• 동의생리병리학회지
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• 제20권6호
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• pp.1477-1484
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• 2006

This experimental study was designed to investigate the effects of Acanthopanax sessiliflorus $S_{EEM}$ extracts following gamma-ray irradiation on the change of weight, the serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level in obese mice induced by high fat diet, and the change of regional cerebral blood flow (rCBF) and blood pressure (BP) in normal rats. Experimental materials were as follows ; 10AS was the bark powder of Acanthopanax sessiliflorus $S_{EEM}$ stems which was exposed in 10 kGy electron beam, 10AS was the bark powder of Acanthopanax sessiliflorus $S_{EEM}$ roots which was exposed in 10 kGy electron beam, 100S was the bark powder of Acanthopanax sessiliflorus $S_{EEM}$ stems which was exposed in 100 kGy electron beam, Experimental groups were as follows ; Normal group was fed with normal diet and administered with distilled water during 5 weeks, Control group was fed with high fat diet and administered with distilled water during 5 weeks, Sample A group was fed with high fat diet and administered with 10AS of 300 mg/kg/mouse/day during 5 weeks, Sample B group was fed with high fat diet and administered with 10AR of 300 mg/kg/mouse/day during 5 weeks, Sample C group was fed with high fat diet and administered with 100AS of 300 mg/kg/mouse/day during 5 weeks. The results were as follows ; Sample A group, Sample B group and Sample C group were significantly decreased body weight and the serum LDL-cholesterol, triglyceride, total lipid level in comparison with Control group. Sample A group, Sample B group and Sample C group were significantly increased the serum HDL-cholesterol level in comparison with Control group. Sample B group and Sample C group were significantly decreased the serum total cholesterol, free fatty acid and phospholipid level in comparison with Control group. This results were suggested that all experimental materials were able to be used for the obesity. 10AS did not changed rCBF and MABP in a dose-dependent manner. 10AR significantly increased rCBR in a dose-dependent manner, and BP did not change in a dose-dependent manner. 100AS decreased rCBF and BP in a dose-dependent manner. This results were suggested that 10 AR significantly increased rCBF by dilating pial arterial diameter. According to above results, the authors suggested that 10AR was able to be used for the obesity and ischemic disease.

• Asian-Australasian Journal of Animal Sciences
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• 제33권11호
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• pp.1779-1786
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• 2020

Objective: To evaluate soy sauce oil (a by-product of making whole soybean soy sauce) as a new dietary lipid source, a large amount of soy sauce oil was administered into the rumen of dairy cows. Methods: Four Holstein dairy cows fitted with rumen cannulae were used in a 56-day experiment. Ruminal administration of soy sauce oil (1 kg/d) was carried out for 42 days from day 8 to day 49 to monitor nutritional, physiological and production responses. Results: Dry matter intake and milk yield were not affected by soy sauce oil administration, whereas 4% fat-corrected milk yield and the percentage of milk fat decreased. Although ruminal concentration of total volatile fatty acids (VFA) and the proportion of individual VFA were partially affected by administration of soy sauce oil, values were within normal ranges, showing no apparent inhibition in rumen fermentation. Administration of soy sauce oil decreased the proportions of milk fatty acids with a carbon chain length of less than 18, and increased the proportions of stearic, oleic, vaccenic and conjugated linoleic acids. Conjugated linoleic acid content in milk became 5.9 to 8.8 times higher with soy sauce oil administration. Blood serum concentrations of non-esterified fatty acid, 3-hydroxybutyric acid, total cholesterol, free cholesterol, esterified cholesterol, triglyceride and phospholipid increased with administration of soy sauce oil, suggesting a higher energy status of the experimental cows. Conclusion: The results suggest that soy sauce oil could be a useful supplement to potentially improve milk functionality without adverse effects on ruminal fermentation and animal health. More detailed analysis is necessary to optimize the supplementation level of this new lipid source in feeding trials.

• 대한본초학회지
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• 제25권3호
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• pp.103-109
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• 2010

Objective : The aim of this study is to investigate the effects of Taeyeumjoweetang (TJT) and Taeyeumjoweebaemahwangtang (TJBM) medication on body weight change and serum total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level, and CBC of obese rats. Methods : Obese rats induced by high-fat fed are medicated for 7 weeks. 32 rats are divided into four groups depending on the medication; normal group (general-fat fed and no-medication), control group (high-fat fed and no medication), TJT group (high-fat fed and TJT medication) and TJBM group (high-fat fed and TJBM medication). After 7 weeks, obesity related index and CBC are analysed. Results : There is a significant statistical difference between control group and TJBM group for the body weight change, the total cholesterol, HDL cholesterol, and triglyceride level: total cholesterol values of control and TJBM are $59.25{\pm}9.56 mg/d{\ell}$ and $39.13{\pm}9.08 mg/d{\ell}$, respectively; HDL cholesterol values of control and TJBM are $22.0{\pm}1.69 mg/d{\ell}$ and $13.75{\pm}2.19 mg/d{\ell}$, respectively; triglyceride values of control and TJBM are $12.75{\pm}3.37 mg/d{\ell}$ and TJBM : $8.13{\pm}1.64 mg/d{\ell}$, respectively. There is a significant statistical difference between control group, TJT, and TJBM group for free fatty acid and phospholipid level: free fatty acid values of control, TJT, and TJBM are $936.25{\pm}89.59 {\mu}m/{\ell}$, $738.75{\pm}109.47{\mu}m/{\ell}$, and $720{pm}150.71{\mu}m/{\ell}$, respectively; phospholipid values of Control, TJT, and TJBM are $87.13{\pm}11.86mg/d{\ell}$, $70.5{\pm}12.22 mg/d{\ell}$, and $60.5{\pm}11.1 mg/d{\ell}$, respectively. Conclusion : These results suggest that medication of TJT and TJBM is effective for the treatment of obesity. Especially, TJBM is more effective than TJT.

• 한국식품영양과학회지
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• 제18권3호
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• pp.307-315
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• 1989

${\omega}3$계와 ${\omega}6$계 PUFA의 함유비율을 달리했을때 흰쥐장기의 지질대사 및 혈청 lipoprotein 조성에 미치는 영향을 알아보고자 실험한 결과를 요약하면 아래와 같다. 뇌 조직중의 총cholesterol농도는 전 식이군 간에 유의성은 없으나 ${\omega}6$계 linoleic acid 함유율이 높은 고추씨기름 10%단독 식이군에서 높은 함량을 보이는 반면 ${\omega}3$계 linolenic acid 함유율이 높은 들깨유 식이군 및 혼합 식이군에서 감소하는 경향을 보였다. 한편 중성지방 및 인지질 농도는 고추종자유 함유율이 높은 식이군에서 서서히 증가하지만 들깨유 함유량이 많아질수록 점차 감소하였다. 신장 조직중의 총cholesterol농도는 전 군간에 유의성이 없었으며, 중성지방 농도는 ${\omega}6$계 linoleic acid함유 비율이 높은 고추종자유 식이군이 가장 높았고 혼합 식이군에서 낮았다. 인지질 농도는 10% 고추종자유 식이군에서 현저히 낮았다. 고환 조직중의 총cholesterol농도는 혼합 식이군 및 들깨유 식이군에서 낮았으며, 중성지방 농도는 들깨유 식이군에서 상승하였고 혼합 식이군에서 감소하였다. 인지질 농도는 5군에서 낮았다. 혈청 lipoprotein pattern에서 HDL은 들깨유 함량이 많은 식이군(1,2,3군)에서 상승된 반면 고추씨기름 식이군에서는 가장 낮았으며, LDL은 들깨유 비율이 높아질수록 점차로 낮아졌다.

• 한국보건간호학회지
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• 제15권2호
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• pp.363-375
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• 2001

The purpose of this study is to analyse the effects of obesity management program in food attitude and food habit, body composition(body fat ratio, body fat weight, lean body mass, total body water), abdominal girth(waist, hip, thigh), and serum lipid level(cholesterol, low density lipoprotein, triglyceride, phospholipid, NE fatty acid, high density lipoprotein) of middle aged women. Data for the study were collected from July 4 to August 25, 2000. The study objects were 20 middle aged women(10 controls and 10 experimental objects) from 40 to 50 years old who had body fat ratio more than $30\%$ and waist girth more than 80cm. The results were as follows: 1. Similarity test between experimental group and control group processed by serum HDL level showed the significant difference(t=3.25, p=0.004), but that processed by age, body weight, body fat ratio, body fat weight, lean body mass, total body water, waist girth, hip girth, thigh girth, cholesterol level, LDL level, triglyceride level, NE fatty acid level, food attitude and food habit score showed no significant difference(p>0.05). These findings imply that the two groups are similar in the sample distribution. 2. The effects of the abdominal obesity management program The obtained results indicate that the abdominal obesity management program in middle aged women changes the food attitude & the food habit. decreases the body fat ratio & the body fat weight and increases the lean body mass, and decreases the girth of waist & hip and the serum level of cholesterol & LDL. Therefore, it is concluded that the abdominal obesity management program can be applied for nursing intervention to decrease the body fat weight and abdominal obesity.

• 동의생리병리학회지
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• 제22권5호
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• pp.1152-1157
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• 2008

Hyperlipidemia has been treated as one of the most important etiological cause factor in 21th century. The cortex and root of Acanthopanax sessiliflorus (AR), a herbal medicine, have been used for several diseases including cardiovascular diseases in Oriental countries. Recently, we reported that AR has anti-hyperlipidemic action. BS-01 was made using extract from AR. For these reasons, we investigated the effects of BS-01 as anti-hyperlipidemic drug through measurement of body weights, cholesterol levels, total lipid, phospholipid in serum. In our results, mice induced by high fat diet elevated body weight level compared to naive group. And total lipid in serum was also elevated by induction of hyperlipidemia. In BS-01 group, body weight of mice was lowered significantly compared to that of control group. Oral administration of BS-01 decreased total cholesterol and triglyceride level back to that of naive mice. HDL and LDL cholesterol levels were not affected by BS-01. In addition, total lipid level, which elevated by induction of hyperlipidemia was also lowered by oral administration of BS-01. Finally, free fatty acid level was lowered in BS-01 group. These results demonstrate that BS-01 lowered body weight and titers involved in hyperlipdemia such as total cholesterol, triglyceride, free fatty acid and total lipid. In these results, we demonstrate that BS-01 has anti-hyperlipidemic action.

• 동의생리병리학회지
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• 제25권4호
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• pp.596-602
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• 2011

The aim of this study is to investigate the effects of onion and acanthopanax senticosus on body weight change, serum total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level, renal and liver function test, and CBC in obese rats and mice. Obese rats induced by high-fat fed are medicated for 7 weeks. Rats are divided into four groups depending on the medication; normal group (general-fat fed and no-medication), control group (high-fat fed and no medication), sample A group (high-fat fed and onion 100% extracted medication), sample B group (high-fat fed and onion 50% & acanthopanax senticosus 50% extracted medication), sample C group (high-fat fed and red onion 50% & acanthopanax senticosus 50% extracted medication). After medication, obesity related index, renal and liver function test, and CBC are analysed. There are significant statistical differences among control group and all experimental groups for the body weight change. There are significant statistical differences among control groups and all experimental groups for the total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride level, free fatty acid, and phospholipid level. These results suggest that medications of onion and acanthopanax senticosus extracted products are effective for the treatment of obesity. Especially, onion 100% extracted product is more effective than the others.

• 대한수의학회지
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• 제30권4호
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• pp.407-412
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• 1990

This study was designed to elucidate the effects of administration with dietary iron and fat-free diet on the contents of unsaturated fatty acid in phospholipid molecules, vitamin E contents and malondialdehyde contents in liver, kidney, muscle and testis of the male rats. The rats were divided into 3 experimental groups, namely, control, iron injection and fat-free diet administration groups. The control group was fed with normal diet, iron injection group injected intraperitoneally 20mg of ferric hydroxide/100g of body weight 20 times every 3 days and fat-free diet group administered lipid extraction diet with hexane in normal diet. All experimental groups were maintained for 60 days with feeding on the respective ration. The results obtained were summarized as follows: 1. In the mean contents of unsaturated fatty acid in phospholipid of liver, kidney, muscle and testis among groups, control group was 21.31mg/g, 19.38mg/g, 1.67mg/g, 13.68mg/g, iron injection group was 13.83mg/g, 16.53mg/g, 0.71mg/g, 10.11mg/g and fat-free diet group was 21.07mg/g, 19.38mg/g, 1.49mg/g and 13.40mg/g, respectively. 2. In the mean contents of vitamin E in liver, kidney, muscle and testis among groups, control group was 6.77mg/g, 1.93mg/g, 0.12mg/g, 0.17mg/g, iron injection group was 3.16mg/g, 0.86mg/g, 0.07mg/g, 0.09mg/g and fat-free diet group was 7.41mg/g, 1.50mg/g, 0.11mg/g and 0.16mg/g, respectively. 3. In the mean contents of malondialdehyde in liver, kidney, muscle, testis and serum among groups, control group was 11.29nM/0.1g, 23.25nM/0.1g, 42.47nM/0.1g, 7.01nM/0.1g, 4.33nM/ml, iron injection group was 34.98nM/0.1g, 40.55nM/0.1g, 72.21nM/0.1g, 12.26nM/0.1g, 11.27nM/ml and fat-free diet group was 8.07nM/0.1g, 20.63nM/0.1g, 39.92nM/0.1g, 6.95nM/0.1g and 4.27nM/ml, respectively.

• 한국식품영양과학회지
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• 제18권3호
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• pp.338-347
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• 1989

${\omega}-3$계와 ${\omega}-6$계 PUFA가 혈청과 간장의 지질대사에 미치는 영향을 규명하기 위하여 ${\omega}-6$계 linoleic acid를 약 64% 함유하고 있는 고추종자기름과 ${\omega}-3$계 linolenic acid 함유비율이 약 60%인 들깨기름을 몇가지 비율로 혼합하여 흰쥐에게 급여하여 얻어진 결과는 다음과 같다. 혈청중 총 cholesterol 농도는 들깨기름 10%를 급여받은 1군이 고추씨기름의 함량이 높은 4군과 5군에 비하여 유의적으로 낮았으며, HDL-cholesterol 농도는 ${\omega}-6$계 linoleic acid의 비율이 높아짐에 따라 점차로 증가하는 경향이었고 ${\omega}-3$계 linolenic acid 함유율이 높아짐에 따라 유의성있게 저하하는 경향이었다. 총 cholesterol에 대한 HDL-cholesterol 농도는 10% 고추종자기름을 급여한 5군에서 가장 높았고 5% 들깨유와 5% 고추종자기름을 혼합 급여한 3군의 순이었다. 혈청중의 중성지질과 인지질 농도는 7.5% 들깨기름과 2.5% 고추종자기름의 혼합 식이군인 2군이 2.5% 들깨유와 7.5% 고추종자유 혼합 식이군인 4군에 비하여 유의적으로 낮았다. 간장중의 총 cholesterol 농도는 고추씨 기름 10% 단독 식이군에서 가장 높았으며 들깨유와 고추씨 기름의 혼합 식이군 (2, 3, 4 군)에서 낮았다. 간장중의 중성지방 농도는 10% 들깨유군 및 10% 고추씨기름의 단독 식이군에서 높은 반면 혼합 투여군에서 감소하는 경향을 보였으며 인지질 농도는 각 군간에 유의적인 차이는 없었다.

• 한국응용과학기술학회지
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• 제1권1호
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• pp.57-64
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• 1984

The study was performed to understand the effects of perilla and pine nut oils on hypercholesterolemia in cholesterol-fed male rats. All rats fed with the experimental diets for 3 weeks were decapitated to take serum. From the serum, the levels of total cholesterol, triglyceride, HDL-cholesterol, free cholesterol, phospholipid, lipoprotein and glucose were measured, and the results were summarized as follows. 1. The experimental diets supplemented with perilla and pine nut did not influence on the body weight and on amount of food intake, but decreased significantly total cholesterol level by the rate of 22-30% 2. The perilla diets decreased the ${\beta}-/{\alpha}-lipoprotein$ value from 0.99 to 0.50-0.51, but the pine nut diets decreased to 0.68-0.69. 3. The 10% diets of perilla and pine nut decreased the triglyceride concentration by the rate of 11-14%, but it was not significant difference. 4. The perilla diets increased the HDL-cholesterol level by the rate of 53-72%, and the pine nut diets 72-92%, but both of these diets did not influence on the free cholesterol concentration. 5. The perilla diets decreased phospholipid concentration by the rate of 20-23%, but it was not significant difference. 6. The diets of 10% perilla and 5% pine nut decreased significantly the free fatty acid concentration by the rate of 48% and 34% respectively. 7. The diets of 10% perilla and pine nut decreased a little the glucose level, but it was not significant difference.