted to investigate effects of the mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus on improve late-onset hypogonadism. The experimental subjects consisted of three groups: a control group consisting of 8-week-old male ICR mice that had undergone no treatment, an aging-elicited group (AE group) consisting of 50-week-old ICR male mice that had undergone no treatment, and a Mixed herbal extract treatment group (MT group) consisting of 50-week-old ICR male mice that had undergone the mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus treatment (0.1 g/kg/day) for 6 months. After the experiment, the mice from all the experimental groups were dissected, and they were analyzed through histochemical and immunohistochemical methods. The mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus reduces aging-induced cell damage and oxidative stress and increases the secretion of serotonin and B-endorphin in aged mice, and promotes spermatogenesis in seminiferous tubules and reduces apoptosis and oxidative stress, and increases androgen receptor, $17{\beta}-HSD$ and GnRH, increases the ratio of smooth muscle to collagen fibers in the corpus cavernosum, increases eNOS, decreases PDE-5 and oxidative stress in aged mice, so it improves depression, reproductive, sexual problems caused by Late-onset hypogonadism. the mixture extract of Fructus amomi Amari, Eucommiae cortex, Bombyx batryticatus inhibits the induction of osteoporosis by increasing decreased bone matrix distribution due to aging, increasing the activities of OPC and OPN, which are produced in osteoblasts, and decreasing RANKL, MMP-3 activity, increasing OPG activity. It also reduces muscle damage, oxidative stress, inflammation and apoptosis of muscle tissue, and increases Myo-D in the sartorius muscle of aged mice for improving muscle atrophy caused by by Late-onset hypogonadism.

• 한국인삼전략화협의회:학술대회논문집
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• 한국인삼전략화협의회 2003년도 제4차 한국인삼약초산업 전략화 세미나
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• pp.77-88
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• 2003

"Ginseng (Panax ginseng C.A. Meyer) has been a popular herbal remedy used in eastern Asian cultures for thousands of years, and a number of health claims are made for it. Modern therapeutic claims for ginseng refer to vitality, immune function, cancer, cardiovascular diseases, diabetes and sexual function. These claims are mostly based on uncontrolled or non-randomized studies. Among modern therapeutic claims, however, therapeutic effects for diabetes can reasonably be accepted. Following experiment was done recently in our lab: this study was designed to compare the antidiabetic activities between Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR) and Panax Quinquefoli Radix (PQR) in multiple low dose (MLD) streptozotocin (STZ) (20mg/kg i.p injection for 5 days) induced diabetic rats. In the glucose tolerance test, 500mg/kg of each ginseng ethanol extract was admoinistered intraperitoneally 30min before glucose challenge. While GRA failed to lower blood glucose level, GRR and PQR both significantly prevented the hyperglycemia when compared with the control group. In the MLD STZ-induced diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as for as blood parameters and diabetic symptoms such as polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenoside were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT) : proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia effects."

• 한국버섯학회지
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• 제15권3호
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• pp.134-138
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• 2017

양송이의 국내 생산량은 9,732톤으로 5번째로 가장 많이 생산되는 버섯이다. 양송이가 속한 주름버섯속은 리그노셀룰로오스 분해력을 가진 버섯으로 알려져 있다. 양송이의 영양생장과 생식생장동안 기본적으로 셀룰로오스, 해미셀룰로오스, 리그닌 성분의 분해는 변화한다. 우리는 양송이에서 celluase, xylanase, ligninolytic enzyme의 세포외효소 활성도로 효과적인 생물학적 분해력을 가진 균주를 선발하였다. 각 효소의 생물학적 분해는 0.5% CMC-MMP ((malt-mops-peptone), 0.5% Xylan-MMP, 0.5% ligin-MMP 배지에서 14일 동안 균주들을 배양하여 측정하였다. 그리고 배양된 균사체는 0.2% trypan blue에 염색되었다. MMP배지내 각 효소의 생물학적 분해의 효율성에 따라 선발된 균주 18점은 6개로 그룹화되었다. 또한 이 균주들은 볏짚발효퇴비배지에서의 균사생장과 세포외효소 활성도의 연관성을 알아보기 위해 볏짚발효퇴비배지에서 10일, 20일 각각 배양되었다. 본 연구로 ligninolytic enzyme 활성도가 볏짚발효퇴비배지에서의 균사배양과 상관도가 가장 높아 균주내 ligninolytic enzyme의 활성도 비교로 볏짚발효퇴비배지에서 균사배양이 우수한 균주를 간단하게 선발 할 수 있다고 사료된다.

• 한국지반공학회논문집
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• 제16권1호
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• pp.179-189
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• 2000

본 연구에서는 바닥층을 점토포설의 대안으로 기존의 원지반 해성점토에 시멘트와 벤토나이트 및 고화재를 혼합한 새로운 고화처리토를 이용하여 안전하고 경제적이며 효율적인 매립지 바닥층을 조성하고자 한다. 그러나 매립지 바닥층의 시공에 있어서 고화처리토를 이용한 표층고화 처리층을 바닥층의 재료로서 사용하는데 토목역학적인 안전성에 대한 기술적 자료가 전무한 실정이다. 특히 고화처리토를 포설한 후 겨울철 동상에 대한 연구문헌 및 사례는 국내, 외를 막론하고 쉽게 찾아볼 수 없었다. 따라서 본 조사연구를 통하여 기초적인 자료를 수집하고 겨울철 조건하에 고화처리층의 동결/융해 현상에 대한 바닥층의 안전성 및 동상현상을 검토하여 설계 및 시공에 반영될 수 있도록 하였다.$^4),6),21),25)$ 또한 본 연구에서는 폐기물매립지 바닥층의 포설에 가장 중요한 실패 원인중 하나인 동절기에 동상에 따른 고화처리층의 동결/융해 현상에 대한 연구를 실시하여 향후 해안폐기물매립지 건설에 기술적으로 이바지 하고자 한다. 고화처리층은 지지력을 목적으로 하는45 cm의 고화토층과 차수를 목적으로 하는30 cm의 불투수층의 $P_A와\; P_B$층으로 구성되었으며 고화처리층 하부에는 30 cm의 지하수 배제층, 상부에는 60 cm의 침출수 집배수층으로 설계되었다. 결과적으로 동결깊이는 동일한 조건에서 인공강우를 고려한 실험에서 동결깊이가 증가하였으며 동상현상은 수mm정도 증가하였고 국부적으로 표면균열이 발생하였다. 이러한 결과로 볼 때 매립지 바닥층의 설계에서 고화처리토를 사용한 바닥층이 점토층으로 구성된 설계보다 더욱 신뢰할 수 있다고 생각할 수 있다. (이송 외 2인, 1999; 이송 외 3인, 1999)e experimental group who was exposed to the A-V media produced by the author showed the higher score of androgyny sexual role identity than the control group who didn′t watch the A-V program. 2) The experimental group showed the higher rate of the androgyny than the control group, On the other hand, their rate of the masculinity turned out to be lower than the latter group. 3) The experimental group didn′t show the difference of SAS score from the control group .In conclusion, "Our sexuality is Healthful" A-V program for sexual education brought about the significant change of sexual role identity of the middle school boys, but didn′t affect their attitude toward sexual activity.ypothesis 4: The 4th hypothesis that "There will be significant difference of the pulse rate just before surgery in the experimental group and control group"was supported(P= .004).

• 동의생리병리학회지
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• 제25권6호
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• pp.1069-1078
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• 2011

The purpose of this study was to examine health promotion level and related of patients hospitalized. The participants for this study 225 of oriental medicine hospital inpatients. Health promotion, sleep, anxiety and discomfort are measured structured questionnaires each. Data were collected using structured questionnaires and analyzed using t-test, ANOVA and multiple regression. The general health promotion score is 98.12, mortality health promotion 20.31, mental health promotion 12.89, dietary health promotion 15.28, activity and rest health promotion 12.84, exercise health promotion 7.23, sleepy health promotion 15.42, seasonal health promotion 7.60 and sexual health promotion 9.31. There were significant differences in health promotion level according to spouse (p=0.003), sleep (p<0.001), anxiety (p<0.001) and discomfort (p<0.001). The significant predictors of health promotion were spouse (p<0.001), religious (p<0.001), drinking (p=0.036), sleep (p<0.001) and discomfort (p<0.001), explaining 33.7% of the variance in health promotion. Health promotion influenced not only the physical condition but also the psychological condition. The result suggest the health promotion level and predictors of health promotion is a useful index for improvement of health and prevention of disease in oriental medicine.

• Asian-Australasian Journal of Animal Sciences
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• 제27권4호
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• pp.479-487
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• 2014

Leptin plays an important role in energy homeostasis and reproductive function in fish, especially in reproduction. Migrating fish, such as salmonoids, are affected by external environmental factors, and salinity changes are a particularly important influence on spawning migrations. The aim of this study was to test whether changes in salinity affect the expression of leptin, estrogen receptors (ERs), and vitellogenin (VTG) in chum salmon (Oncorhynchus keta). The expression and activity of leptin, the expression of ERs and VTG, and the levels of estradiol-$17{\beta}$ and cortisol increased after the fish were transferred to FW, demonstrating that changes in salinity stimulate the HPG axis in migrating female chum salmon. These findings reveal details about the role of elevated leptin levels and sex steroid hormones in stimulating sexual maturation and reproduction in response to salinity changes in chum salmon.