• Journal of Neurogastroenterology and Motility
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• 제26권1호
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• pp.106-116
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• 2020

Background/Aims Emerging evidence shows that the mechanism of irritable bowel syndrome (IBS) is associated with neurotrophic factors and tight junction proteins (TJPs). It is known that there are sex differences in the pathophysiology of IBS. The aim of the present study is to determine expression levels of neurotrophic factors, TJPs, and cytokines according to IBS subtype and sex. Methods From 59 IBS (33 IBS-constipation, 21 IBS-diarrhea, and 5 IBS-mixed) and 36 control patients, colonic mucosa mRNA expression levels of transient receptor potential vanilloid-1 (TRPV1), nerve growth factor (NGF), glial cell-derived neurotrophic factor (GDNF), and various TJPs were assessed by real-time polymerase chain reaction. Western blot was performed to determine levels of zonular occludens-1 (ZO-1). Serum levels of cytokines were measured by enzyme-linked immunosorbent assay. Results TRPV1, GDNF, and NGF mRNA levels were significantly increased in those with IBS-constipation compared to those in controls (all P < 0.05). However, they showed no significant difference between those with IBS-diarrhea and controls. Expression level of TRPV1 correlated with that of GDNF (r = 0.741, P < 0.001) and NGF (r = 0.935, P < 0.001). ZO-1 RNA expression levels were lower (P = 0.021) in female IBS-diarrhea than those in controls, although they showed no significant differences between male IBS-diarrhea and controls. Serum IL-1β levels in female IBS were significantly higher than those of male IBS, especially in IBS-constipation (P < 0.001). Conclusion Our results suggest that neurotrophic factors and IL-1β are closely related to IBS-constipation and that decrease of ZO-1 is an important factor in female with IBS-diarrhea.

• 대한가정학회지
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• 제39권9호
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• pp.95-102
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• 2001

The Effects of Self-Esteem and Sociocultural Attitude toward Appearance on Clothing Behavior. The purpose of this study was to investigate to relation between self-esteem and sociocultural attitude toward appearance and clothing behavior i.e. individuality/self expression, body improvement, social approval, sex appeal. Measurements were included Rosenberg's self-esteem, Thompson's sociocultural attitude toward appearance questionnaire and clothing behavior. The data were collected from 498 female university students in Seoul and Kyongki Province. The collection works were undertaken between the 15th of June and 30th of June, 2001, The data were analyzed using factor analysis, reliability test, analysis of variance, and multiple regression analysis. The results of this study were as follows : 1) Three dimensions of sociocultural attitude toward appearance were identified: internalization, social awareness, and concrete awareness. 2) Self-esteem and internalization of sociocultural attitude toward appearance had an effect on clothing behavior i.e. individuality/self expression, body improvement, social approval and sex appeal. Social awareness of sociocultural attitude toward appearance had an effect on body improvement, social approval, and sex appeal.

• 환경생물
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• 제39권2호
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• pp.160-168
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• 2021

Doublesex and mab-3 related transcription factor(dmrt) play crucial roles in sex determination and sex differentiation in vertebrates and invertebrates. Although dmrt genes have been identified in vertebrates, little is known about aquatic invertebrates. In this study, two dmrt genes, namely, Dc_dmrt93B and Dc_dmrt99B, were identified from brackish water flea, Diaphanosoma celebensis. Transcriptional changes were observed in the dmrt genes when the flea was exposed to bisphenol(BP), an endocrine disruptor. Sequence and phylogenetic analyses showed that both dmrt genes contained two conserved domains, namely, DM and DMA, closely clustered with those of Daphnia spp. Additionally, a significant increase in the Dc_dmrt99B mRNA expression level was observed upon exposure to intermediate concentrations of BP (bisphenol A>bisphenol S=bisphenol F, p<0.05), while the expression of Dc_dmrt93B mRNA was slightly modulated. These findings imply that the two dmrt genes may be involved in sex differentiation of D. celebensis. Furthermore, it was found that the ability of BP to modulate dmrt genes could affect development and reproduction. This study provides a basis for understanding the function of the dmrt genes and the molecular mode of action of BP in small crustaceans.

• The International Journal of Costume Culture
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• 제12권1호
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• pp.13-25
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• 2009

This research is progressed to look out for efficient expression-elements of eroticism used in advertisements. Since these expressions of eroticism appealing to sex which is one of the primitive instincts of mankind are increasing in advertisements of cosmetic products which are used more often by recent high-rate-growth and the elevation of living conditions. The most usual expression-elements of eroticism in advertisement are exposure, pose, fashion style, make up, hair style and color. To analyze those expression-elements we made four pieces of fashion advertisement photos with four different types and surveyed both fashion majored students and non-fashion majored students. We applied regression analysis, ANOVA, and frequency analysis to verify the hypothesis. We found that in eroticism, the pose was the most important cognitive feature among the expression-elements and degree of cognition are varied according to major field and sexual interest. As a result, degree of cognition which effected by expression-elements will be varied even in same advertisement. In particular, convincing that the pose was the significant factor of eroticism cognition, expression of eroticism in advertisement would be more diverse and daring.

• 복식문화연구
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• 제3권2호
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• pp.277-291
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• 1995

The purpose of this study is to consider the internal meaning and the external from of Dualism in Unisex Mode : to investigate the dualistic expression appeared on the Unisex Mode by analyzing the general fashion magazine. The results of the study were as follows : First, the phenomenon of Dualism in Unisex Mode may be clues indication that some roles, once assigned exclusively to either males or females, are becoming mutually shared, or what may be called human roles. Second, the expression of Dualism in Unisex Mode whether direct away of symbolic way is represented by metaphoric manner such as unisex look(mono sex look, or trans sex look) with spirit of the time’s. Third, the formality and contents that related dualistic mode shows a various method in style, coordination of texture or item.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.677-681
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• 2012

The aim of the present research was to investigate clinicopathologic correlations of immunohistochemically-demonstrated axin (axis inhibition) and ${\beta}$-catenin expression in primary hepatocellular carcinomas (HCCs), in comparison with paraneoplastic, cirrhotic and normal liver tissues. Variation in Axin expression across groups were significant (P < 0.01), correlating with alpha fetoprotein (AFP), HBsAg, cancer plugs in the portal vein, and clinical stage of HCCs(P < 0.05); however, there were no links with sex, age, and tumour size (P > 0.05). Differences in cell membrane ${\beta}$-catenin expression were also statistically significant (P < 0.01), again correlated with AFP, HBsAg, cancer plugs in the portal vein, and clinical stage in HCCs (P < 0.05) but not with sex, age, and tumour size (P > 0.05). Axin expression levels in tissues with reduced membrane ${\beta}$-catenin were low (P < 0.05), also being low with nuclear ${\beta}$-catenin expression (P < 0.05). Axin and ${\beta}$-catenin may play an important role in the genesis and progression of HCC via the Wnt signal transmission pathway. Simultaneous determination of axin, ${\beta}$-catenin, AFP, and HBsAg may be useful for early diagnosis, and metastatic and clinical staging of HCCs.

• Biomolecules & Therapeutics
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• 제28권6호
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• pp.491-502
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• 2020

Sex/gender disparity has been shown in the incidence and prognosis of many types of diseases, probably due to differences in genes, physiological conditions such as hormones, and lifestyle between the sexes. The mortality and survival rates of many cancers, especially liver cancer, differ between men and women. Due to the pronounced sex/gender disparity, considering sex/gender may be necessary for the diagnosis and treatment of liver cancer. By analyzing research articles through a PubMed literature search, the present review identified 12 genes which showed practical relevance to cancer and sex disparities. Among the 12 sex-specific genes, 7 genes (BAP1, CTNNB1, FOXA1, GSTO1, GSTP1, IL6, and SRPK1) showed sex-biased function in liver cancer. Here we summarized previous findings of cancer molecular signature including our own analysis, and showed that sex-biased molecular signature CTNNB1^High, IL6^High, RHOA^High and GLIPR1^Low may serve as a female-specific index for prediction and evaluation of OS in liver cancer patients. This review suggests a potential implication of sex-biased molecular signature in liver cancer, providing a useful information on diagnosis and prediction of disease progression based on gender.

• 대한의생명과학회지
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• 제19권1호
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• pp.17-24
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• 2013

Animals show a sexual dimorphism in metabolic responses. We investigated to verify whether the peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) agonist fenofibrate regulates obesity and skeletal muscle lipid metabolism with sexual dimorphism and to determine the changes in skeletal muscle expression of $PPAR{\alpha}$ target genes. After both sexes of C57BL/6J mice received a high fat diet with or without fenofibrate for 7 weeks, we examined the effects of fenofibrate on not only body weight, adipose tissue mass, and skeletal muscle lipid accumulation, but also the mRNA expression of $PPAR{\alpha}$-related genes in skeletal muscle. Male mice given a fenofibrate-supplemented high fat diet showed decreased body weight gain and adipose tissue mass compared with mice fed a high fat diet alone, whereas fenofibrate did not reduce them in high fat diet-fed female mice. Lipid accumulation in skeletal muscle was inhibited by fenofibrate in male mice, but not in female mice. Gene expression analysis revealed that fenofibrate increased the mRNA levels of $PPAR{\alpha}$ target enzymes only in male mice. Therefore, our results suggest that sex-dependence differences in obesity and intramuscular lipid levels under fenofibrate treatment could be due in part to the differences in skeletal muscle $PPAR{\alpha}$ activation between male and female mice.

• 만화애니메이션 연구
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• 통권36호
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• pp.281-302
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• 2014

인류는 본능적 욕구를 해소하기 위한 노력을 통해 발전을 지속해왔다. 인간의 욕구중 성욕은 식욕과 함께 가장 본능적인 것의 하나로 분류되며, 선사시대로부터 현재에 이르기까지 다양한 방식으로 표현되고 있다. 성적인 이미지 표현은 사회적, 윤리적 제약 하에서도 시대의 변화와 매체의 발전을 수용하며 더욱 앞서 진화하고 있다. 20세기 초반 사진기술의 발명으로 인해 포르노그래피 이미지는 매우 극적인 변화를 보였다. 영상은 사진보다 직접적인 이미지를 전달하는 매체로써 이러한 변화를 더욱 촉진하였고, 영상매체 중 하나로서 애니메이션은 장치에 의한 이미지인 실사영상이 가진 재현성의 한계를 넘어 실험을 거듭해왔다. 이 논문에서는 애니메이션에서 성적욕망을 어떻게 표현하고 있는가와 이를 있게 한 사회적 배경으로서의 성문화를 연결하여 논의하고자 하며, 그 분명한 사례로써 일본 포르노그래피 애니메이션을 선정하여 분석하였다. 일본 포르노그래피 애니메이션은 문화와 사회제도적 역사로부터 비롯된 결과물로써 해석되어야 한다. 헤이안시대와 에도시대를 거쳐 메이지시대 초기에 이르기까지 일본의 성문화는 매우 개방적이고 때로 파격적인 상태를 유지하였다. 일본 애니메이션에 자주 등장하는 변신, 변태, 미소년 소녀 성애, 촉수성교, 신체 특정부위의 빈번한 노출 등은 와카슈, 처방혼, 혼숙, 남색 등과 같은 고대 일본의 개방적인 성 풍습을 통해 해석할 수 있다. 이와 같은 일본 특유의 성문화는 세계 어느 곳에서도 찾아보기 쉽지 않은 일본 애니메이션 특유의 성적 표현으로 자리한다. 이러한 상황은 20세기에 이르러 2차 세계 대전의 종결과 함께 외부로부터 강제된 서구 근대화에 의해 제도적으로 단절되었다. 그렇지만 내용적으로는 현재까지도 일정한 방식으로 영향력을 지속하고 있는 것으로 보인다. 이 연구에서는 고대 일본의 자유로운 성문화가 제도에 의해 변화되는 일련의 과정을 살펴봄으로써 포르노그래피 애니메이션 또한 문화현상이라는 틀 안에서 해석되어야 함을 논의하였다. 일본 애니메이션 전반에서 발견되는 선정성은 그들의 역사로부터 비롯되며, 여성에 대한 이분법적 표현은 제도적으로 규정된 성 의식에 의해 굴절된 것으로 이해할 수 있다. 일본의 역사와 문화는 포르노그래피 애니메이션에 성적표현의 자유로움을 부여함과 동시에 타자화 된 여성 신체에 대한 두려움이자 뿌리칠 수 없는 매혹이라는 이분법으로 변형되어 드러나고 있음을 알 수 있다.

• 아동학회지
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• 제27권6호
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• pp.97-106
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• 2006

This research examined the relation between emotional expression of parents and self-regulation in children. The subjects were 116 3rd and 6th grade Sunday school children and their parents in 13 churches in Seoul and Kyunggi Province. Data were analyzed by the sex, age and self-regulation of the children and emotional expressiveness of the parents using two-way ANOVA and multiple regression analysis. Results were that mothers showed higher levels of emotional expression than fathers. Positive emotional expression of fathers was related to the self-regulation of sons but not daughters. Positive emotional expression of mothers was related to the self-regulation of daughters but not sons.