• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2771-2776
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• 2014

Background: Breast cancer screening and higher quality mammography have resulted in an increase in the diagnosis of ductal carcinoma in situ worldwide. We compared the incidence and other factors in our cases of ductal carcinoma in situ between two recent decades. Materials and Methods: Medical records of cases of ductal carcinoma in situ who had been admitted to the surgery wards of the Cancer Institute of Tehran, Iran were evaluated from March 1993 to March 2003 as phase 1, and from April 2003 to April 2013 as phase 2. Results: Ratio of ductal carcinoma in situ to overall breast cancer was 1.27 and 3.93 in phases 1 and 2, respectively. Rates of excisional or incisional biopsies versus core needle biopsies and clinically versus mammographically detected cases as well as median size of tumors dropped between the 2 phases while a substantial rise in the number of patients attending for screening was seen in this time period. Surgical treatments followed a trend from modified radical mastectomy and axillary lymphatic dissection toward breast conserving surgery and sentinel node dissection or no axillary intervention. Conclusions: Our study shows a considerable trend toward earlier detection of breast cancer and evolution of treatment strategies toward standard less invasive surgery of DCIS in Iran.

• Journal of Preventive Medicine and Public Health
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• v.41 no.4
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• pp.219-224
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• 2008

Due to heightened concerns regarding possible bioterrorist attacks, the Korea Center for Disease Control and Prevention introduced syndromic surveillance systems, which have been run by emergency departments in hospitals throughout Korea since 2002. These systems are designed to identify illness clusters before diagnoses are confirmed and reported to public health agencies, to mobilize a rapid response, and thereby to reduce morbidity and mortality. The Korea Center for Disease Control and Prevention performed drop-in syndromic surveillance successfully during the World Cup Football Games in 2002, the Universiad games in 2004, and the Asian Pacific Economic Cooperation meeting in 2005. In addition, sustainable syndromic surveillance system involving the collaborative efforts of 125 sentinel hospitals has been in operation nationwide since 2002. Because active data collection can bias decisions a physician makes, there is a need to generate an automatic and passive data collection system. Therefore, the Korea Center for Disease Control and Prevention plans to establish computerized automatic data collection systems in the near future. These systems will be used not only fur the early detection of bioterrorism but also for more effective public health responses to disease.

• Journal of the korean society of oceanography
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• v.37 no.2
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• pp.82-89
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• 2002

Butyltins (BTs) were measured in 2 species of shellfish and 16 species of fish collected along the Korean coast. Tributyltin (TBT) was detected in the mussels and oysters of sentinel organisms (20 to 940 ng Sn/g dry wt), indicating widespread contamination of TBT in the Korean coast. The elevated concentrations of TBT in the shellfish found in the sites near harbors or shipyards suggested that antifouling paints are probable major sources of butyltins in these areas. The TBT compound was detected in 12 out of 16 fish samples. The concentrations of TBT in fish muscles wee between 7 and 151 ng Sn/g dry wt, while the level in whole body of anchovy was very high (793 ng Sn/g dry wt). Exposure doses to Korean people via consumption of these marine products wee evaluated. The results suggested that the environmental levels of TBT were below the level of concern.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5057-5061
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• 2016

The present study was conducted to assess error rates with diagnosis using intra-operative frozen sections, and to indicate ways to increase overall performance. Over a period of two years, 227 cases were biopsied intra-operatively. Errors were observed in 14 cases. Four of these were sampling errors, one by a pathologist and three by surgeons. In seven cases incorrect interpretations were made. Epithelial dysplasia was observed on definitive histology in two cases which was not reported intra-operatively. One case was of ectopic thyroid. In cases of oral cancer where sentinel lymph nodes were sampled, immunohistochemistry for cytokeratin was performed to facilitate identification of micrometastasis. Only single case displayed tumor deposits which was not evident morphologically. Resection margins were reported in seventy eight cases. Some 18% (14/50) benefited from revision of margins; overall sensitivity of intra-operative frozen sections for marginal status was 71.4%, with a specificity of 90.3%. Overall sensitivity was 75% and specificity was 97.5%. Careful observation, pathologist experience and knowledge of limitations help in improving the overall diagnostic outcome.

• Fisheries and Aquatic Sciences
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• v.20 no.6
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• pp.8.1-8.18
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• 2017

Background: Metallothionein (MT) is a multifunctional protein playing important roles in homeostatic regulation and detoxification of metals. Mollusk species have been considered as useful sentinel platforms for MT-based biomarker approaches, and they have been reported to display an extraordinary structural diversity of MT proteins. However, potential diversity of molluskan MTs has not been fully explored and recent updates have suggested the need of revision of evolutionary hypothesis for molluskan MTs. Results: Based on bioinformatic analysis and phylogenetic evidences, novel divergence mechanisms and paths were hypothesized in both gastropod and bivalve MT groups. Our analyses are suggestive of the taxon- or lineage-specific domain multiplication/duplication from the ancestral or prototypic MT. Diversification and selection of molluskan MTs might be driven by the needs for acquiring metal selectiveness, specialized novel function, and improved capacity of metal detoxification under environmentally stressed conditions. Conclusion: The structural diversity and variations of molluskan MTs are significantly larger than previously understood. Undoubtedly, molluskan MTs have undergone dynamic divergent processes in their evolutionary histories, giving rise to the great diversity of domain structures in extant MT isoforms. Novel evolutionary paths for molluskan MTs newly proposed in this review could shed additional light onto the revision of the hypothesis for evolutionary differentiation of MTs in the molluskan lineage.

• Korean Journal of Ecology and Environment
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• v.43 no.1
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• pp.24-34
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• 2010

This study was carried out to analyze some influences on ecological health conditions, threaten by various stressors such as physical, chemical and biological parameters. We collected samples in 2008 from three zones of upstream, midstream and downstream, Gap Stream. We applied multi-metric fish assessment index (MFAI), based on biotic integrity model to the three zones along with habitat evaluations based on Qualitative Habitat Evaluation Index (QHEI). We also examined fish fauna and compositions, and analyzed relations with MFAI values, QHEI values, and various guild types. Chemical parameters such as oragnic matter (BOD, COD), nutrients (TP, $NH_3$-N), coli-form number (as MPN), and suspended solids (SS) were analyzed to identify the relationship among multiple stressor effects. Using the sentinel species of Zacco platypus, the population structures and condition factors were analyzed along with DNA damages related with genotoxicant effects by comet assay. This study using all these parameters showed that stream condition was degraded along the longitudinal gradient from upstream to downstream, and the downstream, especially, was impacted by nutrient enrichment and toxicant exposure from the point source, wastewater treatment plant. Overall results indicated that our approaches applying various parameters may be used as a cause-effect technique in the stream health assessments and also used as a pre-warning tool for diagnosis of ecological degradation.

• Perspectives in Nursing Science
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• v.13 no.1
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• pp.1-9
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• 2016

Purpose: The purpose of this study was to identify the current state of research on healthcare professionals who make medical errors, who are known as "second victims", and support systems for them. Methods: An extensive search was conducted in electronic databases, Google, and websites related to patient safety using search terms such as "second victims", "medical errors", "adverse events", and "sentinel events". Results: Research to date in Korea has rarely focused on healthcare professionals' experiences after making medical errors. Abroad, there are comprehensive and systematic reviews of the impact of medical errors on healthcare professionals, their coping responses, and support systems for these second victims. Additionally, several institutes related to patient safety provide official guidelines and accessible support systems to support second victims in the aftermath of medical errors, especially serious adverse events. Conclusion: The impact of medical errors on healthcare professionals is profound and complex. Although systematic support systems for second victims are imperative, this has been overlooked in Korea. Thus, more research about the experiences of healthcare professionals after medical errors needs to be conducted prior to developing support systems or programs. Additionally, further efforts are required to raise awareness of the necessity of supporting healthcare professionals in healthcare systems.

• Journal of Korean Academy of Nursing Administration
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• v.15 no.2
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• pp.169-181
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• 2009

Purpose: The purpose of this study was to examine the effect of patient surveillance on nurses' adherence to the guidelines on peripheral vascular catheter management. Method: A one group time series design was used. Seventy six nurses participated in the study. The data were collected from October 1 to November 4, 2008. Result: The effects of patient surveillance were significant on nurses' average adherence rates to the guidelines estimated by observers and by themselves, and the levels of nurses self recognition on the importance of the guidelines. In addition, overall occurrence rates of phlebitis tend to decrease after patients surveillance. Even though 33 nurses didn't follow the guidelines perfectly, most patients did not provide feedbacks to the nurses' non-adherence. Among the nurse participants, 36.8% answered that patient surveillance was acceptable. Conclusion: This study found that patients with peripheral catheters could positively influence nurses' adherence to the catheter management guidelines. Therefore, inviting patients in nursing activities could benefit to the quality of patients care. However, it seems essential to create an environment fostering nurses' acceptance of the patients' surveillance. Further research warrants the potential benefits of the patient's participations in nursing activities.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.66-66
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• 2019

침수흔적도는 풍수해로 인한 침수기록(침수심, 침수위, 침수시간 등)을 조사하여 표시한 도면으로 자연재해 경감 및 신속한 대피를 위하여 작성하도록 자연재해대책법에 따라 규정되어있다. 이러한 침수흔적도는 국가 방재에 따른 기초자료로 사용되지만 광범위한 지역을 신속 정확하게 조사하기에는 예산 부족 및 관리 미흡으로 한계가 있다. 따라서 본 연구는 2018년 10월초 경북 영덕군에서 발생한 태풍 콩레이 침수피해사상을 대상으로 위성영상기반 침수판별지도를 작성하였고, 이를 실제자료와 비교하여 침수흔적도 작성 시 첨단영상의 활용가능성을 확인하였다. 위성영상으로는 ESA의 Sentinel-1과 PlanetLab사(社)의 PlanetScope를 활용하였고, 검증에 활용한 자료는 CCTV를 영상자료를 활용하여 정확성을 평가하였다. 침수심과 침수규모를 확인하기 위해 사용한 지형자료는 10m DEM자료와 드론영상자료를 통해 구축한 DSM을 활용하였다. 그 결과 위성영상을 활용한 침수판별지도는 실제 CCTV영상자료와 높은 상관관계를 보이는 것으로 나타났으며, 드론영상을 통해 지형자료를 구축한 경우 DEM에 비해 정확도가 높아지는 것을 확인할 수 있었다. 또한 위성영상자료의 해상도가 높을수록 실제자료와 유사하게 침수규모를 판별할 수 있는 것으로 나타났다. 첨단영상을 활용한 침수흔적도 작성은 기존조사보다 신속하고 광범위하게 자료를 수집할 수 있을 것으로 기대한다.

• Journal of the Korean Medical Association
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• v.61 no.11
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• pp.655-661
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• 2018

Incidence of basal and squamous cell carcinoma is increasing among Korean. With increasing this incidence we need to attend the management and prevention of these cutaneous malignancies. Basal cell carcinoma (BCC) is the most common skin malignancy. Sun exposure is the most important environmental cause of BCC. Daily sun protection especially avoiding sun exposure between 10 a.m. and 4 p.m. provides most effective prevention against chronic ultraviolet-induced skin damage. Hedgehog pathway inhibitors are used locally advanced and metastatic BCC lesions in Korea. Until recently, there are no reports whether it developed resistance of Hedgehog pathway inhibitors with advanced BCC in Korean patients. Among malignant skin tumors, 19.1% were squamous cell carcinoma (SCC). The incidence of SCC was rapidly increased over the past years. However, the incidence rate of SCC in Japan has not been changed from the period 1976-1980 to 1986-1990. Sentinel lymph node biopsy for SCC did not provide diagnostic value. Bowen's disease and Erythroplasia of Queyrat are considered as carcinoma in situ of the skin. Erythroplasia of Queyrat have worse prognosis with a higher rate of malignant degeneration. Dermoscopy may helpful tool in assisting the noninvasive diagnosis of carcinoma in situ of the skin.