• Journal of Nutrition and Health
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• 제31권8호
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• pp.1307-1314
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• 1998

Chrominum (cr) plays an important role in carbohydrate and lipid metabolism , and Cr deficiency impairs glucose tolerance and increases serum cholestero and triglyceride. The relationship of serum Cr with serum blucose and lipids was examined in 79 female college students in Choong-Nam areas. Subjects were divided into underweight , normal , and overweight groups according to their BMI. The average age, wiegth , height and BMI were 21.9yr, 55.9kg, 158.5cm and 22.6kg/$m^2$, respectively. Heights were not different between groups. Serum Cr and glucose concentrations werenot significantly different between groups. However, there was a tendency toward lowered serum Cr levels in under and over-weight groups. Serum cholesterol and LDL-cholesterol concentrations were significant lower in the underweight group than in other groups. BMI had positive correlation with LDL-cholesterol , AI and LPH , and negative corelations with HDL -cholesterol /total cholesterol ratio. Low serum Cr concentration was related to increased LDL-cholesterol and total cholesterol, and related to decreased HDL cholesterol in all groups . Therfore, serum Cr levels were lowered in abnormal weight groups and Cr may playan important role in coronrary heart diesease.

• Journal of Nutrition and Health
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• 제14권3호
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• pp.136-145
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• 1981

This study was designed to observe the effects of both control and atherogenic diets on the cholesterol and triglyceride (TG) in serum and liver of adult rats fed diets supplying two levels of dietary fat and two different sources of dietary protein in early life. For the first experimental period, the rats were assigned into the four diet groups: High fat, casein (HC); High fat, gluten (HG); Low fat, casein (LC): Low fat, gluten (LG). Each group was subdivided into control and atherogenic groups for the second experimental period. Cholesterol and TG were determined in serum and liver after 7 hr fasting. The body weight gain was greater in the rats of the casein groups than those of the gluten groups tut not influenced by the level of the dietary fat. The difference in body weight from the quality of dietary protein in the first period was not disappeared even after the second period. After the first period, higher serum cholesterol was observed in the rats fed either casein or high fat diets. With the second experimental diet, rats fed atherogenic diet showed higher serum cholesterol concentration but lower serum TG levels compared to those fed control diet, regardless the diets fed in the first period. Serum cholesterol level of the rats of both groups which had been fed high fat diets in early life was increased compared to those of the low fat diet groups. This effect was more pronounced with the atherogenic diet groups than control groups. However, no differences were found in serum cholesterol levels resulted from the different types of dietary protein fed in the first period. Serum TG concentration was not influenced by the quality of protein and level of fat in the diet but seemed to be mere affected by the amount of carbohyrates in the diet. Liver cholesterol per unit weight was greater in the gluten diet groups than in the casein groups but total cholesterol was higher in casein fed rats. There were no differences in liver TG among the groups.

• 한국식품영양과학회지
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• 제24권1호
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• pp.121-126
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• 1995

The purpose of this study was to investigate the effects of Natto supplementation on lipid metabolism in rats. Male rats were fed on casein(CON group), steamed soybean(SS group), conventional Natto(N-1 group), garlic(2%) added Natto(N-2 group), red pepper oleoresin(0.2%) added Natto(N-3 group) and galic(2%) and red pepper oleoresin(0.2%) added Natto(N-4 group) as a protein source for 4 weeks. Serum and liver cholesterol levels were significantly lower in the experimental groups than in the control group. Especially, dietary N-2, N-3 and N-4, compared with CON, reduced markedly the concentration of serum cholesterol. The concentration of serum HDL-cholesterol was higher markedly in the N-4 group than in the control group. The concentration of serum triglyceride was significantly lower in the N-1, N-2, N-3 and N-4 groups than in the control group. Garlic and red pepper added Natto fed groups(N-2, N-3, N-4) showed more excreion of fecal bile acid when compared with those values of casein fed group. The results indicate that spice added Natto supplementation may have more beneficial roles in lipid metabolism through reduced cholesterol levels and increased fecal bile acid excretion.

• Journal of Nutrition and Health
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• 제32권4호
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• pp.437-447
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• 1999

The intake of fatty acids, and the effects of fatty acid intake patterns on serum lipid concentrations was investigated in 112 postmenopausal women. Dietary intakes of fatty acids were assessed by means of a semi-quantitative food questionnaire with food models and other measuring tools. The intakes of saturated fatty acid(SFA), monounsaturated fatty acid(MFA) and polyunsaturated fatty acid(PUFA) were 10.85g, 11.89g and 12.09g, respectively. The ratios of P/M/S and $\omega$6/$\omega$3 fatty acid were 1.19 : 1.10 : 1 and 6.65 ; 1, respectively. Serum lipid concentrations were adjusted for age, menopausal period, BMI, stress scores, exercise habit and energy intake and the relationship between fatty acid intake and serum lipids was measured using Pearson's correlation coefficient. Serum cholesterol concentration was positively correlated with dietary intake of SFA (p<0.10), MUFA(p<0.05), palmitic acid(p<0.10), stearic acid(p<0.05), oleic aicd(p<0.05), and arachidonic acid(p<0.10). Serumk LDL-cholesterol concentration was positively correlated with MUFA(p<0.10), oleic acid(p<0.10), oleic acid(p<0.10), and arachidonic acid (p<0.10). Serum triglyceride concentration was positively correlated with arachidonic acid(p<0.10). However, serum HDL-cholesterol concentration was not found to be significantly correlated with any fatty acids.

• 대한예방한의학회지
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• 제9권1호
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• pp.105-118
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• 2005

Objectives : The purpose of this study is to investigate the effects of Polygonum multiflorum THUNB(何首烏) on decresing concentration of serum lipid which are triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol. Thiobarbituric Acid Reactive(TBARS) in high cholesterol diet induced hyperlipidemia rats. Methods : Sprague-Dawley rats were divided into 3 groups, Normal group (supplied enough water and feeds only, Normal Group), high fat diet administered group(AIN-76 high fat diet #100496 used beef tallow for 4 weeks, Control Group) and Polygonum multiflorum THUNB(何首烏). administered group(AIN-76 high fat diet #100496 used beef tallow and Polygonum multiflorum THUNB(何首烏) extracts 85.0mg/200g 1time/day for 4 weeks, HSO Group). Rats were sacrificed and concentration of triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol, TBARS were measured in rat's serum lipid. Results : There was no significant difference in the level of weigh between Control and HSO Group.(by Duncan test) Concentration of Total lipid has no significant difference in each group. (F=0.702, p=0.511, ANOVA test) Concentration of triglyceride has no significant difference in each group. (F=0.727, p=0.500, ANOVA test) Concentration of LDL-cholesterol was significantly different in each group.(F=.9.894. p=0.002, ANOVA test) It was significantly increased in the Control group compared with the Normal group and it significantly decreased in the HSO group compared with the Control group. Concentration of HDL-cholesterol has no significant difference in each group. (F=1.079, p=0.365, ANOVA test) TBARS values(Thiobarbituric Acid Reactive Substances) were significantly different in each group.(F=15.580, p=0.0001, ANOVA test) It was significantly increased in the Control group compared with the Normal group and significantly decreased in HSO group compared with the Control group. Conclusions : According to the above results, it is considered that Polygonum multiflorum THUNB(何首烏) is effective in decreasing concentration of serum lipid in high cholesterol diet induced hyperlipidemia rats.

• 한국식품영양학회지
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• 제21권3호
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• pp.328-335
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• 2008

The principal objective of this study was to assess the effects of chitosan oligosaccharide supplementation on the improvement of blood glucose, lipid components and enzyme activities in the serum of streptozotocin(STZ, 55 mg/kg B.W., I.P. injection)-induced hyperglycemic rats fed on experimental diets for 5 weeks. The concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, triglycerides(TG) and phospholipids(PL) in serum were remarkably higher in the hyperglycemic group(group BSW) and STZ(I.P.)+chitosan oligosaccharide supplementation group(group ECW) than those in the control group(group BW, basal diet+water). However the concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, tree cholesterol, cholesteryl ester ratio, TG and PL in serum were lower in the ECW group than in the BSW group, whereas the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration in the ECW group were higher than in the BSW group. The activities of alkaline phosphatase(ALP) and aminotransferase(AST, ALT) in serum were lower in the ECW group than in the hyperglycemic BSW group. The results shown above suggested that chitosan oligosaccharide supplementation effectively improves blood glucose, lipid composition and enzyme activities in the sera of STZ-induced hyperglycemic rats.

• 한국식품영양과학회지
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• 제30권1호
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• pp.107-111
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• 2001

This study was carried out to investigate the effect of Meristotheca papulosa on lipid concentration of serum and liver in rats fed high fat diet for 4 weeks. Experimental groups ere divided into normal group (5% corn oil), high fat diet group (5% corn oil+20% lard), high fat diet and 5% or 10% Meristotheca papulosa treated group. The weights of kidney, heart and tests were not significantly different among the group, but weight of liver was significantly decreased by supplement of Meristotheca papulosa (10%). The contents of serum total lipid, trigly-ceride, total cholesterol, free cholesterol, cholesterol ester and atherogenic index were decreased, while HDL-cholesterol was increased by Meristotheca papulosa supplementation compared to high fat diet group. Meristotheca papulosa supplement has obvious effects on lowering hepatic total lipid, triglyceride and total cholesterol. Our findings suggest that Meristotheca papulosa supplement can improve lipid metabolism in high fat fed rats.

• 한국식품영양과학회지
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• 제28권2호
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• pp.492-500
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• 1999

The aim of this study was to assess the association between total vitamin A, retinol and carotene intakes and serum concentration of total carotenoids in Korean male smokers and nonsmokers. Food frequency and nutrient intakes of 64 healthy college students were estimated by the 24 hour recall method and food frequency questionnaire and analyzed by smoking status. Serum total cartenoids and lipid profiles were measured in 28 smokers and 36 nonsmokers. The mean total vitamin A, retinol and carotene intakes of smokers were not significantly different from nonsmokers. However, carotene intakes of the smokers who have smoked more than 5 packyears were significantly lower than those of nonsmokers. Smokers consumed green yellow leafy vegetables more often(P=0.005) and fresh fruits less often(P=0.017) than nonsmokers. The serum total carotenoids of smokers consuming the same amount of retinol and carotene as nonsmokers, 1.79 g/ml, were 17% lower than nonsmokers, 2.15 g/ml(P<0.05). The lipid profiles including total cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides of smokers were not significantly different from nonsmokers, however, the concentration of HDL cholesterol of smokers were significantly higher than that of nonsmokers. The serum carotenoids concentration was positively associated with fruit consumption frequency in smokers, and also was positively associated with green yellow leafy vegetable consumption frequency in non smokers. There were no correlations between dietary and serum carotenoids for smokers as well as nonsmokers. It was concluded that smoking could be inversely related to the serum concentration of carotenoids at constant carotene intakes and smokers might require more carotene to reach the same concentration comparable to nonsmokers.

• 한국영양학회:학술대회논문집
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• 한국영양학회 1998년도 춘계학술대회 초록
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• pp.49-49
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• 1998

Chrominum(cr) plays an important role in carbohydrate and lipid metabolism and Cr deficiency impairs glucose tolerance and increase serum cholestrol and triglyceride. The relationships of serum Cr with serum glucose and lipids was examined in 79 female college students in Choong-Nam ares. Subjects were devided into underweight. normal and overweight groups according to their BM11. The average age, weight, height and BMI were 21.9yr, 55.89kg, 158.54cm and $22.62kg/m^2$, respectively. Height were not di fferent between groups. Serum Cr and glucose concentrations were not signi ficantly different between groups. However, there were tendency of increasing serum Cr level with increasing body weight. Serum cholesterol and LDL-cholesterol concentrations were significantly lower in underweight group than other groups. BM! had positive corelations wi th LDL-cholesterol, Al and LPH, and negative corelations with HDL-cholesterolltotal cholesterol ratio. Serum Cr concentration had positive corelation with serum glucose concentration and negative corelation with LDL-chloestrol and LPH.nd LPH.

• 대한지역사회영양학회지
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• 제5권2호
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• pp.289-296
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• 2000

The purpose of this study was to investigate the relationship and lipids in healthy adults on self-selected diets. These subjects consisted of 40 female college students residing in Chungnam. Anthropometric measure-ments, diet intake measurements, and blood collection were conducted. Serum concentrations of 5 microminerals(As, Cr, Mn, Se, Ni), lipids(triglyceride, total cholesterol, HDL-cholesterol), and glucose were measured by an ICP spectrometer and biochemical analyzer. The results were as follows. The mean age of the subjects was 22.34 years and the mean weight, height, and BMI were 52.89kg, 161.29cm and 20.34, respectively. The mean serum concentrations appeared to be 14.60ug/dl(As), 1.87ug/dl(Cr), 0.18ug/dl(Mn), 23.50ug/dl(Se), 0.21ug/dl(Ni), 60.73mg/dl(triglyceride), 138.49mg/dl(total cholesterol), 65.95mg/dl(HDL-cholesterol), 60.39mg/dl(LDL-cholesterol) and 88.82mg/dl(glucose). When analyzed by Pearson’s correlation coefficient, the serum concentration of Cr was negatively correlated with Ca and vitamin B12 intake(p〈0.05, p〈0.05) respectively, Mn was negatively correlated with Na intake(p〈0.05), Ni, however, was positively correlated with K intake(p〈0.05). The serum concentration of Se was positively correlated with LDL-cholesterol(p〈0.05), Ni, however, negatively correlated with total cholesterol, HDL-cholesterol, LDL-cholesterol, and glucose, respectively(p〈0.001, p〈0.01, p〈0.05). Further studies are needed to clarify the precise micromineral intakes, nutritional assessment of microminerals, and cause-effect relation of microminerals and serum lipids.