• The Korean Journal of Physiology and Pharmacology
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• v.20 no.6
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• pp.605-611
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• 2016

Ketamine is an anesthetic with hypertensive effects, which make it useful for patients at risk of shock. However, previous ex vivo studies reported vasodilatory actions of ketamine in isolated arteries. In this study, we reexamined the effects of ketamine on arterial tones in the presence and absence of physiological concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) by measuring the isometric tension of endothelium-denuded rat mesenteric arterial rings. Ketamine little affected the resting tone of control mesenteric arterial rings, but, in the presence of 5-HT (100~200 nM), ketamine ($10{\sim}100{\mu}M$) markedly contracted the arterial rings. Ketamine did not contract arterial rings in the presence of NE (10 nM), indicating that the vasoconstrictive action of ketamine is 5-HT-dependent. The concentration-response curves (CRCs) of 5-HT were clearly shifted to the left in the presence of ketamine ($30{\mu}M$), whereas the CRCs of NE were little affected by ketamine. The left shift of the 5-HT CRCs caused by ketamine was reversed with ketanserin, a competitive 5-$HT_{2A}$ receptor inhibitor, indicating that ketamine facilitated the activation of 5-$HT_{2A}$ receptors. Anpirtoline and BW723C86, selective agonists of 5-$HT_{1B}$ and 5-$HT_{2B}$ receptors, respectively, did not contract arterial rings in the absence or presence of ketamine. These results indicate that ketamine specifically enhances 5-$HT_{2A}$ receptor-mediated vasoconstriction and that it is vasoconstrictive in a clinical setting. The facilitative action of ketamine on 5-$HT_{2A}$ receptors should be considered in ketamine-induced hypertension as well as in the pathogenesis of diseases such as schizophrenia, wherein experimental animal models are frequently generated using ketamine.

• Proceedings of the KIEE Conference
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• 2003.07a
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• pp.305-307
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• 2003

This paper presents an apparent impedance calculation procedure for distance relaying of transmission line involving FACTS (Flexible AC Transmission System) devices, particularly the UPFC (Unified Power Flow Controller), between Kangjin and Jangheung in Korea. With the changes of UPFC's parameters, the measurement and protective range (trip boundaries) of the adaptive distance relay can also be changed. So, it is the most important part in the field of system protection to analyze the operating characteristic of relaying system. The presence of UPFC significantly affects the trip boundaries which are also adversely affected by fault resistance combined with remote end infeed. This paper presents the apparent impedance calculations and the distance relay setting characteristics for faults involving the UPFC in the KEPCO system.

• Journal of Korean Society for Quality Management
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• v.25 no.1
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• pp.100-115
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• 1997

Shewhart control chart is a basic technique to monitor the state of a process. We observe samples of size four or five and plot some statistic(e.g., mean or range) of each sample on the chart. When setting up the chart, we need to obtain u, pp.r and lower control limits. It is common practice that those limits are calculated from the preliminary 20-40 samples presumed to be homogeneous. However, it may ha, pp.n in practice that the samples are contaminated by outlying observations caused by various reasons. The presence of outlying observations make the control limits wider and hence decrease the sensitivity of the charts. In this paper, we introduce robust control charts with tighter control limits when outlying observations are present in the preliminary samples. Examples will be given via simulation study.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05d
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• pp.82-87
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• 1996

An optimized method for determining beta-emitting $^{241}$ Pu in the presence of alpha-emitting nuclides was developed using a liquid scintillation counting system. PSA-level was setting using pulse-shape discrimination. The $^{241}$ Pu counting channel was adjusted for maximum value of FM using the $^{241}$ Pu standard source. The volume of scintillant was determined for the maximum value of counting efficiency. The optimized method of $^{241}$ Pu has been applied to environmental samples to measure concentration of $^{241}$ Pu in soils and mosses. Also it has been identified the origin of Pu deposited in Korea from the activity ratio $^{241}$ Pu / $^{239,240}$Pu.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.54
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• pp.77-85
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• 2000

One form of job shop scheduling problem in contemporary automated manufacturing such as flexible manufacturing systems (FMS's) is presented which we call the FMS dispatching priority problem. The FMS dispatching priority problem seeks the best dispatching priority of parts and operations, and is essentially a combinatorial optimization problem. Because of the complicated mechanism of the system, the performance of a given dispatching priority must be evaluated via simulation. Simulated annealing have been applied to the problem, and it is found that appropriate parameter setting will be desirable to get good, if not the optimal, solutions within a limited amount of time under the presence of heavy computational burden due to simulation. More specifically, experiments reveal that initial temperature is the single most important factor among other parameters and factors, and that the appropriate initial temperature depends on the allowable computer time in such a way that the less time one can afford to spend, the lower the appropriate initial temperature should be.

• Restorative Dentistry and Endodontics
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• v.41 no.4
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• pp.296-303
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• 2016

Objectives: The purpose of the present study was to evaluate the effects of proanthocyanidin (PAC), a crosslinking agent, on the physical properties of a collagen hydrogel and the behavior of human periodontal ligament cells (hPDLCs) cultured in the scaffold. Materials and Methods: Viability of hPDLCs treated with PAC was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The physical properties of PAC treated collagen hydrogel scaffold were evaluated by the measurement of setting time, surface roughness, and differential scanning calorimetry (DSC). The behavior of the hPDLCs in the collagen scaffold was evaluated by cell morphology observation and cell numbers counting. Results: The setting time of the collagen scaffold was shortened in the presence of PAC (p < 0.05). The surface roughness of the PAC-treated collagen was higher compared to the untreated control group (p < 0.05). The thermogram of the crosslinked collagen exhibited a higher endothermic peak compared to the uncrosslinked one. Cells in the PAC-treated collagen were observed to attach in closer proximity to one another with more cytoplasmic extensions compared to cells in the untreated control group. The number of cells cultured in the PAC-treated collagen scaffolds was significantly increased compared to the untreated control (p < 0.05). Conclusions: Our results showed that PAC enhanced the physical properties of the collagen scaffold. Furthermore, the proliferation of hPDLCs cultured in the collagen scaffold crosslinked with PAC was facilitated. Conclusively, the application of PAC to the collagen scaffold may be beneficial for engineering-based periodontal ligament regeneration in delayed replantation.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.83-91
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• 2019

Gameplay exists not only in game activities, but also in other art forms. An animated film with strong gameplay whose gameplay narrative follows the presupposition principle, achieved through unimaginable sound effects, exaggerated visual styling, hypothetical time and space concepts, fictional storylines and character performances. The strength or the presence or absence of gameplay in animated films is reflected in the grasp and use of these gameplay elements in the process of animated film narratives. The gameplay narrative of animated films fully utilizes the characteristics of gameplay thinking. In the process of scriptwriting and narrative, it combines entertainment, action, adventure, competition and other elements to fully reflect the characteristics of "gameplay". Gameplay narratives often use the strategies of reverse setting, repetition and interaction, and rules and challenges setting, which not only enhances the fun of animated film narratives, but also attracts the attention of the audience, which then can enhance the audience's viewing experience.

• Asia-Pacific Journal of Business
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• v.14 no.4
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• pp.163-174
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• 2023

Purpose - This study examines the effect of consumers' motivations on the perception and purchase intentions of electric cars. Specifically, it empirically analyzes how moral motivations based on personal environmental values and norms in car usage and purchasing influence the perceived usefulness and purchase intentions of electric cars. Furthermore, it investigates whether the influence of moral motivations on perceived usefulness and purchase intentions varies according to the user's driving characteristics. Design/methodology/approach - An online survey was conducted with 234 respondents, by setting criteria for participants as car owners or primary car users within their households, ensuring the sample composition was not biased in terms of the presence or absence of experience with eco-friendly cars. Findings - The research findings indicate that perceived usefulness mediates the effect of consumers' moral motivations on their intention to purchase electric cars. The results of the moderating effect of driving distance on perceived usefulness revealed a significant interaction effect; however, there was no significant interaction effect on purchase intentions. Specifically, for individuals with shorter driving distances, as consumers' moral motivations increase, their perception of the usefulness of electric cars also increases. In contrast, for those with longer driving distances, the increase in perceived usefulness due to moral motivations shows a decreasing trend. Research implications or Originality - This study considered individual driving characteristics that previous research on electric vehicle adoption overlooked, and suggested that setting specific communicating points for electric cars according to driving distance levels might be effective. Lastly, it proposes directions for future research that motivations influencing eco-friendly vehicle purchases may differ based on driving characteristics

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.4 s.316
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• pp.67-73
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• 2007

An optical pick up generally has coupled dynamics between focusing and tracking servos. The coupled dynamics reduces tracking performance of optical disk drives. A conventional control method is holding the previous tracking control command in the presence of surface defect. The method has a long settling time. If the defective area is getting larger, objective lens will get away from the following track. In order to overcome this problem, this paper proposed a new control method for optical disk drives based on a prediction of tracking error and focusing error. We present how to compensate the coupled dynamics so that reduced setting time is achieved. It is verified by experiments that the proposed method brings an improved performance in the presence of surface defect as well as in the normal operating condition.

• Proceedings of the Mineralogical Society of Korea Conference
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• 2003.05a
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• pp.54-54
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• 2003

The metasedimentary rocks together with various granitoids are the main constituents in Taebaeksan gneiss complex, northern Yeongnam Massif. Chemical compositions of sedimentary rocks may reflect the nature of the provenance and could be crucial for understanding the evolution of early continental crust. Previous workers have suggested that the provenance and tectonic studies based on the geochemistry of sediments are applicable to the Precambrian samples. In this study we analyzed the major, trace and REE elements of metasedimentary rocks to understand their provenance and tectonic setting during sedimentation. The overall geochemical characteristics of metasedimentary rocks are similar to those of average shale of the post-Archean. Major element chemistry indicates mature and sorted nature of the sediments. The degree of weathering in the source rocks the is not uniform, as inferred from a large scatter in chemical indices of weathering (CIW). The immobile trace elements such as Th, Sc, and REE can be used to discriminate various sedimentary processes. The Th/sc ratios (0.9 - 4.4) are larger than those of the upper crust and average shale, suggesting that the felsic source predominates. The contents of Ni and Cr and the variations in the ratio of compatible to incompatible elements are similar to the average post-Archean shale. Uniform chondrite-normalized REE pattern with the LREE enrichment (LaN/SmN = 4.9 ${\pm}$ 0.4) and slight negative Eu anomalies (Eu/Eu$\^$*/ = 0.7 ${\pm}$ 0.1) also support this observation. The presence of negative Eu anomaly indicates that intracrustal igneous processes involving plagioclase separation have affected the provenance rocks. The LREE enrichment implies the major role of felsic rocks in source rocks. The eNd (1.9 Ga) values of metasediment rocks vary from 9.4 to 6.7, corresponding to TDM of 2.9 - 2.7 Ga. On the other hand, the 147Sm/144Nd ratios are 0.1079 - 0.1101, corresponding to typical tettigenous sediments. The geochemical features of metasedimentary rocks such as high abundances of large ion lithophile elements, high ratios of Th/Sc and La/Sm, commonly high Th/U ratios, negative Eu anomalies, and negative eNd, suggest a provenance consisting virtually entirely of recycled upper continental crust in passive margin environment. Tectonic discrimination diagrams based upon major element compositions also support this suggestion. In conjunction with igneous activity and metamorphism in the convergent margin setting at 1.8 - 1. 9 Ga, the transition from passive margin to active margin characterize the Paleoproterozoic crustal evolution in northern Yeongnam Massif.