• 생물정신의학
• /
• 제3권2호
• /
• pp.258-261
• /
• 1996

Objective : Several studies hove suggested that reduction of cholesterol concentration and low cholesterol level increases suicide, homicide, and depression. The authors sought to determine whether low cholesterol is associated with a history of suicidal attempts among major depression patients. Method : The subjects were 105 patients with major depression, diagnosed according to the DSM-III-R criteria, and 105 age, sex matched healthy controls. Blood was token following overnight fast and serum cholesterol concentration were measured by a enzymatic method Results : The serum cholesterol level was significantly lower in the patients with major depression than in healthy controls($180.4{\pm}43.4mg/dl$ vs $199.7{\pm}35.8mg/dl$). And the serum cholesterol level was significantly lower in major depression patients with suicidal attempt than in major depression patients without suicidal attempt($156.7{\pm}38.2mg/dl$ vs $ 187.8{\pm}42.5mg/dl$) Conclusion : It is hypothesized that low cholesterol level is associated with depression by modifying the serotonin metabolism and the production of interleukin-2, low cholesterol concentration should be further investigated as a potential biological marker of suicidal risk in major depression. Prospective study with serial cholesterol determinations should be done.

• 동아시아식생활학회지
• /
• 제9권1호
• /
• pp.27-34
• /
• 1999

This study was carried out to investigate the effects of the kinds and the amounts of dietary fiber on serum lipid composition in rats. Seventy-two male Sprague-Dawley rats weighting 160$\pm$10g were fed diets containing 1.0%, 3.6%, 6.0% and 10.0% $\alpha$-cellulose, pectin and alginic acid fer 4 weeks. Daily food intake of experimental groups was significantly higher in the u-cellulose 10.0% group than in the other groups. Increasing the dietary fiber level decreased the food efficiency ratio of the $\alpha$-cellulose, pectin and alginic acid groups. Serum triglyceride concentration was significantly lower in the rats fed the alginic acid diet. Serum total cholesterol concentration showed no significant difference in the kind and the amount of three dietary fibers. Serum HDL-cholesterol concentration was higher in $\alpha$-cellulose and pectin diet. HDL-cholesterol/total cholesterol ratio was higher in u-cellulose and pectin diet than alginic acid diet. In conclusion, alginic acid is good for the serum triglyceride decrease, pectin is good for HDL-cholesterol increase, $\alpha$-cellulose and alginic acid are good for HDL-cholesterol/total cholesterol ratio increase. But the different effects according to the dietary fiber's contents did not show a significant trend.

• 한국식품영양과학회지
• /
• 제19권2호
• /
• pp.180-186
• /
• 1990

For the investigation of the effects of G. lucidum on prevention and attention of hypercholeste-rolemia and atherosclerosis dietary hypercholesterolemic rats were fed with 2.0g% G. lucidum extracts for 4 weeks. And then concentrations of total cholesterol triglyceride phospholipid in serum and liver and those of HDL-cholesterol lipid peroxide glucose in serum were analyzed. Concentration of total cholesterol in serum was the lowest in the control group(basal diet+ wa-ter) and HDL-cholesterol in serum were significantly higher in groups of control 2(hyperchole-sterolemic ratslongrightarrowbasal+water) and 4(hypercholesterolemic ratslongrightarrowbasal+G.l. extract) The concentration of triglyceride in serum were signficantly lower in groups 4 and 5(hypercholeste-rolemic ratslongrightarrowcholesterol+G. l. extract) than in the control group. Phospholipid content in serum were not significantly different among all groups. Ttal cholesterol in liver was significa-ntly higher in hypercholesterolemic rats than in the control group and triglyceride concentration were signficantly higher in groups of 3(hypercholesterolemic ratslongrightarrowcholesterol+water) and 5 than others. Phospholipid in liver was significantly higher in group 3 than in the control group but groups of 4 and 5 were lower. As for lipid peroxide in serum was the lowest in group 4 and glucose concentration was lowest in group 5 than in other groups.

• 대한약리학회지
• /
• 제17권2호
• /
• pp.69-74
• /
• 1981

Increased incidence of myocardial infarction, arteriosclerosis and hypertension in oral contraceptive steroids users has been recognized as serious problem. Evidence have been accumulated that oral contraceptive steroids cause an increase in serum lipid levels, mainly triglyceride as well as an increase in serum cholesterol concentration in some women. Effect of oral contraceptives on serum lipids have been predominantly confirmed in Europian and American women. It should be emphasized that effects of contraceptives may he influenced by differences in nutrition, climate, socioeconomic status and race. The present study was, therefore, attempted to determine the effect of oral contraceptive steroids on serum lipid levels in Korean women and also to demonstrate whether the duration of pill treatment may affect serum lipid levels. Ten women, who had never taken contraceptive steroids, served as a control. One hundred women on combined oral contraceptive steroids were grouped according to the duration of pill use: duration of less than one year(14 women), 1-2 years(12 women), 2-5 years(29 women), 5-10 years(33 women) and more than 10 years(13 women). Serum levels of cholesterol, phosholipid and triglyceride were measured by enzymatic method, Fiske-SubbaRow method and Sugiura method respectively. The results obtained are as follows; 1) Oral contraceptive steroids increased serum cholesterol concentration by 4.8% as compared with cholesterol value of control group. But this increase was not statistically significant. 2) As compared with control value, concentration of serum phospholipid in pill-treated women decreased by 14.3%, which was statistically significant (p<0.05). 3) Concentration of serum triglyceride in pill-treated women increased by 10.6% over control value, but this increase was not statistically significant. 4) Duration of pill-treatment did not affect serum concentrations of cholesterol, phospholipid and triglyceride. From the results mentioned above, it may be concluded that combined oral contraceptive steroids, at least used for subjects involved in this study, decreased serum phospholipid significantly, thereby influencing serum lipid concentration.

• 한국식품영양학회지
• /
• 제25권4호
• /
• pp.1047-1054
• /
• 2012

The purpose of this study was to compare the anthropometry, serum lipid levels, dietary behavior and health-related behaviors of shipbuilding workers. The education level was significantly higher in office workers than laborers, while age, monthly income and working years were not significantly different between both groups. The serum triglyceride, glucose concentration and AI were significantly higher in office workers than in laborers, but the serum LDL-cholesterol and HDL-cholesterol concentrations were significantly higher in laborers than in office workers. The frequency of breakfast and coffee intake was significantly higher in office workers than in laborers. In the office workers, age was positively correlated with systolic blood pressure but was negatively correlated with hemoglobin and hematocrit concentration In the laborers, working year was negatively correlated with hemoglobin, total cholesterol and serum LDL-cholesterol concentrations. Exercise was negatively correlated with total cholesterol concentration, triglyceride and LDL-cholesterol concentration and AI in the office workers. The results of this study showed that office workers are more prone to related chronic degenerative diseases. Therefore, nutritional education for the provention of chronic degenerative diseases of shipbuilding workers needs to be more focused on improving the health status of office workers.

• 동아시아식생활학회지
• /
• 제8권1호
• /
• pp.1-8
• /
• 1998

This study was designed to investigate the optimum recommendation level on Gatrodia rhizoma and the effects on the improvement of the lipids in the dietary hypercholesterterolemic rats. Experimental diets mixed with 5% Dioscorea batatas(Group 2), 10% Dioscorea batatas(Group 3), 15% Dioscorea batatas (Group 4) 5% Gastrodia rhizoma (Group 5), 10% Gastrodia rhizoma (Group 6), and 15% Gastrodia rhizoma (Group 7), were administered to the male rats of the Sprague Dawley for 3 weeks. Concentration of total cholesterol in serum was lower in the Gastrodia rhizoma groups than in the other groups, especially total cholesterol concentration of 10% Gastrodia rhizoma(Group 6) was the lowest in the Gastrodia rhizoma groups. Concentration of HDL-cholesterol in serum was higher in the 10% Gastrodia rhizoma and 15% Gastrodia rhizoma than in the other groups. Concentrations of cholesteryl ester, LDL, LDL-cholesterol in serum were the lowest in the 10% Gastrodia rhizoma. Concentration of glucose and activity of GPT in serum were the lowest in the 10% Gastrodia rhizoma group. The activity of GOT in serum was lower in the 10% Gastrodia rhizoma group and 15% Gastrodia rhizoma group than in the other groups. Therefore, we consider that there are effects on the improvement of the lipids in the Gastrodia rhizoma and the optimum recommendation quantity of Gastrodia rhizoma is 10% to quantity of food composition.

• Journal of Nutrition and Health
• /
• 제20권1호
• /
• pp.38-45
• /
• 1987

This study was performed to investigate the effect of dietary vitamin E supplement and kinds of lipid on the vitamin E concentration and lipid composition in serum of the rats fed fro seven weeks. Supplemented vitamin E was 300mg/kg diet as DL-α-tocopherol acetate, and 15% of corn oil or beef tallow was added to standard diet. The results were as follows ; 1) Body weight and feed efficiency ratio were significantly increased by supplement with vitamin E, corn oil and beef tallow. 2) Serum vitamin E concentration increased significantly by supplement of vitamin E and beef tallow on the diets, while one of corn oil fed group decreased significantly . 3) The contents of triglyceride, total cholesterol, phospholipid in serum were significantly increased in the beef tallow group, and the vitamin E only -supplemented group showed significantly lower serum cholesterol in serum increased significantly in the vitamin E only -fed group and vitamin E plus corn oil-fed group. 4) The content of HDL-cholesterol in serum increased significantly in the vitamin E only -fed group and vitmain e plus corn oil -fed group. 5) The ratio of VLDL, LDL-cholesterol content to HDL-cholesterol one in serum was significantly low in the vitamin E only-supplemented group and corn oil group, and was significantly higher in the beef tallow group than in the corn oil group.

• 생약학회지
• /
• 제27권3호
• /
• pp.246-253
• /
• 1996

Coptis rhizoma was extracted with methanol or hot water. Methanol extracts had higher berberine content than water extracts, whereas the contents of Ca, Mg, Zn and K were higher in the water extracts. Rats were fed on the purified diets rich in 0.12% cholesterol only or supplemented with 0.5% of each extracts for four weeks. The concentration of total serum cholesterol was significantly lower in the rats given the extracts, irrespective of the extractants. Although the concentration of serum HDL-cholesterol was comparable among the groups, the ratio of HDL-/total-cholesterol was higher in rats given the extracts. The concentration of serum free fatty acids and ketone body were significantly elevated in rats given the extracts. On the other hand, the extracts supplements significantly decreased the contents of liver cholesterol and triacylglycerol. The amount of fecal bile acids was markedly higher in rats given the extracts, especially in those given water extracts. The results show an effective hypocholesterolemic action of Coptis rhizoma and it seems that the lower concentration of serum and liver cholesterol is resulted from the increased fecal bile acids in rats.

• 생명과학회지
• /
• 제8권5호
• /
• pp.532-536
• /
• 1998

식이성 고지혈증 유발 Sprague Dawley계 숫흰쥐를 사용하여 용담 열수 추출액을 급여하므로써 혈당 및 혈청의 지질 개선 효과를 규명하기 위해 4주간 실험 사육한 결과, 혈당 농도는 대조군인 1군(물)에 비해 2군(콜레스테롤+물) 및 3군(콜레스테롤+용담추출액)이 높게 나타났으며, 콜레스테롤과 용담 추출액을 급여한 3군이 2군(콜레스테롤+물)보다 다소 낮은 경향을 보였지만 혈당 저하효과는 유의성있게 관찰되지 않았다. 혈청중 총콜레스테롤 농도는 2군에 비하여 3군이 유의적으로 낮게 나타났다. LDL-콜레스테롤 농도는 2군에 비해 3군에서 유의성있게 감소하였으며, 총콜레스테롤에 대한 HDL-콜레스테롤 농도비는 용담 추출액 급여군이 높게 나타났다. 혈청 유리 콜레스테롤 및 콜레스테롤 에스테르 농도는 콜레스테롤 급여군인 2군에 비해 용담 추출액 급여군(3군)이 유의성 있게 감소하였다. 중성지질 및 인지질 농도는 3군의 농도가 낮았다. 혈청 AST 및 ALT활성은 대조군에 비하여 여타 실험군에서 증가하는 경향을 보였다. 이상의 결과에서, 용담 열수 추출액이 식이성 고지혈증 흰쥐에 대한 혈청지질 개선효과가 다소나마 있는 것으로 사료된다.

• Journal of Nutrition and Health
• /
• 제30권2호
• /
• pp.187-194
• /
• 1997

The effects of diet induced hyperlipidemia on kidney function were studied in Sprague-Dawley rats fed high fat diet containing 20% beef tallow and high cholesterol diet containing 5% cholesterol for 8, 12, 16 weeks, respectively. The concentrations of serum total lipid, total cholesterol and LDL-cholesterol were significantly high cholesterol diet groups during all experimental periods (p<0.05). HDL-cholesterol concentration was the lowest value in high cholesterol diet group of 16 weeks(p<0.05). Triglyceride concentration was not affected by experimental diets. Serum total protein, albumin and creatinine concentration tended to higher in high cholesterol diet groups than those in high fat diet groups. And serum urea-N concentration was higher in high fat diet group of 16 weeks than that in other diet groups. Urinary total protein and urea-N were higher in high cholesterol diet groups than those in other diet groups regardless of experimental period period. There was no significant difference in urinary creatinine concentratin among diet groups(p<0.05). GFR was lower in high cholesterol diet groups than that in high fat diet groups at 8, 16 weeks, respectively. Wet weight per body weight, total lipid, triglyceride, total cholesterol concentations of liver tissue were apparently high in high cholesterol diet groups(p<0.05). Kidney wet weight per body weight wer not affected by experimently diets, total lipid concentration of kidney tissue was significantly high in high fat diet groups of 12 weeks(p<0.05), kidney tissue triglyceride concentrations of high cholesterol diet groups of 12, 16 weeks apparently low, and total cholesterol concentration of kidney tissue was higher in experimental diet groups than that of control groups at 12, 16 weeks(p<0.05). Fecal excretion, total lipid, triglyceride and cholesterol concentrations of feces were markedly high in all high cholesterol diet groups except high fat diet group of 16 weeks. The results of light microscopic examination indicated that glomerulosclerosis was not obsrved in rats fed experimental diets.