• 한국식품영양과학회지
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• 제23권2호
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• pp.192-197
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• 1994

6주간 고지방식이를 섭취한 흰주에 있어 송화분과 탈지 송화분이 혈청과 간장에서의 지방 축적과 대사에 미치는 효과를 관찰하였다. 혈청에서의 total lipid, total cholesterol 농도는 고지방 식이군에 비해서 탈지 송화분과 송화분 투여군이 유의적으로 감소하였다. 혈청에서의 triglyceride 농도는 탈지 송화분과 송화분 투여군이 고지방 식이군과 비교했을 때 뚜렷한 감소를 보였으며, 이는 정상군과 비슷한 농도를 나타내었다. 혈당 농도는 송화분, 탈지 송화분 투여군에서 유의성 있게 감소하였다. 간장을 조직학적으로 관찰한 결과, 고지방식으로 인한 조직의 지방 침착은 송화분 투여군에서 다소 억제함을 보였다. 이상의 결과를 미루어 볼 때 송화분은 동맥경화증 및 순환기계 질환의 예방과 치료에 효과적일 것으로 사료된다.

• 한국식품영양과학회지
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• 제23권1호
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• pp.23-30
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• 1994

This study was carried out to investigate the effect of the feeding mixture of linseed oil, rich in n-3 PUFA and the sunflower seed oil, rich in n-6 PUFA on the lipid metabolism in the dietary hyperlipidemic rats. After male Sprague-Dawley rats were induced hyperlipidemia by feeding the diet containing lard, butter and cholesterol for 3 weeks, then they were fed with the diet containing lard 3.0 % and butter 12.0% for control, the mixture in different proportion of both linseed oil and sunflower seed oil and antihyperlipidemic drugs for 2 weeks. Analysis of the lipid component of the serum showed following results. Concentration of total cholesterol in serum was significantly lower in the other groups except group 2 (lard 3.0 % + olive oil 12.0%) than in the control group , especially in groups 3 (cholestyramine 2.0%) and 5 (lard 3.0% + linseed oil 12.0%). HDL-C and the ratio of HDL-C to total cholesterol concentration were higher in groups 1, 3, 5 and 9 (lard 3.0% + sunflower seed oil 12.0%) , while the atherosclerotic index was low in groups3, 5. Concentrations of free cholesterol and choesteryl ester in serum were significantly lower in the other groups except group 2 than in the control group, especially lower in grop 5. Concentration of LDL was significantly higher in group 2 while it was remarkably lower in groups 3 and 5, while those of triglyceride in groups in 3 and 4 (lipraroid) were significantly higher than in the control groups. From the data on concentration of total choelsterol , HDL-cholesterol, LDL, phospholipid and triglyceride in serum, the results suggested that the feeding mixed with 3.0% lard and 12.0% linseed oil or 2.0% cholestyramine were most effective for the improvement of the serum lipids.

• Food Science and Biotechnology
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• 제17권2호
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• pp.287-294
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• 2008

Protective effects of cheonggukjang fermented with 20% red ginseng (RC) were observed in streptozotocin (STZ)-induced diabetic rats by measuring levels of blood glucose, serum lipid profiles, and hepatic reactive oxygen species generating and scavenging enzymc activities. RC diet was prepared by mixing with AIN-76 diet at the final concentration 2%, and it was fed to STZ-induced diabetic rats for 3 weeks. The RC dict was significantly improved body weight, feed efficiency ratio, levels of serum glucose, and serum and hepatic lipids in diabetes. The significantly elevated O type activity of xanthine oxidase in diabetes was also greatly decreased by the RC diet. The treatment of RC showed the improved hepatic glutathione s-transferase activities in the diabetic animals. The present study indicates that cheonggukjang fermented with red ginseng could ameliorate STZ-induccd diabetic symptoms such as aggravated blood glucose levels, serum lipid profiles, and even the conditions of oxidative stress.

• 한국식품영양학회지
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• 제25권4호
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• pp.697-705
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• 2012

This research was planned and executed to evaluate how the composition of Yack-sun (oriental diet therapy) tea can effect the health conditions of people who are suffering from diet-related diseases such as being overweight, obese and hyperlipidemic, by taking Yack-sun tea in a form of nutritional supplement with daily meals. We produced Kangjieum with Lycense Mill., Polygonum multflorum Thunb, Cassia tora L., Crataegus pinnatifida Bge and Salvia miltiorrhiza Bge. We evaluated the effects of this tea on serum lipids, on homocysteine concentration, and on active oxygen contents, oxidative stress by clinical practices. We have determined that this tea has a significant effect on decreasing body fat content, decreasing total cholesterol, decreasing LDL-cholesterol, and decreses triglyceride and homocysteine concentrations. In addition, blood active oxygen content and oxidative stress were significantly decreased. We think that scientific and objective evaluation was performed on the components of Kangjieum prescription. We concluded that we could apply the components, not only in a form of tea, but also in other forms of various foods. The information we received from this conclusion will be basic information on how we can apply oriental medicinal resources into other food and will be a steppingstone for medicinal herbs to place a foot in the field of functional food research, which already draws sizable attention world-wide.

• Journal of Nutrition and Health
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• 제26권6호
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• pp.672-679
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• 1993

This study was designed to determine changes of serum glucose and lipid levels in noninsulin dependent diabetes mellitus patients during different doses of docosahexaenoic acid (DHA)-rich fish oil supplementation. All patients had a fasting blood glucose of less than 180mg/dl, a LDL-cholesterol of less than 160mg/dl, and a triglyceride of more than 160mg/dl. None had clinical evidence of renal, hepatic or coronary vascular disease. Sixteen patients served as control. Seven patients ingested 2.00g of fish oil(low dose group), consisting of 0.30g eicosapentaenoic acid(EPA) and 0.55g DHA. The group of modest dose(n=9) was provided 3.91g of fish oil, consisting 0.59g EPA and 1.08g DHA. After 4 weeks, serum triglyceride concentration showed a mild but nonsignificant elevation in control group, a 9% decrease(194 to 177mg/dl) in the group of low dose of fish oil and a 28% decrease(206 to 161mg/dl) in the group of modest dose. The level of high density lipoprotein(HDL), HDL2, HDL3 and total cholesterol in all groups were not changed. There was a mild increase in malondialdehyde and low density lipoprotein(LDL)-cholesterol concentration and decrease in $\alpha$-tocopherol concentration. However, these changes were not significant.

• Preventive Nutrition and Food Science
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• 제7권1호
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• pp.72-77
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• 2002

The purpose of this study was designed to observe the effects of Zizyphus jujuba seed extract on the concentrations of the lipids and blood glucose in the S.D. rats fed the experimental diets for 4 weeks. Concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, triglyceride (TG), phospholipid (PL) and blood glucose in serum were significantly higher in the cholesterol administration groups (group 2 (cholesterol+water), group 3 (cholesterol+Zizyphus jujuba seed extract)) than those in the control group (group 1, basal diet+water). But the concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum ware remarkably lower in the group 3 than those in the group 2. In the ratio of HIDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration, Zizyphus jujuba seed extract administration group was higher percentage than in the group 2. The activities of aspartate aminotransferase (AST), alanine amino-transferase (ALT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in serum were rather lower in the Zizyphus jujuba seed extract administration group (group 3) than in the cholesterol diet group (group 2). From the above research, Zizyphus jujuba seeds were effective on the improvement of the blood glucose, lipid compositions in serum of dietary hyperlipidemic rats. And particularly, Zizyphus jujuba seeds were more effective as a therapeutic regimen for the control of metabolic derangements in adult disease.

• 대한지역사회영양학회지
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• 제10권4호
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• pp.493-500
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• 2005

There is some evidence that soy isoflavone has beneficial effects on the concentration of blood lipids. In this study, we investigated habitual isoflavone intake levels and the relation among dietary isoflavone intake, blood pressure, and blood lipids of adult men (n = 149) and women (n = 205). Anthropometric measurements including blood pressure, dietary in-take assessment using 24-hour recall method, and biochemical assessment using blood were conducted. The average age, height, weight, and BMI were 54.7 years, 168.5 cm, 67.3 kg, and 24.5 $kg/m^2$ for men and 53.9 years, 153.8 cm, 59.2 kg, and 25.0 $kg/m^2$ for women, respectively. The mean daily intakes of total food and energy were 1219.1 g and 1740.9 kcal for men and 1071.3 g and 1432.6 kcal for women, respectively. The mean daily isoflavones (daidzein + genistein) intake of men and women were 20.0 mg and 14.2 mg, respectively. Blood pressure of the subjects was 128.3/75.5 mmHg for men and 124.1/73.7 mmHg for women. Serum lipids of men and women were 180.2 and 184.9 mg/dL for total cholesterol, 160.8 and 137.6 mg/dL for triglyceride, 41.5 and 44.7 mg/dL for HDL-cholesterol, 106.6 and 112.7 mg/dL for LDL-cholesterol, and 3.5 and 3.3 for atherogenic index, respectively. Serum triglyceride and atherogenic index of men were significantly higher than those of women. In men, isoflavone intake and the level of total serum cholesterol were negatively (p < 0.05) correlated, after adjusted age. In women, there were significant correlations between isoflavone intake and blood pressure (systolic and diastolic), after adjusted age (p < 0.05). Based on these results, we concluded that higher isoflavone intake seemed to be related to a better lipid profile in men and lower blood pressure in women. But more epidemiological studies and controlled clinical trials would help to confirm the optimal amount required for the prevention and treatment of cardiovascular disease.

• 대한지역사회영양학회지
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• 제7권1호
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• pp.102-110
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• 2002

Cigarette smoking has long been recognized as a major risk factor in the development of coronary heart disease. Several investigators have reported the strong association between smoking and high serum cholesterol, triglyceride concentration, SFA and low HDL cholesterol, PUFA and $\omega$6 concentrations. Therefore, this study was done to investigate the effect of smoking on the serum lipid profile and fatty acid composition of college women. Sixty-one non-smokers and twenty-seven smokers were selected from college women students in the Seoul area. Their lipid intake, serum lipid concentration and fatty acid composition were examined. There were no differences in the general characteristics and anthropometric indices between the smokers and non-smokers. However, alcohol consumption was significantly higher in smokers than non-smokers (p<0.001). The daily caloric intake of smokers and non-smokers were 1875.84 kcal and 1915.53 kacl, respectively. On the other hand, the mean daily intake of lipids and cholesterol were significantly lower in smokers (p<0.05). In smokers, the mean concentrations of serum total cholesterol, LDL-cholesterol and the LDL-C/HDL-C ratio were higher, and the compositions of EPA and DHA were lowe than in non-smokers. There was a negative correlation between the serum triglyceride and PUFA levels in the two groups. Also, serum HDL-C correlated negatively with MUFA in smokers and non-smokers (p<0.01). These results suggest that smoking cause inadequate changes in serum lipid profile and serum fatty acid composition, thereby increasing the tendency for coronary heart disease.

• 한국식품영양과학회지
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• 제25권6호
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• pp.963-968
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• 1996

20% 생콩가루 및 생콩가루에 마그네슘 첨가 식이로 streptozotoxin 유발 당뇨쥐를 4주간 사육하여 체중, 간과 췌장무게, 혈당, 혈중 지질 농도 및 간의 지질 농도에 미치는 영향을 조사하였다. 모든 당뇨군은 당뇨병으로 인한 대사장애로 정상군에 비하여 체중이 감소되었다. 간의 총 무게는 대조군과 모든 당뇨군이 비슷한 무게를 보였으나, 체중에 대한 간 무게의 %비율은 모든 당뇨군이 대조군 보다 유의하게 증가하였다. 췌장의 무게는 대조군 및 당뇨대조군에 비하여 당뇨생콩군 및 당뇨생콩+마그네슘군이 유의하게 증가되었다. 혈당량은 당뇨대조군에 비하여 당뇨생콩군 및 당뇨생콩+마그네슘군이 각각 73% 및 44% 유의하게 감소되었으나, 정상대조군에 비하여는 당뇨생콩군 및 당뇨생콩+마그네슘군이 각각 77및 111%증가되어 정상수준으로 혈당을 낮추지는 못하였다. 혈청의 중성지질, 인지질 및 총 콜레스테를 농도는 당뇨생콩군과 당뇨생콩+마그네슘군이 당뇨대조군에 비하연 유의하게 감소되어 정상대조군과 비슷한 경향으로 혈청의 지질 농도는 정상 수준으로 개선되었다. 간의 총 지질과 중성지질 농도는 대조군에 비하여 각 당뇨군이 유의하게 감소 되었으며, 특히 당뇨생콩+마그네슘군이 가장 낮은 농도를 보였다. 인지질 농도는 당뇨생콩+마그네슘군이 유의하게 감소되었다. 그리고 간의 총 콜레스테를 농도는 각 실험군이 변화를 보이지 않았다. 혈청의 HDL-콜레스데를 농도는 대조군과 당뇨실철군이 비슷한 수준을 보였다. 이상의 결과로 보아 생콩이 당뇨쥐의 혈당을 낮추어 주는 작용이 있고, 혈청 지질대사의 개선효과 등 부분적인 개선 효과가 있는 것으로 나타났으나 앞으로 많은 연구가 이루어져야 할 것으로 사료된다.

• 한국식품영양학회지
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• 제13권4호
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• pp.312-318
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• 2000

대두(Glycin max Merrill) 배아의 기능적 활성을 조사하기 위하여 대두를 발아시켜 만든 배아(soybean sprout)을 시료로 하여 0.75% 콜레스테롤 첨가식이로 유발된 고지혈증 Sprague Dawley계 수컷의 흰쥐에 대두 배아의 유기용매 추출물을 급여시킨 후 혈청의 지질 개선효과를 알아보기 위하여 4주간 동안 대두 배아를 섭취시켰다. 식이 급여가 대조군의 체중 및 장기 무게에 미치는 영향은 거의 찾아볼 수 없었으며 혈청 총 콜레스테롤 및 LDL-콜레스테롤의 농도는 대조군에 비하여 낮았고. 콜레스테롤 식이군에 비하여 콜레스테롤 식이와 대두 배아 메탄올 추출물의 혼합투여시 낮게 나타났다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비는 대두 배아 추출물 급여군이 높게 나타났으며, 동맥경화 지수는 고콜레스테롤 식이군에 비하여 대두 배아 추출물이 낮았다. 또한 혈청중의 유리 콜레스테롤 및 고콜레스테롤 에스테르의 농도는 고콜레스테롤 식이군에 비해 대두 배아의 혼합 급여군이 감소하였고, 인지질의 농도도 콜레스테롤 식이군 보다 콜레스테롤 식이와 대두 배아 급여군이 낮은 경향을 나타내었다.