• Nutrition Research and Practice
• /
• v.6 no.2
• /
• pp.120-125
• /
• 2012

The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, $57.4{\pm}13.1$ yrs), anthropometric and biochemical parameters such as lipid profiles and LDL particle size were measured. Dietary intake was estimated by a developed semi-quantitative food frequency questionnaire. The study subjects were divided into two groups: LDL phenotype A (mean size: $269.7{\AA}$, n = 44) and LDL phenotype B (mean size: $248.2{\AA}$, n = 13). Basic characteristics were not significantly different between the two groups. The phenotype B group had a higher body mass index, higher serum levels of triglyceride, total-cholesterol, LDL-cholesterol, apolipoprotein (apo)B, and apoCIII but lower levels of high density lipoprotein (HDL)-cholesterol and LDL particle size than those of the phenotype A group. LDL particle size was negatively correlated with serum levels of triglyceride (r = -0.732, $P$ < 0.001), total-cholesterol, apoB, and apoCIII, as well as carbohydrate intake (%En) and positively correlated with serum levels of HDL-cholesterol and ApoA1 and fat intake (%En). A stepwise multiple linear regression analysis revealed that carbohydrate intake (%En) and serum triglyceride levels were the primary factors influencing LDL particle size ($P$ < 0.001, $R^2$ = 0.577). This result confirmed that LDL particle size was closely correlated with circulating triglycerides and demonstrated that particle size is significantly associated with dietary carbohydrate in Korean women.

• Journal of the East Asian Society of Dietary Life
• /
• v.8 no.1
• /
• pp.9-19
• /
• 1998

The purpose of this study was to investigate the effect of calcium intake on lipid contents and enzyme activities in rats of different ages. Lipid levels in serum and liver and GOT, CPK and LDH activities in serum were compared in rats of different ages(4 weeks and 10 months) that were fed various levels of calcium(50, 100, 200% of requirement)for 3 weeks. Body weight gain and feed efficiency ratio were significantly higher in young rats than in adults. Serum calcium level was increased by elevation of calcium intake levels were decreased. Liver phospholipid and triglyceride levels in the high-cal-terol and triglyceride levels were decreased. Liver phospholipid and triglyceride levels in the high calcium group were significantly lower than those in other groups. Serum GOT and LDH activities of adults were significantly higher in low-calcium group than those in adequate/high-calcium groups. However, serum CPK activity of adults was significantly higher in high-calcium group than that in low/adequate-calcium groups. The results of this study suggest that adequate calcium intake may have protective effects ont he alteration of lipid and enzyme activity in rats.

• Nutrition Research and Practice
• /
• v.1 no.1
• /
• pp.65-69
• /
• 2007

We examined the associations between adiponectin or leptin and serum ICAM-1 levels in seventy-six hypercholesterolemic patients (mean age 59 yrs, 25 males and 51 females, LDL-cholesterol>=130mg/dL at screening). Blood lipid profiles and HOMA-IR derived from fasting glucose and insulin concentrations were determined. Serum levels of adiponectin, leptin and ICAM-1 were analyzed using ELISA The results showed that serum levels of leptin were positively associated with serum levels of ICAM-1 independent of age, sex and BMI (r=0.392, p<0.001). Serum levels of adiponectin were negatively associated with serum levels of ICAM-1 independent of age, sex and BMI (r=-0.343, p<0.005). Stepwise multiple linear regression analysis showed that serum leptin was an independent factor to be associated with serum ICAM-1 levels after adjusting for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.001). With respect to adiponectin, its association with serum ICAM-1 was attenuated but still significant when further adjustments were made for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.005). In conclusion, this study suggests that adiponectin and leptin are associated with endothelial derived inflammation.

• Korean Journal of Community Nutrition
• /
• v.2 no.1
• /
• pp.44-51
• /
• 1997

Secrum lipid and vitamin E levels were determined and smoking, alcohol drinking and exercise habits were asked in 357 healthy male subjects aged 49.4$\pm$6.7 years in Taegu. Average serum levels of total cholesterol, HDL-cholesterol and triglyceride(TG) were 189$\pm$43mg/이, 42$\pm$13mg/dl and 136$\pm$73mg/이, respectively. Serum level of lipid peroxide measured as thiobarbituric acid reactive substances(TBARS) of the subjects was 2.01$\pm$0.73MDA nmoles/ml and that of $\alpha$-tocopherol was 9.53$\pm$3.14ug/ml. The correlation coefficients between $\alpha$-tocopherol and serum lipids were 0.3631 for triglyceride, 0.2993 for cholesterol, and 0.3025 for total lipid. Heavy smokers who smoked more than 20 cigarettes a day had higher levels of TG and TBARS than those who smoke less. Alcohol drinkers had higher levels of TG and TBARS than nondrinkers. Vitamin E level(per ml serum)was significantly higher in the heavy smokers and drinkers, which was reflected by the higher level of serum lipid. When the level of $\alpha$-tocopherol was expressed as $\alpha$-tocopherol/triglyceride, it was negatively correlated with serum TBARS level and was lower in the heavy smokers than in the moderate smokers. It is concluded that vitamin E level as $\alpha$-tocopherol/triglyceride would be better compared to $\alpha$-tocopherol/total cholesterol or $\alpha$-tocopherol/total lipid for the evaluation of vitamin E status in Korean men.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.23 no.5
• /
• pp.718-724
• /
• 1994

The study was conducted to investigated the effect of dietary levels of zinc (Zn) on lipid metabolism in cadmium (Cd) treated rats. Sixty male Sprague-Dawley rats weighing about 110$\pm$10g were divided into 6 groups. The Zn levels were low (0ppm), control (30 ppm) and Cd-treated groups were administrated with Cd chloride (5.0mg/kg of body weight) by oral intubation at the same time once a week. Serum total lipid, triglyceride , total cholesterol and DHL-cholesterol contents decreased significantly in low Zn group. In serum dietary high Zn group, it decreased significantly in the content of triglyceride but total cholesterol and HDL- cholesterol revealed increase slightly . Total lipid and triglyceride contents increased by Cd oral intubation, but triblyceride content of control group decreased significantly in Cd-treated groups. HDL-cholesterol content also decreased by Cd oral intubationl. Cd-treatment increased total cholesterol content in low Zn group. Liver triglyceride content increased as dietary Zn level became more increasing and total lipid was not influenced by dietary Zn levels. Liver cholesterol content was higher in low and high Zn groups than that of control group. Liver phospholipid content decreased in low Zn group . Oral intubation of Cd increased in the contents of triglyceride and total lipid. The content of liver Zn was not influenced by the dietary low Zn but that of serum showed a remarkable increased . Oral Cd intubation increased the Cd contents of liver and serum.

• Journal of Nutrition and Health
• /
• v.28 no.5
• /
• pp.387-396
• /
• 1995

This study was undertaken to investigate the effect of increase in the ratio of zinc to copper and alcohol consumption on serum lipid content in Sprague-Dawley male rats during five weeks. Sixty rats were divided into six groups, CZ < zinc 30ppm diet >, CZA < zinc 30 ppm diet plus alcohol 5% solution >, HZ < zinc 300ppm diet >, HZA < zinc 300ppm diet plus alcohol 5% solution >, SHZ < zinc 600ppm diet >, SHZA < zinc 600 ppm diet plus alcohol 5% solution >. High ratio of zinc to copper groups < HZ, SHZ > were significantly decreased in high-density lipoprotein (p<0.01) and increased in total cholesterol, triglyceride, total lipid in serum(p<0.001, p<0.001, p<0.01). Triglyceride levels of serum in alcohol groups < CZA, HZA, SHZA > were significantly higher (p<0.001) than non-alcohol group < CCZ, HZ, SHZ >. Copper levels of serum were reduced in group high ratio of zinc to copper. These results present that high ratio of zinc to copper increase cholesterol(p<0.001) and alcohol consumption increase triglyceride(p<0.001) in serum. This close association to lipid metabolism in rats draw attention to the potential significance of zinc and alcohol nutriture in relation to cardiovascular disease.

• The Korean Journal of Community Living Science
• /
• v.26 no.2
• /
• pp.351-360
• /
• 2015

The study examines the effects of the Cnidium officinale Makino water extract on hyperlipidemia. For this, three levels (low, moderate, and high) of the Cnidium officinale Makino water extract were supplemented to six-week-old male sprague Dawley rats for five weeks. According to the results, serum total lipid, triglyceride, total cholesterol, and LDL cholesterol levels showed significant decreases (p<0.05) in the group with the Cnidium officinale Makino water extract. The serum total lipid level decreased by 8~22%; the triglyceride level, by 13~25%; the total cholesterol level, by 6~23%; and the LDL cholesterol level, by 14~25%. Total cholesterol and triglyceride levels in the liver were significantly lower in the group with the Cnidium officinale Makino water extract than in the control group (p<0.05), and fecal total cholesterol and triglyceride levels were significantly higher in the group with the Cnidium officinalle Makino water extract. These results suggest that the Cnidium officinale Makino water extract in the hypercholesterol diet may reduce hyperlipidemia, a major cause of cardiovascular disease, by reducing serum cholesterol and triglyceride level in the liver through the facilitation of their excretion by feces.

• Journal of the Korean Applied Science and Technology
• /
• v.1 no.1
• /
• pp.11-21
• /
• 1984

The purpose of the study was to find an effect of medium chain triglyceride (MCT)diet on the serum lipids and lipoprotein of Sprague-Dawley rats when the were fed with cholesterol. All experiment-groups were fed with different diet such as soybean oil, shortening,MCT and MCT mixed with oil respectively. After fed to each group, the levels of serum lipids and lipoprotein among fed rats were examined and the data from the experiment were compared with a control group. The results obtained from the study are as follows : (1) The average boby weight gain in MCT diet and soybean oil diet groups were lighter than that of the control group, while the food efficiency ratio in each experimental diet group was almost same as than in the control group. (2) Total cholesterol levels in serum of all experimental diet groups were lower than that of the control group except the level in shortening diet group. Especially, the levels of total cholesterol in MCT diet and soybean oil diet groups were significantly lower than that of the control group. (3) VLDL, LDL-cholesterol levels of all experimental groups were almost same except the case of the MCT diet and soybean oil diet group which was significantly low. (4) The ratio of VLDL, LDL-cholesterol to HDL-cholesterol, so called, atherogenic index in serum of MCT and soybean oil diet groups were significantly lower than that of the control group. (5) The ratio of total cholesterol to phospholipids in serum of MCT diet group was decreased, because total cholesterol levels were decreased more than phospolipid levels. (6) The ratio of the serum VLDL, LDL to HDL in MCT diet group. in MCT and soybean oil mixed diet group, and in soybean diet group was decreased. In other wards, it means that the decrease of the serum VLDL, LDL in each group and the increase of the serum HDL.

• Journal of Nutrition and Health
• /
• v.26 no.8
• /
• pp.925-932
• /
• 1993

To study the effects of dietary protein and magnesium level on serum lipid contents and enzyme activities, male Sprague-Dawley rats were divided into six groups. Six groups of animals were fed six experimental diets different with protein(8% and 20%) and magnesium levels (Mg-free, 400mg/kg diet and 800mg/kg diet). The serum lipid contents and enzyme activities of rats fed different dietary protein and magnesium levels were examined. Serum triglyceride contents was significantly decreased as the dietary magnesium level was increased. Serum phospholipid contents was significantly higher in magnesium deficient group than those in the other groups. Serum alkaline phosphatase activity was significantly decreased in magnesium dificient group compared with other groups, but serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities was significantly increased in magnesium dificient group than other groups. In conclusion, serum triglyceride contents in low protein level was remarkably decreased as the dietary magnesium level was increased.

• The Journal of Pediatrics of Korean Medicine
• /
• v.10 no.1
• /
• pp.221-244
• /
• 1996

In order to study the effects of Jamyong-oil(蠶?油) on the diabetic rats induced by streptozotocin, during 15days rats were administered Jamyong-oil after streptozotocin injection(50mg/kg). On 2nd, 9th and 15th day, I investigated the levels of serum glucose, serum total cholesterol, serum triglyceride, serum amylase, and body weight. The last day, I killed rats and investigated hepatic lipid peroxide, tissue amylase. The results were obtained as follows: 1. Serum glucose levels of the sample group decreased effectively (p < 0.05) at the 15th day as compared with the control group. 2. Serum total cholesterol levels of the sample group decreased effectively (p < 0.05) at the 9th and 15th day as compared with the control group. 3. Serum triglyceride levels of the sample group decreased effectively (p < 0.05) at the 15th day as compared with the control group. 4. Activities of the serum amylase of the sample group increased respectively at the 9th (p < 0.05) and 15th (p < 0.01) day as compared with the control group. 5. Body weights of the sample group increased effectively (p < 0.05) at the 15th day as compared with the control group. 6. Hepatic lipid peroxide levels of the sample group decreased significantly (p < 0.01) as compared with the control group. 7. Tissue amylase levels of the sample group increased but not effective as compared with the control group.