• 한국보건간호학회지
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• 제25권1호
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• pp.38-47
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• 2011

Purpose: The study investigated the effects of 9 weeks of group music rope-jumping training on health-related physical fitness and blood lipid in obese elementary school boys and girls. Method: Subjects were randomly assigned to either a training group (37 boys and 18 girls) or control group (36 boys and 19 girls). The training group exercised for 1 hour, 2 days per week during the 9-week supervised music rope-jumping training program. The control group was asked to maintain their normal daily physical activities. The effects of the interventions on physical fitness and blood lipids were analyzed by two-way repeated measures ANOVA (group ${\times}$ time). Results: There were significant group ${\times}$ time interaction effects on body weight (p<.023), %body fat (p=.09), body mass index (p=.018), and body fat mass (p=.019) in school girls. However, there was not an interaction effect on serum lipids in both genders. Conclusion: The 9-week music rope-jumping training program used was effective for improving body composition in obese elementary school girls.

• The Korean Journal of Physiology and Pharmacology
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• 제25권5호
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• pp.403-411
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• 2021

This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced rats. The gastroprotective ability was verified by determining the ulcer score, total acidity, hemoglobin, inflammatory cytokines, lipid peroxides, and enzymatic antioxidants superoxide dismutase (SOD) and catalase (CAT) in gastric tissue and serum biochemical analysis. The results showed a favorable increase in the hemoglobin level, antioxidant enzymes (SOD and CAT), restored electrochemical balance (carbon dioxide & anion gap) while a noticeable decrease in ulcer index, total acidity, lipid peroxides, inflammatory cytokines (interleukin-1 beta [IL-1β], IL-6, and tumor necrosis factor alpha) in rats treated with the cirsilineol. The serum biochemical analysis on liver markers (alkaline phosphatases, alanine aminotransferase, and aspartate aminotransferase), kidney markers (urea, creatinine, albumin, globulin, total protein), and lipid profile (triglyceride, high-density lipoprotein, total cholesterol) were attenuated by cirsilineol treatment in rats. Histopathology showed enhanced gastric protection and preserved the integrity of gastric mucosa upon cirsilineol administration. These results ultimately suggest that cirsilineol has gastroprotective effects that prevent the development of gastric ulcer.

• 한국식품영양과학회지
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• 제23권5호
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• pp.731-735
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• 1994

달팽이의 생리활성 작용을 연구하기 위하여 흰쥐를 모델동물로 하여 달팽이 엑스분을 전처리하고 strepto-zotocin(STZ)를 투여했을 때 혈중당의 농도, 지질의 변동 및 동맥경화지표와의 상관관계를 실험하였다. 달팽이 엑스분을 15일, 30일간 전처리하고 STZ투여군으로 증가하였으나 달팽이 엑스분의 투여로 감소되었다. 혈중 total cholesterol, VLDL, LDL-cholesterol 함량 및 동맥경화의 지표는 STZ 처리군에서는 증가하였으나 달팽이 엑스분의 처리로 감소되었으며 HDL-cholesterol은 STZ 처리군에서는 감소하였으나 달팽이 엑스분의 투여로 증가되었다. 한편 혈중 lipase의 활성은 STZ 처리군에서는 억제되었으나 달팽이 엑스분의 투여로 활성이 증가되었다. 이상의 실험 결과로 볼 때 달팽이 엑스분이 STZ로 유도되는 당뇨병의 예방 목적으로 유용하게 이용할 수 있는 기초자료를 제시하였다고 생각된다.

• 한국식품과학회지
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• 제39권2호
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• pp.189-193
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• 2007

This study investigated the effects of Gymnema sylvestre (GS) extract on body weight, adiposity, and lipid metabolism in leptin-deficient ob/ob mice. The experimental mice were divided into the following 4 groups: basal diet (AIN-93G diet) and 0.5%, 1%, and 1.5% GS supplemented groups. Each group was fed the experimental diet for 9 weeks. The final body weights, adipocyte sizes, and epididymal fat weights of the GS groups were significantly lower than those of the control group. There were no significant differences in food intake and food efficiency ratios among the treated groups. Serum triglyceride levels and the atherogenic index were significantly lower in the GS groups compared to the control group. Serum HDL cholesterol levels were significantly higher in the 1% and 1.5% GS groups compared to the control group. Serum glutamate oxaloacetate transaminase and glutamate pyruvate transaminase activities did not differ among the four experimental groups. The total hepatic lipid content was significantly lower in the GS groups, and hepatic cholesterol and triglyceride contents tended to be reduced in the GS groups compared to the control group. These results suggest that GS extract may be useful for ameliorating dyslipidemia and fatty liver.

• 생약학회지
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• 제37권3호
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• pp.169-176
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• 2006

This study was designed to observe the effects of Korean mistletoe(Viscum album L. var. coloratum Ohwi) hot-water extract administration on the improvement on the lipid components, apolipoprotein and blood pressure level in spontaneously hypertensive rats (SHR, Wistar strain, male) fed the experimental diets for 33 days. Concentrations of total cholesterol, triglyceride (TG), LDL-cholesterol, free cholesterol and atheroscieotic index in serum were significantly lower in the Korean mistletoe extract administration group [group KM(Korean mistletoe 10.0 g% hot-water extract)] than those in the control group. In the ratio of HDL-cholesterol concentration Korean mistletoe 10.0% hot-water extract administration group were higher percentage than in the control group. However, concentrations of total cholesterol and TG in liver and brain were significantly lower in the group KM than those in the control group. But the components of apolipoprotein (Apo) A-I and Apo A-II in serum were significantly higher in the KM group than in the control group. However, components of Apo C-II, Apo C-III, Apo E and ratio of Apo B to Apo A-I in serum were fairly reduced in the group KM than in the control group. The levels of systolic and diastolic blood pressure were significantly lower in KM cup than control group. From these results, Korean mistletoe hot-water extract administration were effective on the improvement of the lipid components, coronary heart disease and hypertension in spontaneously hypertensive rats. And particularly, Korean mistletoe extract administration were more effective as a therapeutic regimen for the control of blood pressure in hypertension.

• 대한의생명과학회지
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• 제11권3호
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• pp.383-388
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• 2005

This study reports that the effect of Mori radicis cortex, Mulberry root-bark, on the lipid peroxidation products formation in the liver, blood serum and atherosclerosis of hypercholesterolemia rabbits fed Mulberry root-bark for eight weeks. The rabbits were permitted a fixed quantity to extract of Mulberry root-bark mixed hypercholesterol fodder. The lipid peroxidation products, malondialdehyde (MDA) was significantly diminished. Total cholesterol in serum worthily decreased. Also, triglyceride and high density lipoproteins (HDLs) increased after feeding Mori radicis cortex. Besides, thicky atheromatous plaque on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by Mulberry root-bark extract. These results support and substantiate the extract of Mulberry root-bark as protection against lipid peroxidation in the liver, blood serum and atherosclerosis.

• 한국식품영양학회지
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• 제26권1호
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• pp.8-14
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• 2013

This study was performed to investigate the effects of ethanolic extract of Ulmus davidiana root (UE) on lipid metabolism in mice fed a high-fat diet (HF) for 7 weeks. Forty male ICR mice were randomly divided into four groups; normal diet group (N), high-fat diet group (HF), HF with 0.5% UE (HF-L) and 1% UE (HF-H) group. Body weight, body weight gain, and liver weight in the HF group was significantly higher than in the N group, while those of the HF-L and HF-H group were unchanged. UE improved HF-induced dyslipidemia by reducing serum triglyceride, total cholesterol, and the atherogenic index. There was no difference in serum HDL-cholesterol among experimental groups. However, the HDL-cholesterol/total cholesterol ratio was significantly increased in the HF-L and HF-H group. Histological analysis showed that HF-fed mice developed hepatocellular microvesicular vacuolation as a result of fat accumulation. These changes were attenuated by 1% UE supplementation. In addition, hepatic triglyceride and cholesterol levels in the HF-H group significantly reduced. Taken together, these results demonstrated that lipid levels in the blood and liver were reduced by UE, suggesting that it might be beneficial for the prevention and treatment of hyperlipidemia and fatty liver.

• 한국식품영양과학회지
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• 제32권8호
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• pp.1364-1369
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• 2003

해조 올리고당 함유 음료, 해조 음료 소재 및 해조 추출물 제품을 식이성 고지혈증을 유발시킨 실험동물에 처리하여 체중 증가, 혈중 지질성분 및 간 지질성분의 변화에 미치는 영향을 시험하였다. 식이성 고지혈증을 유도한 흰쥐에 해조 음료 및 해조 추출물 제품을 7일간 투여한 결과, 현저하게 증가되던 체중이 감소하였으며, 체중 대 간장의 무게비도 식이성 고지혈증 유도군에 비해 감소하였다. 혈청중 중성 지질 및 인지질의 함량은 식이성 고지혈증의 유도로 증가되던 것이 해조 음료 및 해조 추출물 제품의 투여로 감소되었으며, 식이성 고지혈증에 의한 혈청중 total-, LDL-, HDL-cholesterol및 동맥경화지수도 해조올리고당의 투여로서 조절되었다. 고지혈증의 유도로 증가되었던 간장 중의 총지질은 해조 음료 및 다시마 추출 음료의 투여로 현저히 감소되었으며, 지질 성분중에서 cholesterol의 함량은 혈청에서와 마찬가지로 크게 감소하였고, 중성 지질(TG, triglyceride)의 함량은 해조 올리고당 음료 식이로 30%와 다시마 추출 음료 식이로 45% 정도가 감소하는 것을 확인하였다.

• 동아시아식생활학회지
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• 제7권4호
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• pp.429-444
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• 1997

This study aimed at investigating correlation of nutrients intake and serum lipids in middle-aged korean male and female workers. One hundred sixty eight(male ;105, female ;63) for adult aged 30-59yr(average age male ;36.5yr, female ;44.5yr) were selected as subjects during 2 months, from April to May, 1996. Nutrients intake status was investigated by questionnaire, 24-hour recall method. Antropometric assessments, serum lipids and blood pressure of the subjects were investigated. The results as follows: 1. Nutrients intake status ; male was superior to female. Vitamin A intakes of 40-49yr group were inferior to other group but amounts of intake were above Korean RDA(recommended dietary allowances), Intakes of calcium and vitamin C of 30-39yr and over 50yr group in female were below Korean RDA. In overweights group of male and underweight group of female, most nutrients intake were increased than other groups. 2. Antropometric assessments ; female was higher than male in BMI (body mass index). All subjects increasingly with age were increased in BMI. 3. Blood components were above normal range in triglyceride in both sexes and all subjects increasingly with age were increased In level of serum lipids and blood pressure, especially in male's forty and in female's fifty were higher than other groups In serum lipids and blood pressure. In overweights group, serum lipids and blood pressure had a significantly($\alpha$=0.05) increasing tendency in both sexes. 4. Serum lipids and connected factors; atherogenic index correlated positively with triglyceride, total-chol(total cholesterol), LDL-chol(low density-lipoprotein cholesterol) and negatively with HDL-chol(high-density-lipoprotein cholesterol) significantly(P＜0.001). Systolic blood pressure correlated positively with total-chol and diastolic blood pressure correlated positively with total-chol, LDL-chol significantly(P＜0.05). 5. Serum lipids and nutrients intake status: energy correlated positively(P＜0.05) with BMI, dietary fiber correlated positively with LDL-chol(P＜0.05), calcium correlated positively with triglyceride, atherogenic index and dietary fiber correlated negatively with BMI in male significantly(P＜0.05). Triglyceride correlated positively with vitamin C and phosphorus correlated negatively with BMI in female significantly(P＜0.05). Above results, in male's forty and in female's fifty were liable to variation in terms of serum lipids and blood pressure. As increasing triglyceride, total-chol, LDL-chol and decreasing HDL-chol Increased atherogenic index that suggest increasing risk of atherosclerosis. But, this point will be considered more subdivided study.

• Nutritional Sciences
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• 제6권4호
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• pp.209-215
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• 2003

This research was performed to investigate the effects of the supplementation of multi-extracts of mori folium (MF) and of exercise on blood lipid profiles and tissue differentiation in streptozotocin (STZ)-induced diabetic rats. The animal groups consisted of a normal-control group, a STZ-control group, three STZ-induced diabetic groups supplemented ad libitum with various amounts of MF extracts (MF-720, MF-360, and MF-180 groups), and a STZ-induced diabetic group supplemented with MF-360 combined with exercise; eight male Sprague-Dawley rats, 4 weeks old, were assigned to each experimental group and were raised in the laboratory for a 10 week experimental period. The MF supplementation group showed a significant reduction in levels of serum total cholesterol and triglyceride compared to the STZ-control group. HDL-cholesterol levels were significantly increased in the MF supplementation group compared to STZ-control group. The ratio of HDL-cholesterol to total cholesterol was significantly higher in MF supplementation group compared to the STZ-control group. The Atherogenic Index (AI) values in the MF supplementation groups were found to be significantly lower than in the STZ-control group. Serum AST and ALT levels were significantly reduced in the MF-supplementation groups compared to the STZ-control group. Total cholesterol level in the liver tissue was significantly decreased in the MF-360 group and in the MF-360 + exercise group compared to the STZ-control group. In immunohistochemical staining of the pancreatic islets of the MF-supplemented groups, a significantly higher number of insulin-immunoreactive cells were observed compared to the STZ-control group. In the MF supplementation groups, Bowman's capsules were clearly observed as hypertrophy of the glomeruli was not obvious. In the MF supplementation groups, a relative reduction in the hypertrophy of the basement membrane of the glomeruli and a significant reduction in the mesangium were observed compared to the STZ-control group. The results of this study suggest that supplementation of MF has beneficial effect in improving plasma lipid and tissue metabolism in streptozotocin-induced rats.