• 환경생물
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• 제21권2호
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• pp.189-193
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• 2003

본 연구는 여자 축구선수 25명을 대상으로 혈중 지질성분과 철분지표를 조사 .분석하고, 훈련기 동안의 철분보충이 혈청 지질과 지단백 콜레스테롤에 미치는 영향을 살펴보았다. 여자축구선수들의 평균연령은 23.3$\pm$2.5세였고, 평균 신장과 체중은 각각 164.4$\pm$5.7cm과 57.4$\pm$4.6kg이었고, 체지방율은 23.9$\pm$3.0%였다. 혈액 철분지표 분석결과 평균 적혈구 용적, 헤모글로빈, 총철결합력은 정상범위 내에 있었으나 낮은 수준이었으며, 특히 평균 페리틴 (ferritin) 농도는 18.7$\pm$ 19.7 ${\mu}g$ $1^{-1}$로 낮았다. 혈청 지질과 지단백 분석 결과, 중성지질은 81.7$\pm$26.3mg $dl^{-1}$로 정상이나, 총 콜레스테롤과 LDL 콜레스테롤은 224.3$\pm$58.3 mg $dl^{-1}$과 162.2$\pm$59.0 mg $dl^{-1}$으로 높게 나타났다 상관관계 분서 결과 운동선수들의 적혈구 세포수가 많을수록 중성지질 농도가 낮고, 평균 적혈구 용적이 클수록 HDL-콜레스테롤 농도가 높아서 선수들의 철분 상태가 바람직할수록 혈액 지질 상태가 바람직한 것으로 나타났다. 한편, 철분 보충 여부는 혈청 지질 상태에 영향을 미치지 않았고,4주간 하계 훈련은 철분 투여에 관계없이 혈청 중성지방과 콜레스테롤을 낮추는 경향으로 나타났다. 결론적으로 여자 프로 축구 선수들의 혈청 굴성지질은 정상 범위 내에 속했으나, 콜레스테롤, 특히 LDL-콜레스테롤 수준이 정상보다 높았으며, 단기간의 철분 보충은 혈청 지질과 지단백 콜레스테롤에 큰 영향을 미치지 않았다.

• Preventive Nutrition and Food Science
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• 제16권3호
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• pp.202-209
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• 2011

This study was initiated to investigate the effects of lyophilized purslane (Portulaca oleracea) powder (5% and 10%) on lipid levels in rats fed a hypercholesterolemia-inducing diet (1% cholesterol). During the four week study, there were no significant differences in either weight change or the food efficiency ratio between the group fed the hypercholesterol diet alone (HC) and the groups fed the purslane powder (HCPO-I and HCPO-II, 5% and 10% purslane, respectively). In serum, the levels of total lipid, total cholesterol and LDL-C decreased significantly for the group fed the 10% purslane powder (HCPO-II) in comparison with the group fed the 5% purslane powder (HCPO-I). The atherogenic index (AI) was reduced by about 51% for the group fed the 10% purslane powder (1.47) in comparison with the HC group (3.03). The activities of GOT, GPT, ALP and LDH decreased significantly for the groups fed the purslane powder in comparison with the HC group. Regarding liver tissue, the levels of total lipid, total cholesterol and triglyceride decreased significantly for the purslane powder-fed rats compared to the HC group. The fecal lipid profiles increased significantly as the amount of purslane powder was increased. Compared to the HC group, the fecal total cholesterol and triglyceride levels were higher in the group fed the 10% purslane powder by about 2.8 times and 2.3 times, respectively. For the serum and liver tissue, the content of lipid peroxide decreased significantly in the groups fed purslane powder compared to the HC group. The data from this experiment show an increase in the lipid levels discharged in feces, suggesting that the supplementation of purslane powder to a hypercholesterolemia-inducing diet reduces lipid levels.

• Journal of Nutrition and Health
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• 제31권3호
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• pp.263-270
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• 1998

The purpose of this study was to investigate the effect of Lycii fructus on the serum lipid in rats fed high fat diet. We compared the effects of L. fructus and L.fructus water extract both adminstered with high fat diets on rats that had previously been on high fat or standard diets. Two separate experiments were conducted for 6 weeks. respectively. In experiment I, 4 groups of rats were fed experimental diets consisting of either \circled1 6 weeks of a standard diet(control), \circled2 6 weeks of a high-fat diet(HHC), \circled3 3 weeks of a high-fat diet followed by 3 weeks of a high-fat diet containing L. fructus(HHL) or \circled4 6 weeks of a high-fat diet with L. fructus extract in place of water for the last 3 weeks (HHT). In the second set of experiments, a high-fat diet (SHC), high-fat diet containing L.fructus(SHL) or high-fat diet with L. fructus extract in place of water (SHT) were fed for 3 weeks after 3 weeks of standard diet feeding. Rats fed L. fructus diet consumed more diets than high-fat diets. THe results of experiment I showed significant decreases(p<0.05) in serum triglyceride(TB) and low density lipoprotein-cholesterol (LDL-C) levels with L. fructus feedings, but did not show andy changes in total cholesterol (TC) level. High density lipoprotein-cholesterol (HDL-C) level was increased significantly(p<0.05) with L. fructus feedings. Therefore, the ration of LDL-C to HDL-C(LDL-C/HDL-C) which is used as an atherosclerosis index was significantly (p<0.05) low, while the HDL-c/TC ration was significantly(p<0.05) high with L.fructus intake. However, no significant were found in serum cholesterols and TG levels in experimentII. The results of these experiments indicate that , regardless of the feeding from, L. fructus can be beneficial in lowering serum TG and LDL-C levels for habitual high-fat diet intakers. L.fructus also seems to be effective in elevating serum HDL-C level, theregy having beneficial effects on atherosclerosis by influencing the serum lipoprotein profile.

• Journal of Nutrition and Health
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• 제38권4호
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• pp.289-296
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• 2005

This study was performed to investigate the effect of dietary $\beta$-carotene supplementation on lipid peroxide levels and antioxidant enzyme activities in alcoholic fatty liver rats. Forty five Sprague-Dawley male rats aging 8 weeks were used as experimental animals, which were divided into the control diet (CD) and the ethanol diet (ED) and the ethanol + $0.02\%$ $\beta$-carotene diet (EPD) groups and fed the experimental diet respectively for 5 weeks. After the feeding, rats were sacrificed to get blood and liver to analyze lipid and lipid peroxide levels and antioxidant enzyme activities. The mean body weight and food intake of the ethanol diet group was significantly lower than that of the control diet. The liver index (LI) of the ethanol diet group was significantly higher than those of the control diet and the $\beta$-carotene supplementation group. Serum levels of total lipid, triglyceride of the ethanol diet group were significantly higher than those of the control diet and the $\beta$-carotene supplementation group. Total cholesterol levels were not significantly different among all groups. HDL-cholesterol of the ethanol diet group was significantly lower than those of the control diet and the $\beta$-carotene supplementation group. Liver TBARS of the ethanol diet group was significantly higher than those of the control diet and the $\beta$-carotene supplementation group. Liver lipofuscin and conjugated diene levels were not significantly different among all groups. The superoxide dismutase activity of the ethanol diet group was significantly lower than those of the control diet and the $\beta$-carotene supplementation group. Catalase and glutathione peroxidase activities were not significantly different among all groups. Because v-carotene supplementation significantly decrease the serum total lipid, triglyceride, liver TBARS revels and increase the superoxide dismutase activity in alcoholic ratty liver rats, $\beta$-carotene supplementation seems to give beneficial effect for the alcoholics.

• 동아시아식생활학회지
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• 제25권2호
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• pp.278-286
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• 2015

The overall purpose of this study was to investigate the effects of Chunggukjang and Greentea-Chunggukjang on the lipid profile, lipid peroxidation and antioxidative enzyme activities of liver tissue in growing male rats fed cholesterol. Twenty seven rats were divided into three treatment groups (Control, Chunggukjang and Greentea-Chunggukjang) and were given experimental diets with 1% cholesterol for 9 weeks. All rats in this study were fed a casein-based diet. Chunggukjang groups were fed diet containing 33.1% Chunggukjang powder. The Chunggukjang and Greentea-Chunggukjang groups showed significantly lower weight gain, food efficiency ratio than the control group regardless of Chunggukjang type. Serum total cholesterol was significantly lower in the Chunggukjang group than in the control group, whereas serum triglyceride and atherogenic index were significantly lower in the Greentea-Chunggukjang group than in the control group. Hepatic triglyceride contents was not significantly different among the diets. However, hepatic cholesterol content was significantly lower in the Greentea-Chunggukjang group than in the control group. Lipid peroxidation of malondialdehyde (MDA) contents was significantly lower in the Chunggukjang and Greentea-Chunggukjang groups than in the control group. Activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in liver tissue of the Chunggukjang and Greentea-Chunggukjang groups were not significantly different. It can be concluded that Chunggukjang and Greentea-Chunggukjang influence lipid profile and hepatic malondialdehyde contents in growing male rats fed cholesterol.

• 대한예방한의학회지
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• 제10권1호
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• pp.67-74
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• 2006

Objectives: This study was carried out to establish the normal values of Serum Total Cholesterol, HDL-cholesterol by age and sex for healthy adult and the frequency of dyslipidemia as a risk factor of coronary atherosclerosis. Methods: Total cholesterol, and HDL-cholesterol measured among 14,485 in general growing people (8,712 males and 5,773 females) aged 20 to 69 years and analyzed to use the auto-analyzer Hitach 7600 in enzyme method. Result: 1. The levels of total cholesterol, HDL-cholesterol and atherogenic index were slightly positively correlated with age in both sexes. The mean values of serum lipid profiles were $190{\pm}32.9mg/dl$ in men and $181{\pm}32.8mg/dl$ in women for cholesterol, $50.1{\pm}11.4mg/dl$ in men and $54.5{\pm}12.0mg/dl$ in women for HDL-cholesterol, $3.9{\pm}1.0$ in men and $3.4{\pm}0.8$ in women for atherogenic index. 2. Mean values of total cholesterol and atherogenic index higher in men than in women at the age 20-40 years but significantly higher in women than in men at the age group 60 years.(p<0.001) 3. The frequency of hypercholesterolemia(${\geq}200mg/dl$) and low HDL-cholesterol(<35mg/dl) were increased with age in both sexs, significantly higher in women at the age group 60 years. The frequency of hypercholesterolemia(${\geq}200mg/dl$) and low HDL-cholesterol(<35mg/dl) in men and women was 37.5%, 25.3%, and 5.5%, 2.8%. Their requencies were higher in men than in women. Conclusion: Theses findings suggest that the mean concentrations of total cholesterol and HDL-cholesterol in men and women vary with age. The frequency of hypercholesterolemia(${\geq}200mg/dl$) in men and women was about 31.4% and increased with age.

• 한국식품영양과학회지
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• 제31권2호
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• pp.284-289
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• 2002

동의보감에서 소갈증에 응용되는 옥천산 분말이 당뇨 암쥐의 혈당, 혈청과 간의 지질 및 단백질 농도에 미치는 영향을 조사하고자, 평균체중 313.6$\pm$18.5 g되는 Spraque-Dawley계 암쥐를 정상군, 당뇨 대조군 및 당뇨 옥천산군 등 3군으로 나누어 각 실험식 이로 5주간 사육한 결과는 다음과 같다. 5주간 체중변화는 정상군은 3.5 g 증가하였으나, 당뇨 대조군과 당뇨 옥천산군은 당뇨로 인한 대사장애로 각각 97.8 g과 99.1 g씩 체중이 감소되었다. 췌장의 무게는 정상군에 비하여 당뇨 대조군은 유의하게 증가되었으나 당뇨 옥천산 군은 정상군과 비슷하였다. 비장의 무게는 정상군에 비하여 당뇨 대조군과 당뇨 옥천산군이 유의하게 감소하였다. 혈청의 중성지질, 총 콜레스테롤, LDL-콜레스테를 및 간의 콜레스테를 농도는 당뇨 옥천산군이 당뇨 대조군보다 유의하게 감소되어 정상군과 비슷한 수준을 보였다. HDL-콜레스테를 농도와 HDL-콜레스테롤/총 콜레스테롤의 비율은 정상군과 당뇨 실험군들이 비슷한 수준을 보였다. 동맥경화지수 및 혈당량은 정상군에 비하여 당뇨 실험군들이 증가하였다. 간의 총 지질 및 중성지질 농도는 정상군에 비하여 당뇨 대조군과 당뇨 옥천산군이 유의하게 감소되었다. 혈청의 단백질과 알부민 농도는 정상군에 비하여 당뇨 대조군과 당뇨 옥천산군이 유의하게 감소되었다. 이상의 결과로 보아 당뇨 쥐에 옥천산 분말이 혈당 및 동맥경화지수를 낮추는 효과는 없었으나, 혈청의 중성지질, 총 콜레스테롤, LDL-콜레스테를 및 간의 콜레스테를 농도를 낮추는 효과가 나타났다.

• 생명과학회지
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• 제12권1호
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• pp.1-7
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• 2002

약용 및 가공 식품 등의 재료로 활용되고 있는 대추의 가공 부산물 중 대추씨(Zizyphus jujuba seed)의 각종 생리 활성물질을 구명하여 생체 대사학적 측면에서 검증하고 당뇨병 등 성인병 예방 및 치료효과에 대한 개선 방안을 검토하여 기능성 건강음료 등의 자원으로서 이용 가능성을 검토하기 위하여, Sprague Dawley계 숫 횐쥐에 기본식이를 급여한 대조군(1군)과 streptozotocin(STZ 55mg/kg B.W., I.P injection)으로 유발된 당뇨성 실험동물군(2군), 당뇨유발 실험군에 대추씨 3.5g% 추출액(3군)을 각각 급여하여 4주간 실험 사육한 결과는 다음과 같다. 혈당 농도, 혈청 총 콜레스테롤 농도, 동맥경화지수, LDL 및 LDL-콜레스테롤, 유리 콜레스테롤, 콜레스테롤 에스테르, 중성지방 및 인지질 농도 등은 STZ으로 유발된 당뇨성 실험동물군(2군)에 비해 대추씨 생리활성 추출액 급여군(3군)에서 저하 효과를 관찰할 수가 있었다. HDL-콜레스테롤 농도 및 총콜레스테롤에 대한 HDL-콜레스테롤의 농도비는 2군 보다 대추씨 추출액을 급여한 3군의 농도 및 비율이 높은 것으로 나타났다. AST, ALT, LDH 및 ALP 활성변동은 2군에 비해 대추씨 추출액을 급여 (3군) 함으로써 감소되는 것으로 나타났다. 이상의 결과들을 미루어 볼 때, 대추씨 중의 생리활성 물질이 혈당 및 혈청의 지질 개선 효과가 있는 것으로 사료되며, 당질 및 지질대사 장애 등에서 오는 당뇨병 등 성인병 예방 및 개선에 효과가 있을 것으로 추정된다.

• Journal of Community Nutrition
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• 제4권3호
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• pp.151-158
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• 2002

The purpose of this study was to investigate the correlations among the anthropometry, serum lipid levels and nutrient intake in Korean female university students. The subjects were 119 female students at a university located in Incheon. This study was conducted using a self-administered questionnaire. Anthropometric data were measured and blood lipid levels were analyzed. Nutrient intake collected from 3 day-recalls was analyzed by the Computer Aided Nutritional Analysis Program. The data were analyzed by SPSS 10.0 program. Average age, height and weight of the subjects were 20.9 years, 160.1cm and 54.3kg, respectively. Average serum TG (triglyceride), total cholesterol, HDL-C (high density lipoprotein-cholesterol) and LDL-C (low density lipoprotein-cholesterol) levels of the subjects were 69.47mg/dl, 146.85 mg/dl, 50.49mg/dl and 82.52mg/dl, respectively. Average AI (atherogenic index) of the subjects was 2.03, which was in the normal range based on risk values. Average intake of most nutrients except protein, vitamin B$_1$, vitamin C and phosphorus were lower than the Korean RDA. Especially calcium and iron intakes of the subjects were under 65% of the Korean RDA. Serum TG, total cholesterol and LDL-C levels were negatively correlated with DBP (diastolic blood pressure). HDL-C/LDL-C and HDL-C/total cholesterol were positively correlated with height. Age was positively correlated with phosphorus intake. DBP of the subjects was positively correlated with calcium and iron intakes. Serum TG level was positively correlated with total cholesterol, HDL-C, LDL-C and AI, while negatively correlated with HDL-C/total cholesterol. Total cholesterol level was positively correlated with HDL-C, LDL-C and AI, while negatively correlated with HDL-C/LDL-C, HDL-C/total cholesterol. HDL-C level was positively correlated with LDL-C, HDL-C/LDL-C and HDL-C/total cholesterol, while negatively correlated with AI. LDL-C level was negatively correlated with HDL-C/LDL-C and HDL-C/total cholesterol, while positively correlated with AI HDL-C/LDL-C ratio was positively correlated with HDL-C/total cholesterol and AI. HDL-C/total cholesterol was negatively correlated with AI. Fat intake was positively correlated with total cholesterol, HDL-C level, and vitamin B$_2$ intake was positively correlated with TG, HDL-C/LDL-C. Therefore, nutrition education is necessary for female university students to promote the lipid profile and to optimize the nutritional status. (J Community Nutrition 4(3) : 151∼158, 2002)

• 한국식품영양과학회지
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• 제34권5호
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• pp.626-631
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• 2005

새송이버섯이 고지방식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 성숙한(생후 21주령) 숫쥐에 표준식 이에 $20\%$ 돈지를 첨가한 식이를 급여한 대조군, 대조식이에 새송이 버섯 분말을 $3\%$ 및 $5\%$씩 첨가한 식이를 급여한 군($3\%$ 및 $5\%$ 새송이버섯군) 등 3군으로 나누어 10주간 사육한 결과는 다음과 같다. 실험동물의 체중증가량 및 식이효율은 대조군에 비하여 $3\%$ 및 $5\%$ 새송이버섯군이 유의하게 감소되었다. 간과 신장 및 부고환지방의 무게는 대조군과 새송이버섯군들이 비슷하였다. 간의 총 지질 및 중성지질 농도는 대조군에 비하여 새송이버섯군들이 유의하게 감소 되었다. 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 새송이 버섯군들이 유의하게 감소되었다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 새송이버섯군들이 유의하게 증가되었다. 변의 g당 총 지질배설량은 새송이버섯군이 대조군보다 유의하게 증가된 것으로 나타났다. 이상의 결과로 보아 고지방식이에 새송이버섯 분말 첨가 급여시 흰쥐 간의 중성지질 농도, 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수를 낮추고, 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율을 증가시키는 것으로 나타났다.